using graphs to mine brain dynamics icann09users.auth.gr/laskaris/...brain_dynamics_icann09.pdf ·...
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Future trends
Introduction
Methodological framework(short description)
Application to Auditory M100-responsesto detect the influence of attention
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Introductory commentsIntroductory comments
Graph theoryis the study of graphs: mathematical structures used to model pairwise relations
between objects from a certain collection.
Initiated with Euler’s paper in 1736
‘‘Seven Bridges of Königsberg’’
A "graph" is collection of vertices (or 'nodes‘)and a collection of edges that connect pairs of vertices.
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Graphs in Brain Research :
network analysis (small-world network) systems-approach (MI-maps)
created by O. Sporns
�
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Graphs for Single-Trial Analysis
� Future-trends (mining information from multisite recordings)
����
Liu, Ioannides, Gartner
Elect. and clinical Neurophysiology 106 (1998) 64–78
� Past
� Current-practise
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A synopsis of response dynamics and its variability by means of Semantic Geodesic MapsSemantic Geodesic Maps
Graphs play an instrumental role in :
computing neighborhood relations,
deriving faithfull visualizations of reduced dimensionality
describing and contrasting the essence of response variability in an objective way
MST, WW-test , ISOMAP, Laplaceans , commute times, etc
I. Outline I. Outline ofof ourour methodologicalmethodologicalapproachapproach
Brain dynamics can be comparedat a glance
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[ Laskaris & Ioannides, 2001 & 2002]
IEEE SP Magazine, 2004
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Step_Step_��the spatiotemporal dynamics are decomposed
Design of the spatial filterspatial filter used to extract
the temporal patternstemporal patterns conveying
the regional response dynamics
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Step_Step_��Pattern Pattern & & GraphGraph--theoretictheoretic AnalysisAnalysisof the extracted ST-patterns
Interactive Study Interactive Study
of pattern variabilityof pattern variability
Feature Feature
extractionextractionEmbedding Embedding
in Feature Spacein Feature Space
Clustering & Clustering &
Vector QuantizationVector Quantization
Minimal Spanning TreeMinimal Spanning Tree
of the codebookof the codebook
MSTMST--ordering ordering
of the code vectors of the code vectors
Orderly presentation Orderly presentation
of response variabilityof response variability
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Step_Step_��Within-group Analysisof regional response dynamics
-
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Step_Step_��Within-group Analysisof multichannel single-trial signals
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Step_Step_��Within-group Analysis of single-trial MFTMFT--solutionssolutions
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WaldWald--WolfowitzWolfowitz testtest (WW(WW--testtest))
A non-parametric testfor comparing distributions
{ X i} i=1...N vs {Y j} j=1...M
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R=12
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SimilarDissimilar
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� P-value
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II. II. ApplicationApplication toto MEG MEG AuditoryAuditory (M100) (M100) responsesresponses
The Scope :
to understand the emergence of M100-response(in averaged data)
characterize its variablility (at Single-Trial level)
and describe the influence (if any) ofattention
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The Motive : ‘‘ New BCI approaches based on selective Attention to Auditory Stimulus Streams ’’
N. Hill, C. Raths (mda_07)Exogenous (i.e. stimulus-driven) BCI's relyon the conscious direction of the user's attention.
For paralysed users, this meanscovert attentionCovert attention do affect auditory ERPs.
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CTF-OMEGA (151-channels)
MEG-data were recorded at RIKEN (BSI, Japan)
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Repeated stimulationRepeated stimulation ( ISI: ( ISI: 22secsec))
binaural-stimuli [ 1kHz tones, 0.2s, 45 dB ],passive listeningtask ( 120 trials ) & attenting task ( 120 ± 5 trials )
left-hemisphere
response
right-hemisphere
response
Count #2 sec
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IIaIIa . . EnsembleEnsemblecharacterizationcharacterizationofof (M100(M100--related) related) brainbrain waveswaves
IIcIIc . . EmpiricalEmpirical ModeModeDecompositionDecompositionforfor enhancingenhancing (M100(M100--related) related) brainbrain waveswaves
IIbIIb . . UnsupervisedUnsupervisedclassificationclassificationofof (M100(M100--related) related) brainbrain waveswaves
andand PrototypingPrototyping
[ 3-20 ] Hz
mutiscale analysis
singlesingle--channelchannel ICAICA for oscillatory components
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IIaIIa . . EnsembleEnsemblecharacterizationcharacterizationofof (M100(M100--related) related) brainbrain waveswaves
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time-aligned ST-segments are extracted
brought to common feature spaceand subsequenlty transfromed ( viaMDS MDS )
to point-diagrams representing brain-waves relative scattering
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24Attentive-responsesshow significantlyreduced scattering: smaller MST-length
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25Clustering tendenciesare apparent inphase-representation spaceand higher for theattentive responses
normalizei
ii X
X X →
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Similar observations can be madefor the other hemisphereof the same subject
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And for other subjects as well
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30The variability of (snaphosts of) Brain-waves
is smaller for the attentive task
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31The clustering of (snaphosts of) Brain-waves
is higher within the phase-representation domain
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IIbIIb . . UnsupervisedUnsupervisedclassificationclassificationofof (M100(M100--related) related) brainbrain waveswaves
andand PrototypingPrototyping
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DiscriminativeDiscriminative PrototypingPrototypingDiscriminativeDiscriminative PrototypingPrototypingKokiopoulou & Saad, Pattern Recognition :
‘‘Enhancedgraph-baseddimensionality reductionwith repulsion Laplaceans’’
By contrasting brain-waves fromcontrol conditionagainst the M100-related brain waves
we deduce an abstract spacewherein Neural-Gas based Prototypingis first carried outand then prototypes are ranked based on an‘‘SNR-classification index’’
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Repulsion-graph
Laplacean & eigenanalysis
D-r1
D-r2
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By embedding brain-waves fromcontrol condition, we can the define high-SNR regions in the reduced-space
Exploiting the abundance ofspontaneous brain activitysnapshots, we can accurately/preciselyrank the differnt voronoi regions.
