the final step in anabolism… where new muscle is bornthe final step in anabolism… where new...

The Final Step in Anabolism… Where New Muscle is Born

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© 2009, Medical Research Institute 888.448.4246 mri-performance.com REV 022309

Table of ConTenTs

Additional Results-Multiplying Tips 64

PArtv:WHAttoexPectWHentAkIngHSPActIve™ 65 Day 1 – 3 66 Day 4 – 7 67Day 8 – 14 67Day 15– 22 68 Day 22 – 28 68 Day 29 and Beyond 68

PArtvI:PrIncIPleSoFexercISe 69 Your Gains Start Right Here 70 One Goal at a Time – Divide and Conquer 70 Body Fat Calculator 72 Training for Mass – Forcing Immediate And Continual Gains In Lean Mass 72 3-Part Mass Building Technique 72 Hypertrophy 73 Strength 73 Power 74 Maximum-Intensity Training — When Failure is Good! 75 Resting Intervals — Not a Second Too Long! 75 Maintaining Strict Form — You “Cheat,” You Lose 76 Tempo Rules — Timing is Everything 77 Compound Movements — Double Your Impact 77 Your Starting Weight — Well Begun is Half Done 77 When to Add Weight — Not a Moment Too Soon 77 Training vs. Overtraining — Less is More 78 Warm Ups — Your 5-Minute Insurance Policy 79 Summary of Mass – Training Cycles — Four Part Harmony 79 Cycle I: HYPERTROPHY 81 Cycle II: STRENGTH 82 Cycle III: POWER 83 Cycle IV: RECUPERATION 84 Cardio During Mass Building — Yea or Nay 84 Cardio — Do’s and Don’ts 84 Role of Cardio 84 Cardio Technique 85 Training for Fat Loss - Definition Time 86 HSP ACTIVE, Cardio, and Calories 87 Caution: Catabolic Spiral Ahead — Avoiding the BIG Mistake 88 Mind Over Body! 88 Stop Counting Please 89 Strict Pre-Contest Mode 90

Table of ConTenTs

PArtvII:PrIncIPleSoFnutrItIon 91 Matching Your Nutrition with Your Training Goals 92 Establishing Your Daily Caloric Intake 92 MRI’s Baseline Caloric Intake 93 Mass-Building Caloric Intake (MBCI) 93 Fat Loss Caloric Intake 94 Nutrient Ratios 95 Nutrient Ratio Calculator 95 Carbs - Your Energy Source and More 96 Getting the Glycemic Index Right — Maximum-Energy Input 96 Protein — Building New Muscle, FASTER! 97 Complete Protein 98 “Off-Season” Proteins 98 “On-Season” Proteins 99 A Word About Fats 99 Saturated Fats – NO GO 99 Mono and Poly Unsaturated Fat – GO! 100 HSP Active and Water 100

PArtvIII:StrIctPre-conteSttrAInIngMode! 101 Step 1: Swap Carbs Types 102 Step 2: Reduce Calories 102 Step 3: Carb Deplete/Cut Cardio 103 Step 4: Carb Overload/Stop Training 103 Step 5: Cut Protein 104 Step 6: Cut Water 104 Step 7: Pre-Judging Meal 104

PArtIx:trAInIngFortHe(very)BuSyMAn! 105 What to Do When… 106

gloSSAry 108

FootnoteS 111

SPecIAlSectIonS:

FocuSonreSeArcHFrom the Literature: What Heat Shock Proteins Are 9From the Literature: The Purpose Heat Shock Proteins 11From the Literature: HSPs and Anabolism 19From the Literature: Negative vs. Positive HSP Induction 38From the Literature: Opuntia 40

Table of ConTenTs

IntroductIon 1

PArtI:HeAtSHockProteInS 7HSP: What’s (Immediately) Ahead for You! 8 So What Are HSPs? 10 What’s the Purpose of HSPs? 13 Protein Folding 14 Journey to the Center of Anabolism! 18 HSPs: Repair/Replace “Dead Weight Proteins” 26 Tex-OE®: Preventing Damage In the First Place 29 HSPs and Muscle Protein Density (MPD) 29 HSP: The Need for Speed – in Time to Activation 30 HSPs and Hypertrophy 31 HSPs and Hyperplasia 32 HSP Active – Works up to 72 Hours 33

PArtII:tex-oe 35 Why Did MRI Choose Tex-OE? 36 HSP Induction: “Negative” versus “Positive” 37 The Facts about Heat Shock Factors 39 Tex-OE … Funny Name, Serious Results! 41

PArtIII:HSPActIveMytHSAndFActS 43 Fairy Dusting 45 The Myth of More is Better 49 “In Vitro” versus “In Vivo” 51 The Infamous “Spokesman” 52 The Ever-Obscure “Proprietary Blend” Story 52 When a “Test” is Not a “Test” 53

colordIAgrAMS:The Birth of a New Protein D1HSP Chaperones D1Folding “Perfect Proteins” D2Journey to the Center of Anabolism D2Usable versus Unusable Proteins D3“Dead Weight” Protein Clearing D3Up to 1800% Faster HSP Activation D4Up to 510% More Satellite Cells D4

PArtIv:gettIngoFFtotHerIgHtStArt 55 HSP Active: Do’s and Don’ts 56 Dosing HSP Active 58 Weight Dependant Dosing 59 Frequency of Dosing 59 Timing of Dosing 61

Introduction

Where Innovations Spring to Life

InTroduCTIon

2

I’ll admit something to you. Each time MRI comes out with an innovative product, I say, “That’s it, we can’t do better. Not possible.”

But fortunately, each time I seem to be proven wrong! That’s especially true with new HSP Active™.

Now listen to this. I believe NO2® and CE2® are just a “set-up” for new HSP Active™ and Heat Shock Activation! I am not kidding you.

To get the story out, I enlisted the help of Jeff Kob. I had worked with Jeff, off and on, for over a decade. Jeff was there at the launch of NO2 and CE2, and has written a lot of what bodybuild-ers know about nitric oxide and ester creatine. Jeff knows how to take highly complex science and present it in a way even the cable guy can understand. I asked Jeff to write this HSP book

– so you could fully understand why HSP Activation can take your training to the next level to help change your physique – and life – in ways you couldn’t possibly imagine.

redIreCTIng nuTraCeuTICal sCIenCe – agaIn!

Walk into a health food store. Roam down the aisles of sports supplements. How many do you see? Hundreds, right? Do you know how many represent genuine innovation? In my opinion, the number of presidents on Mount Rushmore is a higher number!

Until MRI introduced HSP Active, you had creatine, nitric oxide, and maybe one other. I’m not counting the proteins and “macro-molecule” supplements, of course. And MRI literally “owns” two of them with NO2 BLACK® and CE2 HI-DEF®.

NO2 “hit” a new molecular target, nitric oxide, with extended release technology. CE2 em-ployed the “ester” delivery technology, the same system employed by pharmaceutical companies.

You see, nitric oxide and creatine work “outside” your muscle cell. They “aid” the anabolic process. But HSP Active ventures “inside” your muscle cell, deep inside, to the very “center” of anabolism. To the birthplace of new muscle protein.

I’ll take it a step farther. HSPs affect the sum total of your body’s ability to “adapt” (like adding new muscle) to a “stress” (like lifting weights.)

Let me give you a little “taste” of the power of heat shock activation (from page 7).

Keep in mind, HSP Active works on a molecular target nobody in bodybuilding had ever heard of before: Heat Shock Proteins (HSPs). So some of the physiological terms may sound almost strange: Like “Protein Folding.”

3

hsp aCTIve

I won’t give it all away here, but…

In order for proteins to become part of new muscle (in other words, before you can add new muscle), they must be folded into what’s known as a “perfect protein.”

Now listen to this…

1. only perfect proteins become new Muscle…

2. only hsps Create perfect proteins…

3. only Tex-oe® in hsp active has Clinical studies demonstrating It elevates hsps by up to 200% (starting as soon as 6 minutes, and lasting for up to 72 hours – and in already well-trained athletes)!

In fact, without HSPs, you couldn’t even gain an ounce of new muscle. And you’re about to find out the power of activating up to 200% additional HSPs.

I know it sounds like innovation comes “easy” to MRI. It does not. It takes hard work. And a bit of luck.

The “rIng” of TruTh

We launched our investigation of HSPs years ago. Few people knew HSPs existed then. Fewer talked about them. And nobody in bodybuilding suspected that a new molecular target existed.

Even today, in the medical community, ask your doctor if your HSPs are doing okay! You’ll likely hear a lot of “ummms” and “uhhhs.” Not that you would actually enjoy seeing your doctor at a loss for words.

We suspected that HSPs were at the “center” of muscle growth.

But what we did not know was, what compound could most effectively activate these molecular dynamos. We understood that exercise increased levels of HSPs a little bit, but we were looking for more. A whole lot more.

Understand, this was not a casual search. I had some of the brightest minds in science dedicated to our HSP project.

Months went by. Years.

Then late in 2007, we found a compound called schisandra, a good HSP activator. One you’ll find in our post workout WAR - WORKOUT ANABOLIC RECOVERY™. But we still contin-ued to search for the “Big Bang” of HSP activators!

InTroduCTIon

4

When our R&D team told me they discovered what they believe is the most powerful HSP acti-vator in the world, I said, “Talk to me!”

Our lead researcher explained how he had located an overseas group that owned the patent on a compound named Tex-OE. He went on to say how Tex-OE amplified Heat Shock Proteins (HSPs) by up to 200%. Sped up activation time by up to 1500% (as early as 6 minutes versus 90 minutes). And it increased duration of effectiveness up to 1800% (up to 72 hours versus 4 hours).

I liked what I heard. Still, I remained skeptical. Numbers like those had to be in animals – not humans.

Wrong!

These staggering statistics came from actual clinical research in real live human beings. And not just any old humans. They got these mind-boggling improvements in already highly trained athletes! That’s impossible isn’t it? Absolutely not!

At this point my mind is racing. I’m looking for the “fine print.” It has to be there.

Wrong again!

But you know, it’s a funny thing. The better something sounds, the more I tend not to trust it. I wanted more proof. Especially if MRI was going to put their name on it.

I suggested that MRI would do our own trial with Tex-OE before deciding to push forward. They agreed. So I enlisted what we refer to at MRI as our CBOs – “Chief Bodybuilding Officers.”

They’re a special breed within the athletic world. Trained to the max. If these guys see results – you’ve really got something.

I had some sample batches made up. Passed them out.

I thought it would be impossible to get improvement in only two weeks.

And for the third time – Wrong!

After 14 days I got: “Best supplement I’ve ever tried!” “Awesome, simply awesome!” “Give me more!”

But these were MRI guys. Maybe they were biased. Unintentionally, of course.

So I had another batch made up. I headed for the gym – looking for the alpha dogs!

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hsp aCTIve

Two weeks later – I got the exact same comments! “Is this stuff legal?” (In fact, it is – it passes IOCC standards).

Tex-OE finally had the “ring” of truth for me. Needless to say, I pushed the “go” button. And after a few painstaking years, I’m proud to place in your hands new HSP Active!

But innovation has a down side as well.

InnovaTIon: The “good,” “bad,” and down-right “ridiculous” of MrI Innovation

When MRI launched NO2 in 2002, ears perked up. All eyes started focusing on MRI. Whatever we did, other companies seemed to copy.

But here’s the thing. They could steal our ideas – but not our technology!

So I’ve come to the conclusion that innovation has an “upside” (good for you) and a “downside” (not so good for you).

I’ll start with the “Good” part of innovation.

This needs no explanation. And new HSP Active is a perfect example of the “good.” It reaches a new molecular target, with patented technology, and produces genuine clinically-demonstrable results.

Now to the “Bad.”

The “bad” part is, of course, the knock offs. I believe they intentionally mislead you. Confuse you. They “boast” the same benefits as innovative MRI products, but as far as I can see, simply cannot deliver the goods. It’s sort of like taking a toy gun into battle.

What I think happens is, these imposters “pollute” the entire category.

CE2 continues to help bodybuilders maximize their strength in the gym. And our competitors products? Just more statistics heaped in the great junk pile of over-hyped knockoffs.

And it’s precisely what will (and I believe is) happening with our HSP Active. I’m already seeing “so-called” heat shock ads that, from my point of view, play fast and loose with the facts. In fact, check out page 44 in Part III “HSP Myths.” You won’t believe your eyes!

InTroduCTIon

6

My one regreT

You just heard me talk about the truth. Well the truth is, I wish I didn’t have to call HSP Active a “supplement.” Any more than I’d call DNA, “genes”, or “ribosomes” supplements. You see, HSPs are so deeply entrenched in the human stress response – they don’t supplement (verb) adaptation, they cause it!

But the U.S. government makes you pick a category. So supplement it is.

My pledge To you

I read the same ads you do. Some rise to the level of fiction at best, lacking “hard science” and “research-based claims.” I also see the same “for hire” juiced up guys swearing it’s the product in their hand that made the large iron animal that they are.

Talk about creating confusion – especially with guys just coming into bodybuilding for the first time.

As Jeff likes to say: “Confusion is a friend of the knockoffs.” But guess who loses here? You do.

How are you to know who is telling the truth? You can’t, of course, until after you lay down your hard-earned cash. Too late.

So here’s my pledge to you:

As long as I am at the helm of MRI, we will only bring you thoroughly researched, scientifically-validated, innovative products designed to give you bona fide results. No compromises.

Now I’m proud to introduce new HSP Active to you. As you’re about to find out in the next 30 minutes, it is unlike any product you have ever tried. In your life.

It’s my pleasure to hand it over to Jeff Kob now…

Enjoy the book!

Harun SimbirdiChief Operating Officer, Medical Research Institute

heat shock proteinsThe Newly-Discovered Mechanism of Evolution…Adaptation…New Muscle

part I

parT I HEAT SHOCk PROTEINS

8

W e finally meet. This is actually MRI’s fourth book. And bodybuilders still call to say “thanks” for writing them. Why, after so long?

Because what they discovered in those pages significantly improved their lives. In many ways. We get letters all saying the same thing. In fact, bodybuilders emphatically state – “I didn’t read your book, I studied it!”

But I have to tell you, this new book is the most exciting one I’ve ever written. It represents the crowning achievement in Medical Research Institute (MRI) technology. That’s saying a lot when you think of NO2®, CE2® and Black Powder®.

This book reveals the one mechanism that controls and directs “adaptation” and “evolution.” The one mechanism that makes everything else a “set up” in the creation of new muscle. The mecha-nism that functions deep inside your muscle cells - beyond the DNA. Introducing the scientifically stunning Heat Shock Proteins (HSPs). The new era in bodybuild-ing begins now!

hsp: What’s (Immediately) ahead for you!

Before we dive in, I want to give a little sampling of what you’re about to experience here. The new science. New terms. New results for you.

You’ll discover muscle-building pathways (and physiological events) you’ve never heard of before. Unless you’re an obsessed molecular biologist, that is!

Yet they’re at the epicenter of the entire muscle-building process.

And… each and every one is related to HSP Activation!

Here are some examples:

post ribosomal protein folding (prpf) �

nascent Muscle-protein Transfer �

hormonal antagonism Mediation �

hsp Induced Cell proliferation �

“dead Weight” protein Clearing �

Muscle protein dis-aggregation �

Chaperonin Complex activity �

• foCus on researCh

from the literature: What heat shock proteins are

HSPs are ancient proteins that have been conserved all the way up the evo-

lutionary ladder from single celled organisms, such as the first single celled

amoeba, to humans and thought to be present in all species. This gives an

idea of how important these proteins are. Researchers initially defined heat

shock proteins (HSPs) broadly as a family of proteins activated in cells when

those cells are exposed to elevated temperatures or other stress. In 1962, it

was discovered that exposure to temperature shock induced the activation

of specific genes in the larvae of the fly Drosophila melanogaster,1 although

the phrase “heat shock protein” was not introduced until 1974.2 At the time,

it was found that expression is triggered when body temperature rises 5 to

10°C above normal. It was also then that researchers discovered that HSPs

were involved in protein synthesis.

Later, it became understood that the heat shock response is actually a gen-

eral “stress response” and thus the proteins involved sometimes are termed

“stress proteins.” Not just heat, but a wide variety of challenges or stressors

can trigger HSPs, for example, biological (infection, inflammation, oxidative

stress, nutritional deficiencies), physical (radiation, hypoxia), chemical (alco-

hol, toxic metals) and, in general, factors that reduce ATP levels in the cell.

The fundamental role of the HSPs is to maintain cell homeostasis in the face

of challenges and changing conditions.

Note that “stress” means any challenge that causes protein unfolding, mis-

folding, or denaturing that may destabilize the cell. The stabilization and re-

folding of proteins reestablishes the balance among protein synthesis, as-

sembly and degradation.


10

And that’s the short list!

You’ll find out the enormous (make that unfair) muscle-building advantages you get with Tex-OE® found in HSP Active™:

amplifies hsp quantity by up to 200% �

speeds up hsp activation by up to 1500% (6 minutes versus 90 minutes) �

Increases the Time of hsp activation by up to 1800% � (up to 72 hours versus 4 to 5 hours)

I know, I know, those percentages seem astronomically high. Almost unbelievable. But they’re straight from the Tex-OE clinical trials.

You’ll also hear staggering statistics from emerging laboratory research showing Tex-OE may help you:

Increase net protein Content of Muscle up to 18% �

amplify new Muscle Cell Creation by up to 510% �

And a whole lot more!

