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The 7th International Symposium in QuantitativePharmacology·2019
THE THIRD ROUND NOTIFICATION OF ISQP
November 8-10, 2019
Sunshine Hotel Guangzhou
Dear Colleagues and Friends,
On behalf of the organizing committee, it is my great pleasure to announce that the 7thInternational Symposium of Quantitative Pharmacology (ISQP) will be held on Nov. 8th-10th,2019, Guangzhou, China. It is sponsored by the Quantitative Pharmacology Committee ofthe Chinese Pharmacological Society and organized by Guangdong Pharmacological Society,the Fifth Affiliated Hospital of Guangzhou Medical University, School of Pharmacology ofGuangzhou Medical University, the Sixth Affiliated Hospital of Guangzhou MedicalUniversity (Qingyuan People's Hospital).
With the successful practice of "model-based drug development (MBDD)", quantitativepharmacology has become an indispensable tool for new drug research & development. Itruns through the whole process of new drug research & development, greatly improving theefficiency and success rate. At the same time, it has also become the key technology of newdrug scientific evaluation. Since 2007, the Quantitative Pharmacology Committee of theChinese Pharmacological Society has successfully held six ISQP symposiums in Nanjing,Xiamen, Beijing and Shanghai, which have become one of the most influential quantitativepharmacology communication platforms in the world. The 7th ISQP in 2019 will invitewell-known experts from FDA of the United States, NMPA of China, the QuantitativePharmacological Societies of Japan and Korea, as well as academic institutions and majorpharmaceutical companies at home and abroad. The theory, method and practice ofquantitative pharmacology guiding new drug research & development will be discussedacademically and the experience will be exchanged.
The symposium will include conference reports and discussion, quantitativepharmacology forum of East Asia, China, Japan and South Korea, speech of young scholars,and the selection of excellent wall posters. During the symposium, a working conference ofthe Quantitative Pharmacology Committee of the Chinese Pharmacological Society will alsobe held.
Thank you in advance for your participation and support.
Organizer
Sponsor
Professional Committee of Pharmacometrics, Chinese Pharmacological Society
Co-sponsor
Guangzhou Medical University (The Fifth Affiliated Hospital, School of
Pharmacology, The Sixth Affiliated Hospital )
Chairmen
Qingshan Zheng Shanghai University of Traditional Chinese Medicine
Yi Fang People's Hospital of Peking University
Executive Chairmen
Xinke Zhou Xiyong Yu Haibo Zhou Guangzhou Medical University
Academic Committee (in alphabetical order by last name)
Shanshan Bi Pfizer
Nengneng Cheng School of Pharmacy, Fudan University
Yuancheng Chen Huashan Hospital affiliated to Fudan University
Yimin Cui The First Hospital of Peking University
Zeneng Cheng School of Pharmacy, Central South University
Yanhua Ding The First Hospital of Jilin University
Junjie Ding Novartis
Sheng Feng Roche
Yi Fang People's Hospital of Peking University
Tianxing Gong Northeast University
Rui Gao Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine
Feng Guo Sihuam Pharm
Zongyuan Hong Wannan Medical College
Jianchang HeAffiliated Hospital of Yunnan University of Traditional Chinese
Medicine
Xiaowen Hu Shanghai Tumor Hospital
Pei Hu Peking Union Medical College Hospital
Xiaohui Huang School of Pharmacy, Anhui Medical University
Qin Huang Former minister of Center for Drug Evaluation, NMPA
Shuangmin Ji Center for Drug Evaluation, NMPA
Yuhong HuangSecond Affiliated Hospital of Tianjin University of Traditional
Chinese Medicine
Jin Yuyan Roche
Zheng Jiao Chest Hospital Affiliated to Shanghai Jiaotong University
Guofei Li Shengjing Hospital Affiliated to China Medical University
Gailing Li Johnson & Johnson
Jia Li Lilly
Huafang Li Shanghai Mental Health Center
