wang chung han. asd impaired brain development behavioral cognitive physical abnormalities social...
TRANSCRIPT
ASDimpaired brain development BehavioralCognitivephysical abnormalitiessocial interaction
Gut distressdysbiosis of the microbiotainflammatory bowel diseaseObesitycardiovascular disease
INTRODUCTION
Mice and humansocial Emotionalanxiety-like behaviorsbrain development and function
EXPERIMENTAL PROCEDURES(maternal immune activation;MIA)Mice
i.p. on E12.5 with saline or 20 mg/kg poly(I:C)
OffspringBacteroides fragilis
every other day for 6 days at weaning
Intestinal Permeability4 kDa FITC-dextran
Behavioral Testing
MIA Offspring Exhibit GI BarrierDefects
DSS:Dextran sulfate sodium S:saline+vehicleP:poly(I:C)+vehicle