virtual bio-instrumentation - ni.com bio-instrumentation jon b. olansen, ph.d. ... russian chibis...
TRANSCRIPT
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Virtual Bio-Instrumentation
Jon B. Olansen, Ph.D.Lead Shuttle Upgrades Safety Engineer, NASA/JSC
President, VBI Development CompanyR&D Director, KaDa Research, Inc.
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Potential VBI Applications
ØBasic Researchå Medical Schools / Universities
å Private Research Companies (e.g. Pharmaceuticals)
å Typically Animal based (Human data available in some cases)
å Freedom to acquire and analyze data according to individual investigators requirements
ØClinical Researchå Collect data from existing equipment
å Often includes statistical analysis based on treatment protocols
å Typically conducted by MDs who may or may not be computer literate
å Not many willing to devote time to learn or program in LabVIEW
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Potential VBI Applications
ØMedical Informatics
åHospital/Bed Management
åICU Data Monitoring / Display
ØHospital / Clinic Diagnostic Tools
åDiagnostic Equipment
• e.g. Plethysmograph, Echocardiograph Machine
åTreatment Equipment• e.g. TEMS Unit, Ventilator
ØExtended Applications
Governed by FDA}
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Biomedical Fields for DAQ
ØCommon Mechanical Stimuli
åPressures, Flows, Temperatures
ØBiopotentials
åECG, EMG, ERG, EEG, ENG, etc
åµV/mV levels, > 20 kHz Sample Rate
Ø Imaging Techniques
åEchocardiogram, blood vessel contraction
åEdge detection, microscopic imaging
ØClinical Instrumentation
åAcquisition from existing equipment (mostly serial)
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Generic DAQ/Instrumentation Issues
Ø Amplifier Frequency Response
Ø FFT of Nerve CAP
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Role of Virtual Instrumentation
Ø User-Friendly GUI Interface for Experiments and Analysis
Ø Modular Development Scheme
Ø Flexibility/Adaptability
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Generic VI Development Issues
Ø Simultaneous I/O
Ø Data storage for post-processing
Ø Automation and HMI
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Basic Research
Ø Basic Research Field ideal for incorporation of existing NI
hardware & LabVIEW / LabWindows.
å Requires NI personnel be familiar with biomedical applications and sufficiently able to converse in medical lingo.
å Requires stronger ties with research equipment suppliers [e.g. World Precision Instruments (WPI)].
å BioBench has been retooled to accommodate a wider variety of experiments and analysis.
Ø NI, suppliers and users should exercise a substantial list of typical
biomedical experiments to understand and document issues. à e.g. to understand the appropriate equipment required to record ENG data at
10 µV and 50 kHz, while supplying a 10 sec stimulus pulse every 100 msec.
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Basic Research Applications
ØVertebrate SystemsØMammalian Systems
ØCellular Technology
ØElectroneurologyØCardiopulmonary
ØMathematical Modeling
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Electrophysiology
Ø RecruitmentØ Conduction VelocityØ Excitability
Ø Restitution
Ø Excitation-Contraction Coupling
Ø Tetany
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Stimulus Artifact Rejection
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Volume Conductor Problem
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Cardiac Electrophysiology
ØElectrocardiography ØVectorcardiography
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Research Topics
åHeart-Rate Variability
åParasympathetic Neural ControlåPhase Response
åEntrainment
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Cardiovascular HemodynamicsØCardiac Function ØP-V Characterization
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Modeling
ØClosed-loop Circulatory Modeling
ØRight-Left Ventricular Interaction
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Cardiovascular Modeling
åOnline Parameter Sensitivity Analysis
åNonlinear Parameter Estimation
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Lung Model Parameter Estimation
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Lung Tissue Parameter Estimation
åPulmonary System Modeling
åWork of Breathing
åPulmonary Energy Analysis
åIntegrated CO2 / Airway Mechanics Analysis
åNonlinear Parameter Estimation
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Clinical ResearchØ Clinical Research also has potential for significant infiltration
of VBIå Requires NI personnel be familiar with biomedical applications and
sufficiently able to converse in medical lingo.
å Requires stronger ties with clinical equipment suppliers.
å BioBench / LabVIEW incorporate a user-friendly means of collecting and automatically synchronizing data from multiple serial, GPIB, and
analog sources.à Serial (RS232) output is most common form available from commercial equipment.
å BioBench now has additional flexibility in allowing data to be analyzed
during or after collection
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Cardiopulmonary Analysis
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Pulmonary Function Testing
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Ventilatory Patient Management
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Imaging Techniques
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Medical Informatics
Ø The process of transforming data into information in healthcare
å Electronic Medical Record (EMR)/Computerized Patient Record (CPR)
å Decision support
å Information retrieval
å Imaging / Telemedicine
å Medical education
å Consumer health information systems
å Public health information systems
å Bioinformatics
å Outcome analysis
å Patient monitoring
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Medical Imaging
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Patient Monitoring
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Telemedicine
ØTelerobotic control and data feed
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Hospital Information Management
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Commercial Medical Devices
ØHospital / Clinical Diagnostic Tools
åTesting and/or development
åRequires FDA involvement / approval.
åSignificant time / resource cost for each piece of
equipment developed.
åRecommend this development be left to third party
vendors for the near future.
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Medical Device Testing
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Medical Device Development
ØRSI Diagnostic Aid
Ø FDA Approved
Ø Controlled with LabVIEW-
based executable
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Space Environment
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Med Ops Hardware & Operations
ØMedical Restraint SystemØIntegrated with diagnostic/therapeutic equipmentØPatient transport during return and recovery
ØCardiac Defibrillator/MonitorØAdhesive conductive padsØInsulation to protect avionics from EMI
ØAdvanced Life Support PackØStowage of emergency meds and equipmentØHuman factors strongly influence successØMed shelf-life and waste concerns
ØVentilatorØSelf-contained or overboard dump to prevent O2 buildup in confined volume
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Med Ops Hardware & Operations
ØStored Intravenous FluidsØMust use pressure infusion device
ØMedical Computer SystemØDiagnostic AidØProficiencyØMedical RecordsØOccupational Exposure Tracking
ØEndoscopic CapabilityØDiagnostic/Therapeutic
ØSplints and Traction Devices
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Cellular Bio-Technology
ØCharacterization of the response of the human body to the space environment
Ø Primary outlook is InvestigationalØResults are
viewed in terms of Scientific Return
Colon Cancer cells cultured in a Bioreactor
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Research Hardware & Operations
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Research Hardware & Operations
The effects of µG can be difficult to anticipate without operational experience.
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Space Medicine
ØProactive and Reactive Care of the human organism to optimize physical, physiological and mental well-being
Ø Primary outlook is OperationalØResults are
viewed in terms of Mission Impact
Cardiovascular Assessment on ISS in Russian Chibis Suit
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Space Medicine (Proactive Care)
Exercise is one of the most important proactive medical countermeasures. ØBut how do you get
good exercise in µG ?
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Space Medicine (Reactive Care)
Reactive care also requires special attention to operability in µG.Ø e.g. How do you
respond to cardiac arrest? CPR?
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Conclusions
ØAcademic ApplicationsåInstructionalåBasic ResearchåClinical Research
ØCommercializationåDevelopmentåTest
ØExtraterrestrial
Virtual Bio-Instrumentation