Top 200 Pharmaceutical Products by Worldwide Sales in 2009Compiled and Produced by the Njardarson Group (Cornell University): Daniel J. Mack, Matthew Brichacek, Alexandra Plichta, Jón T. Njarðarson

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20Lipitor(Atorvastatin)

Plavix(Clopidogrel)

Nexium(Esomeprazole)

Seretide(Fluticasone & Salmeterol)

Seroquel(Quetiapine)

Enbrel(Etanercept)

Remicade(Infl iximab)

Crestor(Rosuvastatin)

Zyprexa(Olanzapine)

Humira(Adalimumab)

Avastin(Bevacizumab)

Singulair(Montelukast)

Mabthera(Rituximab)

Abilify(Aripiprazole)

Lovenox(Enoxaparin)

Actos(Pioglitazone)

Aricept(Donepezil)

Lantus(Insulin Glargine)

Diovan(Valsartan)

Herceptin(Trastuzumab)

$13288 Million $9059 Million $8236 Million $8098 Million $5974 Million $5863 Million $5453 Million $5383 Million $5295 Million $5032 Million $5013 Million $4986 Million $4681 Million $4657 Million $4552 Million $4116 Million $4013 Million $3968 Million $3912 Million $3890 MillionCholest&Trigly.Regulator Platelet Aggr.Inhibitors Antiulcerants B2-Stimulants+Corticoids Antipsychotics Spec Antirheumatic Agent Immunosuppressive Agents Cholest&Trigly.Regulator Antipsychotics Spec Antirheumatic Agent All Oth. Antineoplastics Antileuk Anti-Asthmatics All Oth. Antineoplastics Antipsychotics Heparins Glitazone Antidiabetics Anti-Alzheimer Products Human Insulin+Analogues Angioten-II Antag, Plain All Oth. Antineoplastics

21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40Takepron(Lansoprazole)

Neulasta(Pegfi lgrastim)

Spiriva(Tiotropium)

Glivec(Imatinib)

Oxycontin(Oxycodone)

Effexor(Venlafaxine)

Cymbalta(Duloxetine)

Epogen(Epoetin Alfa)

Lyrica(Pregabalin)

Aranesp(Darbepoetin Alfa)

Taxotere(Docetaxel)

Lexapro(Escitalopram)

Co-Diovan(Valsartan & Hydrochlorothiazide)

Valtrex(Valaciclovir)

Celebrex(Celecoxib)

Truvada(Tenofovir & Emtricitabine)

Erypo(Epoetin Alfa)

Copaxone(Glatiramer Acetate)

Atripla(Tenofovir & Emtricitabine & Efavirenz)

Zetia(Ezetimibe)

$3778 Million $3678 Million $3499 Million $3419 Million $3410 Million $3358 Million $3317 Million $3099 Million $2937 Million $2752 Million $2689 Million $2655 Million $2617 Million $2510 Million $2487 Million $2476 Million $2474 Million $2432 Million $2414 Million $2397 MillionAntiulcerants Immunostim Ag Ex Intfron Anticholinergic+B2-Stim All Oth. Antineoplastics Narcotic Analgesics Antidepress.& Mood Stab. Antidepress.& Mood Stab. Erythropoietin Products Anti-Epileptics Erythropoietin Products Vinca Alkaloids Antidepress.& Mood Stab. Angioten-II Antag, Comb Antivirals Excl Anti-HIV Antirheumatic N-Steroid HIV Antivirals Erythropoietin Products Immunostim Ag Ex Intfron HIV Antivirals Cholest&Trigly.Regulator

41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60Symbicort(Budesonide & Formoterol Fumarate)

Pariet(Rabeprazole)

Vytorin(Simvastatin & Ezetimibe)

Viagra(Sildenafi l)

Risperdal(Risperidone)

Alna(Tamsulosin)

Lucentis(Ranibizumab)

Cozaar(Losartan)

Avonex(Interferon Beta-1a)

Novorapid(Insulin aspart)

Prograf(Tacrolimus)

Norvasc(Amlodipine)

Arimidex(Anastrozole)

Januvia(Sitagliptin)

One Touch Ultra()

Rebif(Interferon beta-1a)

Zometa(Zoledronate)

Levaquin(Levofl oxacin)

