umc floortje scheepers
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Big data changing lives
Floortje Scheepers, MD PhD, head of the department of Psychiatry UMC Utrechtbig data expo 21 september 2016
Volume
velocityvalu€
veracity
variety
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01-05-2023
What is changing?
Egge vd Poel, datascientist, Erasmus
Patient citizen
Doctor ICT
treatment Based on TrialsBased on clinical intelligence
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data explosion
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Exposome
Genome
Microbiome
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• Sensordata
• Data and user driven science and patient empowerment
• risk profiling based on normative models in stead of causality
• (complex) models and analytics
• P4 medicine (predictive, preventive, personalized, participating)
• Combining domains!!
< TNO>
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From ‘big’ to one and back
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Symptoms Brain function Genes
What do we know about the disturbed mind?
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1. DSM was born 1952
schizophrenia mania depression Autism
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2. Investigating the brain
Structure Activity Function
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3. Investigating genes
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4. EPI-genetics
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5. Vulnerability versus resilience
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1. Selection bias: ‐ severe patients not included‐ Co-morbidity not included
2. Brain changes over time:‐ Brain plasticity/adaptation‐ Effect of development‐ Effect of medication
3. Environmental influences changes over time!
4. Results overlap, don’t stick to classification
Problems current research to overcome
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Research vs real life
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Governance
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National data like psychiatric (Nemesis) and healthy (CBS)
Regional data like psychiatric (casusregister) and healthy (municipal/youth cohort)
All psychiatric patients of one local hospital
individual psychiatric
patient profile
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collectIntegrate
Explore
Analyse
Research Data Platform (RDP)
Lokale opslag
RDP Python Jupyter Excel
SynerScope Postgres
SynerScope R
PseudonymisePrepare
apply
Applications
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Two different worlds meet
Hackathons
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Aanpak
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From descriptive through predictive to prescriptive…
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themes• Medication use (short acting vs long acting)
• Aggression (prediction models; written notes in EPF)
• Duration of submission (blue, green)
• Wearables (stress level, activity, sleep)
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New problems to overcome
• FAIR (findable, accessible, interoperable, re-usable)
• Privacy, ownership• From molecular to system level to organism level• Data storage and processing• Management and analytics (error correction,
normalization, mathematical modelling, computational simulation)
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Compute visits the data → mental health consortium
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Aggregation/conclusion algorithms on serial/parallel analyses of (encrypted) datasets → norm profiles replicate/validate
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2020: A patient is referred to the hospital
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The psychiatric fingerprint is already known
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Enough time for a personal conversation about needs
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A personalized diagnose and treatment plan
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Questions?