Liang Li FDA
Jianguo Li Kelun
Li Li Center for Drug Evaluation, NMPA
Lujin Li Shanghai University of Traditional Chinese Medicine
Xingang Li Beijing Friendship Hospital Affiliated to Capital Medical University
Xin Li Changsha Third Hospital
Yuhong Li Shaoxing People's Hospital
Beibei Liang General Hospital of PLA
Zhiling Li Pediatric Hospital Affiliated to Shanghai Jiaotong University
Dongyang Liu The Third Hospital of Peking University
Hongxia Liu Shanghai University of Traditional Chinese Medicine
Xiaodong Liu School of Pharmacy, China Pharmaceutical University
Wei Liu The Third Hospital of Peking University
Xiaofen Liu Huashan Hospital Affiliated to Fudan University
Xiaoxi Liu Novartis
Wei Lu School of Pharmacy, Peking University
Guangli Ma Heng Rui
Jianfeng Lu AskGene Pharma, Inc
Cheng Lyu CSPC
Jing Nie Johnson & Johnson
Peimin Ma GSK
Qi Pei Third Xiangya College of Central South University
Jianfeng Pei Peking University
Yan Ren BeiGene
Furong QiuShuguang Hospital Affiliated to Shanghai University of Traditional
Chinese Medicine
Dewei Shang Huiai Hospital, Guangzhou Medical University
Jianzhong Rui Eastern War Zone Hospital
Jianzhong Shen Tu The First Affiliated Hospital of Zhejiang University
Yucheng Sheng Sinovant Sciences
Haifeng Song Academy of Military Medical Sciences
Jun Shi dMed
He Sun Tasly
Bo Sun Shanghai Drug Review and Verification Center
Chaoyang Tong Academy of Military Sciences
Xin Tian The First Affiliated Hospital of Zhengzhou University
Hongyun Wang Peking Union Medical College Hospital
Dan Wang Pfizer
Xipei Wang Guangdong People's Hospital
Kun Wan Shanghai Qiangshi information Technology Co., Ltd.
Lijue Wang People's Hospital of Peking University
Xinting Wang Novartis
Yuzhu Wang Center for Drug Evaluation, NMPA
Yaning Wang FDA
Chunmin Wei Center for Drug Evaluation, NMPA
Kai Wu SIMR Biotechnology Co., Ltd
Minji Wei Institute of Clinical Pharmacology, Peking University
Xiaojie Wu Huashan Hospital Affiliated to Fudan University
Xiaoqiang Xiang School of Pharmacy, Fudan University
Kehua Wu School of Pharmacy, Peking University
Yuanyuan Xia Tianjin Institute of Pharmaceutical Research
Haitanf Xie Yijishan Hospital Affiliated to Wannan Medical College
Junyu Xu The First Hospital of Peking University
Hongrong Xu Zhongshan Hospital Affiliated to Fudan University
Ling Xue The First Affiliated Hospital of Suzhou University
Ling Xu Shanghai University of Traditional Chinese Medicine
Guoping Yang Third Xiangya Hospital of Central South University
Miao Yan Second Xiangya Hospital of Central South University
Jin Yang China Pharmaceutical University
Jiansong Yang Mosim
Shoujun Yuan Academy of Military Medical Sciences
Peng Yu School of Pharmacy, Central South University
Fan Zhang GSK
Chao Zhang Tongren Hospital Affiliated to Capital Medical University
Jing Zhang Huashan Hospital Affiliated to Fudan University
Liang Zhao FDA
Libo Zhao Beijing Children's Hospital
Qian Zhao Peking Union Medical College Hospital
Ping Zhao Bill & Melinda Gates foundation
Qingshan Zheng Shanghai University of Traditional Chinese Medicine
Wei Zhao School of Pharmacy, Shandong University
Guoping Zhong School of Pharmacy, Sun Yat-sen University
Xin Zheng Peking Union Medical College Hospital
Xuan Zhou GSK
Tianyan Zhou School of Pharmacy, Peking University
Xiaocong Zuo Third Xiangya Hospital of Central South University
Organizing Committee (in alphabetical order by last name)
Li Ban The Fifth Affiliated Hospital of Guangzhou Medical University
Zeneng Cheng School of Pharmacy, Central South University
Yi Fang People's Hospital of Peking University
Shuren Guo Luye Pharma
Jin He The Fifth Affiliated Hospital of Guangzhou Medical University
Hongliang Jiang Huazhong University of Science and Technology
Lujin Li Shanghai University of Traditional Chinese Medicine
Yongmei Li The Fifth Affiliated Hospital of Guangzhou Medical University
Gailing Li Johnson & Johnson