Blopress(Candesartan)

Tamifl u(Oseltamivir)

$2353 Million $2349 Million $2315 Million $2308 Million $2297 Million $2290 Million $2163 Million $2135 Million $2100 Million $2100 Million $2018 Million $1977 Million $1922 Million $1893 Million $1840 Million $1837 Million $1811 Million $1743 Million $1705 Million $1606 MillionB2-Stimulants+Corticoids Antiulcerants Lip.Reg.Co.W.Oth.Lip.Reg Erectile Dysfunction Prd Antipsychotics BPH Products Ocular Antineovasc.Prods Angioten-II Antag, Plain Interferons Human Insulin+Analogues Immunosuppressive Agents Calcium Antagonist Plain Cyto Hormone Antagonists Dpp-IV Inhibitor A-Diabs Diabetes Tests Interferons Bone Calcium Regulators Fluoro-Quinolones Angioten-II Antag, Plain Antivirals Excl Anti-HIV

61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80Cialis(Tadalafi l)

Tricor(Fenofi brate)

Hyzaar(Losartan & Hydrochlorothiazide)

Xalatan(Latanoprost)

Humalog(insulin lispro)

Eloxatine(Oxaliplatin)

Benicar(Olmesartan)

Nasonex(Mometasone)

Betaferon(Interferon beta-1b)

Pulmicort(Budesonide)

Cellcept(Mycophenolate Mofetil)

Alimta(Pemetrexed)

Stilnox(Zolpidem)

Neorecormon(Epoetin Alfa)

Actonel(Risedronate)

Concerta(Methylphenidate)

Micardis(Telmisartan)

Keppra(Levetiracetam)

Erbitux(Cetuximab)

Topamax(Topiramate)

$1599 Million $1594 Million $1592 Million $1556 Million $1538 Million $1538 Million $1533 Million $1517 Million $1515 Million $1505 Million $1505 Million $1495 Million $1483 Million $1482 Million $1472 Million $1463 Million $1422 Million $1406 Million $1398 Million $1375 MillionErectile Dysfunction Prd Cholest&Trigly.Regulator Angioten-II Antag, Comb Miotics+Antiglauc.Preps. Human Insulin+Analogues All Oth. Antineoplastics Angioten-II Antag, Plain Topical Nasal Preps Interferons Corticoids Immunosuppressive Agents Antimetabolites Hypnotics & Sedatives Erythropoietin Products Bone Calcium Regulators Psychostimulants Angioten-II Antag, Plain Anti-Epileptics All Oth. Antineoplastics Anti-Epileptics

81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100Reyataz(Atazanavir)

Synagis(Palivizumab)

Flixotide(Fluticasone Propionate)

Pantozol(Pantoprazole)

Neupogen(Filgrastim)

Voltaren(Diclofenac)

Varivax(Varicella zoster)

Gemzar(Gemcitabine)

Zeldox(Ziprasidone)

Detrusitol(Tolterodine)

Novomix(insulin aspart)

Femara(Letrozole)

Velcade(Bortezomib)

Sifrol(Pramipexole)

Prevnar(Pneumococcal conjugate)

Pegasys(Peginterferon Alfa-2a)

Tazocin(Tazobactam & Piperacillin)

Bonviva(Ibandronate)

Namenda(Memantine)

Zyvox(Linezolid)

$1338 Million $1337 Million $1330 Million $1324 Million $1322 Million $1319 Million $1300 Million $1292 Million $1287 Million $1275 Million $1257 Million $1238 Million $1237 Million $1232 Million $1207 Million $1189 Million $1186 Million $1161 Million $1140 Million $1100 MillionHIV Antivirals Specf Imm-Glob Antiviral Corticoids Antiulcerants Immunostim Ag Ex Intfron Antirheumatic N-Steroid Pure Vaccines Antimetabolites Antipsychotics Urinary Incontinence Prd Human Insulin+Analogues Cyto Hormone Antagonists All Oth. Antineoplastics Anti-Parkinson Preps Pure Vaccines Antivirals Excl Anti-HIV Broad Spectr.Penicillins Bone Calcium Regulators Anti-Alzheimer Products Other Antibacterials

101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120Tarceva(Gefi tinib)

