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OFFICIAL JOURNAL OF THE CONTROLLED RELEASE SOCIETYAND THE JAPANESE SOCIETY OF DRUG DELIVERY SYSTEM

VOLUME 199, 10 FEBRUARY 2015 ISSN: 0168-3659

COVER STORYTissue penetration of bacteria into quiescent regions of tumors

Vol. 199 JOURNAL OF CONTROLLED RELEASE 10 FEBRUARY 2015

CONTENTS

Cited in: BIOSIS/Biological Abstracts; CAB Abstracts; Chemical Abstracts Services; Current Contents (Life Sciences); EMBASE/Excerpta Medica; International Pharmaceutical Abstracts; PUBMED/MEDLINE/Index Medicus; Polymer Contents; Science Citation Index. Also covered in the abstract and citation database Scopus®. Full text available in ScienceDirect ®

Available online at www.sciencedirect.com

05054

Cover Story Tissue penetration of bacteria into quiescent regions of tumors

K. Park (West Lafayette, USA) 198

Reviews Amphiphilic poly(amino acid) based micelles applied to drug delivery: The in vitro and in vivo challenges and the corresponding

potential strategies H. Xu , Q. Yao , C. Cai , J. Gou , Y. Zhang , H. Zhong and X. Tang (Shenyang, Nanchang, PR China) 84

Development of topical therapeutics for management of onychomycosis and other nail disorders: A pharmaceutical perspective M.M. A. Elsayed ( Alexandria, Egypt ) 132

Research Papers In vivo evaluation of different formulation strategies for sustained release injectables of a poorly soluble HIV protease inhibitor

J. Meeus , D.J. Scurr , K. Amssoms , K. Wuyts , P. Annaert , M.C. Davies , C.J. Roberts and G. Van den Mooter (Leuven, Beerse, Belgium; Nottingham, UK ) 1

An assessment of the ability of the obstruction-scaling model to estimate solute diffusion coeffi cients in hydrogels N.A. Hadjiev and B.G. Amsden ( Kingston, Canada ) 10

Buccal mucosal delivery of a potent peptide leads to therapeutically-relevant plasma concentrations for the treatment of autoimmune diseases L. Jin , B.J. Boyd , P.J. White , M.W. Pennington , R.S. Norton and J.A. Nicolazzo (Parkville, Australia; Louisville, USA) 37

In vitro dry powder inhaler formulation performance considerations S. Ziffels , N.L. Bemelmans , P.G. Durham and A.J. Hickey ( Chapel Hill, USA; Basel, Switzerland ) 45

A rapid drug release system with a NIR light-activated molecular switch for dual-modality photothermal/antibiotic treatments of subcutaneous abscesses W.-L. Chiang , T.-T. Lin , R. Sureshbabu , W.-T. Chia , H.-C. Hsiao , H.-Y. Liu , C.-M. Yang and H.-W. Sung ( Hsinchu, Taiwan, ROC ) 53

Antiangiogenic and anticancer effect of an orally active low molecular weight heparin conjugates and its application to lung cancer chemoprevention J.-y. Kim , T.A. Al-Hilal , S.W. Chung , S.Y. Kim , G.H. Ryu , W.C. Son and Y. Byun ( Seoul, South Korea) 122

Biodistribution and delivery effi ciency of unmodifi ed tumor-derived exosomes T. Smyth , M. Kullberg , N. Malik , P. Smith-Jones , M.W. Graner and T.J. Anchordoquy (Aurora, USA; Ulm, Germany) 145

A thermo-responsive protein treatment for dry eyes W. Wang , A. Jashnani , S.R. Aluri , J.A. Gustafson , P.-Y. Hsueh , F. Yarber , R.L. McKown , G.W. Laurie , S.F. Hamm-Alvarez and J.A. MacKay ( Los Angeles, Harrisonburg, Charlottesville, USA) 156

Peptides as skin penetration enhancers: Mechanisms of action S. Kumar , M. Zakrewsky , M. Chen , S. Menegatti , J.A. Muraski and S. Mitragotri (Santa Barbara, Oro Valley, USA ) 168

Trg-defi cient Salmonella colonize quiescent tumor regions by exclusively penetrating or proliferating M. Zhang and N.S. Forbes ( Amherst, Springfi eld, USA ) 180

Topical delivery of Cyclosporine A into the skin using SPACE-peptide M. Chen , S. Kumar , A.C. Anselmo , V. Gupta , D.H. Slee , J.A. Muraski and S. Mitragotri (Santa Barbara, Oro Valley, USA ) 190

Nanomedicine A novel antitumour strategy using bidirectional autophagic vesicles accumulation via initiative induction and the terminal

restraint of autophagic fl ux Y. Wang , X. Tai , L. Zhang , Y. Liu , H. Gao , J. Chen , K. Shi , Q. Zhang , Z. Zhang and Q. He ( Chengdu, China ) 17

(Contents continued at inside back cover)