Xin Li School of Pharmacy, Guangzhou Medical University
Xianbo Li The Fifth Affiliated Hospital of Guangzhou Medical University
Chang Liu The Sixth Affiliated Hospital of Guangzhou Medical University
Hongxia Liu Shanghai University of Traditional Chinese Medicine
Dongyang Liu The Third Hospital of Peking University
LiZhong Liu The Sixth Affiliated Hospital of Guangzhou Medical University
Haiyan Liu The Fifth Affiliated Hospital of Guangzhou Medical University
Ouyang Dongsheng Duxact
Shuang Ren Hua Medicine
Yan Ren BeiGene
Jun Shi dMed
Qingchun Song Proswell Medical Company
Hongyun Wang Peking Union Medical College Hospital
Wei Wang Genrix Bio
Hongdong Wang ASMO
Tenghua Wang The Fifth Affiliated Hospital of Guangzhou Medical University
Li Wang The Fifth Affiliated Hospital of Guangzhou Medical University
Ning Yang The Fifth Affiliated Hospital of Guangzhou Medical University
Qiongshan Yang Guangzhou Fugao Pharmaceutical Industry
Yaoxuan Zhan The Fifth Affiliated Hospital of Guangzhou Medical University
Xiyong Yu School of Pharmacy, Guangzhou Medical University
Xinke Zhou The Fifth Affiliated Hospital of Guangzhou Medical University
Sichao Zheng The Fifth Affiliated Hospital of Guangzhou Medical University
Haibo Zhou The Fifth Affiliated Hospital of Guangzhou Medical University
MeiYin Chou Excellence Future
Symposium Theme & Areas of Concern
The theme of the symposium will be "Innovation • Application" and the areas of
concern will include:
Model-based drug development strategy: perspectives and cases
Pharmacometric consideration in cell therapy trial
Model-guided clinical trial design for innovative drugs
Clinical trial design for special population (such as children)
Mechanism-based PK/PD model: principles and cases
Physiologically based pharmacokinetics (PBPK) research and cases
Model based precision medication
Bridging study based on PK/PD model: design and cases
New techniques and methods in pharmacometrics
Adaptive design, Model-based meta-analysis cases
Pharmacometric methods in research and development of
Biopharmaceuticals
Symposium Communication Form
Plenary lecture: Famous pharmacometric experts make keynote reports
on the research progress and frontier problems of pharmacometrics
panel discussion
Posters exhibition
7th ISQP Schedule
Nov 8, 2019 Friday 7:30-17:30
Pre-conference course
Registration
Nov 9, 2019 Saturday 7:30-12:00 AM
7:30-8:30 Registration
8:30-8:50 Opening Ceremony
Chaired by Professor Yi Fang
Welcome Speech by Professor Qing-shan Zheng, Chairman, Professional
Committee of Pharmacometrics, Chinese Pharmacological Society (PCPC)
Nov 9, 2019 Saturday 8:50-13:00 AM
Plenary Meetings
Time Topics and Speakers
8:50-9:20 FDA’s Initiatives to Improve Efficiency in New Drug Development
Dr. Yaning Wang, FDA
9:20-9:50 Building, evaluation, application and value of the models in drug
development: cases and analysis
Dr. Liang Zhao, FDA
9:50-10:20 Pharmacometric review of new drug application in China: present
situation and prospect
Invited, CDE NMPA
10:20-10:30 Tea Break
10:30-11:00 Recent progress of modeling & simulation in drug clinical
development in China
Prof. Qing-shan Zheng, Shanghai University of Chinese Medicine,
China
11:00-11:30 Application of pharmacometrics in drug bridge trials in Japan
Prof. Yusuke Tanigawara, Keio University, Japan
11:30-12:00 Moving from basic towards systems PKPD models for corticosterioids
Prof. William Jusko, State University of New York at Buffalo, USA
12:00-13:00 Brown bag session
Demonstration of MaS Studio for pharmacometric work
Nov 9, 2019 Saturday 13:30-17:30 PM
APC (Asian Pharmcometrics Conference)
Welcome Speech by Chairwoman of APC 2019, Professor Pei Hu
Topic: The value of pharmacometrics and its application in Asia
Time Topics and Speakers
13:30-15:00 Application of Pop-PK/PD in bridging study
Prof. Pei Hu
PK/PD Driven Drug Discovery – example of development of cytokines
for cancer immunotherapy
Dr. Jeff Lu,AskGene Pharma, Inc.)