I think you’re gonna like this a lot…

so WhaT are hsps?

Let’s start with what Heat Shock Proteins are not: dietary proteins.Most bodybuilders hear the word “protein” and visions of whey packets, tuna cans, and hard boiled eggs (whites only, please) instantly pop up. HSPs are not food.

Let me clear up something before we go on. In building new muscle, your body employs three types of proteins: dietary, structural and functional. HSPs are functional. It is the interaction between the three that get you bigger and stronger. The higher degree of interplay, the faster you get the results you want.

And it’s important that you see how they work together, and know what you can do to maximize their muscle-building effect.

Keep in mind, in this book we’re only talking about the muscle building application of proteins. They do a lot more, of course. But that book would be 2,500 pages!


from the literature: The purpose heat shock proteins

Until recently, the role of HSPs in sports has been overlooked. It is easy to

focus on the impact of hormones and miss what is going on at a deeper level.

When athletes train hard, it causes the release of hormones, including steroid

hormones, which act on androgen receptors. The hormones enter the cell,

act on receptors in the cell, triggers the production of messenger RNA, acti-

vate ribosomes and initiate the production of new proteins. But it is the HSPs

that function as the cellular engineers and control how newly minted proteins

are shaped and whether these proteins become actual muscle fiber.

If a protein strand or a group of peptides becomes damaged, HSPs, likewise,

are involved in repair and replacement of these misfolded proteins. HSPs are

especially important for the production of globular proteins. Globular proteins

(GP) act as biological messengers transporting molecules through mem-

branes. Especially vital for athletes and bodybuilders is the GP myoglobin. It

carries and stores oxygen while also scavenging free radicals. It is important to

phosphocreatine recovery after exercise.3 When called into action by stressors,

such as heat or intensive exercise, HSPs reduce damage to the cell and acceler-

ate the process by which synthesized protein becomes functional.

The bad news comes in two parts: First, it can take considerable time to ac-

tivate the heat shock response, usually one or two hours. This allows consid-

erable damage to be done before countermeasures initiate. Second, certain

of the body’s responses to challenge may interfere with the actions of HSPs.

Chief amongst these is the action of gluccocorticoids in inhibiting Akt1. Akt1,

also known as protein kinase B (PKB) is able to induce protein synthesis path-

ways and is therefore a key signaling protein in the cellular pathways that lead

to skeletal muscle hypertrophy.4 Moreover, gluccocorticoid receptor activation

may interfere with the activation of heat shock proteins.5 The good news is that

the heat shock protein response can now be augmented and accelerated.


12

1. dIeTary proTeIns – buIldIng bloCks of MusCle

Your body breaks down dietary proteins into amino acids. After a complex chain of events (I lay them out below) they get reassembled into actual muscle protein.

2. sTruCTural proTeIns – aCTual MusCle

You’re very familiar with the structural proteins actin and myosin. They create your actual muscle fiber. You can easily “see” this type of structural proteins on your biceps! More actin and myosin mean more muscle fiber for you. The more muscle fiber you have, the bigger you look, the stronger you are - it’s that simple. But there are other types of structural proteins that give shape, form and sturdiness to the entire architecture of your muscle cell. As you’ll see, HSPs play a major role in the quantity of all types of structural proteins your body makes. I mean a HUGE part! (more on this below).

IMporTanT: Up to 18% of your body is made up of proteins (And that’s just structural proteins!)

Now to the “misunderstood” proteins…

3. funCTIonal proTeIns – MusCle-buIldIng WorkforCe

The name gives it away. These proteins serve a function not only in building new muscle, but in sustaining life itself. Some examples of these proteins are enzymes, cell-signaling proteins, and HSPs! Unlike their “sexy” structural counterparts, you cannot see them. But they keep that highly complex machine – called you – functioning at peak levels. Every micro second, func-tional proteins blast out millions of signals to your brain, heart, muscles. To every single part of your body… even the ones with tongue-twisting Latin names that nobody ever talks about – except a tight-knit group of molecular biologists clad in leather-elbowed corduroy jackets at their yearly convention!

And when it comes to new muscle for you, HSPs may be the most powerful functional proteins of them all!

Now here’s my plea to the scientific community…

“Please put HSPs in a category all by themselves. They have no peer in physiology!”

!!

1. dIeTary proTeIns – buIldIng bloCks of MusCle

Your body breaks down dietary proteins into amino acids. After a complex chain of events (I lay them out below) they get reassembled into actual muscle protein.

2. sTruCTural proTeIns – aCTual MusCle

You’re very familiar with the structural proteins actin and myosin. They create your actual muscle fiber. You can easily “see” this type of structural proteins on your biceps! More actin and myosin mean more muscle fiber for you. The more muscle fiber you have, the bigger you look, the stronger you are - it’s that simple. But there are other types of structural proteins that give shape, form and sturdiness to the entire architecture of your muscle cell. As you’ll see, HSPs play a major role in the quantity of all types of structural proteins your body makes. I mean a HUGE part! (more on this below).

IMporTanT:Up to 18% of your body is made up of proteins (And that’s just structural proteins!)

Now to the “misunderstood” proteins…

3. funCTIonal proTeIns – MusCle-buIldIng WorkforCe

The name gives it away. These proteins serve a function not only in building new muscle, but in sustaining life itself. Some examples of these proteins are enzymes, cell-signaling proteins, and HSPs! Unlike their “sexy” structural counterparts, you cannot see them. But they keep that highly complex machine – called you – functioning at peak levels. Every micro second, func-tional proteins blast out millions of signals to your brain, heart, muscles. To every single part of your body… even the ones with tongue-twisting Latin names that nobody ever talks about – except a tight-knit group of molecular biologists clad in leather-elbowed corduroy jackets at their yearly convention!

And when it comes to new muscle for you, HSPs may be the most powerful functional proteins of them all!

Now here’s my plea to the scientific community…

“Please put HSPs in a category all by themselves. They have no peer in physiology!”

!

hsp aCTIve

13

heaT shoCk proTeIns – a neW CaTegory please!

Sure, scientists officially classify HSPs as “functional proteins.” But whoever these scientists are, I can tell you one thing: they probably never lifted a weight in their lives! You see, for anyone who wants to pack on massive amounts of muscle and increase raw strength, “grouping” the HSPs in with other functional proteins is just plain wrong. Misleading.

So how does your body “get” these HSPs?

Unlike protein you eat, HSPs are generated (synthesized) “inside” your body. Exercise increases the number of HSPs by 50% for about 4 hours. And as you’ll see, Tex-OE increases HSPs by up to 200% for up to 72 hours!

WhaT’s The purpose of hsps?

You may have heard about HSPs and their role in “protein folding.” “Folding” is the buzzword now. It should be! In fact, MRI was the first to seriously focus on the concept of folding – and the whole category of heat shock activation itself. The truth is MRI began investigating HSPs years ago. They’re so complex, it took that long to “get it right”. And “get it right” we did! But as you’re going to find, protein folding is only a tiny fraction of the real HSP story.

The 4 key funCTIons of hsps

Remember, we’re not just talking about your muscle proteins and muscle fiber, but the total muscle cell itself.

1. proTeCTIon from future damage

problem: Training can cause damage. Heavy training can cause heavy damage. It can destroy the muscle you already have.

hsp solution: HSPs fortify muscle proteins, muscle fiber, and muscle cells. And HSPs do more than protect cells, they can repair existing damage.

A) ProBleM: A single-cell layer of cells, 30 minutes after being exposed to intense stress. Many damaged or dead.

B) SolutIon: The same cells preconditioned with Tex-OE® after being exposed to the same intense stress. Intact and healthy.

A B

(Dramatization. Results not typical.)


14

2. repaIr of existing damage problem: The muscle’s “Growth Cycles” can shut down when existing proteins or cells are damaged.

hsp solution: HSPs rapidly repair the proteins that become damaged by exercise. If the proteins are irreparably damaged, HSPs clear out these “dead weight” proteins and instantly replace them. HSPs do the same for entire muscle cells, not just individual proteins. Now your body is primed for adaptive growth.

3. addITIon and acceleration of “Muscle protein” production

problem: New muscle growth requires the production of the proteins actin and myosin.

hsp solution: HSPs help generate, and even accelerate, the production of these muscle proteins.

4. neW MusCle groWTh - hyperTrophy and hyperplasIa

problem: New muscle proteins must be perfectly folded before they can be “affixed” to muscle.

hsp solution: HSPs “fold” proteins into “muscle-usable form.” These “muscle-usable” proteins become part of existing muscle fiber (hypertrophy) or help generate new muscle fiber (hyperplasia).

There you have it in a nutshell.

Now to the real eye-openers! “How” HSPs work.

The logical place to start is protein folding. And we will. But as you’ll soon discover, HSPs go much, much farther! In fact, HSPs take part in nearly every anabolic, and anabolic-related event!

Since you’ve probably not heard about folding, it’s a good place to start.

proTeIn foldIngenTerIng a neW realM In bodybuIldIng

Say your body “makes” a new protein strand – intended to be used in creating new muscle. It’s a “newborn” protein. Until very recently, scientists assumed those strands would automatically become part of new muscle fiber. No questions asked. Pick up a university text book on molecu-

hsp aCTIve

15

lar biology, and that’s what you’ll see. (They’re probably printing the HSP version as we speak.)

Not so fast.

Before these “newborn” (okay, “nascent” for you science guys) proteins become part of your muscle fiber, they must be “folded.” This seems like a very common term for such a complex physiological event. But it describes the bio-action perfectly.

Take a look at Diagram 1 on page D1. You’ll see how these nascent proteins come out of the ribosome almost straight. Let’s call it wavy. Officially, “unfolded.” If the protein strands remain unfolded, these new proteins would be “stuck” there. They would not have the ability to pass through cell membranes surrounding your muscle fiber. They could not “affix” themselves to the existing fiber.

Net result: You do not get bigger.

But once properly folded, the new proteins easily pass through the membranes and “add to” the size of your muscle fiber.

Net result: You do get bigger.

IMporTanT: The scientific term for new muscle growth is hypertrophy. In hypertrophy, new proteins “attach” themselves to existing muscle fiber – making them longer (bigger). I can hear you asking, “But what happens when you can’t “cram” additional protein in, when there’s just no more room left for even one more protein, does that mean my growth comes to a screeching halt?” Logical question. You’ll be happy to know that growth can continue. And should. It has to do with cell proliferation, the scientific name for hyperplasia. Don’t worry, I’ll go through all that with you in a few moments. But I’ll leave you with this: cell proliferation is influenced by – HSPs.

Let’s get back to “folding.”

perfeCT proTeIns – perfeCT MusCle – perfeCT physIque!

With muscle protein, just “any old fold” is not good enough. (These are not your t-shirts!) The fold must be exact. The proteins must be folded into a precise, pre-determined, 3-dimensional

!


16

form. Zero margin of error exists here.

In other words, the folding must be perfect. In fact, the MRI researchers who worked on HSP Active, use the term “Perfect Proteins.”

Now you can probably guess what does the folding. I should say “perfect folding.” Yes, it’s your HSPs!

Here’s how it works.

A newly-formed “unfolded” protein enters a HSP. In a physiological flash, the HSP “spits out” a “Perfect Protein.” (See Diagram 3). Voila! This perfect protein now becomes part of new muscle fiber. You’ve just gotten one protein bigger.

Perfect, isn’t it! All thanks to the HSP that made the perfect fold!

IMporTanT: How difficult is it to “fold” a protein strand? Scientists engaged a computer, thinking it would fold the protein in a few seconds. After all, if computers could defeat the world chess champion, how hard could it be to give a protein strand a few turns? Three years later, these scientists were still staring at the computer screen. No luck. But real sci-entists are a pesky group. No quit in them. So they marched to a major university research center and engaged what they call a (drum roll here) Super Computer. Hopes soared high. But a second defeat followed. Shaking their heads in disbelief, and completely frustrated, they sent out e-mail blasts to scientists throughout the whole world seeking use of all their super computers during off hours. They got the use. They did not get the fold! We’re talking about hundreds of thousands of computers – acting col-lectively – to try and complete one tiny fold. The clock is still ticking. Interestingly, our harried scientists are hedging their bets on computers. Engaging humans to work in parallel with computers. They figured that humans calculate spatially better.

I’m telling you, this is exciting stuff here!

!

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Now if you take away only one thought here, make it this one (okay, three).

only perfect proteins become new Muscle1.

only hsps Create perfect proteins2.

only the Tex-oe in hsp active has Clinical studies demonstrating It elevates hsps 3. by up to 200% (starting as soon as 6 minutes, and lasting for up to 72 hours – and in already well-trained athletes)!

This is the new science of bodybuilding! And you’re at the forefront. But like I said, protein fold-ing is just the opening act. Now see how this amazing muscle building story ends!

Let me briefly set the stage here.

venTurIng InsIde your MusCle Cell, To The deepesT ChaMbers

We leave the outside portion of your muscle cell and venture inside to the deepest chambers. To the place new muscle is born.

You’ll finally see how the whey, tuna and eggs you ate finally become actual muscle fiber. Make no mistake, this is the real story – the one nobody has told you before!

The seT up: WhaT already happened ouTsIde

So here’s the set-up. What already happened “outside” your muscle cell.

you ate your protein. �

The protein got broken down into amino acids �

Insulin escorted the aminos inside your muscle cell. �

Let’s pause one moment here.

I’m not a big fan of purely “intellectual” answers. Can you remember your teachers droning on and on about subjects that bored you to tears? Especially history.

And take today. You listen to the talking heads on TV talk about a war. As Shakespeare said, “words, words, words.” Words, you’ll most likely forget a few days later.

But wouldn’t it be a different story if you were a newspaper reporter at the actual battleground. Infrared helmet on. Bullets flying. Bombs exploding. You’ll remember that for life.


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Why am I saying this? Because I want you to experience your own new muscle growth at the very place it’s happening. Right on the front lines, inside your muscle cell.

So let’s take a journey, through your muscle cell. Where new protein is born and becomes new muscle. We’ll travel along the entire anabolic pathway. Very shortly, you’ll see why I call it “The Fantastic Voyage” – and this one is real.

IMporTanT: You’re about to embark on a journey to previously unexplored territory.

Journey To The CenTer of anabolIsM!The fanTasTIC voyage

You’ve just lifted your last weight. Now’s the time. We dive into the bloodstream. Moving swiftly through the arteries. We spot your muscle cell. Grab the exterior of the cell and lay anchor. What do we see? (See Diagram 3, Page D2). Here is a visual representation of the 9 stages of the Journey to the Center of Anabolism.

StAge1: enTer TesTosTerone

The Battle of the Hormones Begins

We watch Testosterone racing through your bloodstream, hurling itself at the walls of your muscle cells. It wants in. It gets in! We follow.

But what we see next comes as a big surprise.

A hormonal battle is raging right before your eyes. It’s fierce. We see the combatants. Cortisol (C) and Testosterone (T).

But who is the good guy? The bad guy? Who are we rooting for? T of course. C is intent on de-stroying your muscle. But our hero is having a rough time. Although Testosterone has the reputa-tion of being the alpha-dog in the “outside” world, inside your body it’s a totally different story.

You see, down at the cellular level, Cortisol is Mr. Mean. Like the schoolyard bully – he’s bent on inflicting pain. And you can see he’s more than “up” for this fight with Testosterone. He’s relishing it. What are they competing for?

Ultimately, the right to “bind” to your muscles’ DNA.

!


from the literature: hsps and anabolism

Anabolism is a highly complex physiological event involving the interplay of

anabolic hormones and heat shock proteins (HSPs). This interaction of HSPs

with anabolic hormones, as well as the anabolic process itself is considered

direct. The steps are as follows:

Testosterone enters the muscle cell.1.

HSP Chaperonin-activated Complex activates the Androgen Receptor (AR).2.

Testosterone binds to Androgen Receptor.3.

The DNA receives the cell signal.4.

The DNA writes/creates the messenger RNA (mRNA) strands (“transcrip-5.

tion”) that instructs the ribosome as to what type of protein to create.

The ribosome creates the new muscle protein (“translation”).6.

HSP prevents improper protein folding.7.

HSPs facilitates the folding of new proteins into muscle-usable form8.

Newly formed “perfect proteins” delivered to muscle.9.


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If T latches on to the receptor, your body constructs new muscle. If, on the other hand, C makes the connection, your body starts tearing down muscle.

All the hours you spent toiling in the gym depend on the outcome of this fight.

You should know that Cortisol wants more than bragging rights. He wants total domination!

At this point, you hear a voice say, “call your bookie, take the odds on Cortisol.”Ignore the advice. Vegas has it wrong. Here’s what the “voice” doesn’t know yet. You have HSPs on your team.

StAge2: hsp Chaperone reCepTor bIndIng

Making Testosterone the Winner by a knockout!

What determines the winner in this “battle of the hormones?” Heat Shock Proteins! You see, both Testosterone and Cortisol want to “lock on” to your DNA. They each want to bark orders to your DNA. T would command: “build muscle.” C would declare: “tear muscle down.”

Next stop: the DNA.

StAge3: dna bIndIng

Unleashing the Power of Testosterone!

HSP pulls the Testosterone-armed transporter (chaperone) up to your DNA.

Things go smoothly here. HSP says goodbye here. Disengages from the “unit” and Testosterone/receptor “binds” to the DNA.

