vitamin c protects dna from radiation

Upload: bernard-frank

Post on 05-Apr-2018

215 views

Category:

Documents


0 download

TRANSCRIPT

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    1/42

    1

    Atsuo Yanagisawa, M.D., Ph.D.Japanese College of IV Therapy

    Effect of Vitamin C and anti-

    oxidative nutrition on radiation-

    induced gene expression in

    Fukushima nuclear plant workers

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    2/42

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    3/42

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    4/42

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    5/42

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    6/42

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    7/42

    !"#$%

    !$%

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    8/42

    There are many scientific studies

    demonstrate protective effects ofVitamin C upon radiation-induced

    cellular injury .

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    9/42

    !"#$%&'()*+, '%()*+,-.%/01,.%/+-(2%-**34,(2%0**)..,4%3(%5666%3(%7-/-(8%9-:,(2;%1

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    10/42

    M0);,%*0)+4%;).@3@,%+,;;%2

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    11/42

    K32-B3(%L%FEGD10&H%&H+#>I11-;%0.-++F%-4B3(3;2,.,4%?0.%Z%4-F;C%-(4%2

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    12/42

    12

    J*1?#'$41EKL1CDEEL1/4.1'.6$).1/.#01(A1M#1/#%.1Q3/#03*1S10.-++F8^%

    5)/4('61(A1M#

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    13/42

    H(2.-T2,;:*)+-.%3(],*:0(%0?%H043(,T5Z5%4,*.,-;,4%;/,.B%

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    14/42

    P+004%;-B/+,;%1,.,%2-[,(%A,?0.,%-(4%5%_[>Q8%%

    `-B/+,;%1,.,%3BB,43-2,+F%3..-43-2,4%);3(>%-%L0A-+2TY#%,%4),%20%3..-43-:0(%-(4%32;%/,-[%,e,*2%1-;%S%,%3(%

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    15/42

    f.-+%3(2-[,%0?%-+/

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    16/42

    `('%3*&1;'()T1(A1R4.1=/#/.0.*/15/6)(1a#*#&36#2#1?BOB 1 1?#6#6431b2#7)L1?BOB1")'/(*1]B1")'%6(*L1?BOB11 1"'#+A('+1=B1`..%6L1?BOB11

    @(*#:+1_)**3*&4#%.L1?BOB1 1=/.8.*1_3$%.>L1-4BOB1R4(0#619.8>L1?BOB1

    It is our strongest recommendation that those

    living in the effected areas regularly take

    antioxidant supplements such as vitamin C tocounteract the negative consequences of long-

    term low dose radiation exposure as well as to

    protect the health of coming generations.

    fi*3-+%`2-2,2B,(2%0?%7LHR%-A0)2%%

    \g(@3.0(B,(2-+%.-430-*:@32F%-(4%

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    17/42

    a.8%V0(%E)((3(>

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    18/42

    -.(T:.124(14#8.1#1T(6637:.13*/.'*#:1#*+H('1.c/.'*#:1'#+3#B1

    %%K32-B3(%L% % % % %%%%5TZ>%% % %ZTS%:B,;%-%4-F%

    %%0.%j3/0;0B-+%K32-B3(%L%5T"%>% % % %213*,%-%4-F%

    %%'+/ %213*,%-%4-F%

    %%`,+,(3)B% % % % %%%%%%X#T"##l> % %213*,%-%4-F%

    %%K32-B3(%g % % % %%%%5##T"##%B>% %213*,%-%4-F%

    %%132

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    19/42

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    20/42

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    21/42

    b-B,+,;;%

    n-*,+,;;%%E,.0,;

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    22/42

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    23/42

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    24/42

    Japanese College of

    Intravenous Therapy(JCIT)

    We are 400 members: 379 physicians

    12 dentists

    9 veterinarians

    More than 10 educational seminars every year.

    IV Vitamin C, IV Lipoic acid, IV Chelation,Myers Cocktail, Ukrain, Nutrition therapy, etc.

    24

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    25/42

    "#!