Evolution of PK/PD modeling of biologics
Prof. Donald Mager , State University of New York at Buffalo, USA
Speakers from Japan
Speakers from South Korea
Speakers from other countries
Tea Break
15:30-16:30 Panel discussion: Which direction we should move forward?
16:30-17:30 Roundtable: Do we need an Asian organization of pharmacometrics?
Nov 10, 2019 Sunday 8:30-12:00 AM
Plenary Meetings
Time Topics and Speakers
8:30-8:50 Population PK and exposure response modeling in accelerating
Alectinib Development
Dr. Yuyan Jin, Roche
8:50-9:10 Pop PK/PD modeling for evaluation of acceptance of foreign data in
China population
Dr. Gailing Li, Johnson&Johnson
9:10-9:30 Dose optimization considerations in oncology drug development
Dr. Jun Shi, dMed
9:30-9:50 Optimization of PK study of Biosimilars by modeling and simulation
Dr. Jianguo Li, Cologne
9:50-10:10 Exposure/response analysis using time-varying exposure matrics for
oncology drugs with significant dose modifications
Dr. Diane Wang, Pfizer
Tea Break
10:20-10:40 Pharmacometrics in the development of a first-in-class glucokinase
activator for type 2 diabetes
Dr. Li Chen, Hua Medicine
10:40-11:00 Pharmacodynamic Investigation of D1DR Agonists in the Treatment of
Breast Cancer Lung Metastasis and Disease
Progression/Pharmacodynamics Modeling
Prof. Tianyan Zhou, Peking University
11:00-11:20 Clinical Decision Support Tools: Pharmacokinetic/Pharmacodynamic
Mediated Dose Optimization
Prof. Jiao Zheng, Chest Hospital Affiliated to Shanghai Jiaotong
University
11:20-11:40 Applications of Modelling and Simulation in 505(b)(2) submission
Prof. Jing Yang, China Pharmaceutical University
11:40-12:00 Pediatric Clinical Trial Optimization
Prof. Wei Zhao, Shangdong University
Nov 10, 2019 Sunday 13:30-17:00 PM
Session 1: Modeling & Simulation
Time Topics and Speakers
13:30-13:45 Durvalumab
Quantatitive clinical pharmacology in drug development of
Durvalumab - dose selection and ethnic sensitivity considerations
Dr. Kai Shen, Astrazeneca
13:45-14:00 The Application of Pharmacometrics in Accerlerating Clinical
Development for Novel Anti-diabetics and Anti-Osteoporosis Drugs
Dr. Dongyang Liu, Peking University Third Hospital
14:00-14:15 Exploration and application of mechanistic PK/PD model in clinical
evaluation of proton pump inhibitors
Dr. Hongyun Wang, Peking Union Medical College Hospital
14:15-14:30 Phase 1 Studies in Chinese Subjects: Assessing Ethnic Difference and
Beyond
Dr. Chen Bin, Bayer
14:30-14:45 Clinical trial design and data analysis of cQTC study
Dr. Ling Xu, Shanghai University of Traditional Chinese Medicine
14:45-15:00 PK/PD modeling and dose selection of a PCSK9-binding agent, and
prediction of a phase 3 study
Dr. Rong Zhou, Jinan Hetai medicine co.,Ltd
15:00-15:15 Systematic evaluation and analysis of population pharmacokinetic
model of vancomycin
Dr. Chao Zhang, Tongren Hospital Affiliated to Capital Medical
University
15:15-15:30 Tea Break
15:30-15:45 Population Pharmacokinetics of Antibiotics in Postoperative
Neurosurgical Patients
Dr. Xingang Li, Beijing Friendship Hospital
15:45-16:00 Exploration of pharmacokinetic/pharmacodynamic index best
predicting efficacy for combination of antibacterial agents
Dr. Yuancheng Chen, Huashan Hospital Affiliated to Fudan University
16:00-16:15 Quantitative Approaches in Cardio-oncology: Toward Individualized