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The derived ranks are utilized to orderthe prototypical responses accordingly
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Taking a closer look at the high-SNR group of STs, a ‘highlighting’ of response dynamics is achieved
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that can be enhanced via a ‘‘Trial-Temporal’’ format
There is an apparent organization in the brain waves @ 100 ms
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And be enriched via contrastwith the ‘void-of-M100-response’ ST-group
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41There is lack of any kind of organization in the brain waves
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DiscriminativeDiscriminativePrototypingPrototypingfor attentive (M100) responses
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44Even for the attentive-task
there are ST-groups‘void-of-M100’
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Thehigh-SNR groupof STs, clearly shows a phase-reorganizationof prestimulus activity accompanied with an enhancement ofoscillations
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portrayed even better in the‘‘ TrialTrial --TemporalTemporal’’ formatformat
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On the contrary, thelow-SNR groupof STs
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shows no prominent stimulus-induced changes
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Similar observations can be madefor the other hemisphereof the same subject
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51AND for this hemisphere ( in theattentive-task !!! )
there is a ST-group‘void-of-M100’
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Phase-reorganizationof brain wavesis apparent in thehigh-SNR STs
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While stimulus-induced dilutionof brain wavescan be seen in thelow-SNR ST-group
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void_trials_right = {26, 33, ...,116 } { 22,49....,120 } = void_trials_left
∩∩∩∩
Count #
Rare coincidence
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Right_trials_group_index = {3, 2,2,1, ...,10,4 }
Left_trials_group_index = {8, 4,3,1, ...,1,9 }
We further pursue any kind of systematic-relationshipbetween the two hemispheres
in the formation of brain-waves groups
by resorting toVariational-Information (VI) measure
(e.g.low-SNRSTs in the left hemispherecould coinside withhigh-SNRSTs in the right hemisphere )
VI = MI for partitions & an adjustment for being atrue-metric
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Based on a randomization test(10000 permutations)
Left and Right hemisphere groupsof (M100-related) brain waves are formedidependently
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IIcIIc . . EmpiricalEmpirical ModeModeDecompositionDecompositionforfor enhancingenhancing (M100(M100--related) related) brainbrain waveswaves
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IntrinsicIntrinsic modemodefunctionsfunctions ((IMFsIMFs ))
Huang et al., Proc. R. Soc Lond. A, 454 (pp.903-995), 1998:
‘‘The EMD and thehilbert spectrumfor nonlinear andnon-stationarytime series analysis’’
It considers the signals at their local oscilation scale, subtracts the faster oscilation,
and iterates with the residual
- An iterative (hierarchical ) sifting-procedure is applied
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Two examples of EMD-analysisapplied to STs from S2 (passive-task)
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By enseble averaging of all ST-IMFs
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With anensemble characterizationbased on a standardSNR-estimator
for all IMFs (individually)
Some IMFs are information-rich, while others not
S2 left-hemisphere
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By (re)combining the more informative ones, an enhanced M100-response can appear
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With a (graph-based) ensemble characterizationbased onWW-index
a similar picture emerges
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5th IMF5th IMF
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68Stimulus-induced modulations of oscillatoryactivity has now become prominent
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Since interactions between oscillatory systems are(often) best described via phase coupling,
we measuredleft-right inter-hemisphere couplingusingPhase Coherence index(P.Tass )
for thewell discriminatingIMF(s)
Hilbert- trans.Left_Instant.-Phase(t)
Right_Instant.-Phase(t)
-∆Phase(t)
Ph-COH
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Ph-COH=0.9
Ph-COH=0.93
Ph-COH=0.13
Ph-COH=0.12
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Phase Coherence, for all conditions, as a function of trial-number
- In both tasks, the Coupling is higher than control
-- Attention increases the coupling
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The same observations can be made for other subjects as well
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ConclusionsConclusions
ST-Variability is lower in attentive task
Trials void of response do not appear simultaneously in both hemispheres
Inter-hemispheric Phase-locking is higher for attentive responses
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FutureFuture workwork andand PerspectivePerspective
Bipartite-graphstechniques for biclustering ( LOIs & ST-group)
Hypergraphsfor analyzing multiple tracesat different scales(from wavelet or EMD analysis)
Mining Graph data
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‘‘If you torture data sufficiently,
it will confess to almost anything’’FRED MENGERFRED MENGERFRED MENGERFRED MENGER
Nikos [email protected]
LHBD site : http://humanbraindynamics.com/