    The 1st JCIT Symposium of IVC for Cancer Patients

    Oct 17, 2010, Tokyo, Japan

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    26/42

    26

    $%&'!()*+!,-.!/012!3'34'&!567+758!%9'&!&*:7%;

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    27/42

    27

    Effect of Vitamin C and anti-

    oxidative nutrition on radiation-induced gene expression in

    Fukushima nuclear plant workers

    - A pilot studyAtsuo YANAGISAWA, M.D., Ph.D. (1)

    Michie IWATA, M.D., Ph.D. (2)

    Shuichi AKIYAMA(3)

    (1) Japanese College of IV Therapy

    (2) Iwata Ladies Clinic,

    (3) Gene Science Co, Ltd.

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    28/42

    H(2.04)*:0(%

    28

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    29/42

    M,2

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    30/42

    M,2

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    31/42

    M,2Q %%

    %KTP5J%5"#B> % %KTP"J %%%%%"B>%% %KTPZ%J% %S#B>%%

    %KTPXJ%%%"XSB>% %KTPYJ% %5"#B>% %KTP5"J%%%%5B>%

    N"Q%a-3+F%0.-+%;)//+,B,(2;%

    %% %jF/0;0B-+%K32-B3(%L%%%5%>% % % %213*,%-%4-F%% %'+/% % %213*,%-%4-F%

    % %`,+,(3)B% % % % %"##%l>%% % %213*,%-%4-F%%% %K32-B3(%g % % % %"##%B>% %% %213*,%-%4-F%

    %M)+:TK32-B3(; % % % % % %213*,%-%4-F%

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    32/42

    Cut-off value 25ng/mL

    Healthy control 17% (n=400)Cancer patients 38% (n=400)

    FreeDNA

    concentration(ng/mLplasma)

    0255075

    100125150175200

    32

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    33/42

    a3;2.3A):0(%0?%L-(*,.%V3;[%`*0.,%0(%%

    E,-+2

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    34/42

    Cancer Risk Score is calculated from the value of 48 cancer-

    related gene expression using logistic analysis.34

    9+-;B-%n.,,%ab'%-(4%L-(*,.%V3;[%`*0.,%%3(%n)[);

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    35/42

    35

    NO.B.#

    ge,*2%0?%-(:T0=34-:@,%()2.3:0(-+%3(2,.@,(:0(%0(%n.,,%ab'%-(4%L-(*,.%V3;[%`*0.,%3(%n)[);

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    36/42

    36

    KL!

    !.

    "#!

    !.

    ge,*2%0?%-(:T0=34-:@,%()2.3:0(%0(%n.,,%ab'%-(4%%L-(*,.%V3;[%`*0.,%A,?0.,%-(4%-D,.%XTY%1,,[;%0?%%

    ()*+,-.%/+-(2%10.[%-2%n)[);

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    37/42

    L0(*+);30(%

    37

    (1) We evaluated the effects of radiation exposure on cancerrelated gene expression in 17 men who worked 5-6 weeks atthe radiation contaminated area of Fukushima nuclear plant.

    (2) After working, plasma free DNA was increased in 2 of 13workers, and cancer risk score was increased in 3. After the2 months intervention with intravenous Vitamin C and oral

    anti-oxidative nutritional supplements, free DNA returned tonormal level and cancer risk score was significantlydecreased (p

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    38/42

    \f(+F%K32-B3(%L%-(4%02.0)/%

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    39/42

    54 yrs. female, stomach cancer

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    40/42

    3 yrs after IVC (58 yrs)

    BW= 40 kg

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    41/42

    MF%9.0/0;-+%

    M-3(2-3(3(>%0/:B-+%-(:T0=34-:0(%.,;,.@,%AF%

    2-[3(>%K32-B3(%L%-(4%023(>C%.-430T/.02,*:0(%-(4%

    0/:B)B%

  • 7/31/2019 Vitamin C Protects DNA From Radiation

    42/42

    P"!

    Thank you !

    http://www. iv-therapy.jp