virologi 2
DESCRIPTION
virologiTRANSCRIPT
-
7/17/2019 Virologi 2
1/23
VirologiDrh. Erina, M.Sc
-
7/17/2019 Virologi 2
2/23
Morfologi Sifat kimia dan sika Replikasi virus
Sistem imunitas host terhadap infeksi viruscara penularan dan siklus hidup virus
Dasar-dasar virologi
-
7/17/2019 Virologi 2
3/23
Perbedaan virus danbakteri
Virus Bakteri
Susunan Kimiawi virus terdiri dariDN atau RN
!akteri terdiri dariDN dan RN
"kuran #$%&$nm '$mikron
(empat hidup )*ligatintraseluler
+ntraselulerekstraseluler
meta*olisme irus tidak adasistem en-im
Mensintesis en-imuntuk
meta*olismeDaa mutasi irus *isa
mengu*ah sifatantigen
/ara *erkem*ang
*iak
Menginfeksi sel
hospes
!inar sion
-
7/17/2019 Virologi 2
4/23
0atogenesitas1 aitu kemampuan organisme untukmenim*ulkan penakit
0enakit1 respon inang2host terhadap infeksi *erupatergangguna fungsi normal
+nfeksi1 m.o memasuki 3aringan tu*uh 4m.o meneranghost5
irus paotgen1 virus ang mampu menim*ulkanpenakit
irulensi1 dera3at kemampuan suatu mikroorganisme
untuk mene*a*kan infeksi 6aktor virulensi1 sesuatu hal ang terdapat dalam m.o
ang mene*a*kan penakit +sohedral1 *entuk dari nukleokapsi
Beberapa defnisi
-
7/17/2019 Virologi 2
5/23
irion1 partikel virus ang lengkap Nukleokapsid1 asam nukleat ang dilapisi oleh selu*ung
protein 4kapsid5, nukleokapsid ada ang *erselu*ungada ang tidak
Kapsid1 selu*ung protein ang melapisi asam nukleat.
Kapsid terdiri dari *anak kapsomer ang merupakanunit dari kapsid terse*ut. !entuk kapsomer ada ang*er*entuk ku*us ada ang *er*entuk spiral 4helikal5
+kosehedral1 *entuk dari nukleokapsid ang tersusundari ku*us simetri, terdiri dari '#, , 7#,... Kapsomer
sedangkan spiral simetris dari nukleokapsid akanmem*entuk silinder ang tersusun dari se*uah sum*urotasi dari asam nukleat ang di*atasi oleh kapsomer%kapsomer
-
7/17/2019 Virologi 2
6/23
!erdasarkan penakit ang ditim*ulkan1
0oliovirus
Ra*ies virus
8enis penakit Marine leukimia virus vian in9uen-a virus
0enemuna Epstein%!arr virus
!agaimana mereka diperkirakan *isa menim*ulkan penakit
Dengue virus 4evil spirit5 +n9uen-a virus 4in9uence of *ad air5
Kom*inasi dari hal%hal terse*ut diatas Rous Sarcoma virus
Cara pemberian nama padavirus
-
7/17/2019 Virologi 2
7/23
Patogenesa virus
-
7/17/2019 Virologi 2
8/23
Virus Classification
Viruses
Nucleic acid: DNA RNA
Envelope: Yes No
Symmetry: Cubic Helical
(Icosahedral) (Cylindrical)
-
7/17/2019 Virologi 2
9/23
hape of Viruses
Spherical
Rod-shaped
Brick-shaped Tadpole-shaped
Bullet-shaped
Filament
-
7/17/2019 Virologi 2
10/23
hapes of Viruses:Spherical
-
7/17/2019 Virologi 2
11/23
Shapes of Viruses:Rod-shaped
-
7/17/2019 Virologi 2
12/23
Shapes of Viruses:Brick-shaped.
-
7/17/2019 Virologi 2
13/23
Tadpole-shaped
-
7/17/2019 Virologi 2
14/23
Shapes of Viruses:Bullet-shaped
-
7/17/2019 Virologi 2
15/23
Shapes of Viruses:Filament
-
7/17/2019 Virologi 2
16/23
hape of Viruses
Spherical
Rod-shaped
Brick-shaped Tadpole-shaped
Bullet-shaped
Filament
-
7/17/2019 Virologi 2
17/23
Virion vs virus
Virionis the infectious particle
composed ofnucleic acid, proteincapsid, :2%envelope
ma *ee;tracellular orintracellular
Virusis an stage of infection
-
7/17/2019 Virologi 2
18/23
Capsid
6unctions 0rotection of N
ttachment for naked viruses
En-me
-
7/17/2019 Virologi 2
19/23
International Congress onTaxonomy o Viruses Morpology
virion si-e
enveloped or nakednucleocapsid
capsid smmetrand structure
!enome"ara"teristi"s
#epli"ationstrategy
Antigenic Properties
-
7/17/2019 Virologi 2
20/23
Viral Replication
i) adsorption (attachment)
ii) entry
iii) uncoating
iv) transcriptionv) synthesis o virus components
vi) assembly
vii) release
-
7/17/2019 Virologi 2
21/23
-
7/17/2019 Virologi 2
22/23
Host - Organism Relationship
Interaction bet!een host and organism
aecting the development and outcome o
an inection includes"
Host#s primary physical barriers
Host#s immunologic ability to control and eliminate the
invading organisms
$rganism#s ability to evade destruction%virulence
Ability o organism to spread in the body
-
7/17/2019 Virologi 2
23/23
Virulence of Viruses & Evasion of the
mmune Response
&oorly understood processes"
Antigenic variation
'ome viruses encode receptors or various
mediators o immunity (eg I* + ,N-) thus bloc.ingtheir ability to interact !ith receptors on their
intended targets
'ome viruses (eg HIV) reduce e/pression o class I
0HC proteins1 thus reducing ability o cytoto/ic ,
cells to .ill the virus2inected cells
Direct cell2to2cell propagation
Attenuated viruses (eg Vaccine strains)