Here, Testosterone does the talking - DNA the listening.

StAge4:T-dna sIgnalIng

Testosterone Gives the Command

“Build new muscle,” comes the order from Mr. T. “I’ll pass the word along, sir,” comes the response.

You see, DNA has a desk job. And he stays at the home office. But he’s got to get the message to build new muscle to your ribosome. The ribosome is the “womb” of new muscle.

So DNA calls the mRNA messenger service. In fact, the small “m” in mRNA stands for “mes-senger.” mRNA quickly arrives, picks up the orders, and heads off to the ribosome.

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StAge5: mrna TranslaTIon

Speaking the Language of Ribosomes

Inside your cells, many different “languages” are spoken. It’s a miniature version of the Tower of Babel in there. The DNAites speak a different language than the Ribosomites. Does anyone have a Rosetta Stone? Yes, mRNA.

You see, in addition to providing an incredibly prompt delivery service, mRNA is an impeccable translator. Totally bilingual. So in the Queen’s ribosomes, he makes the message clear – start making new proteins.

I want to pause here for a moment – and prepare you for what’s to come.

It’s unlike anything you’ve heard before. It will challenge everything you’ve ever believed about new muscle growth. But if you want to make real gains, you have to hear this.

You’re about to see the almost insurmountable obstacles “newborn” proteins face before becom-ing actual muscle. In addition to the “dead weight” proteins and “injured cells” (we’ll cover that shortly) you’ll find mangled proteins, tangled knots of proteins and more. Talk about a Medi-eval-style gauntlet.

But far from being a horror movie, you’ll see why the entire story has a happy ending. You’re about to discover why HSP Active has ushered in a completely new era in bodybuilding.

Read on!

StAge6: TransCrIpTIon

From the “Womb” of Ribosomes

Okay. We left off with the ribosomes receiving orders to construct new proteins. What do ribo-somes need in order to construct these new protein strands? Amino acids. They get them, of course, from dietary protein that’s been broken down into individual amino acids. Assuming you’re eating the proper amount of protein (see Principles of Nutrition on page 97), you’re fine. The ribosomes also need energy, but they easily get that from ATP.

So a deep breath and 3 “pushes” later, a newborn protein comes into the world. Congratulations Dad.

You’ve just witnessed the birth of a new protein strand.But in the cellular world, it’s not time to celebrate. Because as you’ll see, here’s where the real treachery begins.


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You see, this newborn protein is defenseless. It can easily end up in the scrap pile of discarded proteins.

And what you’re about to find out right now, only the tiniest fraction of the world’s population knows. This recently uncharted territory was a mystery even to the scientific community not that long ago. Now you’re about to enter.

And make no mistake. This is the great dividing line in the “Cycle of Muscle Growth.” The “make or break” point. Finally a supplement has dared to go there – HSP Active.

sTage 7: hsps: prevenTIng IMproper foldIng

New Muscle: It’s Now or Never

So we’ve just seen the protein strand come out of the womb of the ribosome. This is a protein that should be destined for your biceps, triceps, pecs and delts (or whatever other body part you trained that day).

And until recently, even text books on physiology declared that once a protein emerged from the ribosome – it was considered a done deal. More muscle. Not any longer.

The fate of your new protein strand depends on a process known as “Protein Folding.” I know that we discussed this before. But you’re seeing it first hand now.

You know that only perfectly folded proteins can be used by muscle. This is such an overwhelm-ingly critical point in building new muscle, I want to say it again. If protein folding is even slightly “off,” the new protein gets flushed out of your system. All of your hard work in nutri-tion and exercise gets thrown out right along with it. All the money spent on supplements that increase creatine, nitric oxide and so on. Gone!

But before the proteins ever reach the HSP “folding site” it faces a danger. It can become “im-properly folded.” When that happens, you can kiss it goodbye.

What’s the solution? Once again, HSPs.

HSPs surround and protect the new proteins from improper folding and other metabolic forces. Like protective parents carrying their newborn from the birth room to the car seat. Once sur-rounded, the proteins are immune to danger (maybe a better analogy would be the diver and the shark cage). (See Diagram 2, on D2)

But what happens when there are not enough HSPs? When the proteins strands out-number the HSPs?

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The protein gets “flushed away” and never heard from again.

I think you’re beginning to see why having up to 200% more HSPs gives you an unfair advantage in the game of muscle growth.

All right. We were observing how HSPs surround and protect the new protein. But now we see they’re on the move. We follow.

They are delivering these newborns to the “Protein Folding” site.

What follows is simply mind-boggling. Breathtaking.

Almost in slow motion, the new protein emerges from the protective HSP. It’s deliberate. Orderly. Inevitable. The protein “slides” out of the “protective HSP” and, with an eerily precise preor-dained motion – slips into the “Protein Folding HSP.”

It’s as if the entire evolutionary process is unfolding (forgive the pun) right before our eyes. And it is.

StAge8:hsps: proTeIn foldIng

Creating “Perfect,” Muscle-Usable Proteins

All of a sudden, the HSP shoots out a perfectly folded protein.Ideally, there should be enough HSPs to fold every protein strand. That’s not the case.

In fact, protein strands can go to waste for lack of HSPs that do the folding.After all the work you - and your body – went through to get to this point, imagine the protein remaining unfolded. Not becoming new muscle.

One athlete using HSP Active calls it this way:

“It’s like driving the ball 99 yards down the field - and coming away without even a field goal. And that missed score cost you the game.”

MRI’s new products guru says it like this:

“The sum of all your muscle building efforts depends on the amount of heat shock proteins you can activate.”

But you have the assurance of the Tex-OE in HSP Active. It’s been clinically shown to amplify HSPs by up to 200%.


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Now on to the final stage of building new muscle. Transport of your perfect proteins.

Wait . . . before we travel on, we look back one more time to savor what just happened.

But we’re shocked. No one told us there would be a big surprise.

Please understand that in spite of all the effort to prevent improper folding, there are always the “ones that get away.” Here’s what can happen to the newborn protein before it gets perfectly folded and transported to the muscle fiber. (See Diagram 5 on D3)

Mis-foldingMis-folding means that the protein is “randomly” twisted into a shape not usable by muscle. Remember it has to be a “perfect fold.” Mis-folded proteins pass harmlessly out of your system. Never see the light of muscle fiber.

Clumping/TanglingThis tangling is known as “aggregation.” These mangled and tangled newborn proteins cannot be transported. Not even by the most determined HSPs.

Incomplete-foldingHere, the perfect fold starts off the right way, but the folding process halts before the process is complete. Again, you have proteins that can’t be put to use to build new muscle.

unfoldingOccasionally an already perfectly folded protein becomes “unfolded.”

But we suddenly see the extraordinary. The unexpected. The same HSPs that “wrapped” and protected the newborn proteins are doing something else now…

hsps untwisting � the tangled proteins and folding them into perfect proteins.

hsps straightening � out the mis-folded mangled protein strands, then perfect- folding them.

hsps Completing � the fold of partially folded proteins.

hsps refolding � the proteins that were once folded but became “undone.”

All so these valuable muscle-building proteins do not go to waste. And can become new muscle for you!

Again, you’ve got an enormous advantage with HSP Active. Remember, only Tex-OE has been shown, in real live human beings to amplify HSPs by up to 200%. No other “so-called” HSP activator can make that claim. Not one.

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Now on to the final step…

StAge9: proTeIn TransporT

Hello new Muscle!

There’s only one step left. Getting those perfectly folded proteins to the muscle fiber.

And if you’re wondering if HSPs have something to do with it, the answer is a resounding YES!

Now we watch as the HSPs shuttle the new “muscle-usable” proteins to the place where they become genuine new muscle!

And please keep in mind, without HSPs, those new perfectly-folded proteins would never reach their target.

That was a lot to take in. Let me summarize what we know about HSPs up to this point.

aT a glanCe

hsps “select Testosterone” to bind to androgen � receptors

hsps help “prevent mis-folding” of new protein strands emerging from the ribosome �

hsps “fold” protein strands into muscle-usable form �

hsps “fix” damaged protein strands �

hsps transport new proteins to the muscle fiber �

Now if this is everything HSPs did, you can see why activating these HSPs - especially by up to 200% - could easily be called the biggest breakthrough in bodybuilding.

But we’re just getting started!

So far we’ve mainly looked at HSPs’ ability to generate more size and strength proteins.

But ask yourself these questions about your “total” muscle growth:

What happens if my size and strength proteins become damaged? Can they be � repaired?

What about the proteins that make up my “entire muscle cell?” Aren’t they vitally �important to my muscle growth as well?

What happens if any protein becomes damaged? How would it affect my ability to �grow new muscle? Would it diminish my strength? Could it be repaired?


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� What happens if there’s too much protein damage, and my muscle cell dies? Can I help prevent that?

Is it possible to protect my proteins, and muscle cell, from damage in the first place? �

You probably suspected it – but I’ll say it anyway. The answer to all your questions is an unequiv-ocal YES! And it all hinges on HSPs!

HSPs help:

repair damage to size and strength proteins �

repair damage to the whole muscle cell �

protect your muscle cell from structural damage �

replace overly-damaged muscle cells �

prevent premature cell death �

hsps: repaIr/replaCe “dead WeIghT proTeIns”

Let’s face it. Working out stresses your entire muscle cell. It can damage proteins everywhere. In muscle fiber. On cell walls. Cell membranes. Even HSPs themselves.

Remember, up to 18% of your body is made up of proteins.

Damaged proteins are “dead weight” proteins. That means they just “take up space,” but cannot perform their function.

But HSPs can “fix” the damage.

your hsp repaIr CreWs

HSPs “roam” through (and around) your muscle cells searching for “cracks in the dam.” Specific-ally, damaged or weak proteins that continue to “try” to function within the group of healthy ones.

Once an HSP locates a damaged protein, it springs into action. (See Diagram 6 on D3)

step 1: First, HSPs “pull out” the damaged protein and try to fix it. If all goes well, the refolded protein is returned to its original site. Everything is back to normal.

But what if the protein is beyond repair? Unfixable? Do the HSPs just pack up and go home? Not at all!

step 2: HSPs simply “replace” the protein with a new one.

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You may be asking, “why didn’t the HSP just replace the damaged protein in the first place.Why did it try to repair it?”

In a word: efficiency.

It takes less energy to repair than replace. And the human body is a marvel of efficiency. And your HSPs are efficiency experts!

You may be asking, “what if the damage was not repaired? Would I really notice a difference?”

You bet you would.

For example:

daMaged sIze and sTrengTh proTeIns

Can you imagine the havoc a weak and hobbled (damaged) protein can do here?That crippled protein cannot participate in the lifting of weight. It just takes up room, but adds no strength. That’s why it’s referred to as a “dead-weight” protein.

Net Effect: You become one protein weaker.

Think of a tug of war. You have 100 determined guys on each side. But on one of the sides, some guys start spraining wrists and ankles. They can no longer pull their weight. But they hopelessly keep hanging on to the rope. Defeat, for that team, is not far behind.

Why do you think over-training is so bad? Over-training is just an expression that means you’re damaging your strength proteins. Imagine if 20% of the function of your strength proteins was lost. Instead of benching 240 pounds, you’d be down to 192.

And that’s just the effect on your strength. How about size?

Consider this…

Without HSPs, damage to the protein would accumulate. Workout after workout, stress would get heaped on top of stress. Eventually the protein would die. And get hauled to the cellular waste dump site.

Net Effect: You become one protein smaller.

But rest easy. You now have Tex-OE working on your side. And up to 200% more HSPs on your protein repair crews!


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But make no mistake. Without HSPs, the devastating effect of damage would go far beyond your size and strength proteins.

daMage To “oTher” MusCle Cell proTeIns

By “other” proteins, I mean cell wall proteins, nucleic proteins and proteins that make up the essential organelles.

The truth is, you may not notice a difference when a few of these get damaged. But when enough of these proteins become damaged beyond repair (and do not get replaced fast enough) the muscles’ growth cycle comes to a grinding halt. You stop growing.

Worse yet, when more of the proteins become unusable, the entire cell dies. Shrivels, disinte-grates, evaporates. That’s a muscle cell with countless size and strength proteins in it.

Net Effect: You become one muscle cell smaller and weaker.

When your HSP repair crews can keep pace with the amount of proteins that get damaged from grueling workouts - you’re safe. Your cell lives. And you continue to grow.

And I’m absolutely convinced that at this moment, you fully comprehend the enormous benefit Tex-OE can give you with up to 200% more HSPs, activated up to 1500% faster, working for up to 72 hours (as opposed to 4 to 5 hours with exercise alone). More on that in a moment.

You may be asking, “isn’t there a way to help prevent damage from occurring in the first place?”MRI scientists believe that HSPs have a role here too!

Tex-oe: prevenTIng daMage In The fIrsT plaCe

Training puts enormous stress on your cells. You now know that HSPs “counter” that stress. But it takes your body between 90 minutes and 120 minutes to activate HSPs after you train.

IMporTanT: Current research shows that age plays a significant role in how your body responds to stress, including exercise. As we age, not only are smaller quantities of HSPs produced, but it takes longer for HSPs to be activated.

But say it takes your body only 90 minutes. What happens in those 90 minutes is that dam-

!

hsp aCTIve

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age keeps accumulating. So when the HSPs finally get activated, all their attention goes to the “repair” of existing proteins – not to “building” new muscle proteins. That’s exactly what you do NOT want. But there’s a solution!

Tex-oe – pre-aCTIvaTIng hsps

What you do want is for your HSPs to kick into action as close to the time you start exercising as possible.

That can happen (and does, with Tex-OE).

Here’s how it works.

Before your body releases HSPs, it must first activate heat shock factors (HSFs). That’s why the whole process takes 90 minutes.

But Tex-OE “pre-activates” your HSFs. It’s the reason why with Tex-OE, your HSPs get acti-vated as early as 6 minutes after you lift your first weight.

It’s how Tex-OE helps protect your muscle cells from becoming damaged in the first place. And why your HSPs are free to fixate more of their focus on building new muscle – instead of repair-ing old muscle!

Now on to the exciting part – the measurable changes that HSPs can make on your physique!

hsps and MusCle proTeIn densITy (Mpd)

You say you want bigger, harder, denser muscles. Keep your eye on your muscle cells’ “protein density.” The more proteins you can pack in, the larger and more defined your muscles appear. And actually are.

So take note here.

Emerging scientific research in laboratory animals demonstrates that HSPs:

Increase the Muscle’s Net Protein Content Protein up to 18%.

You heard right. 18%.

How big is 18%? Imagine a professional golfer driving the ball an extra 70 yards. Are you kidding me!


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Look down at your bicep. Okay, flex it. Now imagine the difference 18% would make.

You get it.

But, like I said – Tex-OE is backed by clinical trials.

And it gets better…

hsp: The need for speed – In TIMe To aCTIvaTIon WITh Tex-oe, IT’s up To 1500% fasTer!

So it’s clear. You see the HUGE advantage in having up to 200% more HSPs at work for you.

But there’s another factor that’s even more important for your muscle growth. Timing.

The question is: how fast can your HSPs activate?

Let’s compare “exercise alone” to Tex-OE.

For exercise-induced HSPs, the answer is a disappointing: 90 – 120 minutes after you exercise. An hour and a half to two hours.

But in the world of training, “Time Is Muscle.” And you can hear the Catabolic Clock ticking.

So the faster you get your HSPs going, the greater results you’ll get.

Now listen to this. The Tex-OE in HSP Active activates your HSPs up to 1500% faster than ex-ercise alone. In fact, with HSP Active, your HSPs start kicking into action in as little as 6 short minutes! Again, based on clinical research – not marketing hype!

You’ve just gained up to 84 minutes of new muscle-protein formation. If you train five times a week, that comes to 420 additional minutes! That’s up to 7 hours – practically an entire work day. Think: More Muscle Monday!

1500%

1250%

1000%

750%

500%

250%

1500%

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hsps and hyperTrophyexperIenCe “IMpossIble” MusCle groWTh

You and I say growth. Exercise physiologists (and bodybuilders out on a first date) say hypertrophy.

It means the same. The systematic enlarging of muscle fiber by attaching more and more proteins to the fiber.

I could write volumes here on the subject. I won’t. I’ll just make a few quick points about HSPs and hypertrophy (I mean growth).

With � no hsps at work, zero growth is possible.

With � extra hsps at work, huge growth is possible.

With Tex-oe, you have up to � 200% extra hsps at work.

You remember the muscle-building journey we just took?

You saw how HSPs activate the androgen receptor site, allowing Testosterone to bind. You no-ticed how HSPs surround and protect the newborn protein as it came out of the ribosomes. You saw how HSPs folded the new protein into muscle-usable form – perfect proteins.

And finally, when you “looked back” you observed HSPs detangling and refolding proteins so they could be used by your muscle.

That all adds up to support for muscle growth (hypertrophy) for you.

And with up to 200% more HSPs hard at work, you may be able to make muscle gains you once thought impossible!

200%200%

150%

100%

50%

We’re just about at the end here.

Okay. So HSPs help “fill up” your muscle cell with proteins. There’s only one question left. Whathappens when the muscle cell is filled to the brim? It can’t hold any new proteins? Do you stop growing?


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You know I wouldn’t ask a negative question without having a positive answer. So keep reading!

hsps and hyperplasIa

So the “Lot Full” sign hangs on your muscle cell. Now what?