Cancer Therapy
Dr. Hua He, China Pharmaceutical University
16:15-16:30 Model-Based Estimation of Probability of Pharmacological Success
for CNS Compounds
Dr. Xuan Zhou, GSK
16:30-16:45 Drug Drug Interaction Between Salvianolate Infection and Aspirin
Based on the Metabolic Enzyme
Dr. Rui Li, Xiyuan Hospital
16:45-17:00 Application and research strategy of PBPK in special population
Dr. Aixin Shi, Beijing Hospital
Nov 10, 2019 Sunday 13:30-17:05 PM
Session 2: Clinical Trials & Individualized medication
Time Topics and Speakers
13:30-13:45 Challenges and opportunity of global therapeutic antibody industry:
Investment/Innovation/Differentiation
Dr. Joe Zhou, Genor Biopharm
13:45-14:00 ICH E17 and impact on China clinical development
Dr. Lei Diao, Bristol-Myers Squibb
14:00-14:15 TBD
Prof. Haifeng Song, Academy of Military Medical Sciences
14:15-14:30 Cancer Immunotherapy:The Beginning of the End of Cancer
Prof. Yu Wang, Beijing 301 Hospital
14:30-14:45 An exploratory study in personalized medicine: an clustering
methodology based on supercomputing
Prof. Guoping Yang, Third Xiangya Hospital of Central South
University
14:30-14:45 An exploratory study in personalized medicine: an clustering
methodology based on supercomputing
Prof. Guoping Yang, Third Xiangya Hospital of Central South
University
14:45-15:00 Model-based adaptive design
Prof. Haitang Xie, Yijishan Hospital Affiliated to Wannan Medical
College
15:00-15:15 Mechanism, clinical and quantitative study of pharmacokinetics
interaction of traditional Chinese medicine
Prof. Furong Qiu, Shuguang Hospital Affiliated to Shanghai University of
Traditional Chinese Medicine
15:15-15:30 Tea Break
15:30-15:45 In vivo absorption kinetics and dissolution kinetics in pharmacokinetic
studies
Prof. Zeneng Cheng , Central South University
15:45-16:00 Using PBPKPD to accelerate the application of New Type 3 drugs
Dr. Bo Liu, Lizhu
16:00-16:15 Application of physiologically based pharmacokinetic model in the
research of personalized drug therapy
Dr. Xiaoqiang Xiang, Fudan University
16:15-16:30 Population Pharmacokinetics of Vancomycin in Chinese ICU
Neonates: initial dosage recommendations
Dr. Zhiling Li, Children's Hospital of Shanghai
16:30-16:45 The rational use of psychotropic medications based on population
pharmacokinetics
Dr. Dewei Shang, Huiai Hospital, Guangzhou Medical University
16:45-16:55 Population pharmacokinetics and pharmacodynamics of cyclosporine
in the treatment of systemic lupus erythematosus
Qi Wang, People's Hospital of Peking University
16:55-17:05 Thoughts on quantitative pharmacology in cell clinical trials
Dr. Tenghua Wang, The Fifth Affiliated Hospital of Guangzhou Medical
University
The Youth Outstanding Poster Award
There will be a Excellent Poster Award in the conference this year. The age of the candidatesshall be under 45 years old (born after December 31, 1974), and the English Poster should besubmitted in PDF format to the Organizing Committee's mailbox by October15:[email protected] size of the poster is 60cm*90cm in the exhibition. The winners willbe awarded certificates and bonuses to encourage them. The poster requirements are asfollows:
Language: English. Dimensions: Width 60cm* Height 90cm (see image below) .The title、
authors’ names and workplaces should be in the top of the poster and consistent with thesubmitted abstract.