Xeloda(Capecitabine)

Evista(Raloxifene)

Adderall(Amphetamine & Dextroamphetamine)

Lidoderm(Lidocaine)

Kaletra(Lopinavir & Ritonavir)

Sandostatin(Octreotide)

Provigil(Modafi nil)

Levemir(insulin detemir)

Augmentin(Amoxicillin & Clavulanic Acid)

Cipralex(Escitalopram)

Gardasil(Human Papillomavirus)

Niaspan(Niacin)

Zoladex(Goserelin)

Temodal M-Co(Temozolomide)

Enantone(Leuprorelin Acetate)

Duragesic(Fentanyl)

Lamictal(Lamotrigine)

Combivent(Ipratropium)

Novoseven(eptacog alfa)

$1081 Million $1079 Million $1063 Million $1062 Million $1062 Million $1053 Million $1051 Million $1021 Million $1021 Million $992 Million $987 Million $972 Million $964 Million $962 Million $958 Million $957 Million $951 Million $950 Million $938 Million $938 MillionAll Oth. Antineoplastics Antimetabolites Serms Psychostimulants Anaesthetics, Local HIV Antivirals Hypothalamic Hormones Psychostimulants Human Insulin+Analogues Broad Spectr.Penicillins Antidepress.& Mood Stab. Pure Vaccines Cholest&Trigly.Regulator Cytostatic Hormones Alkylating Agents Cytostatic Hormones Narcotic Analgesics Anti-Epileptics Anticholinergic+B2-Stim Blood Coagulation

121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140Salamol(Salbutamol)

Recombinate(octocog alfa)

Exelon(Rivastigmine)

Atacand(Candesartan)

Vesicare(Solifenacin)

Losec(Omeprazole)

Omnipaque(Iohexol)

Yaz(Drospirenone & Ethinylestradiol)

Sutent(Sunitinib)

Ascensia Contour()

Sandimmun(Cyclosporine)

Genotropin(Somatropin)

Avodart(Dutasteride)

Epzicom(Lamivudine)

Suboxone(Buprenorphine & Naloxone)

Casodex(Bicalutamide)

Avelox(Moxifl oxacin)

Premarin(Estrone Sulfate)

Adalat(Nifedipine)

Coversyl(Perindopril)

$936 Million $935 Million $933 Million $921 Million $904 Million $895 Million $889 Million $885 Million $881 Million $876 Million $869 Million $868 Million $865 Million $859 Million $851 Million $840 Million $838 Million $833 Million $828 Million $814 MillionB2-Stimulants Blood Coagulation Anti-Alzheimer Products Angioten-II Antag, Plain Urinary Incontinence Prd Antiulcerants Low Osmolar Angio-Urogrp Hormonal Contracept Syst All Oth. Antineoplastics Diabetes Tests Immunosuppressive Agents Growth Hormones BPH Products HIV Antivirals Drugs Used In Opioid Dep Cyto Hormone Antagonists Fluoro-Quinolones Oestrog Ex G3A,G3E,G3F Calcium Antagonist Plain Ace Inhibitors Plain

141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160Asacol(Mesalazine)

Sector(Ketoprofen)

Forteo(Teriparatide)

Seroxat(Paroxetine)

Metoprolol Par-(Ropinirole)

Avandia(Rosiglitazone)

Merrem(Meropenem)

Lupron(Leuprorelin)

Zemplar(Paricalcitol)

Coaprovel(irbesartan hydrochlorothiazide)

Yasmin(Drospirenone & Ethinylestradiol)

Actraphane Hm(Insulin Human Aerius)

Aprovel(Irbesartan )

Byetta(Exenatide)

Betaloc(Metoprolol)

Ventolin(Salbutamol)

Karvea(irbesartan)

Benicar Hct(Olmesartan)

Lunesta(Eszopiclone)

Aerius(Desloratadine)

