Top 200 Pharmaceutical Products by Worldwide Sales in 2008Compiled and Produced by the Njardarson Group (Cornell University): Nicholas McGrath, Matthew Brichacek, Alexandra Plichta, Daniel J. Mack, Jón T. Njarðarson

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 LIPITOR PLAVIX NEXIUM SERETIDE ENBREL SEROQUEL ZYPREXA REMICADE SINGULAIR LOVENOX MABTHERA TAKEPRON EFFEXOR HUMIRA AVASTIN CRESTOR RISPERDAL ACTOS NEULASTA HERCEPTIN (Atorvastatin) (Clopidogrel) (Esomeprazole) (Fluticasone & Salmeterol) (Etanercept) (Quetiapine) (Olanzapine) (Infliximab) (Montelukast) (Enoxaparin) (Rituximab) (Lansoprazole) (Venlafaxine) (Adalimumab) (Bevacizumab) (Rosuvastatin) (Risperidone) (Pioglitazone) (Pegfilgrastim) (Trastuzumab)

$13658 Million $8635 Million $7845 Million $7704 Million $5703 Million $5406 Million $5028 Million $4956 Million $4674 Million $4440 Million $4338 Million $4321 Million $4264 Million $4075 Million $4033 Million $3943 Million $3899 Million $3872 Million $3779 Million $3764 MillionCHOLEST&TRIGLY.REGULATOR PLATELET AGGR.INHIBITORS ANTIULCERANTS B2-STIMULANTS+CORTICOIDS SPEC ANTIRHEUMATIC AGENT ANTIPSYCHOTICS ANTIPSYCHOTICS IMMUNOSUPPRESSIVE AGENTS ANTILEUK ANTI-ASTHMATICS HEPARINS ALL OTH. ANTINEOPLASTICS ANTIULCERANTS ANTIDEPRESS.& MOOD STAB. SPEC ANTIRHEUMATIC AGENT ALL OTH. ANTINEOPLASTICS CHOLEST&TRIGLY.REGULATOR ANTIPSYCHOTICS ORAL ANTIDIABETICS IMMUNOSTIM AG EX INTFRON ALL OTH. ANTINEOPLASTICS

PFIZER BRISTOL-MYERS SQB. ASTRAZENECA GLAXOSMITHKLINE AMGEN ASTRAZENECA LILLY JOHNSON & JOHNSON MERCK & CO SANOFI-AVENTIS ROCHE TAKEDA WYETH ABBOTT ROCHE ASTRAZENECA JOHNSON & JOHNSON TAKEDA AMGEN ROCHE

21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 DIOVAN ABILIFY ARICEPT ARANESP LANTUS GLIVEC SPIRIVA EPOGEN TOPAMAX OXYCONTIN CYMBALTA ERYPO VYTORIN TAXOTERE LYRICA LEXAPRO CELEBREX CO-DIOVAN VALTREX ZETIA (Valsartan) (Aripiprazole) (Donepezil) (Darbepoetin Alfa) (Insulin Glargine) (Imatinib) (Tiotropium) (Epoetin Alfa) (Topiramate) (Oxycodone) (Duloxetine) (Epoetin Alfa) (Simvastatin & Ezetimibe) (Docetaxel) (Pregabalin) (Escitalopram) (Celecoxib) (Valsartan & Hydrochlorothiazide) (Valaciclovir) (Ezetimibe)