The clarity of the text size and graphics should be clear enough at a distance of 2m. Poster sample:
Note: Please indicate the words "The 7th International Symposium of QuantitativePharmacology" in submission emails.
Conference Registration Method:
Online Registration: http://meeting.drugchina.org On-site Registration: November 8, 2019, registration of the conference registration area.
Date and Place of the Meeting:
Registration Time: November 8, 2019
Meeting Time: November 9-10, 2019
Meeting Location: Soluxe Hotel Guangzhou. No.199, Huangpu Avenue, Tianhe District,
Guangzhou
Payment:
Registration FeeCommon
Representative
Student
RepresentativeRegistration includes
Domestic
¥2000 for one adult,¥200
payment discount for one
adult Early-bird
Registration before Oct
10,2019 (10th included).
¥900 for one student,
student ID is needed
while registration, no
early payment
discount .
Organizing Committee
will offer working lunch
and Information
package.
Accommodation will be
carried out under the
unified arrangement by
organizing committee,
and the cost at
audience's own
expense.
Foreign
$600 for one adult,$600
payment discount for one
adult Early-bird
Registration before Oct
10,2019 (10th included).
$300 for one student,
student ID is needed
while registration, no
early payment
discount .
Payment Method:Bank/Internet Banking TransferBank: Guangzhou Guangfa Building BranchAccount Name: Guangdong Pharmacological SocietyAccount number: 101001516010010542Notes: Please indicate "ISQP meeting fee" when transfer.
\
Conference Group Contact Information:Tel: 020-85959124; 02085959126Contact: Yongmei Li 13640691018
Haiyan Liu 13802736049Sichao Zheng 13760747504Tenghua Wang 13560396395Zhiqin Hu 18802043672
Accommodation Information
1、Soluxe Hotel Guangzhou:(No.199, Huangpu Avenue)
Room type Check-in date Check-out date Rates (singlebreakfast)
Superior Twin Room November 8 November 10 RMB630/room/nightSuperior Queen Room November 8 November 10 RMB630/room/night
Deluxe suite November 8 November 10 RMB1100/room/night
2、Hotels around Soluxe Hotel:
Hotel name address
DistancefromSoluxeHotel
Contactnumber
Room Rate
GuangzhouZhujiang NewTown Hilton
Hotel
NO.495,HuangpuAvenue
recommendation
Linhui Chen18022329943
QueenRoom
RMB638/room/night
GuangzhouvanburghHotel
NO.126,HuangpuAvenue
recommendation
Miss Cui13922474532
QueenRoom
RMB650/room/night
GuangzhouGuanshengKingstyleHotel
No. 11,zhongtianfu
road, huangpuavenue
recommendation
Miss Xu18811854076
QueenRoom
RMB420/room/night
GuangzhouYueda
Financial CityInternational
Hotel
No. 322,HuangpuAvenue
Straightline
distance800m
020-61133700020-61133977
QueenRoom
StandardRoom
GuangzhouLavande
Hotels(yuancun SubwayStation)
Dongjinggarden, no. 1,erheng road,daoyuanvillage,huangpu
district, tianhedistrict,
guangzhou
Straightline
distance450m
020-85618088
About 568yuan /room /night
About 568yuan /room /night
Insail hotels(guangzhou
zhujiangnew town
racecourse)
141 huangpuavenue,tianhe district,guangzhou, 7minutes bybus from exitB of yuancunsubwaystation
Straightline
distance1km
(020)85558688
About 400yuan /room /night
About 450yuan /room /night
GuangzhouRiver Classverfurtonapartment
Linjiangshangpinapartment,683 linjiangavenue
Straightline
distance1.5km
020-29003030
About 660yuan /room /night
About 688yuan /room /night
Elaine savileinternational
hotelapartment
Floor 1, feilibusiness
building, 665huachengavenue,
tianhe district,guangzhou
Straightline
distance2.4km
(020)38888560
About 418yuan /room /night
About 488yuan /room /night
GuangzhouYueda
Financial CityInternational
Hotel
No. 322,HuangpuAvenue
Straightline
distance800m
020-61133700
;
020-61133977
About 469yuan /room /night
About 500yuan /room /night