Here’s the good news. When your muscle cell is maxed out with proteins, and cannot - even with nuclear force - cram in even one more protein, your body instantly switches gear.

It abandons the futile fight and creates a new muscle cell! Very entrepreneurial. “If I can’t play on this field, I’ll build a new one.”

Here’s how our new products guru explains it:

“When you keep lifting increasingly heavy weights, and your body cannot make the existing fiber bigger, your body goes into “overload response.” It creates a new muscle cell. It’s a matter of “cell survival.”

And at the center of it all HSPs!

Here’s a simple way to look at it.

hypertrophy: expanding the size of an existing cell

hyperplasia: making new muscle cells

What actually happens is, “dormant” satellite cells spring to life. Become full blown muscle cells. Yes, the new cell has to be filled up again with proteins, but hey, it’s a muscle cell you didn’t have before!

You just got a new storage container – go fill it up.

And if you’re one of those bodybuilders going out on a first date, don’t call it hyperplasia - call it “Cell Proliferation” or “Fiber Splitting.”

“But this isn’t news,” you say. “I’ve seen products that promise me I can instantly ignite thou-sands of satellite cells – and gain massive amounts of new muscle – FAST!!!”

I’ve seen ‘em too. It’s simply mind-boggling they put that stuff out for unsuspecting body-builders to read.

Have you ever tried one of those? I hate to even call it a product. You don’t get hyperplasia, you get hyper-broke.

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But HSPs do activate the satellite cells. Just listen to this!

Emerging scientific research in laboratory animals demonstrates that:

HSPs Increase Hyperplasia up to 510%!

Yes, up to 510%. And it’s for real! (See Diagram 8 on D4)

hsps: CounTerIng CorTIsol

Saving Your Muscle

When you train - your body releases Cortisol. Beyond the limits of what’s naturally produced. And the harder you train, the more Cortisol your body produces.

Cortisol, as you know, tears apart muscle. We saw how HSPs function “inside” the muscle, help-ing to “choose” Testosterone over Cortisol to bind to the DNA receptor sites.

And finally…

hsp aCTIve – Works up To 72 hours for pre… posT… and durIng… your TraInIng

Let’s see where we are so far.

We’ve got up to 200% more HSPs acting up to 1500% faster (6 minutes as opposed to 90 minutes).

For most companies, that would be called “exceeding expectations.” At MRI, we call it “a good start.”

Now here’s the best part. The Tex-OE in HSP Active continues to work for up to 72 full hours. That’s 3 days. Take a guess at how long exercise alone activates HSPs? Four to 5 hours.

With HSP Active, the moment you lift your first weight, HSPs start their “6-minute dash” and begin working their molecular magic. And with new HSP Active, you have up to 200% more HSPs showing up to your muscle site!

And please listen closely to what I’m about to say.

You build the majority of muscle while you sleep! It’s true. Post workout is actually the “second most important time.” But you’re covered with HSP Active – it keeps working for up to 72 full hours!Even while you’re sleeping, your HSP Active is hard at work, making you bigger, Z by restful Z.


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IMporTanT: Both Testosterone and Growth Hormone rise to their high-est levels while you sleep. Now you’ve got the extra HSPs to help put them to good muscle-building use!

Bodybuilders are sure to report spectacular results with HSP Active. The best in their lives.

It’s all because HSP Active is making genuine physiological changes.

Getting your body to make significant improvements - safely - is an enormous challenge.

a fInal Word...

You train extremely hard to get the results you want. I should say, the results you deserve. It takes immense dedication, relentless willpower, and unimaginable sacrifice.

Now think of the perfect harmony that exists between you and your HSPs in achieving those results. The extraordinary interplay of “stress” and “adaptation.” It’s the ultimate evolutionary partnership.

And thanks for staying with me through all these pages!

!

part II

Tex-oe®

Unlocking the Primal Power of Heat Shock Proteins

parT II TEx-OE®

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A ll right. So you’ve seen the sheer biological power of the HSPs. You know what they can do for you. Faster HSP Activation may help you realize bigger, harder muscles, increased lean

mass and faster growth.

There’s only one question left to answer. And it’s a big one. How do you unleash the awesome power HSPs? Now I know I’ve given parts of the Tex-OE story away already. But there’s a lot of meat left on this bone!

IMporTanT: I’ve been using the words “HSP Active” and “Tex-OE” almost interchangeably. To be clear, HSP Active is the name of MRI’s product. Tex-OE is the actual compound.

Why dId MrI Choose Tex-oe?over all oTher hsp aCTIvaTors

Here’s the short answer. Tex-OE is the most powerful HSP activator that MRI researchers found. Tex-OE is the first – and only – HSP Activator we found that was clinically tested in real human beings.

But there’s always more to the story.

You know MRI launched an investigation into heat shock proteins years ago. But MRI holds itself to standard that’s inconceivable to other companies. And it’s been that way from day 1.

So for a HSP activator with MRI’s name on it, we set the bar so high it was almost out of reach.

Could We fInd….

a hsp activator with clinical trials in humans, “in-vivo” (not “in-vitro” tests)? �

hsp elevation of 100% (exercise alone produces 50%)? �

hsp activation in 30 minutes (exercise activates hsp in 90 minutes)? �

hsp activation that lasted 12 hours (exercise alone lasts 4 – 5 hours only)? �

With no side effects? �

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Did we find it? No. We found something better! Tex-OE! The first and only HSP activator that:

has clinical trials not only in humans… but in already well-trained athletes! �

elevates hsps not just 100%... but up to 200%! �

activates hsps not in 30 minutes… but as fast as 6 minutes! �

keeps working not for just 12 hours… but for up to 72 hours! �

And I’ll be honest with you. We didn’t even know all the right questions to ask back then.

But MRI (and now you) got lucky. Luck seems to follow the hard working – doesn’t it?

Check this out…

hsp InduCTIon: “negaTIve” versus “posITIve”The good squares off agaInsT The bad

You have two ways to get what you want in life. One uses honey and the other, well you know. The same is true for your body.

Before I talk about Tex-OE, let me give you an example of Good versus Bad induction.

We’ll use your immune system.

Method One: You swallow a toxin and “shock” your body into a sudden immune response.

Method Two: Take a bona fide immuno-stimulator that strengthens your immune system through positive activation.

The real benefit with “positive activation” is that you’re better armed for any foreign invaders that enter your system at any time. Contrast that to method one, where your immune system is actu-ally suppressed when the toxin is purged.

Now apply that same logic to HSP Activation.

Now you have another reason why MRI chose Tex-OE – it’s a “positive” HSP activator! “But how,” you may ask, “does Tex-OE accomplish its positive action?”

The answer is simple.


from the literature: negative vs. positive hsp Induction

There are many ways to activate HSPs. One is by introducing a stressor, such

as extreme heat, an injury or toxicity. Interestingly HSPs can be induced by

introducing excessive amounts of copper or zinc. The problem with this

method is that copper, as a transition metal, causes oxidative damage, hence

the elevation of HSPs to combat free radical damage. This “negative” way of

promoting HSP activity may be likened to purposefully poisoning yourself in

order to “strengthen” your immune system.

Another approach is to “hyper stimulate” the body with large amounts of

compounds such as caffeine to create a stress response. Although this may

indeed induce a stress response and HSP Activation, the stress hormone

Cortisol is also elevated. Cortisol, a catabolic hormone, is counter-productive

to the creation of a desired anabolic environment.

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The faCTs abouT heaT shoCk faCTors geT your faCTors sTraIghT fIrsT!

Remember, the key here is to have your HSPs “on call” ready to rush into action at the first sign of “stress” – like lifting a heavy weight.

But how do HSPs become activated?

It’s not a “direct” activation. It’s a “chain reaction” activation. The first link is activating your Heat Shock Factors.

In molecular biology, heat shock factor (HSF), is the name bestowed on the transcription fac-tors that regulate the expression of your heat shock proteins.

But here’s the problem.

This whole process can take up to 2 hours or more.

For bodybuilders it means suffering the negative effects of cell-damaging, muscle-reducing Cortisol for those 2 hours (remember from Part I, that HSPs counter the effect of Cortisol). And excessive damage to your muscle cells during your workout could mean cell death. Not the ideal situation.

Now here’s the Tex-OE solution.

The Tex-OE “Pre-activates” your HSFs.

Now, your HSPs are ready to spring into action within minutes of exercise-induced stress. As early as 6 minutes! Thank you, Tex-OE.

Just so you know Tex-OE is patented. In fact, MRI holds the exclusive rights on Tex-OE for bodybuilders in the United States and other areas of the world. Period.

You may have been wondering, “where did you get that exotic name Tex-OE come from?”

I thought that would come up.


from the literature: opuntia

Tex-OE is a patented extract of Opunita ficus indica, a cactus also known as

Nopal cactus, prickly pear cactus or Barbary Fig. The Opuntia cactus is one

of the hardiest plants in the world, able to survive extreme temperatures both

hot and cold, high altitudes, solar radiation and the most arid of climates. The

cactus is so well adapted to survival that it populates about 30% of the entire

land area of Earth. One way it has achieved this “die hard” status is its abil-

ity to rapidly elevate Heat Shock Proteins to protect, repair and maintain its

cellular integrity. This was a great place to look for powerful, fast acting HSP

Activation. Scientists had observed that animals eating the Opuntia were also

thriving in otherwise uninhabitable environments. However, the real ques-

tion was if humans could also benefit from the Opuntia. Before testing this

hypothesis, researchers first wanted to identify the part of the plant with the

greatest ability to elevate HSPs. The greatest activity of HSPs was found in

the actual skin of the fruit since it takes the brunt of climate extremes and

the sun’s radiation.

Unfortunately, humans do not possess the digestive enzyme required to

break down the plant fiber that the HSP activator is bound to. This unfortu-

nate truth was a disappointing setback. Possibly the most potent HSP activa-

tor was not bio-available.

Fortunately, one company found a way to process the Opuntia fruit skin and

remove the fiber to unlock the key HSP activator. This company quickly pat-

ented the extraction process and the compound claims. MRI now has an ex-

clusive partnership with this cutting edge company which enables us to of-

fer to the bodybuilding world the only bio-available HSP activating Opuntia

extract - Tex-OE.

This patent covers all cacti, so do not be fooled by imitations. Any other com-

pany claiming HSP Activation with cactus extracts other than Tex-OE is sell-

ing a cactus extract that has no clinically validated HSP Activation in humans.

It is important to note that because the Tex-OE does bind to fiber, it needs

to be taken on an empty stomach away from fiber containing foods, drinks

and supplements.

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Tex-oe … funny naMe, serIous resulTs!

Tex-OE is named after the company that did the initial research. It happens a lot with com-pounds, extracts, drugs, molecules and even elements on the periodic table.

In fact, some take their name from places (“Berklium,” “Californium”). Others, from people (“Einstienium,” “Nobelium,” – Alfred Nobel, Nobel prize).

Still, at MRI we all lobbied to change the name. Some suggestions included: Jeffium, Harunium, and Debbium.

It remains, however, Tex-OE.

Now from the sublime to the ridiculous. From clinically validated Tex-OE to the super-hyped knock-offs. Please take a look at the next section: HSP Myths and Facts. You won’t believe what you see.

hsp active Myths and factsAnd Mistakes You’ll Never Make Again!

part III

parT III HSP ACTIVE MYTHS AND FACTS

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I wish I didn’t have to write this chapter. Believe me. But in the last few weeks, some so-called “muscle-shocking” pills have clawed their way into the market. And you wouldn’t believe the

utter nonsense I’m seeing. Just like with NO2®, this is the one chapter that had to be written.

Look. Over the last 43 pages, you’ve seen for yourself the mind-bending power of HSPs. And you’ve witnessed – first hand – the overwhelming advantage that HSP Active™ gives you. Like up to 200% more HSPs with up to 1500% faster activation. And especially the up to 3-day acti-vation time – giving you potent HSP benefits before, during and after your workouts.

Now here’s what I don’t want to happen: for you to try a “so-called” HSP product and then you don’t get the all benefits you expect. So you say, “Hey Jeff, what’s up here with HSP Activation?” Worse yet, you give up on the whole category of HSP activators.

That would be a crime.

Listen. These HSPs are so powerful, so scientifically elegant, so life changing, I want you to get the full head-on experience. And get it 100% right.

Isn’t it interesting that no one ever mentioned HSPs until MRI came out with WAR - Workout Anabolic Recovery™ a short while ago.

And please understand, it took MRI’s brightest scientific minds years to develop HSP Active. Yet you’re already seeing the knockoffs.

Here’s what typically happens. Other companies read the bodybuilding pubs. They have people dedicated to pouring through these mags – looking for the next “wave.” So if they spot MRI’s WAR – the first HSP activator – and see the words Heat Shock Activation, it’s probably for the first time in their lives.

Trust me, ever since MRI came out with NO2® and CE2®, all eyes are on us. I’m convinced you’ve got the heads of product development putting out red alerts every time MRI releases a new product.

“Find me an HSP activator – NOW!” rages the word from the top. Of course the bigger com-panies could get there first. They have more money. You know the ones. Count the number of pages of ads they put out!

But think of it from their point of view. WAR, and now HSP Active, hit them like a ton of 45 pound plates. They “had” to react. They needed a product to fill what they call in sales “shelf space.”

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Can’t you just hear it? “I want to see a formula today! Nobody leaves this building until it’s done … and get the graphic department to bang out a label – NOW!”

I know I’ve said this before, but I’ll say it again. Getting your facts right means getting the results you want. It’s that simple. So right now I’m going to arm you with the ability to instantly spot all the “red flags” of the supposed HSP activating products. Please, whatever you do, don’t gloss over this section. I’ll take it a step further. If you only look at one section of this entire book – make it this one. I mean it.

A word before we start…

I’m not going to talk about, or specifically name, other products here. They can speak for them-selves. I am going walk you through exactly why MRI selected Tex-OE® and rejected other HSP activating compounds. This is important. Even more important, you’ll see how to “interpret” labels and ads – before you plunk down your hard-earned cash.

I’ll start in “Fairyland.”

faIry dusTIngsellIng “sTorIes” noT “resulTs”

This trick is so old, I’m surprised some companies are still trying to pull the wool over your eyes with it. It simply amazes me.

You want to know exactly what’s in a product – before you take it right? Of course you do. So you read the label. You carefully go down the ingredient list. They look good. You immediately want to know the exact amount of every single ingredient that you’re getting in each serving. You want to see if the amount is considered “efficacious.” In other words, are you getting enough milligrams (mgs) per serving to give you results? You’ve just hit the nail on the head.

But something is missing on the label. To the right of each ingredient, where there should be a number followed by the letters “mgs,” there’s nothing. It’s blank. Was this a misprint? No. It was intentional. Then you notice at the bottom of the ingredients is one “composite” amount of mil-ligrams. They’re all neatly bundled up. What does it tell you? Nothing.

And here’s where it gets tricky for you. Let me give you an example.

Let’s say you saw a product, we’ll call it CreArgiGlut (I made this up, of course). As you’ve already guessed, it contains creatine, arginine and glutamine. But like we just talked about, they

“bundle” milligrams per serving you get. It reads, “6,000 mgs.”


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Looks innocent enough. Right? You’re getting three good ingredients – all in one. 6,000 milli-grams every time you take it. What could the problem be?

Put your detective hat on. We know the “effective” dose of creatine is 5,000 mgs, arginine is 3,000 mgs, glutamine, 4,000 mgs. Oops! We’re already at 12,000 mgs per serving.

See the problem? That means this company would have sprinkled a “fairy dusting” of the “ac-tives” so they can tell the “story” of the creatine, arginine and glutamine. You know, “gain strength, get pumped, recover faster, etc.”

Consider this. Some products have more than 10 ingredients! All crammed into under 10,000 mgs.

You get the point. My advice is, know your amounts!

That’s exactly why you’ll see full disclosure on MRI’s HSP Active label. It’s the dose clinically shown to produce results!

Enough said.

I want to pause a moment here. After we launched NO2, within a few years there must have been over 50 knock offs. I’m not kidding you. And I predict that’s going to happen with HSP Active. But with one difference.

The Tex-OE in HSP Active is patented – and MRI has the exclusive rights in the United States. That means the potent Tex-OE can not be abused or misused. No chance of imitations.

But, like I said, companies will frantically search for an alternative HSP activator. No doubt about it. I’m not sure what they will come up with, but I want you to see the compounds MRI investigated – and rejected. And more importantly, why we rejected them. It’s very eye opening. Here are just a few . . .

The “dIdn’T Make IT” bIn

#1. Peoniflorin

If this word reminds you of the peony flower – it should. It comes from the peony. It sounds pretty innocent right? After all, peonies are garden flowers.

But here’s the thing. Our researchers discovered that peoniflorin may inhibit Testosterone. Of all things to annihilate – Testosterone! The very thing you – and all bodybuilders – want to increase, in safe levels, of course.

You remember from Part I (see page 18) how HSPs and Testosterone work together to generate

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new muscle. What do you think happens to your results when you remove T from the muscle-building equation? You got it.

Now I wish I could tell you that’s the end of the peoniflorin story. It isn’t. Here’s the grizzly part.

Experimental research suggests that Peoniflorin possibly increases estrogen. I remember our lead researcher saying, “just what you need, huh? More estrogen coursing through your system smack dab in the middle of your bench press.”

Not a pretty picture. But that’s even not the worst part.

In this study Peoniflorin actually stimulated aromatase activity. Do you know what aromatase does? Sit down please.

