the rna world · the origins of the rna world. cold spring harbperspectbiol. 2012, 4. joyce gf,...
TRANSCRIPT
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The RNAWorldTony Z. JiaEarth-Life Science InstituteTokyo Institute of Technology
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The Modern Cell
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The Modern Cell
DNA
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The Modern Cell
DNA
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The Modern Cell
DNAP
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The Modern Cell
DNA RNAP
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The Modern Cell
DNA RNAPP
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The Modern Cell
DNA RNA ProteinsPP
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The Modern Cell
DNA RNA ProteinsPPPP
Ribosome
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The Central Dogma
DNA RNA ProteinsPPP
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RNA World Theory• RNA can store and pass down genetic information
• Similar in structure to DNA
G
A
T
A
C
T
A
T
GC
DNA
G
A
U
C
U
RNA
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RNA World Theory• RNA can store and pass down genetic information• RNA can catalyze chemical processes (ribozymes)
Martick, Scott, Cell. 2014
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RNA World Theory
Blain, Szostak, Annu. Rev. Biochem. 2014
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RNA World Theory
Blain, Szostak, Annu. Rev. Biochem. 2014
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RNA World Theory
Blain, Szostak, Annu. Rev. Biochem. 2014
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RNA World Theory
Blain, Szostak, Annu. Rev. Biochem. 2014
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Nonenzymatic RNA Polymerization
Blain, Szostak, Annu. Rev. Biochem. 2014
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Nonenzymatic RNA Polymerization
Blain, Szostak, Annu. Rev. Biochem. 2014
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Nonenzymatic RNA Polymerization
Blain, Szostak, Annu. Rev. Biochem. 2014
![Page 20: The RNA World · The origins of the RNA world. Cold Spring HarbPerspectBiol. 2012, 4. Joyce GF, SzostakJW. Protocellsand RNA Self-Replication. Cold Spring HarbPerspectBiol.2018, 10](https://reader035.vdocuments.site/reader035/viewer/2022063019/5fde16fe8280a73dd13a75fa/html5/thumbnails/20.jpg)
Nonenzymatic RNA Polymerization
Blain, Szostak, Annu. Rev. Biochem. 2014
![Page 21: The RNA World · The origins of the RNA world. Cold Spring HarbPerspectBiol. 2012, 4. Joyce GF, SzostakJW. Protocellsand RNA Self-Replication. Cold Spring HarbPerspectBiol.2018, 10](https://reader035.vdocuments.site/reader035/viewer/2022063019/5fde16fe8280a73dd13a75fa/html5/thumbnails/21.jpg)
Nonenzymatic RNA Polymerization
Blain, Szostak, Annu. Rev. Biochem. 2014
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Outstanding Issues
Blain, Szostak, Annu. Rev. Biochem. 2014
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Outstanding Issues
Mariani et al., Biochemistry. 2019He et al., Nature Chem. 2016
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Outstanding Issues
Blain, Szostak, Annu. Rev. Biochem. 2014
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Outstanding Issues
Li, et al., JACS. 2017
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Outstanding Issues
Blain, Szostak, Annu. Rev. Biochem. 2014
Degradation
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Outstanding Issues
Blain, Szostak, Annu. Rev. Biochem. 2014
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Outstanding Issues
Blain, Szostak, Annu. Rev. Biochem. 2014
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Suggested Reading● Robertson MP, Joyce GF. The origins of the RNA world.
Cold Spring Harb Perspect Biol. 2012, 4.
● Joyce GF, Szostak JW. Protocells and RNA Self-Replication. Cold Spring Harb Perspect Biol. 2018, 10.
● Hud NV. Searching for lost nucleotides of the pre-RNA World with a self-refining model of early Earth. Nat Commun. 2018, 9.
● Hoshika S, et al. Hachimoji DNA and RNA: A genetic system with eight building blocks. Science. 2019, 363.