CosMedical TechnologiesAnti-Aging & Acne Regimens

Loretta Ciraldo, M.D., F.A.A.D.

Founder and CEO,

CosMedical Technologies, Inc.

CosMedical Technologies, Inc.

1. Dermatologist owned and guided since 19932. Dr. Ciraldo personally formulates every product to

support and enhance the results of cosmetic treatments she uses such as laser, peels, and injectables.

3. She uses these products on her own patients whether or not they also have procedures. Patients achieve great clinical results, which of course means they keep coming back!

CosMedical TechnologiesAnti-Aging Regimens

1. Promote

2. Prevent

3. Protect

CosMedical Technologies,Inc.

Anti-Aging Philosophy

1. Promote “barrier repair”/healthy skin 2. Prevent visible signs of aging & further skin

damage3. Protect skin from environmental insults

such as UVA & UVB rays, nitrogen & oxygen free radicals,

Promote Barrier RepairHealthy Skin Texture, Function

“Barrier Repair” refers to improving the health and appearance of the stratum corneum, the skin’s surface

Healthy barrier function prevents water loss, improves tolerance to potential irritating procedures and products.

Promotes healing, protects against bacterial and other infections

Promoting barrier repair refers to maintenance and repair of surface stratum corneum (SC) & follicular SC

Skin Barrier: Not Just Dead Cells…

1. Lipids (inter-cellular)

2. Natural Moisturizing Factor (intra-cellular)

The Skin Barrier: Anatomy

Benefits to Promoting Healthy Barrier

Everyone needs this, to improve one or more of the following:

1. Dryness & roughness2. Redness3. Irritation4. Acne 5. Rosacea & facial flushing6. Fine lines 7. Uneven skin tone.

CosMedical Technology Products to Promote Barrier Repair

1. All CosMedical Cleansers

2. Lipid Drops and Vita Soothe

3. Nutra Fill

Obagi Regimen….

Rash on day 2, 7 of Obagi regimen….

www.yestheyrefake.net/obagi_marianne.htmwww.yestheyrefake.net/obagi_marianne.htm

All CosMedical Cleansers:

1. are all SLS-free

2. leave a deposition of beneficial ingredients after wash off

CosMedical CleansersPromote Barrier Repair

Dermatologic Therapyhighlights irritation caused by SLS

Vol 17, 2004Vol 17, 2004

Cleanser Selection

Use Salicylic Face and Body Wash on most patients,

BUT: Use Chamomile Facial Cleanser on: pregnant women, people with irritation from products or

procedures, scaly skin rosacea with redness

Lipid Replacement Promotes Barrier Repair

Lipid Replacement promotes barrier repair in two ways:

1. Traps in water

2. Promotes tolerance to skin insults from both environmental insults as well as medical grade skincare

Why We Use Lipid Drops & Vita Soothe Lipid Drops and Vita Soothe both promote

barrier repair, which is necessary since:

1. Aging depletes Lipid and Vitamin levels in skin

2. Many topicals containing retinoids, AHA’s, Hydroquinone and other anti-aging ingredients inevitably trigger breakdown of skin barrier

Before/After 2 Weeks: Chamomile Facial Cleanser/Lipids (VitaSoothe)

Lipid Drops

Lipid Drops promote barrier repair because its made with bio-identical intercellular stratum corneum lipids – the same type of lipids that are found in healthy skin

When Lipid Drops are applied to the skin, they have very good penetration due to microfluidization of the formula to guarantee rapid absorption

CosMedical Techologies Vita Soothe Corrective Serum

Use after cleansing and before moisturizer to promote a healthy skin barrier and infuse antioxidants Vitamin E and F (linoleic acid)

Why Vita Soothe Works Vita Soothe promotes barrier repair because its made with bio-

identical intercellular stratum corneum lipids – the same type of lipids that are found in healthy skin – it’s also packed with antioxidants Vitamin E and F (linoleic acid aka, omega 3 fatty acid) that are essential to younger, healthier looking skin.

Also note that in preliminary studies, linoleic acid has been shown to be deficient in most skin types, but markedly in acneic patients. By repairing the barrier function, Vita Soothe normalizes the skin thus preventing and healing the follicular plug.

In addition, Vita Soothe has visible anti-inflammatory results so important to skin health and radiance

Tazarac vs. Vita-Sooth Acne patients*

Tazarac x 3days VitaSoothe x 5 days

*5 Day Comparison*5 Day Comparison

Clinical Results

Vita Soothe & Lipid Drops clinical testing results: Increase skin smoothness by 55% Increase hydration by 47% Steady state hydration for a full 6-8 hours after one

application

The patients cleanse with a CosMedical Cleanser, apply Vita Soothe and then they will move on to the next step and PREVENT environmental damage and aging of the skin.