$3669 Million $3619 Million $3569 Million $3497 Million $3331 Million $3139 Million $3090 Million $3008 Million $2836 Million $2828 Million $2825 Million $2722 Million $2682 Million $2639 Million $2626 Million $2625 Million $2504 Million $2497 Million $2455 Million $2366 MillionANGIOTEN-II ANTAG, PLAIN ANTIPSYCHOTICS ANTI-ALZHEIMER PRODUCTS ERYTHROPOIETIN PRODUCTS HUMAN INSULIN+ANALOGUES ALL OTH. ANTINEOPLASTICS ANTICHOLINERGIC+B2-STIM ERYTHROPOIETIN PRODUCTS ANTI-EPILEPTICS NARCOTIC ANALGESICS ANTIDEPRESS.& MOOD STAB. ERYTHROPOIETIN PRODUCTS LIP.REG.CO.W.OTH.LIP.REG VINCA ALKALOIDS ANTI-EPILEPTICS ANTIDEPRESS.& MOOD STAB. ANTIRHEUMATIC N-STEROID ANGIOTEN-II ANTAG, COMB ANTIVIRALS EXCL ANTI-HIV CHOLEST&TRIGLY.REGULATOR

NOVARTIS OTSUKA EISAI AMGEN SANOFI-AVENTIS NOVARTIS BOEHRINGER INGEL AMGEN JOHNSON & JOHNSON MUNDI INT LILLY JOHNSON & JOHNSON MERCK & CO SANOFI-AVENTIS PFIZER FOREST PFIZER NOVARTIS GLAXOSMITHKLINE MERCK & CO

41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 NORVASC PARIET VIAGRA COZAAR LAMICTAL ELOXATINE TRUVADA AVONEX COPAXONE SYMBICORT KEPPRA PROGRAF LEVAQUIN ARIMIDEX CELLCEPT ALNA ONE TOUCH ULTRA NOVORAPID PANTOZOL REBIF (Amlodipine) (Rabeprazole) (Sildenafil) (Losartan) (Lamotrigine) (Oxaliplatin) (Tenofovir & Emtricitabine) (Interferon Beta-1a) (Glatiramer Acetate) (Budesonide & Formoterol Fumarate) (Levetiracetam) (Tacrolimus) (Levofloxacin) (Anastrozole) (Mycophenolate Mofetil) (Tamsulosin) (Insulin aspart) (Pantoprazole) (Interferon beta-1a)

$2331 Million $2247 Million $2197 Million $2191 Million $2162 Million $2130 Million $2097 Million $2037 Million $2032 Million $2012 Million $1992 Million $1933 Million $1858 Million $1848 Million $1805 Million $1796 Million $1773 Million $1740 Million $1694 Million $1693 MillionCALCIUM ANTAGONIST PLAIN ANTIULCERANTS ERECTILE DYSFUNCTION PRD ANGIOTEN-II ANTAG, PLAIN ANTI-EPILEPTICS ALL OTH. ANTINEOPLASTICS HIV ANTIVIRALS INTERFERONS IMMUNOSTIM AG EX INTFRON B2-STIMULANTS+CORTICOIDS ANTI-EPILEPTICS IMMUNOSUPPRESSIVE AGENTS FLUORO-QUINOLONES CYTO HORMONE ANTAGONISTS IMMUNOSUPPRESSIVE AGENTS BPH PRODUCTS DIABETES TESTS HUMAN INSULIN+ANALOGUES ANTIULCERANTS INTERFERONS

PFIZER EISAI PFIZER MERCK & CO GLAXOSMITHKLINE SANOFI-AVENTIS GILEAD SCIENCES BIOGEN IDEC TEVA ASTRAZENECA UCB ASTELLAS PHARMA JOHNSON & JOHNSON ASTRAZENECA ROCHE BOEHRINGER INGEL JOHNSON & JOHNSON NOVO NORDISK NYCOMED PHARMA MERCK KGAA

61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 LUCENTIS PULMICORT VALCOTE ACTONEL GARDASIL ATRIPLA BLOPRESS NEORECORMON XALATAN TRICOR HYZAAR GEMZAR IMIGRAN ZOMETA NEUPOGEN CIALIS STILNOX NASONEX ADDERALL BETAFERON (Ranibizumab) (Budesonide) (Valproic Acid) (Risedronate) (Human Papillomavirus) (Tenofovir & Emtricitabine & Efavirenz) (Candesartan) (Epoetin Alfa) (Latanoprost) (Fenofibrate) (Losartan & Hydrochlorothiazide) (Gemcitabine) (Sumatriptan) (Zoledronate) (Filgrastim) (Tadalafil) (Zolpidem) (Mometasone) (Amphetamine & Dextroamphetamine) (Interferon beta-1b)