Aromatase converts Testosterone to estrogen. It’s true. Aromatase takes the Testosterone inside your body and “converts” it to estrodiol – the most potent form of estrogen.

And now, we come to the main point.

Estrogen blocks the activation HSPs. Yes, it wipes out heat shock proteins. You can understand why MRI passed on this one.

IMporTanT: Today scientists have a working hypothesis about the dif-ferences between men and women in both athletic performance and muscle size. They believe the disparity may be due to the number of HSPs each gender generates. Interesting, isn’t it? But it makes sense. Women have more estrogen. Estrogen blocks the activation of HSPs.

#2. Medicago Sativa – but you can call me “alfalfa”

The word alfalfa conjures up images of harmless-looking sprouts. But get this, alfalfa is a plant phyto-estrogen (there’s that word again). And it’s a “direct” form of estrogen. It doesn’t even have to go through a “conversion” process.

Just remember this. Alfalfa: good for salads, bad for HSPs.

READ IF YOU DARE: In Asia, women use alfalfa to help promote breast growth. Next stop: gynecomastia.

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#3. Eucommia

Eucommia is a small tree found in China. Just what can eucommia can do? According to re-search in laboratory animals, it makes the receptor sites in your cells more sensitive to estrogen. Meaning, it takes the estrogen that’s floating around in your blood stream, helps it to “lock on” to the outside portion of the cell, on its way to getting transported inside.

Once our research and development team found this out, it got 86’d.

Eucommia may also affect the hairs on your head.

Have you heard of DHT? DHT is a hormone that wreaks havoc on your hair. DHT shrinks (never a positive word for men, is it?) the hair follicle, making it smaller and finer. Medical doc-tors refer to this as “miniaturization” (another nasty word) – with the end result of hair falling out. But DHT first has to bind to receptor sites. And guess what ingredient has been shown to cause DHT binding? If you guessed eucommia, you’re right.

I’ll stop. But you have to admit it is ironic. The ingredient that’s called eucomia (EE-you-comb-ee-uh) leaves you with nothing to comb.

#4. Berberine

MRI launched a full scale scientific investigation on berberine a few years back. Not for HSP Activation, but for fat loss. But we rejected it when we discovered what was going on “behind the scenes” of the metabolic stage.

Preclinical research at the time suggested that Berberine may accumulate in your muscle cells where it could literally “choke off” your mitochondria if consumed in large amounts. You prob-ably already know this, but the mitochondria are your cells’ “power houses.” They take all the food you eat and all the air you breathe and convert it into energy. Energy you use to lift more weight. Energy your HSPs use to construct new muscle.

The scientific term for this strangulation hold is “inhibiting mitochondrial respiration.” In plain English, it cuts off all energy production. And it puts the clamps on just when you need it most – during your workout.

But, you can see how berberine was once considered for fat loss (notice I said “once”). You see, when this air constriction takes place, your body does not stand idly by. Not at all. It goes into full-blown panic mode. It frantically searches anywhere and everywhere it can for energy. The body thinks it’s starving. And it is. So it turns to fat – pulling lipids from the fat cells. But guess where your body transports the fat? The mitochondria – where the air restriction prevents any-

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thing, including fat, from being burned and used as fuel.

What happens to the fat? Most likely it gets reabsorbed by the fat cells. But one thing is very clear. You’ve got a lot more to lose than fat with berberine.That’s one of the reasons you won’t find it in HSP Active.

The MyTh of More Is beTTerThe Case of one T-rex versus 11 alberTonykus

Alberto-what? The Albertonykus was a dinosaur about the size of a chicken. I just found that out, too. That’s great, you say, but why mention that in the middle of book on the science of HSPs? It makes the point perfectly. When it comes to HSP Activation, MRI believes one “BIG” power-ful activator is better than many “smaller,” weaker ones. We don’t fool around with “cocktails” of weaker ingredients. The goal is to pound the molecular target with the most potent weapon available.

Make no mistake. That’s exactly why MRI hand-selected Tex-OE for HSP Active. It’s the only – and I mean only – HSP activator that our elite research and development team found that could elevate HSPs by up to 200%, speed the time to activation by up to 1500%, and continue work-ing for up to 3 entire days. Oh yes, and has been clinically shown to be effective. In well trained athletes, to boot!

Look, I know I keep hammering home these same facts over and over. But believe me, these are simply staggering results. I’ve been around clinical trials for decades, and rarely do I see such phenomenal numbers. But don’t look at them as just numbers on a paper. For real. See them for what they are – real muscle, strength, and endurance gains for you.

I’ll finish this section with one quick question. If you had all your money riding on one fight, who would you bet on? One 14,000 pound Tyrannosaurus Rex or 11 chicken-sized Alber-tonykus weighing in at a total of 36 pounds?

Next subject, please!

The CaffeIne quesTIon

Although you won’t find caffeine in HSP Active, many bodybuilders want to know: “Is caffeine good or bad for me?” Or “How much caffeine do you recommend.”

This is a good place to answer that.


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First let me ask you which statement you think is true. Caffeine is good. Caffeine is bad. When you give your answer, think in terms of hard training athletes like you. I mean how caffeine affects performance, muscle mass and … I’ll throw in how it affects HSPs to make it really challenging. Not sure? Let’s dive into the science and come up fully informed.

Caffeine: The GOOD

I’ll tell you right up front, I like coffee. No, I need coffee. Especially when I’m writing past mid-night to keep you informed!

You know that caffeine cranks up your energy in the gym. You feel like you can attack the weights with a greater intensity. Most experienced guys say the same thing. So that’s good.

Caffeine also dials up your mental focus, and gives you a laser-like focus. Most times, anyway. We’ll put that in the plus column, too.

But (and this is a very large “BUT”) …

MRI scientists believe that when you exceed 200 mgs of caffeine in an 8-hour period, a buzzer should go off in your head. STOP! I’ll explain why in a second. At MRI we believe that you can get all the athletic benefits of caffeine with a maximum of 200 mgs. There are plenty of studies that prove that fact.

But here’s what we believe to happen when you start creeping up the mgs to 250, 300, 350 and higher. I’ll tell you right up front, we have no proof of this yet. But we’re so convinced, we’re investigating it further.

Caffeine: The BAD

Our hypothesis says that when you take over 200 mgs of caffeine, your body starts pumping out Cortisol. Cortisol is a corticosteroid hormone produced by your adrenal cortex. It’s a bad dude.

We feel that even non-athletes should keep a distance. Cortisol raises blood pressure, weakens the immune system and hinders bone formation. Now listen to the effect it has on athletes…Cortisol literally “chews up” muscle. Lots of Cortisol chews up lots of muscle. You think pira-nhas are fast? The quickest way to strip muscle off your body is with Cortisol. We suspect the quickest way to elevate Cortisol is with excessive caffeine.

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IMporTanT: Talking about burning the midnight oil. Try not to ingest caffeine after 2:00 pm. It can interfere with your sleep. And you really repair and build muscle during the deepest sleep. Now if you’re one of those guys that can down a cup of coffee at 10:00 at night, then crash at 11:00 – and sleep through fireworks – good for you! Most of us aren’t.

Guess what else too much caffeine may do? Reduces the size of your blood vessel openings. In other words, it’s a vasoconstrictor. That, of course restricts the amount of nutrients that flow to your muscle cells.

I just want to make sure you understand what I’m saying. Caffeine is not bad. It’s a matter of dose – like with aspirin. Two can cure a headache, while the whole bottle does you in.

Our advice is to keep your consumption of caffeine down to 200 mgs per day.

sChIsandra (s) – sTandardIzed for 10% sChIsandrIns

I like schisandra. MRI’s scientists specifically chose S for our post-workout formula WAR. MRI scientists believe that S is an ideal post-workout HSP activator. Especially when combined with the human-ratio amino complex, waxy maize and high bioavailable creatine in WAR.

But, you probably knew this was coming – the devil is always in the details.

Notice the words (above) that say “standardized for 10% extract?”

Our R&D department believes that the 10% extract is vital to producing results. I’m telling you that because if you ever see S with less than 10%, a red flag, in my opinion, should go up.

Inspect every label, ad and web site closely. What are you looking for? The words: “IN VITRO.”

“In vITro” versus “In vIvo”bIgger bodIes or bIgger glassWare?

Do you know what “in vitro” means?

It means that the test on a compound was performed a Petri dish, or a test tube. Cynics like to say: “That would be fine if the supplement was designed for glassware!” But don’t get me wrong. In vitro studies can be important. MRI uses them, too. But only as a “first step.” Before making an absolute claim, we like to see “in vivo” tests. That means in real,

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live human beings. Similar to the ones reading this book! That’s one of the reasons why MRI invested the time (years) and money to ensure that we could offer you “in vivo” (in human) tests with the Tex-OE in HSP Active.

And it wasn’t with a few people we just rounded up. The Tex-OE in HSP Active is solidly backed by robust clinical trials performed on living, breathing human beings. And get this. In already well trained athletes! This is the most difficult test group to see results. They’re already in almost perfect condition!

And what did results show: the Tex-OE in HSP Active:

1. amplified hsps by up to 200%

2. sped up the Time to hsp activation by up to 1500% (6 minutes versus 90 minutes)

3. Worked up to 72 full hours

Now we’ll head over to the “Spokesperson” department

The InfaMous “spokesMan”

You’ve seen the ads. They picture a massive human. Mammoth. Ripped to shreds. Hellacious, vein-popping pumps exploding off the page.

One bodybuilder told me, “at the time they take these kind of pictures, the spokesperson was probably a few seconds away from passing out – completely dehydrated. Body fat under 5%. I’m sure the emergency medical crew stood inches away, just out of the shot.”

Usually in his hands, or shown right next to him, is a candy bar, bottle of pills, sack of powder, you name it.

Do you really believe his unnaturally humongous body was obtained by a few supplements?

Experienced bodybuilders tell it straight up: “This guy is clearly juiced to the gills!”

All I’m saying is, with supplements, look at the science, not the pictures!

This next section comes right out of the NO2 book. I don’t think I can improve on it.

The ever-obsCure “proprIeTary blend” sTory

This one’s been around forever. Back in the 1950s, manufacturers were afraid that companies

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would copy their products. So they were reluctant to give up their actual ingredient list. They legitimately used the proprietary blend story to protect themselves. Not any more. The way I’ve seen it used in the supplement industry is to obscure the facts. They take the “lump ’em together” tactic a step further. Instead of listing all the ingredients and assigning a single gram weight to the lot, they don’t reveal ingredients at all! If you ever see the words “a proprietary blend of HSP activating ingredients”… run!

Now let me say something good about the proprietary blends. I enjoy the names the ad com-panies give to these mixtures. So sciency sounding. Like OxyMegaWheyLine. That’s not a real product, of course. But judging from the amount of times MRI’s products and ideas have been “knocked-off,” don’t be surprised if you see a new protein powder with that name soon. Or VoltaShoxIntensoMax in the HSP category!

And here’s the potentially risky part for you (and frustrating part for me). These companies take out 6 page, full color ads, and bombard you with misinformation. Some of these “ads” even ap-pear as “editorials,” making you think the magazine itself thought the subject was so important that they used their own writers to “keep you informed.” Give me a break.

And how are you to know the difference between hype and truth? Clinical trials! Like the ones conducted on the Tex-OE in HSP Active!

Notice I used a specific word “clinical” not just the word “test.” There’s a reason. Now see this pitfall that awaits you…

When a “TesT” Is noT a “TesT”hoW To spoT “double Talk resulTs!”

Again, let me quote from the NO2 book. It says it best.

“A test is a test is a test.” Right? Wrong! And, when you’re about to hand over your cash for a product – this becomes a major point.

You often see the words “study,” “test,” and “clinical trial” (or clinical test) used interchange-ably. Seems innocent enough. But dig a little deeper. You’ll not only see a huge difference, you’ll understand why some supplement companies delight in this self-made confusion.

Let’s face it. Why would a supplement company put the words “tested” in an ad? I can think of one big reason. To make you think that your results are “guaranteed.” The idea being that people just like you tried the product, got results, and so will you.


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But here’s the deal. Most anybody can run a test or a study. For example, grab a few of your drinking buddies and you’re off to the races. But here’s where it gets tricky. Let’s say you’re sell-ing a new fat loss product. Say your buddies aren’t that overweight. So you enlist 5 of your aunt’s best friends. You reduce their calories by 500 per week. But, you also have them sit in a hot bath filled with your new fat-loss product. We’ll call it “Fatso-Relaxo.” Hey, you’ve just run a “test.” And your ad could say 100% of the participants lost on average 3 pounds in just 2 weeks. True? Yes. Misleading? What do you think?

But that’s not what happens with a genuine clinical. First of all, it’s placebo-controlled, so you have two groups – one taking the bath, the other not. Both reducing calories though. Now the

“test” reveals the truth. By reducing calories, you lose fat! And the clinical has another distinct advantage. Subjects are chosen to match the group of consumers you’re going to sell to. That’s highly significant. Just imagine two clinical trials con-ducted for fat loss. The first group is men who have spent the last 10 years training their butts off. And their body fat composition is less than 10%. For the second group, we’ll invite your aunt’s friends again. Their body fat is in the 30% plus range. Think you might see a difference? You’re right.

That’s why you must look for products with genuine clinical trials – like the Tex-OE in HSP Active. And remember, the subjects chosen for the Tex-OE clinical trials were already highly trained athletes. Do you know how difficult it is to produce results in these guys? Atlas had an easier time! In spite of that fact, the Tex-OE produced significant results. I’m telling you HSP Active is unlike any product you’ve ever tried.

By the way, see if you can get your hands on an NO2® book, it’s worth the read.

Okay, I’m done!

Before you put this book down, please flip open to the next section: “Getting Off to the Right Start.” It lays out for you all the do’s, don’ts and dosing on how to take new HSP Active. You’ll even find valuable results-boosting tips. Please follow these closely. I want you to get the absolute maximum benefit from this remarkable HSP technology.

Diagrams 1 & 2

Diagram 1: In Diagram 1, you’re watching the birth of new proteins. Notice the thin, string-like structures emerging from the ribosomes (orange, round). These are newborn (nascent) proteins. Your mRNA (messenger RNA) gives “orders” to the ribosome on what types of proteins to create. HSPs must then fold the proteins in order for them to become functional.

The Birth of a New Protein

Diagram 2: In Diagram 2, you see the chaperone HSPs (orange globule structures) attaching themselves to the newborn proteins. This prevents the proteins from becoming mis-folded, tangled with other proteins, or damaged (denatured). Then the HSP chaperones escort the newborn proteins to the “folding” HSPs, where they become “perfect proteins” ready for your body to use.

D1HSP Chaperones

RIBOSOMES

mRNA

NASCENT PROTEIN

HEAT SHOCK PROTEINS

Diagram 3: In Diagram 3 you’re seeing the vital process of HSPs “folding” proteins into their “perfect” muscle-usable form. In stage 1, notice the newly created protein entering the HSP Chaperonin Complex. In stage 2, the HSP “closes” and folds the protein. In stage 3, the new “perfect protein” is escorted by another HSP (not pictured) to the actin fiber to become new muscle for you.

Folding to “Perfect Proteins”

Diagram 4: Diagram 4 shows you the remarkable 9 Step “Cycle of Anabolism.” This is where the work you do in the gym, the food you eat, the supplements you take, all come together to create new muscle. Notice how HSPs take part in both the early stage as well as the final steps of this muscle-building process. In fact, HSPs are the rate-limiting factor in the entire Anabolic Pathway. Without sufficient HSPs, the process would come to a grinding halt.

D2

Diagrams 3 & 4

Journey to the Center of Anabolism

Diagram 5: Figures 1 – 4 illustrate proteins that are not “muscle-usable.” You’ll see misfolded, tangled, clumped, incomplete, and unfolded proteins. Figure 5 demonstrates the only muscle-usable protein, the “perfect-fold” protein, created by HSPs. The good news is HSPs can also repair the damaged proteins, converting them into “muscle-usable” proteins.

“Dead Weight” Protein Clearing

Usable versus Unusable Proteins

Diagram 6: Proteins can become damaged beyond repair. These are known as “dead weight” proteins. Dead weight proteins can weaken the cell. HSPs remove dead weight proteins from the cell and replace them with new perfect proteins. Now the muscle is primed for growth.

D3

Perfect Protein

Dead Weight Protein

HSPs

Diagrams 5 & 6

Diagram 7: Diagram 7 shows you the powerful effect of Tex-OE® in HSP ActiveTM exerts on the speed of HSP activation. Notice how with Tex-OE, HSP activation begins as soon as 6 minutes. Now compare that to 90 minutes with exercise alone. You’ve just eliminated 84 minutes of post-training catabolism. What’s more, Tex-OE has been clinically tested in trained athletes and shown to elevate the number of HSPs up to 200% over exercise alone. Plus, Tex-OE lasts for up to 72 hours. This is genuine 24/7 Anabolism.

Diagram 8: Diagram 8 illustrates the dramatic effect that HSPs have on satellite cells, and ultimately hyperplasia (the making of new muscle fiber). Notice the little blue spheres in the diagram. These are satellite cells. Emerging experimental research indicates that the number of satellite cells increase by up to a staggering 510% following HSP activation. The abundance of newsatellite cells can form new muscle cells. That means with HSP activation, each muscle cell becomes denser with protein (hypertrophy), plus you have more muscle cells. The ultimate combination for size and strength.