NutraFillFor Intra-Cellular Barrier Repair

Replacing the Natural Moisturizing Factor of the intra-cellular content of the Stratum Corneum will help to give skin a rejuvenated and healthier look

Specifically, skin will look plumped and there will be correction of fine lines, creases and even shadows cast by creases when using NutraFill

NMF Plumps SC CellsSmoothes Skin Texture

NMF binds water within the corneocytes to keep them plumper

Nutra Fill Ingredients

Urea: A humectant that draws moisture into our dehydrated skin surface and plumps and softens skin.

Lactic Acid: A gentle exfoliator that promotes smooth, healthy skin.

Magnesium, Potassium and Sodium: Minerals that help to restore normal electrolyte balance to skin, reducing inflammation and oxygenating tissue.

Calcium Pantothenate: (Vitamin B5): An essential nutrient to calm skin and decrease appearance of pores

THESE INGREDIENTS ARE THE MAIN COMPONENTS OF NATURAL MOISTURIZING FACTOR (NMF)

Benefits of NutraFill

Replaces Natural Moisturizing Factor (NMF), a mixture of low-molecular-weight, water-soluble compounds first formed within the corneocytes by degradation of the histidine-rich protein known as filaggrin

Components of NutraFill hold up to 4,000 times their weight in water (4 times more than hyaluronic acid)

Application of NutraFill can plump skin appearance and lessen the appearance of lines, wrinkles and sometimes creases after as little as one use!

NutraFillBefore and After one use!

Nutra Fill Provides Same Day Wrinkle Improvement

Nutra Fill: NMF Booster

Directions: Apply a film of gel to entire face and leave on for 15 to 30 minutes and then wash off. Can also sleep with product on top of other evening skincare productsMany people use product twice a day

2. CosMedical Technologies

Prevent Step

In a landmark study published by Haywood in the Journal of Investigative Dermatology (JID) in 2002, results showed that full spectrum sunscreens only prevent 55% of UV-induced free radicals

For optimal prevention of environmental aging and other damaging cutaneous reactions, patients need both sunscreen and antioxidant formula during the day.

Prevent with Ultra Benefits: The Most Complete Antioxidant

Our newest moisturizer, Ultra Benefits,

is a next-generation antioxidant and skin rejuvenator since it provides 3 main benefits all of which come from our trademarked ABF ComplexTM

UltraBenefitsReactive Nitrogen Shield

The Ultimate Antioxidant Moisturizer …with Trademarked ABF ComplexTM

A: Antioxidant superiority (prevent oxidative changes)

B: Brightening and lightening (prevent skin darkening)

F: Firming (prevent wrinkles)

Ultra BenefitsMost Complete Antioxidant

Superior in Four Ways:1. 11 times the antioxidant power of the leading

antioxidant – idebenone (on lipid peroxidation assay)

2. Ranks higher in Antioxidant activity than: Vitamin C, Vitamin E, Rosemary, Grape seed, Green tea, Black tea, Honeybush, Sage

3. Excellent stability compared to Vitamin C4. This is the first formula in the industry created to

prevent formation of nitrogen as well as oxygen free radicals

Prevent Skin Darkening

ABFTM incorporates a soy derivative for skin lightening and brightening:

1. This compound is uniquely photoprotective. So instead of patients being more sensitive to the sun when they use it (as with Hydroquinone and kojic acid), Ultra Benefits actually protects you from the sun to address the 45% of free radical damage not covered by sunscreens

2. It is 50% more effective in clinical testing than kojic at skin lightening/melanocyte inhibition.

3. Ultra Benefits does not break down in the sun, as do other fade ingredients, so your patients get maximum melanocyte inhibition.

Prevent Wrinkles

3 different anti-wrinkle peptides decrease fine lines:

• blocking collagen breakdown, • enhancing synthesis • strengthening fibrils.

Prevent StepCosMedical Night Cremes

Use UltraBenefits in the morning.

At bedtime,some patients will prefer to use either

Multicomplex Night Crème

OR

UltraFirming Marine

Protect StepDaily Replenishing SPF 30+

This product is the gold standard for high efficacy and safety.

It is a totally chemical free, physical block for full spectrum UVA/UVB protection.

7.5% transparent zinc oxide & 2.4% micronized titanium dioxide.

This eliminates the risk of irritating skin or any possibly untoward reactions to chemical UV absorbers

Benefits of Daily Replenishing SPF 30+

Water-Proof: protects up to 80 minutes in water as seen in clinical testing

Its packed with 2 types of MMPI peptides to firm skin and Beta Carotene to provide antioxidant support

It quickly absorbs into skin, and leaves a matte finish for effective oil control

Non-comedogenic: Safe for all skin types