$1640 Million $1634 Million $1628 Million $1606 Million $1599 Million $1591 Million $1583 Million $1558 Million $1556 Million $1523 Million $1516 Million $1513 Million $1504 Million $1487 Million $1446 Million $1443 Million $1441 Million $1437 Million $1417 Million $1359 MillionROCHE ASTRAZENECA ABBOTT PROCTER & GAMBLE MERCK & CO GILEAD SCIENCES TAKEDA ROCHE PFIZER ABBOTT MERCK & CO LILLY GLAXOSMITHKLINE NOVARTIS AMGEN LILLY SANOFI-AVENTIS SCHERING PLOUGH SHIRE PHARMACEUT. BAYER

OCULAR ANTINEOVASC.PRODS CORTICOIDS ANTI-EPILEPTICS BONE CALCIUM REGULATORS PURE VACCINES HIV ANTIVIRALS ANGIOTEN-II ANTAG, PLAIN ERYTHROPOIETIN PRODUCTS MIOTICS+ANTIGLAUC.PREPS. CHOLEST&TRIGLY.REGULATOR ANGIOTEN-II ANTAG, COMB ANTIMETABOLITES ANTI-MIGRAINE PREPS BONE CALCIUM REGULATORS IMMUNOSTIM AG EX INTFRON ERECTILE DYSFUNCTION PRD HYPNOTICS & SEDATIVES TOPICAL NASAL PREPS PSYCHOSTIMULANTS INTERFERONS

81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 PREVNAR JANUVIA HUMALOG SYNAGIS FLIXOTIDE ERBITUX TAZOCIN CONCERTA DETRUSITOL VOLTAREN MICARDIS CASODEX BENICAR REYATAZ VARIVAX ZELDOX KALETRA SIFROL PEGASYS EVISTA (Pneumococcal conjugate) (Sitagliptin) (insulin lispro) (Palivizumab) (Fluticasone Propionate) (Cetuximab) (Tazobactam & Piperacillin) (Methylphenidate) (Tolterodine) (Diclofenac) (Telmisartan) (Bicalutamide) (Olmesartan) (Atazanavir) (Varicella zoster) (Ziprasidone) (Lopinavir & Ritonavir) (Pramipexole) (Peginterferon Alfa-2a) (Raloxifene)

$1354 Million $1342 Million $1339 Million $1334 Million $1323 Million $1315 Million $1310 Million $1308 Million $1298 Million $1260 Million $1245 Million $1243 Million $1216 Million $1205 Million $1197 Million $1193 Million $1154 Million $1131 Million $1101 Million $1089 MillionPURE VACCINES ORAL ANTIDIABETICS HUMAN INSULIN+ANALOGUES SPECF IMM-GLOB ANTIVIRAL CORTICOIDS ALL OTH. ANTINEOPLASTICS BROAD SPECTR.PENICILLINS PSYCHOSTIMULANTS URINARY INCONTINENCE PRD ANTIRHEUMATIC N-STEROID ANGIOTEN-II ANTAG, PLAIN CYTO HORMONE ANTAGONISTS ANGIOTEN-II ANTAG, PLAIN HIV ANTIVIRALS PURE VACCINES ANTIPSYCHOTICS HIV ANTIVIRALS ANTI-PARKINSON PREPS ANTIVIRALS EXCL ANTI-HIV SERMS

WYETH MERCK & CO LILLY ASTRAZENECA GLAXOSMITHKLINE LILLY WYETH JOHNSON & JOHNSON PFIZER NOVARTIS BOEHRINGER INGEL ASTRAZENECA DAIICHI SANKYO BRISTOL-MYERS SQB. MERCK & CO PFIZER ABBOTT BOEHRINGER INGEL ROCHE LILLY

