thermal characterization as part of an empirical process for developing optimized formulations and...

8/20/2019 Thermal Characterization as Part of an Empirical Process for Developing Optimized Formulations and Lyophilization Cycles

http://slidepdf.com/reader/full/thermal-characterization-as-part-of-an-empirical-process-for-developing-optimized 1/65

Thermal Characterization as Part of an

Empirical Process for Developing

Optimized Formulations andLyophilization Cycles

J. Jeff Schwegman

Founder and CEO AB BioTechnologies, Inc.

www.ab-biotech.com

October 2015



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70

80

90

100

110

120

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5.1

5.2

5.3

5.4

5.5

5.6

5.7

-60 -58 -56 -54 -52 -50 -48 -46 -44 -42 -40 -38 -36 -34 -32 -30 -28 -26 -24 -22 -20


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110

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H e a t F l o w ,

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4

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4.6

4.7

4.8

4.9

5

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53

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40

50

60

70

80

90

100

110

120

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40 mg/mL Dextran

!"#$%&'() +,

5

5.5

6

6.5

7

7.5

8

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H e a t F l o w ,

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54

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40

50

60

70

80

90

100

110

120

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Temperature, C

60 mg/mL Dextran

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6

6.5

7

7.5

8

8.5

9

9.5

10

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Temperature, C

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55

A(4#01 K7&69:1 pE

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20

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40

50

60

70

80

90

100

110

120

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Temperature, C

80 mg/mL Dextran

!"#$%&'() +,

5

5.5

6

6.5

7

7.5

8

8.5

9

9.5

10

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Temperature, C

-./ 0 12345678



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thermal characterization as part of an empirical process for developing optimized formulations and...

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