THROXINE (T4) AND TRIIODOTHYRONINE (T3)

Presentation by:

Sofia Vitale

Francesca Canepa

Alexandra Aguero

Sarah Morin

W H E R E I S T H E H O R M O N E P R O D U C E D ?

Thyroid hormone is a metabolic hormone secreted by the thyroid

gland. There are two types of thyroid hormones, thyroxine (T4),

and triiodothyronine (T3).

W H A T A R E T H E T A R G E T O R G A N S / S T R U C T U R E S O F T 3 A N D T 4 ?

T3 and T4 affect every cell and all the organs of the body. Too

much of either of these speeds things up and too little of these

slows things down.

H O W I S T H E S E C R E T I O N O F T H E H O R M O N E R E G U L AT E D / C O N T R O L L E D ?

Too much of TSH result in increased thyroid hormone synthesis and

release into the blood stream, and too little of TSH result in decreased

synthesis and that releases into the blood stream. The amount of TSH

secreted is controlled by the thyroid-releasing hormone, which is

produced by an organ called the hypothalamus. When the amount of

thyroid hormones in the blood reaches a certain level, the hypothalamus

stops secreting thyroid-releasing hormone. This stops the secretion of

TSH, which stops the secretion of T3 and T4.

W H AT I S T H E N O R M A L F U N C T I O N O F T H E H O R M O N E ?

The function for both T4 and T3 would be to regulate Metabolism.

The hormone are basically are specialized substances that

coordinate the activities of specific cells in certain areas of the

body. The hormone are produced by cells in glands, which they’re

secreted by the gland into the bloodstream. After that, the

bloodstream then transports the hormone to certain tissues, where

the hormone has its effect.

H O W D O E S T H E H O R M O N E C O N T R I B U T E T O H O M E O S TA S I S ?

The hormone alter the metabolism of target organs by increasing or

decreasing their activity. Changes in activity are strictly balanced

to maintain homeostasis.

W H AT A R E T H E C A U S E S A N D S Y M P T O M S O F H Y P O S E C R E T I O N O F T H E H O R M O N E

( O R R E C E P T O R B L O C K A G E ) ?

Hyposecretion of ADH is called the syndrome of inappropriate

antidiuretic hormone. This can cause the symptoms retention of

fluid, headache, disorientation, weight gain and also blood

concentration goes down. Hyposecretion of ADH is diabetes

insipidus, which can cause an increase in urine output and

excessive thirst.

W H AT A R E T H E T R E AT M E N T S F O R U N D E R O R O V E R A C T I VAT I O N O F T H E

H O R M O N E PAT H WAY

Hypersecretion are used to treat the underlying causes when

possible, monitor fluid intake, and for very symptomatic patients,

get hypertonic saline.

Hyposecretion are treated with a synthetic hormone called

desmopressin.

H O W, I F AT A L L , I S T H E H O R M O N E U S E D C L I N I C A L O R C O M M E R C I A L LY

ADH is neither used clinically or commercially. ADH is actually a

naturally produced hormone.

RESOURCES

http://emedicine.medscape.com/

http://www.yourhormones.info/

http://www.unomaha.edu/hpa/abnormal.html

http://

www.rightdiagnosis.com/sym/hypersecretion_of_gro

wth_hormone.htm

http://www.dummies.com/how-to/content/general-f

unctions-of-hormones-in-living-creatures.html