$811 Million $800 Million $792 Million $788 Million $777 Million $772 Million $772 Million $768 Million $768 Million $767 Million $766 Million $765 Million $759 Million $758 Million $750 Million $741 Million $734 Million $733 Million $730 Million $728 MillionIntestinal Anti-Infl amm Top A-Rheumatics & Analg Parathyroid Horm&Analogs Antidepress.& Mood Stab. B-Blocking Agents,Plain Glitazone Antidiabetics Oth B-Lactam Ex Pen,Ceph Cytostatic Hormones Vit A & D Inc. Combs Angioten-II Antag, Comb Hormonal Contracept Syst Human Insulin+Analogues Angioten-II Antag, Plain GLP-1 Agonist A-Diabs B-Blocking Agents,Plain B2-Stimulants Angioten-II Antag, Plain Angioten-II Antag, Comb Hypnotics & Sedatives Antihistamines Systemic

161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180Lovaza(Omega-3 Ethyl Esters)

Pantoprazole Pfi z(Pantoprazole)

Vfend(Voriconazole)

Tysabri(Natalizumab)

Champix(Varenicline)

Androgel(Testosterone)

Xopenex(Salbutamol)

Amphetamine Teva(Amphetamine)

Revlimid(Lenalidomide)

Harnal(Tamsulosin)

Norditropin(Somatropin Recombinant)

Vyvanse(Lisdexamfetamine)

Aspirin Bayer(Aspirin)

Avalide(Irbesartan)

Telfast(Fexofenadine)

Isentress(Raltegravir)

Proscar(Finasteride)

Synthroid(Levothyroxine)

Accu-Chek Aviva()

Strattera(Atomoxetine)

$727 Million $720 Million $714 Million $714 Million $713 Million $708 Million $706 Million $705 Million $703 Million $679 Million $675 Million $674 Million $673 Million $673 Million $671 Million $668 Million $663 Million $659 Million $653 Million $652 MillionAnti-Atheroma Natrl Orig Antiulcerants Syst Antifungal Agents Immunosuppressive Agents Antismoking Products Androgens, Excl G3E,G3F B2-Stimulants Psychostimulants Immunosuppressive Agents BPH Products Growth Hormones Psychostimulants Platelet Aggr.Inhibitors Angioten-II Antag, Comb Antihistamines Systemic HIV Antivirals Other Dermatological Prd Thyroid Preparations Diabetes Tests All Other Cns Drugs

Source: Midas World Review (TM), January 2009-December 2009, IMS Health Incorporated. All Rights Reserved.The statements, fi ndings, conclusions, views, and opinions contained and expressed in this poster are based in part on data obtained under license from the following IMS Health Incorporated information service(s): Midas World Review (TM), January 2009-December 2009, IMS Health Incorporated. All Rights Reserved., IMS Health Incorporated. All Rights Reserved. Such statements, fi ndings, conclusions, views, and opinions are not necessarily those of IMS Health Incorporated or any of its affi liated or subsidiary entities.

181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200Efferalgan(Paracetamol)

Viraferon Peg(peginterferon alfa-2b)

Exforge(Amlodipine & Valsartan)

Maxalt(Rizatriptan)

Travatan(Travoprost)

Cravit(Levofl oxacin)

Similac Advance()

Tylenol(Acetaminophen)

Combivir(Lamivudine & Zidovudine)

Xolair(Omalizumab)

Janumet(Sitagliptin)

Renagel(Sevelamer)

Viread(TenofovirF)

Micardis Hct(Telmisartan)

Tracleer(Bosentan)

Pentasa(Mesalazine)

Humalog Mix(insulin lispro)

Atacand Plus(Candesartan)

Sevorane(Sevofl urane)

Baraclude(Entecavir)

$650 Million $646 Million $643 Million $641 Million $640 Million $636 Million $636 Million $635 Million $633 Million $632 Million $631 Million $630 Million $625 Million $615 Million $614 Million $607 Million $599 Million $598 Million $597 Million $596 MillionNon-Narcotic Analgesics Antivirals Excl Anti-HIV Angioten-II Antag, Comb Anti-Migraine Preps Miotics+Antiglauc.Preps. Fluoro-Quinolones Infant Formulas Non-Narcotic Analgesics HIV Antivirals All Oth A-Asthma & Copd Dpp-IV Inhibitor A-Diabs Hyperkal.Hyperphos.Prods HIV Antivirals Angioten-II Antag, Comb Oth Cardiovascular Prds Intestinal Anti-Infl amm Human Insulin+Analogues Angioten-II Antag, Comb Anaesthetics General Antivirals Excl Anti-HIV