D4

Diagrams 7 & 8

Up to 510% More Satellite Cells

Up to 1800% Faster HSP Activation

90 min.vs.6 min.

Muscle Fiber

Satellite Cell

Without HSP Activation

Following HSP Activation

getting off to the right start The Do’s, Don’ts and Directives

part Iv

parT Iv GETTING OFF TO THE RIGHT START

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W hew! That was a lot of science to take in. Especially the new concepts like “protein folding,” “dead-weight” clearing, and nascent proteins. To name a few. (By the way, I put in a glossary

of terms in the back to give you a quick glance definition of these new concepts.)

But I’ll bet you finally understand how HSP Active helps you add muscle in ways no other supplement possibly can.

I’ll also bet you want to pop out a few HSP Active tablets, gulp them down, and start experi-encing the power of this revolutionary heat shock protein activator. The size. The Strength. The Training capacity.

But hold on for just one quick moment.

I’m going to show you how to get the absolute maximum results with HSP Active. I mean every last drop of effects. Here goes.

hsp aCTIve: do’s and don’Ts

1. After dosing HSP Active, wait at least 2 hours before consuming food, drink, or supple-ments that contain fiber. Remember, the reason Tex-OE is bio-available is because of its patented fiber removal technology. That’s also the reason Tex-OE can never be duplicated!

2. Do not consume excess caffeine in an 8 hour period. Please try not to deviate from this. You see, excessive caffeine stimulates the release of the catabolic hormone – Cortisol. What ends up happening is that your HSPs get diverted to fighting off the Cortisol, instead of helping you add new muscle. Just be sure to read the food and supplement labels closely.

3. Be sure to consume plenty of dietary protein. First, HSPs accelerate the rate of protein synthesis. So give your body plenty of “building blocks” to construct that new muscle. Second, because Tex-OE multiplies HSPs by up to 200%, your body has the capacity to fold more proteins into new muscle. So chow down the proteins and keep those HSPs working! By the way your body needs plenty of dietary protein to make HSPs!

IMporTanT: Try consuming smaller amounts of protein more frequent-ly. No need to get carried away, though. Try this. Take a third of your protein first thing in the morning, another third in the afternoon, and the final third before bed. On the days you train, be sure to take one of the protein allotments right after you train.

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IMporTanT: See Part VII: Principles of Nutrition to find out exactly how much protein is right for you.

4. You may find that your appetite increases. What should you do when that happens? Eat! Look, constructing new muscle takes energy. Lots of it. So in addition to the added protein I just rec-ommended, consume extra carbs. And remember, after you dose HSP Active, wait 2 hours before consuming those carbs (see #1 again). PS. Make sure they’re complex carbs. (see Part VII)

5. Get plenty of sleep. Deep sleep. And a full 8 hours of it. This is where real growth takes place. It’s when your body initiates a hormonal cascade, beginning with IGF-1 (insulin-like growth factor - one) and Testosterone.

IMporTanT: HSPs “select” and “direct” Testosterone to bind to the muscles receptor sites (see Page 18). Because Tex-OE increases HSPs by up to 200%, you’ll want that extra Testosterone that deep sleep provides.

Look. I realize this kind of profoundly restful sleep comes easier to some bodybuilders than oth-ers. And let’s face it. A good night’s sleep affects far more that just muscle growth.

So here’s what I recommend. Give your doctor a call and ask him what you can do log in more ZZZs and pack in some major muscle-building REM.

6. Train at maximum intensity. I mean it. HSPs need “extreme” conditions to activate. Like super intense workouts. And keep in mind, the Tex-OE in HSP Active multiplies training-induced HSPs by up to 200%. That means you’ve got twice as many “protein folders” at work. So train all out, create the added “need” for more muscle, then let HSPs perform their physiological magic!

7. We’ve talked a lot about evolution and adaptation. I’m sure you know that increasing the amount of weight (progressively) forces your body to adapt by adding new muscle. But here’s what many bodybuilders may not know. It’s not just the “amount” of weight, but the “order” or “type” of exercise that your body adapts to. I suggest you hop over to Page 70 – in the

“Principles of Exercise” section. It’ll give you lots of ways to “shake up” your training to force your body to adapt even faster.

8. I just told you to train at maximum intensity in all of your workouts. Please do it. But, do not over train. By over training I mean going for the ambitious “2-a-days.” And believe me,

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you’ll be tempted. Don’t be seduced. Here, prudence really is the better part of valor!

9. With HSP Active, there is no loading phase. In fact, HSP Active is so powerful I recom-mend you follow the dosing instructions closely. But don’t worry, for you really hardcore guys, I’ve got a way for you to “push the limits” (see below for “dosing”).

10. There’s no need to “cycle off” HSP Active. Although HSP Active works through a path-way previously unknown to athletes, it’s still a natural process. HSP Active is not inducing your body to do anything that’s foreign to it. It’s helping to give your body the ability to evolve to a higher muscular level – faster. I suspect you’ll enjoy the status of Super-Human!

11. Try taking glutamine after your workouts. We now know that glutamine helps HSPs func-tion at maximum efficiency. And since Tex-OE can increase the amount of HSPs by up to 200% wouldn’t it be nice to know they’re functioning at the highest level possible – to give you the most muscle for your time in the gym. MRI makes a scientifically formulated product spe-cifically for post training – WAR. It’s got glutamine, “human-ratio” amino acids, and a lot more.

12. Drink plenty of water. The added intensity of your training, plus increased perspiration means you need to replace the fluids lost. Be sure to replace your electrolytes, too.

13. Take a multivitamin. Keep the engine humming by ensuring all the essential micro-nutrients are available when your body needs them.

dosIng hsp aCTIve

First, I want to say no two individuals are exactly the same. Like snowflakes, each of us is totally unique. Sure there are some general principles you can come up with that apply to a large per-centage. But that means “most” people, not “all” people. In the medical community, the excep-tions to the rule are called “out-lie-ers.” These people need unique solutions.

I’m telling you this because I’m about to give you some “rules” on taking HSP Active. But I’ll tell you right up front, some rules are made to be broken. But don’t worry, I’m not going to make you guess which ones, I’ll lay all that out for you – step by step – how to break them and in which order to do the breaking. IF you have to that is.

You see, many bodybuilders simply follow the guidelines and report phenomenal results. I’m talking about staggering gains. This is the group you’re probably in. But for a small percentage, we have to fine tune it a bit. I’ll get to that in just a moment.

Now, I feel compelled to tell you something here. Dosing is a matter of painstaking and exhaust-

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ing trial and error. Often times it takes years to come up with what is referred to as “optimal” dosing. For the researchers at MRI, it was no different. And keep in mind, we started looking at HSPs years ago. So we’ve had a lot of “trial” and a lot of “error.” But we also found the Big Success. The dosing that unleashes the full benefit of these astonishing HSPs at the core of size, strength, and muscular endurance. Validated by clinical trials. And ready for you!

We’ll go over Weight-Dependent Dosing, Frequency of Dosing and Timing of Dosing. Please pay close attention here. HSP Activation is a highly complex biological event. HSPs are as old as the first human, yet it’s been a handful of years that we’ve known they exist. And only now, with HSP Active, that we’ve found the bona fide technology to amplify HSPs by up to 200% and speed their action by up to 1500%. Giving you, of course, the power to transform your physique in ways you could never have imagined before. Dosing is critical. Let’s tackle weight-dependent dosing first.

WeIghT dependenT dosIng

Some compounds, like antibiotics, are not weight dependent. That’s because they are targeting invading germs. If the dose depends on weight at all – it’s the weight of the germs!

But dosing on compounds that target muscle do depend on weight. And that’s understandable, more weight usually translates into more muscle. That’s especially true for well-trained athletes – like you.

Start with the following dosing.

If you weigh under 200 pounds… If you are under 200 lbs, take 2 capsules once a day

If you weigh 200 pounds or more… If you are 200 lbs or more, take 3 capsules once a day

And like I said, I’ll talk about fine tuning these recommendations for any “out-lie-ers” in a just few paragraphs.

Now let’s get to frequency of dosing.

frequenCy of dosIng

I’ll admit it. It took MRI’s Research and Testing Protocol Group a long time to get frequency of dosing right. Here’s why.

We knew that our Tex-OE lasted up to 72 hours. In fact, Tex-OE was the only HSP compound we found that did last up to 72 full hours. The other “mild” HSP activating compounds we looked at were unimpressive to say the least. That’s why we flat out rejected them.


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Now, there are 168 hours in a week. So it seemed to make sense that dosing should happen every 2.3 days. As it turned out, that was correct. But we understand it’s not possible for everyone to train exactly every 2.3 days. So we devised 2 regimes. Pick the one that works best for you. Some guys use a combination of the two.

1. 3 To 4 TIMes a Week

I call this dosing “Every 2.” Here’s what you do. Take HSP Active every other day (every 2 days). Be sure to do your “resistance” training on the day you dose HSP Active. In other words, hit the weights. On the in-between days, do your cardio.

IMporTanT: Remember, HSP Active kicks in and amplifies HSPs up to 200% in just 6 short minutes – not 2 hours, like with exercise alone.

This way you get the full, head on, maximum benefit of HSP Active. Now listen to this.

The moment you lift your first weight, the anabolic power of HSP Active is already hard at work repairing damaged intracellular proteins, “folding” new proteins, transporting folded proteins to become part of brand new muscle for you!

But say you’re not able to train exactly every 2 days. You work, have other responsibilities, and on occasion, can’t seem to drag yourself into the gym.

Here’s an alternative.

2. 3 To 4 TIMes a Week – “runnIng days”.

A lot of guys tell me they train with weights 4 consecutive days, and do cardio on the off-weight days. These guys like to train 4 different “groups of muscles” 4 days running.

In this case, you can take HSP Active four consecutive days, but then back off for three days. The bottom line is, you’re still taking four doses in seven days.

By the way, you can use a combination of the two dosing methods. For example, if you train with weights Monday, Tuesday, Thursday and Friday, simply take HSP Active on the days you train.

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Now I can hear you asking, “what if I train 5 or 6 times a week?”

Good question. And some guys train that often with great success. Here’s what I would do.

If you’re training 5 or 6 times in one week, there are going to be back-to-back days. Start by dos-ing every other day, beginning on the first day of the week you train. Maximum 4 doses for the week. See what happens. If your performance remains high on the “non-dosing” days, perfect. If it doesn’t, you can try adding a fifth and even sixth dose. And let me put your mind at ease here.

Tex-OE is completely safe even at 6 doses a week. So it won’t hurt your body – but it may hurt your wallet. We’re looking out for you there, too. Unlike many companies who want to push as much product as they can on you, MRI does not work that way.

I want you to get the greatest results for the least amount of money. Not the other way around! So start with 4 dosings per week, but before you add more, experiment with the timing of dos-ing. In fact let’s dive into “timing” right now.

TIMIng of dosIng

Timing of dosing was probably the most challenging part of dosing HSP Active. It is also the one that is likely to deliver the best results.

Here are the three most effective methods. Pick the one that is most compatible for the way you live.

1. The nIghT before TraInIng.

By training I mean resistance training – not cardio.

You already know that HSP Active shouldn’t be taken with foods containing fiber. So at first, we thought the safest time of the day to take it was right before bed. The night before a resistance training day. For some, that works great.

But other guys might want to take it closer to their actual workout.

2. The MornIng of TraInIng

You can experiment with dosing first thing in the morning on the day of training. The problem is that you can’t eat for 2 hours. Now if you’re not a big fan of breakfast – give it a try.

But you may want to push it closer to their workout.


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heaT shoCk — sTaCkIng regIMen

part IV GettinG Off tO the RiGht StaRt

62

HEat SHOCK — StaCKING rEGIMEN

WEEK 1 Day 1 Day 2 Day 3 Day 4 Day 5 Day 6 Day 7Workout Split Legs arms/Shoulders rest Back rest Chest/abs restMorning Pro-NOS® Pro-NOS Pro-NOS Pro-NOS Pro-NOS Pro-NOS Pro-NOS

Mid morning NO2 Black or Platinum NO2 Black or Platinum NO2 Black or Platinum NO2 Black or Platinum

2 hours pre workout (EOD) HSp active HSp active HSp active HSp active

30 Mins. Pre-Workout Black Powder Black Powder Black Powder Black Powder

During Workout WAR (1 scoop) WAR (1 scoop) WAR (1 scoop) WAR (1 scoop)

Immediately Post-Workout WAR (1 scoop) WAR (1 scoop) WAR (1 scoop) WAR (1 scoop)

1 Hour Post-Workout Quick Gainer or Pro-NOS Pro-NOS Quick Gainer or Pro-NOS Quick Gainer or Pro-NOS

4 Hours Post-Workout NO2 Black or Platinum NO2 Black or Platinum NO2 Black or Platinum NO2 Black or Platinum

WEEK 2 Day 1 Day 2 Day 3 Day 4 Day 5 Day 6 Day 7Workout Split Legs arms/Shoulders rest Back rest Chest/abs rest

Morning Pro-NOS Pro-NOS Pro-NOS Pro-NOS Pro-NOS Pro-NOS Pro-NOS


2 hours pre workout (EOD) HSp active HSp active HSp active



Immediately Post-Workout WAR WAR (1 scoop) WAR WAR





















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HSp aCtIVE

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WEEK 1 Day 1 Day 2 Day 3 Day 4 Day 5 Day 6 Day 7Workout Split Legs arms/Shoulders rest Back rest Chest/abs restMorning Pro-NOS® Pro-NOS Pro-NOS Pro-NOS Pro-NOS Pro-NOS Pro-NOS




































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3. one hour before TraInIng

I actually think this is the best way to dose HSP Active. But it requires a bit of adjustment in eating.

First, don’t eat for 2 hours before dosing. Unless, of course, you can find food or drink that con-tains no fiber. Then go for it. Otherwise, pack in all the food you want up to 2 hours before.

And in case you’re wondering, pre-workout supplements will not interfere with HSP Active – unless they contain over 200 mgs of caffeine or contain fiber. Avoid those caffeine-laden supple-ments at all costs (they induce Cortisol production as well as interfere with HSP Activation).

addITIonal resulTs-MulTIplyIng TIps

You may already know some of these results-multiplying tips, but they’re definitely worth repeating.

1. TraIn aT MaxIMuM InTensITy

“Failure” is good. Make it your best friend. Take every set to failure. Remember, Tex-OE is clini-cally validated to generate up to 200% more HSPs. That means your body can handle far more intense workouts. So push yourself to the limit. Then let HSP Active show you the results!

2. Change IT up

Your body is an incredibly well designed machine. One thing this “machine” does very well is to adapt to what’s “current.” So every time you make a change to your workout, no matter how small, you’ll catch your body “off guard” and force it to readapt. Plus, it keeps your workouts fresh and prevents staleness. Try these:

Change the amount of weights you use. �

Change the “order” of your sets. although it may seem insignificant to you, your �body will perceive it as very meaningful.

Change your resting (between set) interval. reduce the time by 30 – even 60 – seconds. �

Change the “tempo” of your lifts. �

I’ll go over all these and more in Principles of Exercise section on page 70.That’s it. Now go pop the cork on HSP Active!

Oh, one more thing. I want you to know exactly what to expect in the first 45 days of taking HSP Active. You may be surprised. So just flip over to the next section, it only takes a minute or two. You’ll be glad you did.

part v

What to expect When Taking hsp active™

First 4 Weeks – and Beyond

parT v WHAT TO ExPECT WHEN TAkING HSP ACTIVE™

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O kay. You understand how HSP Active works. And you know how to take HSP Active to get maximum effect from your training.

Congratulations. You’re already light years ahead of your competition. Actually with HSP Active, you’re about to completely obliterate the competition!

But before you bolt down to the gym ready to watch your muscles grow before your eyes, please take a glance at the section below.

It’s a road map of the HSP Active experience. I know that everybody is different. They respond to supplements differently. And training differently. But I included this section so you could see what the guys in the HSP Active test group experienced.

Here goes.

day 1 – 3

Some of the guys in the HSP Active group said it took a few days for their bodies to fully react to HSP Active. But they now realize that just because they didn’t ”feel” anything didn’t mean nothing was happening. To the contrary.

Remember, the first job of the HSPs is to start clearing out the “dead weight” proteins. You’ll recall they’re taking up the space inside your muscle cells where strength producing proteins should occupy. And remember, HSPs also ignite protein synthesis for the purpose of replacing those damaged proteins with new, healthy ones.

Days 1 through 3 is also the time when HSPs start repairing damaged cells.

In addition, these first few days are when HSPs start interacting with muscle cells to protect them against the onslaught of your intense workouts.

But I can tell you this. It’s during this initial phase when some of our guys started to notice an increase in appetite. That’s probably because their bodies were expending more energy. And keep in mind there are two types of energy while training:

1. The kind that you need to work longer and harder.

2. The kind your body needs to carry out all the metabolic activity.

And with all the increased HSP activity going on, your body will demand more. You’ll know this because your body will send out hunger signals. Obey them!

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IMporTanT: A handful of guys in our HSP Active test group experi-enced a “paradoxical” reaction and reported a reduction in appetite. This may be due to (I’ll give you the official name here) metabolic ramp-up. Sort of like when you take stimulants, even though HSP Active con-tains no stimulants whatsoever. Like I said, everybody is different. Take mental stress. Some people can’t look at food, others flat out gorge themselves.

day 4 – 7

With damaged proteins under repair, and the cell protection mechanisms in place, the HSPs now turn their attention to making new proteins with the purpose of growth.Even though you may not notice it in the mirror yet, inside your muscle cells – the game of growth is on!

