Vojtěch KupkaBrno, University of Technology,

Faculty of Chemistry

HYALURONIC ACID

DISCOVERY

1934 - Karl Meyer and his assistant John Palmer isolated new glykoaminoglycane from the vitreous humour of bovine eyes

vitreous humour – sklivecbovine – hovězí, kravský

ETYMOLOGY

-hyalos (Greek for vitreous)

-uronic acid (possesses high content of uronic acid)

STRUCTURE

-it consists of repeating disacharides units

D-N‑acetylglucosamine

-D-glucuronic acid

-the units are joined with repeating beta‑1,4 and beta‑1,3 glycosidic bonds

OCCURENCE AND PHYSIOLOGICAL IMPORTANCE

-in the skin (about 50 % of the total hyaluronan in the body)-the vitreous humour of the eye-in the synovial fluid (3‑4 mg/ml)-in the matrix around the oocyt during ovulation (~0,5 mg/ml)-in some situations rapid increase (shock incidents, wound healing, septicaemia)

synovial fluid - kloubní mazwound healing – hojení ransepticaemia – otrava krve

USE

- in the late fifties hyaluronan was applied for the first time to humans - as vitreous humour replacement during eye surgery

- hyaluronan improves properties of synovia and silences pain in joints

surgery – operace, chirurgie

joint - kloub

- for healthy and fresh skin- to improve the effectiveness of

local anaesthesia- to prevent tissue destruction- hyaluronates are widely used in

many branches of medicine like orthopaedia, surgery, ophthalmology, oncology, dermatology, gynaecology

- may have anticancer effects and can suppress tumour progression, however, the findings are rather inconsistent

suppress – potlačovattumour – nádor, otok, zduření

- in plastic surgery (Restylane) – for bigger an better lips

before after

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