using fluorescence x-rays for non-invasive biopsy
DESCRIPTION
Using Fluorescence X-rays for Non-invasive Biopsy. Advisors : Dr. Frank Carroll Dr. Ed Donnelly Mr. Robert Traeger Mr. Gary Shearer. Team members : Savannah Gill Kelvin Lin Mike McHugh Trey Reece Derric Williams. Current Methods. Conventional Methods Mammography - PowerPoint PPT PresentationTRANSCRIPT
Using Fluorescence X-rays for Non-invasive
Biopsy
Team members: Savannah Gill
Kelvin Lin Mike McHugh
Trey Reece Derric Williams
Advisors: Dr. Frank CarrollDr. Ed Donnelly
Mr. Robert TraegerMr. Gary Shearer
Current MethodsConventional Methods
Mammography Cheap, Simple, Ubiquitous High False Negative Rate
10%-20% cancer missed MRI
Safer More Sensitive More Costly
15x that of mammography High False Positive Rate
One study showed 43% of suspicious MRI findings showed no cancer
Twice as many false positive as mammograms
Mammography X-Ray Image
http://history.nih.gov/exhibits/genetics/sect2.htm
Project Background Current Methods are
Invasive
Our Project Hopes To Rid Detection
Process of Needles, Anesthetic, & Pain
Reduce radiation dose to patient
Rid of contrast agent Reduce Time &
Complicationshttp://healtgate.partners.org
Our Method Monochromatic X-
rays Fire X-rays of only
one energy (or wavelength)
Use SAXS emissions from elements in tissue
Theory Behind Our Method
Small Angle X-ray ScatteringSmall Angle X-ray Scattering
θ
Task 1: Decrease the size of the x-ray beam using collimator
Task 2: Block off the extra x-rays using beamstop
Task 3: Detect and analyze scattering pattern
Task 4: Determine material
d
R
Project Description
Diffraction Patterns
Paraffin Wax
• Similar to Adipose Tissue
• No Water
• Major Radial Peaks at: 12.6°, 11.4°, 10.2°
Diffraction Patterns
Adipose/Gland Phantom 100/0
• Major radial peak at: 11.5°
• Possible additional peaks at: 9.1°, 10.3°
Diffraction Patterns
Adipose/Gland Phantom 30/70
• Major radial peak at: 11.5°
• Possible additional peaks at: 9.1°, 10.3°
Diffraction Patterns
Adipose/Gland Phantom 50/50
• Major radial peak at: 11.5°
• New peak emerging at: 15.5°
Diffraction Patterns
Adipose/Gland Phantom 30/70
• Major radial peak at: 11.5°
• New clear peak at: 15.5°
Diffraction Patterns
Adipose/Gland Phantom 0/100
• Major radial peak at: 11.5°, 15.5°
• Possible additional peaks at: 13.8°, 8.9°
Diffraction Patterns
Aluminum
• Dots instead of rings (crystalline)
• Multiple photon energies -> Smears
Aluminum from Cullity, “Elements of X-Ray Diffraction”
Diffraction Patterns
Wood Grain Horizontal Wood Grain Vertical
Wooden Block (1.5” Thick)
Can you tell the difference?
100 2.3 deg
200 4.7 deg
300 7.1 deg
400 9.4 deg
500 11.7 deg
600 14.0 deg
700 16.2 deg
800 18.3 deg
900 20.5 deg
1000 22.5 deg
1100 24.5 deg
Thin Breast
Thin Cancerous Breast
Thick CancerousBreast
Breast Samples
Mouse Muscle
Cancerous Muscle
Muscle Samples
Pig Skin
Pig Fat
Pig Samples
Reducing Noise – Monochromatic Beam
Thin Ring Created
Detector
Incident Beam
Thin Sample
Polychromatic
Reducing Noise – Monochromatic Beam
Thin Ring Created
Detector
Incident Beam
Thin Sample
Monochromatic
Current Status
Collect more images of different material using Kevex X-ray
X-ray more biological specimens
Use monochromatic x-ray laser for clearer results
Develop an algorithm to determine the cancerous tissue from normal tissue
Next Step
Continue imaging biological samples Multiple trials needed
Compare samples of normal tissue to cancerous tissue
Determine composition of unknown images as given by Dr. Carroll
Dates to Come
Finish new collimator By March 23rd
Finish imaging biological samples By April 4th
Image biological samples with monochromatic By April 13th
Complete analyzation & poster By next oral presentation
References
http://www.breastcancer.org/mri_vs_mammogram_high_risk.html
http://www.mrsc.ucsf.edu/breast/what_is_breast_mri.html
http://en.wikipedia.org/wiki/Mammography
Questions?