Here, our researchers believe that you experience the beginning stages of hypertrophy – the scientific name for adding new protein to existing muscle fiber. In plain English – new muscle growth!

Remember, emerging scientific research demonstrates that HSPs increases protein density of cells by up to 18%!

Right around this time, our guys said they began to notice they started sweating very soon into their workouts. We called it the “HSP Sweats.” But like I said, everybody is different – and you may not notice the “sweats” for some time.

day 8 – 14

We just talked about hypertrophy. But there’s another way your body gets bigger: hyperplasia. Or, the making of new muscle cells. Yes, new cells that have to be filled to the brim with protein – just like your existing muscle cells. Preliminary research in laboratory animals demonstrates that HSPs initiate hyperplasia. Adding the benefits of HSP Activation to your training may help promote hyperplasia during your training.

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And at this point, some of the participants gained weight. In one case, up to 4 pounds. And that’s in under 2 weeks. Some of these guys are personal trainers who have been training for many years. Now imagine what HSP Active can do for you.

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day 15 – 21 Here’s where our guys reported eye-popping results. One test subject said, “this is the best I have ever looked in my life.” And something extraordinary happened here. One athlete even noted he stopped feeling fatigued. Even though they were working out harder.

It’s during these days one athlete reported started pushing more weight. And it happened fast. It seemed like each new workout he could pile on additional weight! And that plays right into the strength of HSPs! Remember, with HSPs, the harder you train, the harder they work!

How many other supplements can say that – and have it be the truth? C’mon – be honest. That’s what I thought.

day 22 – 28

Let’s just say that during this time – the fourth and final week of testing – the HSP Active group gave up their test materials, but not without a fight!

day 29 and beyond

Far from this being the end of results, this is just the beginning for you! You’re about to find out that HSP Active has set in place a “high momentum” machine that keeps pushing the limits of adaptation, ever expanding the limits of muscle growth and human performance. Hour after hour.

Day after day. Year after year.

There you have it. You’ve got the entire HSP story. Let me take that back. You see, every day we keep learning more and more about this exciting new HSP Activation category. It keeps chal-lenging all of our old ideas.

But here’s a guarantee from MRI and our worldwide research and development team: we’ll keep pushing further and further into this new realm of HSP – and keep you informed every step of the way.

I don’t know if you’ve ever seen the NO2® or CE2® books. But we always give you the proven tech-niques of exercise and nutrition. Same with this book. Just go to the next section and you’re in.

principles of exerciseApplying the “Stress” that Triggers “Adaptation” and Growth

part vI

parT vI PRINCIPLES OF ExERCISE

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IMporTanT: If you’ve ever seen MRI’s other books (NO2®, CE2®), you know that we always present the principles of exercise and nutrition. These scientifically-based laws do not change with time. What does alter, however, is the way different compounds play a part in these prin-ciples. Now, let’s see it through the “eyes” of Heat Shock Activation.

your gaIns sTarT rIghT here

It all starts here - with exercise. It’s the spark - or in the language of HSPs, “stress,” that ignites your body’s “adaptive response.” Exercise creates the “need” for your body to change – the need to add new muscle – as it’s forced to meet the new, and higher, load demands placed on it. You have to keep “escalating” the demands to continue gaining.

But you now know that without HSPs your body could not put on even an ounce of new muscle.

IMporTanT: Only “perfectly folded” proteins become part of muscle fiber, and only HSPs create the perfect fold.

The one question I keep hearing over and over is, “what’s the best kind of exercise?” Our MRI alpha dogs always say that you can get some results with just about any program, but there’s only one way to make maximum gains for real measurable results. That’s the one you’ll find right here on these pages.

one goal aT a TIMe – DiviDe anD Conquer

Look, I don’t care what anybody tells you - you can’t lose significant amounts of fat and pack on lots of muscle at the exact same time. Your body just won’t allow it. In fact, I know many ama-teur bodybuilders that accidentally fall into the dreaded “catabolic spiral” trying to do so (more about that on page 88). But, you can train to add mass and lose some body fat at the same time. Especially when you’re taking HSP Active.

Likewise, you can train to lose fat and maintain (and even gain some) muscle mass at the same time. And by training intensely for one goal at a time, you can achieve them all.

But it takes discipline and know-how. If you’re reading this book, I know you’ve got the desire, will and discipline. Now, here’s the know-how that will help shift your whole body transforma-tion into the highest gear possible.

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Let’s get organized. First, we’ll divide the workout routines into three separate phases: Mass, Fat Loss, and Pre-Contest. Second, we have to pick a “starting point.” In other words, what phase do we begin with? Here’s the advice MRI always gives to dedicated hard training athletes:

If your body fat percentage is � 21% or less, start with the Mass phase. We can always make adjustments with cardio to step-up the fat loss a little while you’re training for mass (see “body fat calculator” below). If you feel your size is disproportion-ate to your definition, and you want to start stripping off fat at a faster pace, start with the fat loss phase.

If your body fat is � above 21%, start with the fat loss phase, then switch to the Mass phase when you get down to 21%. but, if your main goal is to pack on as much lean mass as possible, start with the Mass phase.

If you’re preparing for a � competition, start with the Mass phase and switch to the pre-Contest phase 14 weeks prior to the show. but I wouldn’t advise the pre- Contest routine for anybody who has to lose more than 10% of their existing body fat to be “show ready.”

Don’t know your body fat? Try this. body faT CalCulaTorThere are a lot of ways to calculate body fat. Some are more precise than others, of course. You have anthropometry, hydrostatic weighing (I’ve used this one), bioelectrical impedance or con-ductivity, and the good old skin-fold method. To the right is a quick calculator Dr. Fred Hatfield devised that you can use right now to calculate body fat.

Okay, now it’s time to dive in.

BODY FAT CALCULATOR

DIRECTIONS EXAMPLE

MULTIPLY YOUR WEIGHT (IN THE NUDE) BY 1.082

IF YOU WEIGH 200,(200) X (1.082) = 216.40

ADD 94.42(WEIGHT FACTOR) 216.40 + 94.42 = 310.82

YOUR WAIST MEASUREMENT (AT NAVEL) X 4.150 (WAIST FACTOR)

IF YOUR WAIST IS 34”(34) X (4.15) = 141.10

WEIGHT FACTOR – WAIST FACTOR310.82 – 141.10 = 169.72

(169.72 IS YOUR LEAN BODY MASS)

ACTUAL WEIGHT – LEAN BODY MASS200 – 169.72 = 30.28

(30.28 IS YOUR BODY FAT)

(BODY FAT/ACTUAL WEIGHT) X (100) (30.28/200) X (100) = 15.14%

YOUR BODY FAT WOULD BE 15.14%


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TraInIng for Mass – forcing Immediate and Continual gains In lean Mass

Most bodybuilders I know don’t understand the complete training technique for adding mass. They do grasp the idea that you have to “overload” your muscles with increased weight in order to force them to “overcompensate” by increasing muscle fiber to match the load. And they do realize that to continue adding muscle, over a period of time, you have to continue overloading your muscles with more and more weight. But that’s usually where it stops, with the knowledge of “what” to do. What they don’t know, is the proper technique of “how” to apply that knowledge. That’s why so many dedicated and highly motivated bodybuilders hit that frustrating plateau. But stick with this plan, and it’s not very likely that will happen to you!

3-parT Mass buIldIng TeChnIque

Adding mass involves 3 separate training objectives, or training goals: hypertrophy, strength, and power. They work in series (training one at a time) and the technique is called “periodization”. The goal, of course, is both immediate and continual gains in mass.

Don’t misunderstand me. Training for hypertrophy, strength, and power, all lead to increased muscle mass. But if one “lags” behind, your gains will slow to a crawl – or come to a grinding halt. So it’s important to understand how to train for each separately. And take note. As you go through these exercise routines you’re going to notice how each of the training goals perfectly match the supplement goals of HSP Active. That’s no accident! It’s a “calculated synergy.” You see, when the supplement you’re taking, and the exercise you’re performing, both target the same

“body-response” you’ve greatly magnified the effects of each! In this case, 1 + 1 = 5.

hyperTrophy

During the hypertrophy cycle, you are forcing your body to create additional proteins inside your muscle cells - known as protein synthesis (sound familiar? HSPs help turn on protein syn-thesis and increase hypertrophy, see page 31 for more). These proteins are actin and myosin. And the more of these proteins that are made inside of your muscle cell, the bigger your muscle gets. That growth is known as hypertrophy. The key words here are “inside you muscle cell” – exactly where HSPs work their molecular magic!) As you’ll see below, you’ll be using a 10-12 rep range when you train for hypertrophy.

What’s more, HSPs spark hyperplasia – the making of new muscle cells!)

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Maybe you’re asking, “why can’t I just train for hypertrophy, and keep adding weight? Why do I have to train for strength and power too?” Good question. It’s because even with the “progressive resistance” load increases, your body will eventually “max out” its ability to adapt, it’ll become almost impossible to keep adding additional weight. That’s why you have to switch to the second part of your training - strength.

sTrengTh

When you train for strength, you are forcing the functional units of each muscle cell to increase their “adaptive response” to increased load bearing. (Again this should have a familiar ring because it’s the HSPs that create the “adaptive response.”) So when you return to hypertrophy training, you can add additional weight, in significant increments, to “re-escalate” your body’s muscle-building adaptive response. So you make gains in size, once again.

I think strength training is very misunderstood by the majority of bodybuilders. During strength training, which for the most part involves a 5-9 rep range, you are forcing your muscles to actively “enlist” additional muscle fibers within each muscle group to perform the workload. Your muscles “engage” more of the actin and myosin proteins inside your muscle cell to take part in the lifting of weights. In essence, you’re creating more contractile units within your muscle. Just consider the power lifter. For a bodybuilder to lift an equal amount of weight to a power lifter, he’d have to be many times heavier than he is!

Strength training also initiates biochemical changes that stimulate your glucose metabolism by activating innercellular enzymes. Strength training also increases phospho-creatine kinase, and improves the structural and functional integrity of both tendons and ligaments. Here again the words “structural and functional integrity” should sound familiar as HSPs repair and replace damaged proteins that create the integrity!)Plus, as you saw in Part I, HSPs clear out the “dead weight” proteins and replace them with functional proteins. Remember “dead weight proteins” are the ones “taking up space” without contributing the “lift.”

But there’s still a third part to the equation if you want to keep making continual gains in lean mass - and that’s power.


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poWer

Power is the part of strength that includes your neuromuscular system. And it’s an important element in adding muscle mass. As you train for power, you’re increasing your strength by increasing the neuron-firing system. Proper power training lowers your neural inhibitory reflexes, stimulates more neural recruitment patterns, and activates your central nervous system (CNS). Interestingly, this type of strength is normally associated with “panic” situations - like when a mother lifts a car off her child’s leg. These sudden “strikes” of ferocious strength are initiated by your autonomic CNS - and are reflexive and reactive. But they can, and must, be trained. As you’ll see, we’ll use the 1-3 rep range to augment your power. One big benefit of power training for bodybuilders is the increased torque and muscle velocity. The greater the torque, the greater your ability to move a weight through space. And that’s particularly helpful at the “beginning” of each lift. An overlooked aspect to power training is its ability to improve the synchronization of your motor units. And that’s essential to maintaining a perfect lifting technique. Have you ever seen a beginner doing dumbbell curls? Notice the “hip thrust.” That’s an example of what is not a perfect technique. And it’s really a waste of time because it’s the combination of the technique of lifting along with the actual weight lifted that gives you the gains.

Okay. Let me sum up the three cycles of Mass training:

hyperTrophy � : you add more protein inside the muscle cell to increase size

sTrengTh � : you increase the functionality of the strength proteins to boost strength

poWer � : you augment your body’s neural response to weight-bearing to further increase strength

Obviously there’s some “overlap.” You can’t train strictly for one without in some way improving the others. But what you are doing with this type of periodization training is making sure that you train each one 100% for a specific period of time (one full cycle). And HSPs are involved in every single phase!

Alright, now we know that we’ll be training for different body adaptive responses at different times. But you’re going to see that the “technical elements” through each cycle will remain the same. Here’s what I’m talking about...

MaxIMuM-InTensITy TraInIng — When failure is good!

Although we train for hypertrophy, strength, and power individually, there are a number of tech-

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niques they all have in common. Here’s the first one: always train at maximum intensity. What is maximum intensity? As I define it, maximum intensity means taking every set to “failure.” Failure, of course, is the inability to complete another functional rep in perfect form.

I believe it’s vital to take every set to failure, in order to maximize the muscle-building power of HSPs.

Maximum intensity is one of the “constants” you’ll use through every training routine. A per-sonal trainer I know always tells his clients, “if you don’t take your sets to failure, you’ll have failure with your sets.” Enough said.

IMporTanT: Taking a set to failure does not mean losing control over the lift and risking the weight falling on you. Maximum intensity really means maximum controlled intensity. That’s why I recommend you use an experienced spotter.

IMporTanT: Not all “failure” is equal. During the different training cycles failure occurs for different physiological reasons. When you train for hypertrophy and strength, failure happens due to “load.” For power, the cause is “neuronal firing.” With “endurance,” failure is because of lactic acid buildup.

resTIng InTervals — not a second Too long!

Here’s another technique all training cycles share: precise resting intervals. With Maximum Intensity training, you do not allow your muscles the time to fully recover their ATP energy sup-ply between sets. That would normally take about 3 - 4 minutes. Instead, by reducing that time, you increase the effectiveness of your sets because you’re forcing your body to adapt to the “load bearing” a lot faster. Here are the rules:

for the hypertrophy phase 1 � 1/2 minutes

for the strength phase 2 minutes �

for the power phase 2 - 3 minutes �

As you’ll see a little later on, I recommend that you limit your workouts to no more than 60

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minutes. In the Strength and Power phases, however, your workouts may have to go anywhere from 75 - 90 minutes due to the longer resting intervals. One alternative is to reduce the num-ber of sets to 12 - 16 in the Strength and Power phases so that you keep all your workouts to 60 minutes.

IMporTanT: If you opt for the longer workouts in the Strength and Power phases, keep sipping a protein and carb drink during your entire workout.

MaInTaInIng sTrICT forM — you “Cheat,” you lose

I can’t stress enough how important it is to maintain strict form. Strict form means stabilizing your body so that the primary muscles included in the lift do the work. That way, you make

“full use” of the weight you’re lifting. In fact, you get far better results with a slightly lower weight and perfect form than you do with higher weights and a flawed form. The rule is:

Never sacrifice form for the sake of increased weight.

By the way, a common mistake many bodybuilders make is thinking that if they just keep piling on weights they’ll keep increasing their gains. They’d be right if - and only if - that increased weight moved through space in perfect form. Please keep that in mind through all your exercises in all cycles.

TeMpo rules — Timing is everything

You’ll notice in the third column of the exercise charts I’ve marked “Tempo.” Tempo is the speed of execution of the three parts of your lift (eccentric, concentric and pause) starting in the locked-out position. Tempo is measured by three numbers, each number equal to one second. Where you see a 0 (zero), that means as little time as possible - an “explosion” to the next part.

For example, take your bench press in the hypertrophy training routine. You’ll see I have marked a tempo of 4-1-0. That means from the arm-extended position, take 4 seconds to lower the weight; pause for 1 full second; then explode up to the arms extended position. And repeat through all reps. When you are unable to complete another rep, maintaining that tempo, and with perfect form, you have taken that set to failure.

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CoMpound MoveMenTs — double your Impact

When you train a muscle group, choose an exercise employing compound movements whenever possible. Compound movement exercises are ones that involve a number of joints moving instead of just one. That’s why you’ll see that most of the exercises I recommend are with free weights and off the bench. I feel you get far better and faster results using compound movements.I’m not saying that you can’t get satisfactory results with cables, machines, and home gyms. You can. I just favor the use of free weights and the compound movements they demand.

your sTarTIng WeIghT — Well begun is half done

Here’s how you determine your starting weight for any exercise in any routine. The starting weight is defined as:

The maximum weight that causes “failure” at the high number of reps in the first set.

For example, with the incline press, you should be doing 4 sets at 10-12 reps, each set going to failure. Your starting weight would be the amount you need to take the twelfth rep to failure - in the first set. Not the thirteenth. Not the eleventh.

When To add WeIghT — not a Moment Too soon

Keep in mind, the aim of exercise is continual progress. Day after day. Year after year. That means you have to continually force your body to adapt to increasing weights. But when is the best time to increase the weights you’re using?

rule: add more weight when you can perform more than the high number of reps in the first set — in perfect form and tempo.

For example, with the incline press, if you can eke out a thirteenth rep in the first set with the weight you’re using, add more weight. Enough weight to take the twelfth rep to failure. You may be asking, “what happens if I can’t make the minimum number of reps in the final set?” Don’t worry, it doesn’t matter. Any increase in weight is dictated by the high rep count in the first set. Your sets you go something like this:

first set failure at rep #12 �

second set failure at rep #10 or #11 �

Third set failure at rep #9 or #10 �

fourth set failure at rep #8 �


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TraInIng vs. overTraInIng — less is More

One final word. With training, more does not mean better. In fact, it usually means less (as in less results). Working out 2 hours a day 6 days a week will not give you the body you want. It will most likely have just the opposite effect. Overtraining causes two very detrimental effects. First, it may launch your body into “Override” response. That’s where your body takes control and overrides any muscle-building signal it receives from your workout. If you’ve ever experi-enced that, you know that’s not where you want to be. Second, your muscles grow BETWEEN workouts not during workouts. You have to give your muscles adequate time to recover and grow. And as you now know, HSPs help you recover faster.

