OFFICIAL JOURNAL OF THE CONTROLLED RELEASE SOCIETYAND THE JAPANESE SOCIETY OF DRUG DELIVERY SYSTEM

VOLUME 247, 10 FEBRUARY 2017 ISSN: 0168-3659

COVER STORYMegakaryocytic microparticles for targeted delivery to hematopoietic stem cells

Vol. 247 JOURNAL OF CONTROLLED RELEASE 10 FEBRUARY 2017

CONTENTS

Cited in: BIOSIS/Biological Abstracts; CAB Abstracts; Chemical Abstracts Services; Current Contents (Life Sciences); EMBASE/Excerpta Medica; International Pharmaceutical Abstracts; PUBMED/MEDLINE/Index Medicus; Polymer Contents; Science Citation Index. Also covered in the abstract and citation database Scopus®. Full text available in ScienceDirect ®

Available online at www.sciencedirect.com

05054

Cover Story Megakaryocytic microparticles for targeted delivery to hematopoietic stem cells

K. Park (West Lafayette, USA) 206

Reviews Safe approaches for camptothecin delivery: Structural analogues and nanomedicines

P. Botella and E. Rivero-Buceta (Valencia, Spain ) 28 Topical and cutaneous delivery using nanosystems

M. Roberts , Y. Mohammed , M. Pastore , S. Namjoshi , S. Yousef , A. Alinaghi , I. Haridass , E. Abd , V. Leite-Silva , H. Benson and J. Grice ( QLD, Adelaide, Perth, Australia ) 86

Nanomedicines for dysfunctional macrophage-associated diseases H. He , S. Ghosh and H. Yang ( Richmond, USA ) 106

Research papers How do megakaryocytic microparticles target and deliver cargo to alter the fate of hematopoietic stem cells?

J. Jiang , C.-Y. Kao and E.T. Papoutsakis (Newark, USA) 1 Rapid and facile quantitation of polyplex endocytic trafficking

M. Lazebnik and D.W. Pack ( Urbana, Lexington, USA ) 19 Sequential HIFU heating and nanobubble encapsulation provide efficient drug penetration from stealth and temperature sensitive

liposomes in colon cancer J. VanOsdol , K. Ektate , S. Ramasamy , D. Maples , W. Collins , J. Malayer and A. Ranjan ( Stillwater, USA ) 55

Inhomogeneous crystal grain formation in DPPC-DSPC based thermosensitive liposomes determines content release kinetics T. Lu and T.L.M. ten Hagen ( Rotterdam, The Netherlands ) 64

Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers R.M. England , J.I. Hare , J. Barnes , J. Wilson , A. Smith , N. Strittmatter , P.D. Kemmitt , M.J. Waring , S.T. Barry , C. Alexander and M.B. Ashford ( Cheshire, Cambridge, Newcastle upon Tyne, Nottingham, UK ) 73

Liposome encapsulated berberine treatment attenuates cardiac dysfunction after myocardial infarction I.E. Allijn , B.M.S. Czarny , X. Wang , S.Y. Chong , M. Weiler , A.E. da Silva , J.M. Metselaar , C.S.P. Lam , G. Pastorin , D.P.V. de Kleijn , G. Storm , J.-W. Wang and R.M. Schiffelers (Enschede, Utrecht, Groningen, The Netherlands; Singapore; Aachen, Germany ) 127

Encapsulation of two different TLR ligands into liposomes confer protective immunity and prevent tumor development B. Bayyurt , G. Tincer , K. Almacioglu , E. Alpdundar , M. Gursel and I. Gursel ( Ankara, Turkey ) 134

A smart aminoglycoside hydrogel with tunable gel degradation, on-demand drug release, and high antibacterial activity J. Hu , Y. Quan , Y. Lai , Z. Zheng , Z. Hu , X. Wang , T. Dai , Q. Zhang and Y. Cheng ( Shanghai, China ) 145

An intraocular drug delivery system using targeted nanocarriers attenuates retinal ganglion cell degeneration L. Zhao , G. Chen , J. Li , Y. Fu , T.A. Mavlyutov , A. Yao , R.W. Nickells , S. Gong and L.-W. Guo ( Madison, USA; Shenyang, Dalian, Shanghai, China ) 153