101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 ZYVOX LOSEC FEMARA YASMIN AUGMENTIN DURAGESIC BONVIVA ZOLADEX ALIMTA NOVOMIX TARCEVA AVANDIA SANDOSTATIN LIDODERM XELODA NAMENDA PROVIGIL OMNIPAQUE SEROXAT CIPRALEX (Linezolid) (Omeprazole) (Letrozole) (Drospirenone & Ethinylestradiol) (Amoxicillin & Clavulanic Acid) (Fentanyl) (Ibandronate) (Goserelin) (Pemetrexed) (insulin aspart) (Gefitinib) (Rosiglitazone) (Octreotide) (Lidocaine) (Capecitabine) (Memantine) (Modafinil) (Iohexol) (Paroxetine) (Escitalopram)

$1089 Million $1060 Million $1060 Million $1055 Million $1052 Million $1052 Million $1048 Million $1027 Million $1025 Million $1015 Million $1015 Million $1005 Million $1001 Million $1000 Million $968 Million $964 Million $964 Million $954 Million $952 Million $949 MillionOTHER ANTIBACTERIALS ANTIULCERANTS CYTO HORMONE ANTAGONISTS HORMONAL CONTRACEPT SYST BROAD SPECTR.PENICILLINS NARCOTIC ANALGESICS BONE CALCIUM REGULATORS CYTOSTATIC HORMONES ANTIMETABOLITES HUMAN INSULIN+ANALOGUES ALL OTH. ANTINEOPLASTICS ORAL ANTIDIABETICS HYPOTHALAMIC HORMONES ANAESTHETICS, LOCAL ANTIMETABOLITES ANTI-ALZHEIMER PRODUCTS PSYCHOSTIMULANTS LOW OSMOLAR ANGIO-UROGRP ANTIDEPRESS.& MOOD STAB. ANTIDEPRESS.& MOOD STAB.

PFIZER ASTRAZENECA NOVARTIS BAYER GLAXOSMITHKLINE JOHNSON & JOHNSON ROCHE ASTRAZENECA LILLY NOVO NORDISK ROCHE GLAXOSMITHKLINE NOVARTIS ENDO PHARM ROCHE FOREST CEPHALON GE HEALTHCARE GLAXOSMITHKLINE LUNDBECK

121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 COVERSYL ATACAND TEMODAL S-PL SANDIMMUN FOSAMAX AVELOX ADALAT ENANTONE CHAMPIX VELCADE GENOTROPIN COMBIVENT ACTRAPHANE HM NOVOSEVEN NIASPAN PREMARIN EPZICOM LUPRON FORTEO MERREM (Perindopril) (Candesartan) (Temozolomide) (Cyclosporine) (Alendronate) (Moxifloxacin) (Nifedipine) (Leuprorelin Acetate) (Varenicline) (Bortezomib) (Somatropin) (Ipratropium) (Insulin Human Aerius) (eptacog alfa) (Niacin) (Estrone Sulfate) (Lamivudine) (Leuprorelin) (Teriparatide) (Meropenem)

$931 Million $919 Million $902 Million $900 Million $891 Million $888 Million $876 Million $869 Million $853 Million $852 Million $848 Million $847 Million $846 Million $836 Million $825 Million $818 Million $817 Million $815 Million $811 Million $801 MillionACE INHIBITORS PLAIN ANGIOTEN-II ANTAG, PLAIN ALKYLATING AGENTS IMMUNOSUPPRESSIVE AGENTS BONE CALCIUM REGULATORS FLUORO-QUINOLONES CALCIUM ANTAGONIST PLAIN CYTOSTATIC HORMONES ANTISMOKING PRODUCTS ALL OTH. ANTINEOPLASTICS GROWTH HORMONES ANTICHOLINERGIC+B2-STIM HUMAN INSULIN+ANALOGUES BLOOD COAGULATION CHOLEST&TRIGLY.REGULATOR OESTROG EX G3A,G3E,G3F HIV ANTIVIRALS CYTOSTATIC HORMONES PARATHYROID HORM&ANALOGS OTH B-LACTAM EX PEN,CEPH

