WHAT IS LDH?

•Enzyme found in a variety of tissues

• Different isoforms

• Role is inter-conversion of pyruvate

& lactate

• Is also a marker of tissue damage

CORI CYCLE

www.wikipedia.org

ROLE OF LDH: A NEW VIEW

Brooks et al. 1999

IMPLICATIONS FOR ENDURANCE

Brooks suggests interval training –

use O2 to “burn” lactate in the

mitochondria:

• Build more mitochondria

• Increase lactate transporter

molecules (MCT-1)

SUMMATION

1. Role of LDH in maintaining muscle

pH

2.Importance of high-intensity

training for LDH production