Longitudinal monitoring of skin accumulation of nanocarriers and biologicals with fiber optic near infrared fluorescence spectroscopy (FONIRS) J.I. Griffin , M.J. Benchimol and D. Simberg ( Aurora, San Diego, USA ) 167

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For a full and complete Guide for Authors, please go to http://www.elsevier.com/locate/jconrel

A simple and highly effective catalytic nanozyme scavenger for organophosphorus neurotoxins E.N. Efremenko , I.V. Lyagin , N.L. Klyachko , T. Bronich , N.V. Zavyalova , Y. Jiang and A.V. Kabanov ( Moscow, Russia; Chapel Hill, Omaha, USA ) 175

Toll-like receptor 2 promiscuity is responsible for the immunostimulatory activity of nucleic acid nanocarriers M. Pizzuto , M. Gangloff , D. Scherman , N.J. Gay , V. Escriou , J.-M. Ruysschaert and C. Lonez ( Brussels, Belgium; Cambridge,UK; Paris, France ) 182

Biodegradable nanoparticle delivery of inactivated swine influenza virus vaccine provides heterologous cell-mediated immune response in pigs S. Dhakal , J. Hiremath , K. Bondra , Y.S. Lakshmanappa , D.-L. Shyu , K. Ouyang , K.-i. Kang , B. Binjawadagi , J. Goodman , K. Tabynov , S. Krakowka , B. Narasimhan , C.W. Lee and G.J. Renukaradhya (Wooster, Columbus, Ames, USA; Gvardeiskiy, Kazakhstan ) 194

Graphical Abstracts Contents Listing doi: 10.1016/S0168-3659(17)30030-5 e1

Calendar I

Official Journal of the Controlled Release Society and of the Japanese Society of Drug Delivery System

The Journal of Controlled Release (JCR) publishes high-quality research articles in the broad field of delivery science and technology. This includes drug delivery systems and all aspects of formulations, such as physicochemical and biologicalproperties of drugs, design and characterization of dosage forms, release mechanisms, in vivo testing, and formulation research and development in the disciplines of pharmaceutical, diagnostic, agricultural, environmental, cosmetic, and food industries. Manuscripts that advance fundamental understanding of principles and/or demonstrate advantages of novel technologies in safety and efficacy over current clinical standards will be given priority. Each issue has the cover story highlighting thesignificance of a selected article published in the issue. At the end of each quarter, the JCR editors select “The Editors’ Choice” from the published research articles.

M.J. Alonso, Santiago de Compostela, SpainT.L. Bowersock, Kalamazoo, MI, USAX. Chen, Changchun, ChinaP. Colombo, Parma, ItalyP. Couvreur, Chatenay-Malabry, FranceM.C. Davies, Nottingham, UKA.J. Domb, Jerusalem, IsraelR. Duncan, Cardiff, UKL. Ensign, Baltimore, MD USAE. Fattal, Chatenay-Malabry, FranceM. Foldvari, Waterloo, CanadaB. Gander, Zürich, SwitzerlandH. Ghandehari, Salt Lake City, UT, USAG. Golomb, Jerusalem, IsraelD.W. Grainger, Salt Lake City, UT, USAR. Gurny, Geneva, SwitzerlandM. Hashida, Kyoto, JapanJ.A. Hubbell, Lausanne, SwitzerlandL. Illum, Nottingham, UKS.Y. Jeong, Seoul, KoreaT. Jin, Shanghai, ChinaA.T. Jones, Cardiff, UK

A. Kabanov, Omaha, NE, USAK. Kataoka, Tokyo, JapanY. Kawashima, Gifu, JapanJ. Kopecek, Salt Lake City, UT, USAG.S. Kwon, Madison, WI, USAS.J. Lee, Seoul, KoreaC.M. Lehr, Saarbrücken, GermanyK.W. Leong, Baltimore, MD, USAT. Li, Lexington, KY, USAK. Mäder, Halle (Saale), GermanyH. Maeda, Kumamoto, JapanE. Mathiowitz, Providence, RI, USAA.G. Mikos, Houston, TX, USAT. Minko, Piscataway, NJ, USAS.M. Moghimi, Stockton on Tees, United KingdomR. Niven, Half Moon Bay, CA, USAH. Okada, Tokyo, JapanT. Okano, Tokyo, JapanD.W. Pack, Urbana, IL, USAN.A. Peppas, Austin, TX, USAY. Perrie, Birmingham, UKM. Prausnitz, Atlanta, GA, USA