SERVIER ASTRAZENECA SCHERING PLOUGH NOVARTIS MERCK & CO SCHERING PLOUGH BAYER TAKEDA PFIZER JOHNSON & JOHNSON PFIZER BOEHRINGER INGEL NOVO NORDISK NOVO NORDISK ABBOTT WYETH GLAXOSMITHKLINE ABBOTT LILLY ASTRAZENECA

141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 APROVEL XOPENEX SUTENT EXELON WELLBUTRIN COAPROVEL AERIUS LUNESTA ASACOL LEVEMIR FOSAMAX PLUS D SIMILAC ADVANCE KARVEA COMBIVIR AVODART RENAGEL VESICARE VIRAFERON PEG ZOCOR ZEMPLAR (Irbesartan ) (Salbutamol) (Sunitinib) (Rivastigmine) (Bupropion) (irbesartan hydrochlorothiazide) (Desloratadine) (Eszopiclone) (Mesalazine) (insulin detemir) (Alendronate) (irbesartan) (Lamivudine & Zidovudine) (Dutasteride) (Sevelamer) (Solifenacin) (peginterferon alfa-2b) (Simvastatin) (Paricalcitol)

$797 Million $790 Million $789 Million $785 Million $785 Million $777 Million $769 Million $762 Million $760 Million $749 Million $749 Million $738 Million $736 Million $734 Million $733 Million $730 Million $715 Million $714 Million $708 Million $707 MillionANGIOTEN-II ANTAG, PLAIN B2-STIMULANTS ALL OTH. ANTINEOPLASTICS ANTI-ALZHEIMER PRODUCTS ANTIDEPRESS.& MOOD STAB. ANGIOTEN-II ANTAG, COMB ANTIHISTAMINES SYSTEMIC HYPNOTICS & SEDATIVES INTESTINAL ANTI-INFLAMM HUMAN INSULIN+ANALOGUES BONE CALCIUM REGULATORS INFANT FORMULAS ANGIOTEN-II ANTAG, PLAIN HIV ANTIVIRALS BPH PRODUCTS ALL OTH.THERAPEUTIC PRDS URINARY INCONTINENCE PRD ANTIVIRALS EXCL ANTI-HIV CHOLEST&TRIGLY.REGULATOR VIT A & D INC. COMBS

SANOFI-AVENTIS SEPRACOR PFIZER NOVARTIS GLAXOSMITHKLINE SANOFI-AVENTIS SCHERING PLOUGH SEPRACOR PROCTER & GAMBLE NOVO NORDISK MERCK & CO ABBOTT BRISTOL-MYERS SQB. GLAXOSMITHKLINE GLAXOSMITHKLINE GENZYME CORP ASTELLAS PHARMA SCHERING PLOUGH MERCK & CO ABBOTT

161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 BYETTA PROSCAR NORDITROPIN LAMOTRIGINE VFEND ASPIRIN BAYER SECTOR PROTONIX PANTOPRAZOLE BUDEPRION AVALIDE EFFERALGAN RECOMBINATE SEVORANE HARNAL PANTOPRAZOLE STRATTERA BENICAR HCT YAZ COSOPT (Exenatide) (Finasteride) (Somatropin Recombinant) (Lamotrigine) (Voriconazole) (Aspirin) (Ketoprofen) (Pantoprazole) (Pantoprazole) (Bupropion) (Irbesartan) (Paracetamol) (octocog alfa) (Sevoflurane) (Tamsulosin) (Pantoprazole) (Atomoxetine) (Olmesartan) (Drospirenone & Ethinylestradiol) (Dorzolamide & Timolol)

