tissue engineering of the heart
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Tissue Engineering of the Heart. By: Dan Tamayo. Problem Being Solved. Regenerate heart tissues that have been damaged by Myocardial Infarction Help those with heart failure End the need for a heart transplant list. History of Tissue Engineering. - PowerPoint PPT PresentationTRANSCRIPT
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By: Dan Tamayo
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Regenerate heart tissues that have been damaged by Myocardial Infarction
Help those with heart failure
End the need for a heart transplant list
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1897-thoughts of growing cells were being discussed
1907- the first cells were grown outside of a living body
1940’s- the ability to specifically grow certain cells was discovered
1970’s- first artificial pancreas was made Mid 1990’s- starting to use direct tissue
delivery to the affected area 1998- the development of stem cells really
broadened the tissue engineering possibilities
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2001-President Bush restricts the funding for stem cell research
Mid 2000’s- FDA approves most cells grafting into human bodies
2009-Obama lifts the ban on federal funding for stem cell research.
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Today, scientists have been able to use the extracellular matrix from pig or rat hearts to make a new one using a technique called decellularization.
In 2011, Columbia University’s Biomedical Engineering researchers developed a new way to patch a heart.
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This is the process of decellularization and recellularization.
Decellularization is when all the cells are removed except for the extracellular matrix (top)
Recellularization is when the new cells are grow in and around the new heart scaffold (bottom)
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Empty Scaffold Scaffold with cultured heart cells from a rat
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Small chance of immunorejection
Cost
Research
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Optimal scaffold for cardiac tissue will be found
Ability to re-grow a heart from your cells to be transplanted into your body
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"Mending Broken Hearts with Tissue Engineering." MIT's News Office. Web. 26 Mar. 2012. <http://web.mit.edu/newsoffice/2008/heart-1102.html>.
Zimmermann, Wolfram-Hubertus, Michael Didie, Stephan Do¨ Ker, Ivan Melnychenko, Hiroshi Naito, Christina Rogge, Malte Tiburcy, and Thomas Eschenhagen. "Heart Muscle Engineering: An Update on Cardiac Muscle Replacement Therap."Cardiovascular Research 17 (2006). Web.
Tandon, Nina, Anna Marsano, Robert Maidhof, Leo Wan, Hyoungshin Park, and Gordana Vunjak-Novakovic. "Optimization of Electrical Stimulation Parameters for Cardiac Tissue Engineerin." JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2011). Web.
Eschenhagen, Thomas, and Wolfram H. Zimmermann. "Circulation Research." 97.1220-1231 (2005). Web.
Van Winterswijk, Peter J., and Erik Nout. "An Overview: History of Tissue Engineering."Tissue Engineering and Wound Healing (2007). Web.
"Engineers Patch a Heart: Tissue-Engineering Platform Enables Heart Tissue to Repair Itself."ScienceDaily. ScienceDaily, 06 May 2011. Web. 26 Mar. 2012. <http://www.sciencedaily.com/releases/2011/05/110506171905.htm>.
Zammaretti, Prisca, and Marisa Jacon. "Cardiac Tissue Engineering: Regeneration of the Wounded Heart." Current Opinion in Biotechnology 15.430-434 (2004).Http://www.sciencedirect.com/. Web.
Columbia University. "Engineers patch a heart: Tissue-engineering platform enables heart tissue to repair itself." ScienceDaily, 7 May 2011. Web. 22 Oct. 2012.