D. Putnam, Ithaca, NY, USAT. Rades, Copenhagen, Denmark M.J. Rathbone, Kuala Lumpur, Malaysia A.P. Rolland, San Diego, CA, USAK. Roy, Atlanta, GA USAW.M. Saltzman, New Haven, CT, USAR.A. Siegel, Minneapolis, MN, USAJ. Siepmann, Lille, FranceP.S. Stayton, Seattle, WA, USAY. Sugiyama, Tokyo, JapanH.-W. Sung, Hsinchu, TaiwanK. Takayama, Tokyo, JapanI. Uchegbu, London, UKK. Ulbrich, Prague, Czech RepublicA. Urtti, Helsinki, FinlandE. Wagner, Munich, GermanyC. Wang, Minneapolis, MN, USAC.-H. Wang, SingaporeC.O. Yun, Seoul, KoreaQ. Zhang, Beijing, ChinaZ. Zhong, Suzhou, China

Founding EditorsProf. J. Feijen, University of Twente, The NetherlandsDr. J. Heller, USA

EDITORS

EDITOR-IN-CHIEFProf. K. Park, Purdue University, Departments of Biomedical Engineering and Pharmaceutics, West Lafayette, IN, USA; E-mail: kpark@purdue.eduAssociate Editors for the AmericasProf. Y.H. Bae, Dept. of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 421 Wakara Way, Salt Lake City, UT 84108, USA; E-mail: you.bae@utah.eduProf. S. Mitragotri, Dept. of Chemical Engineering, University of California at Santa Barbara, Mail Code 5080, Santa Barbara, CA 93106, USA; E-mail: samir@engineering.ucsb.eduProf. S.P. Schwendeman, Dept. of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109, USA; E-mail: schwende@umich.edu

EDITORS FOR EUROPEEditorProf. S.C. De Smedt, Ghent Research Group on Nanomedicines, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium E-mail: Stefaan.desmedt@ugent.beAssociate EditorsProf. T.G.G.M. Lammers, Department of Experimental Molecular Imaging, RWTH Aachen University Clinic, Pauwelsstrasse 30, 52074 Aachen, Germany; E-mail: tlammers@ukaachen.deProf. J.-C. Leroux, Inst. of Pharmaceutical Sciences, Eidgenössische Technische Hochschule (ETH) Zürich, Wolfgang-Pauli-Str. 10, 8093 Zürich, Switzerland E-mail: jleroux@ethz.ch Prof. D. Peer, Department of Cell Research and Immunology, Tel-Aviv University Ramat Aviv, Tel-Aviv, 69978 Israel; E-mail: peer@post.tau.ac.il

EDITORS FOR ASIAEditorProf. I.C. Kwon, Biomedical Research Center, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-Dong, 136-791 Seongbuk-Gu, Seoul, South Korea; E-mail: ikwon@kist.re.krAssociate EditorsProf. H. Harashima, Lab. Mol. Design of Pharmaceutics, Fac. of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-ku, 060-0812 Sapporo, Japan; E-mail: harasima@pharm.hokudai.ac.jpProf. A. Kikuchi, Dept. of Materials Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika, 125-8585 Tokyo, Japan; E-mail: kikuchia@rs.noda.tus.ac.jpProf. Y. Oh, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742 Korea; Email: ohyk@snu.ac.kr

Review EditorProf. V.P. Torchilin, Pharmaceutical Sciences, Northeastern University, 360 Huntington Ave., Boston, MA 02115-5000, USA; E-mail: v.torchilin@neu.eduSpecial Issue Editor Prof. W.E. Hennink, Dept. of Pharmaceutics, Utrecht Inst. for Pharmaceutical Sciences, Universiteit Utrecht, Universiteitsweg 99, 3584 CG Utrecht, NetherlandsTheme Issue EditorProf. J. Hanes, The Wilmer Eye Institute, Johns Hopkins School of Medicine, 400 N. Broadway, Baltimore, MD, USA; E-mail:hanes@jhmi.eduConcept Papers EditorProf. Y.H. Bae, Dept. of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 421 Wakara Way, Salt Lake City, UT 84108, USA; E-mail: you.bae@utah.eduAdvisorProf. T. Nagai, E-mail: nagai-t@mbc.ocn.ne.jp

Editorial Board

Additional material available online.