$706 Million $706 Million $695 Million $692 Million $689 Million $689 Million $671 Million $671 Million $665 Million $662 Million $661 Million $660 Million $660 Million $651 Million $649 Million $642 Million $637 Million $635 Million $630 Million $622 MillionOTHER DRUGS FOR DIABETES OTHER DERMATOLOGICAL PRD GROWTH HORMONES ANTI-EPILEPTICS SYST ANTIFUNGAL AGENTS PLATELET AGGR.INHIBITORS ANTIRHEUMATICS TOPICAL ANTIULCERANTS ANTIULCERANTS ANTIDEPRESS.& MOOD STAB. ANGIOTEN-II ANTAG, COMB NON-NARCOTIC ANALGESICS BLOOD COAGULATION ANAESTHETICS GENERAL BPH PRODUCTS ANTIULCERANTS ALL OTHER CNS DRUGS ANGIOTEN-II ANTAG, COMB HORMONAL CONTRACEPT SYST MIOTICS+ANTIGLAUC.PREPS.

AMYLIN PHARM MERCK & CO NOVO NORDISK TEVA PFIZER BAYER HISAMITSU WYETH TEVA TEVA BRISTOL-MYERS SQB. BRISTOL-MYERS SQB. BAXTER INT ABBOTT ASTELLAS PHARMA WYETH LILLY DAIICHI SANKYO BAYER MERCK & CO

Source: Midas World Review (TM), January 2008-December 2008, IMS Health Incorporated. All Rights Reserved.The statements, findings, conclusions, views, and opinions contained and expressed in this poster are based in part on data obtained under license from the following IMS Health Incorporated information service(s): Midas World Review (TM), January 2008-December 2008, IMS Health Incorporated. All Rights Reserved., IMS Health Incorporated. All Rights Reserved. Such statements, findings, conclusions, views, and opinions are not necessarily those of IMS Health Incorporated or any of its affiliated or subsidiary entities.

181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 LESCOL ZIENAM CRAVIT SYNTHROID CAMPTOSAR REMINYL CADUET ATACAND PLUS TELFAST KLACID MAXALT REVLIMID BETALOC REQUIP SUSTIVA SALAMOL VIREAD AMARYL ASC. CONTOUR SUBOXONE (Fluvastatin) (Imipenem) (Levofloxacin) (Levothyroxine) (Irinotecan) (Galantamine) (Atorvastatin & Amlodipine) (Candesartan) (Fexofenadine) (Clarithromycin) (Rizatriptan) (Lenalidomide) (Metoprolol) (Ropinirole) (Emtricitabine & Tenofovir & Efavarenz) (Salbutamol) (TenofovirF) (Glimepiride) (Buprenorphine & Naloxone)

$622 Million $620 Million $617 Million $610 Million $609 Million $605 Million $602 Million $602 Million $602 Million $595 Million $591 Million $584 Million $583 Million $582 Million $575 Million $568 Million $567 Million $567 Million $562 Million $558 MillionCHOLEST&TRIGLY.REGULATOR OTH B-LACTAM EX PEN,CEPH FLUORO-QUINOLONES THYROID PREPARATIONS VINCA ALKALOIDS ANTI-ALZHEIMER PRODUCTS LIPREG.CV.MULT-TH.COMBS ANGIOTEN-II ANTAG, COMB ANTIHISTAMINES SYSTEMIC MACROLIDES & SIMILR TYPE ANTI-MIGRAINE PREPS IMMUNOSUPPRESSIVE AGENTS B-BLOCKING AGENTS,PLAIN ANTI-PARKINSON PREPS HIV ANTIVIRALS B2-STIMULANTS HIV ANTIVIRALS ORAL ANTIDIABETICS DIABETES TESTS DRUGS USED IN OPIOID DEP

NOVARTIS MERCK & CO DAIICHI SANKYO ABBOTT PFIZER JOHNSON & JOHNSON PFIZER ASTRAZENECA SANOFI-AVENTIS ABBOTT MERCK & CO CELGENE CORP ASTRAZENECA GLAXOSMITHKLINE BRISTOL-MYERS SQB. TEVA GILEAD SCIENCES SANOFI-AVENTIS BAYER RECKITT BENCKISER