So, is there an ideal relationship between length of workout, amount of workouts per week, and the amount of new muscle gained? YES

rule: for optimum gains never train with weights more than 4 days a week or more than 60 minutes per workout (see the exception to this rule on page 75: Resting Intervals).

Listen, we’ve worked with many of the world’s top bodybuilders and other athletes and they’ll all tell you the same thing: “keep it short, keep it INTENSE!”

varIeTy - Keeping Your BoDY “off-guarD”

Every change you make to your workouts - no matter how small - will catch your body “off-guard” and force it to “re-adapt” so you keep your gains moving forward. In addition, changes keep your workouts fresh and prevent a sense of staleness. Here are some changes you should employ:

IMporTanT: When you make one of these changes to your workouts, make sure you stick with it for at least 4 weeks.

1. Change the amount of weight you use (see When to Add Weight, page 77).

2. Change the order of your sets. Although it might seem insignificant to you, your body will perceive it as meaningful.

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3. Change your resting periods. Reduce the time 30 or even 60 seconds. For example, in the hypertrophy phase go from the normal 90 seconds down to 60 or 30 seconds. But never add more time to the recommended resting times I’ve given you (see Resting Intervals, page 75).

4. Change the tempo of your lifts. During the concentric and eccentric portions, add one full second to either or both.

WarM ups — your 5-Minute Insurance policy

You want to perform all your workouts in peak condition. So you just can’t dive into free weights. You have to allow time to “tune” your instrument. That means warm up exercises. Here’s what you do. Perform a few warm up sets at about 60% of maximum exertion. That means lesser weights. The trick is not to expend too much energy. You’re simply getting blood into your body, loosening up your joints, and preparing your muscles for what’s to come. Keep your warm ups to about 5 - 7 minutes. Keep in mind, these warm up sets do NOT count as actual sets.

suMMary of Mass – TraInIng CyCles — four part harmony

Remember, when training for mass your exercises are directly aimed at increasing hypertrophy, strength, and power. And you’ll remember we talked about training for one “goal” at a time. Here’s an overview of a typical 12 - 14 week mass building cycle.

Cycle I hypertrophy 4 weeks �

Cycle II strength 4 weeks �

Cycle III power 4 weeks �

Cycle Iv rest 1 - 2 weeks �

IMporTanT: During the mass building cycles, if you do not exceed your baseline caloric intake (see Part VII on Nutrition) you should not put on body fat. But remember, if your body fat content is above 21%, you should first be training for Fat Loss. Now, here are the 4 mass-building training cycles:

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When you’ve finished the complete cycle, start all over.

Now when I say rest, I mean active rest. In other words, STAY OUT OF THE GYM! I mean it. You can go out and play basketball, baseball, or just about any other sport - but don’t lift weights.

Remember, if you’re preparing for a competition, start 14 weeks out with the Pre-Contest phase.

IMporTanT: The length of each cycle will probably vary from person to person. For example, if you’re training for hypertrophy, and you’re still making noticeable gains in mass, stay with it. Even if it’s for 8 weeks. Then switch to strength, then to power, when you feel your growth start to slow.

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CyCle I: hyperTrophyTIMe: 4 Weeks

Goal: Accelerate protein synthesis - increase muscle tissue - gain sizeObjective: Take fast-twitch and slow-twitch muscle to failure on every setStarting Weight: Maximum weight that causes “failure” at the high number of reps in the first set

dAy1–legS SetS rePS teMPo

squaTs 4 8-12 3-0-1

leg press 4 8-12 4-1-1

deadlIfTs 3 7-9 3-1-1

lunges 4 10-13 3-0-0

Calf raIses 4 10 4-2-1

dAy2–cHeSt SetS rePS teMPo

InClIne press 4 8-12 4-1-0

duMbbell flaT benCh 4 8-12 3-1-0

duMbbell pullover 4 8-12 3-1-1

duMbbell fly 4 8-12 3-1-2

WeIghTed ab CrunCh 3 10-15 3-1-3

dAy3-oFF

dAy4–BAck SetS rePS teMPo

overhand ChIn 4 Failure 3-1-1

barbell/duMbbell roWs 4 8-12 3-1-0

barbell pullover 4 8-12 3-0-1

shrugs 4 8-12 3-1-1

laT pull doWn 3 12 3-1-1

dAy5–SHoulderS/BIcePS/trIcePS SetS rePS teMPo

shoulders:

sTandIng duMbbell press 4 8-12 3-1-1

duMbbell sIde raIse 4 8-12 3-1-2

bICeps:

sTandIng Curl 4 8-12 3-1-1

reverse Curl 4 8-12 3-1-1

TrICeps:

frenCh Curl 4 8-12 3-1-2

press doWn 4 8-12 3-1-2

dAy6-oFF

dAy7-oFF


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CyCle II: sTrengThTIMe: 4 Weeks

Goal: Increase functional capacity of muscles - boost strengthObjective: Actively engaging more muscle fiber within each muscle groupStarting Weight: Maximum weight that causes “failure” at the high number of reps in the first set


squaTs 4 5-9 3-1-0

leg press 4 5-9 4-1-0

deadlIfTs 3 4-6 3-1-0

lunges 4 7-10 3-1-0








dAy3-oFF





shrugs 4 5-9 3-1-0



shoulders:



bICeps:



TrICeps:


press doWn 4 5-9 3-1-0

dAy6-oFF

dAy7-oFF

Notice that when the number of reps you’re doing decreases, the tempo quickens.

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CyCle III: poWerTIMe: 4 Weeks

Goal: Increase strength by augmenting muscle responsivenessObjective: Take neural system to failureStarting Weight: Maximum weight that causes “failure” at the high number of reps in the first set


squaTs 4 1-5 2-0-0

leg press 4 1-5 2-0-0

deadlIfTs 3 3 2-0-0

lunges 4 3-6 2-0-0








dAy3-oFF





shrugs 4 1-5 2-0-0



shoulders:



bICeps:



TrICeps:


press doWn 4 1-5 2-0-2

dAy6-oFF

dAy7-oFF

You’ll notice here that we’re taking the neural system to failure, not the muscular system. If your neural system doesn’t keep pace, it will eventually become a limiting factor in gaining mass.


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CyCle Iv: reCuperaTIonTIMe: 1 - 4 Weeks

Goal: Get all muscles fully recuperated.Objective: Head into the next 12-week Mass cycle with your muscles in optimumgrowth-ready condition.

If you’ve just spent the last 12 weeks doing high-intensity training, and doing it correctly, you should be totally spent. You’ll probably need some rest. In the NO2® book, we suggested taking NO2 may help reduce the recuperation phase to 7 – 10 days. Because of Tex-OE’s ability to help restore and rebuild, you may need even less time!

IMporTanT: During these “rest” periods, you can cycle off HSP Active. Save your money. Remember, HSPs respond to “stress,” and if you’re not training, I don’t see the need to take HSP Active then.

CardIo durIng Mass buIldIng — yea or nay

I would do little or no cardio in the Mass Building Phase. If you’re concerned about adding fat while you’re training for mass - stop worrying. When you take-in the exact number of calories for your body weight and training routine (see Establishing Your Daily Caloric Intake in Part VII: Principles of Nutrition) you shouldn’t put on any fat at all. If, on the other hand, you want to lose fat while you maintain your muscle mass, see the fat loss training routine below. But first, I’d like to give you some dos and don’ts concerning cardio.

CardIo — do’s and don’ts

Many bodybuilders that call MRI ask about cardio. How much cardio? When to do it? What kind of cardio? That’s probably because there’s more misunderstanding about cardio than just about any other part of training.

role of CardIo

Say cardio to a distance runner and he thinks you’re talking about training for endurance. But to a bodybuilder it means only one thing: training for definition. That means “cuts.” The prob-lem is, they think that more cardio means more definition. Wrong. You see, all properly trained

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muscle is “cut” and toned, it’s just “covered up” with body fat. Because many bodybuilders don’t know the right cardio technique they end up getting rid of their muscle along with the fat - like throwing the baby out with the bathwater. But when you do cardio correctly, you can get all the definition you want and keep your muscle. In fact, most times you won’t even have to change your daily caloric intake.

CardIo TeChnIque

I have found that high-intensity interval training to be the most effective, as well as least time consuming, way to lose fat and preserve muscle. Because this type of cardio gets pretty intense, you should approach it conservatively and increase the time as your fitness level increases. Start at 12 minutes of cardio and increase to a maximum of 20 minutes. Here’s how it works.

Cardio has three components. Warm-up, Intervals, and Cool-down. The “interval” section has two parts: high level and low level. Using a “perceived exertion scale” of 1 to 10 where 1 repre-sents very little exertion and 10 is an “all-out” effort, proceed as follows:

Warm-up 2 minutes Level 5

Intervals 8 minutes

Level 8: 20 seconds (high level)

Level 5: 10 seconds (low level)

Level 8: 20 seconds (high level)

Level 5: 10 seconds (low level)

(REPEAT for 8 total minutes)

Cool-down 2 minutes Level 5

In the example above that’s a total of 12 minutes: 2 minutes for warm up, 8 for intervals, 2 for cool down, (2-8-2). It’s conservative, but it’s exactly where you should start. Then you can gradually increase the “interval” section until you reach 16 minutes (2-16-2) - which is a total of 20 minutes.

rule: never do cardio for more than 20 minutes a day

After you reach 20 minutes of cardio, to increase the intensity elevate the “high level” portion of the interval section. For example, raise level 8 to level 9. To increase the intensity even further, do cardio more often. But like I said, take your time with this type of cardio - don’t push it.

With cardio, as with free weights, variety is very important. When you do different types of


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cardio, your body is forced to make continual adaptations - and you progress faster. Here are my recommendations for cardio.

stair Climber1.

stationary bike2.

stadium stairs3.

Wind sprint4.

Treadmill5.

It’s important to stay with the cardio type you choose for 4 full weeks before switching.

IMporTanT: When doing the treadmill, simply step off the belt to ei-ther side during the “low level” portion of the interval section. That’s it. Don’t skip the cool-down section because it gives the blood a chance to

“move out” of the working muscles and back to the brain. Without this cool-down, blood can “pool” in your lower extremities and make you feel faint, dizzy, and even make you pass out.

IMporTanT: If you’re doing your cardio and free weights in the same workout, you should always do the cardio FOLLOWING your weight training - never before. If however, you do your cardio on a different day, or different time of day than your weights, do the cardio before breakfast, that way you’ll burn up the fatty acids more effectively.

Okay, now that you know how to do cardio, let’s see when, and if, you need it!

TraInIng for faT loss — definition Time

Michelangelo used a chisel. Your tools are exercise, nutrition, supplements, and the skill to use them together correctly. First, you have to know what kind of changes you need to make, if any, to your basic mass-building exercise and nutrition routines.

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hsp aCTIve, CardIo, and CalorIes

Like I said before, all trained muscles are toned and defined, they’re just covered up by fat. So a vital part of fat loss is muscle preservation. That’s why I recommend going in “steps” - starting conservative then getting more aggressive if necessary.

sTep 1

If you’ve started taking HSP Active do nothing! I’m not kidding. Do not cut back on your calo-ries, and do not add cardio - not yet anyway. If after three weeks on HSP Active, however, you want to eliminate more fat, go to step 2.

sTep 2

I have come to realize that with relatively well trained people fat loss can be accomplished through high-intensity interval training alone. Here again, you won’t change your caloric intake or nutrient ratio. Review the section on Cardio a few pages back and progress with the following cardio routine:

add cardio to training day #2. remember, start with the (2-8-2) timing and in- �crease the “intensity” every week. Try this for 4 weeks.

If you need more then... � add an additional day, training day #5, of cardio. keep following the “progressive intensity” schedule I gave you in the cardio section. Continue 4 weeks. If you still need more then...

add cardio to training day #4. If that’s still not enough to do the trick, then... �

add cardio to your off-day (#6). �

Don’t forget, do your cardio AFTER your weight training, not before. For bodybuilders who have trained at least one year, steps 1 and 2 should be enough. But if that hasn’t given you the fat loss necessary to get the “cuts” you want, go to step 3, where you actually start cutting calories (please go to Part VII: Nutrition: Fat Loss Caloric Intake, and look at step 3 in its entirety).

IMporTanT: When you cut back on calories, or add cardio, or both, you MUST continue with your high-intensity weight training. That means taking the last set to failure with full weight load. As you scale back on the calories - especially the carbs - your energy may diminish some-what. If that happens, reduce the number of sets not the load. BE SURE TO MAINTAIN THE AMOUNT OF WEIGHTS YOU USE IF POSSIBLE.

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CauTIon: Catabolic spiral ahead — avoiding the bIg Mistake

A final word about fat loss. The biggest mistake most amateur bodybuilders make is de-training with low weights and high reps, cutting back on carbs, and doing 45 minutes of cardio - or more.

First of all, when your body is not being “loaded” with weights (like when you train with low weights and high reps), and does not have enough fuel (like when you cut back on carbs), your body starts burning muscle for fuel as it tries to make up for the calories it is not getting. Here’s what actually happens.

As you know, your body looks at muscle as a liability because it consumes so many calories to maintain. When you cut back on carbs and increase cardio, your body starts consuming its fast-twitch fibers (the valuable size and strength fibers) as it preserves the slow twitch fibers it needs to do the cardio. And long duration aerobics produces Cortisol, a catabolic agent that breaks down muscle proteins. Worse, as your strength diminishes due to less fast-twitch fibers, the amount of weight you can lift decreases. With less load, your body starts dumping even more muscle as it perceives it as unnecessary. This is known as the dreaded Catabolic Spiral. Just look at marathoners, their bodies have literally eaten itself alive.

There’s only one more training aspect you should be aware of. The first part - and I intentionally put it last. It’s the most abstract. And starts well before you ever lift a weight. Yet it’s with you though every workout. I’ll end the suspense…

MInd over body!

Do you know what the #1 mistake most bodybuilders make? They train “generally” not “specifi-cally.” I remember sitting with one of our top trainers during a private training session. He is the most awesome looking natural bodybuilder I’ve ever seen. You’d swear he juiced. But no. Not even once. He studies bodybuilding the way molecular biologists research molecular interactions. And the guys he trains, are right up with him. In his interviews with prospective athletes (he’s highly selective), he would always ask three questions.

1. “What’s your goal?”

I’d hear comments like “I just want to look better.” Or “I want a killer body.” He would listen, then shoot back, “Do you want to look like a superhero or a mortal man?” Then he’d have the guys verbalize what they really wanted. “Focus on the picture,” he’d repeat. He had them articu-late, in great detail, what every body part would look like.

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2. “How fast do you want to get there?”

Often the answer was something like “I don’t know, a few months.”

3. For his third question, he’d have the guy stand in front of a mirror. He’d look at them and say “do you think that’s a reasonable time frame?”

Sometimes it was. Sometimes it wasn’t. The point he was trying to impress on these guys was this: Pick a goal. Set a reasonable time frame.

He spoke from experience. He was once a scrawny 157 pounds. His goal was to look like he was on steroids – without ever taking them. His time frame: 1 year. Did he achieve his goal? He sure did, six years later!

Anyway, once the “long range” outcome was fixed, he would break it down into a series of “short range” outcomes. And I can tell you first hand, the results these guys would get were simply mind-boggling. Self-discipline, played a big part, of course. But it was the well-thought out plan that yielded success. In fact, he still has a quote hanging in his training room that says, “action without thought is a waste of time, thought without action is intellectual suicide.” Oh yeah, he had one other quote hanging right beside that one. It reads: “Show up and train your ass off.”

A word of advice for experienced lifters. If you’ve hit a plateau, you’ve got two things you can do to get over the hump. First, follow my advice that I gave you above about changing resting inter-vals, tempo of lifts, order of your sets, and time spent in each training phase. But before you do any of that, try this. Start to drill down and focus while you’re in the gym. Remember, training is not a social occasion. Keep talking to a minimum. Move from exercise with resolve.

The bottom line with any training regimen is this: Plan. Then act. With focus. You’ll achieve all your goals!

Now here’s a technique you’ll like.

If you want what I call monstrous gains. Almost unnatural. Then I discovered the truth – a technique devised by, of all people, our head of research! I asked him put it on paper and send it to me because I wanted you to know about it.

Here goes.

sTop CounTIng please

I’ll just reprint what he wrote.

“I stopped counting. Reps that is. I leave counting for Sesame Street. I do reps until I can’t do


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them anymore. On each and every set. Period. I found that intensity is required for HSPs to fully unleash their power. Having a mental goal of 10 reps means I ‘plan’ (mentally) to finish at 10. That’s what I used to do. I could feel myself literally giving up and ‘making’ 10. Then I realized that I could fool my mind with this, but not the HSPs. I imagined HSPs sleeping right through that kind of a workout. Then I stopped counting. I went to “complete collapse” on every set. I had read about HSPs and adaptation to stress and realized it doesn’t matter how many reps I did, but how much stress I put on my muscle. It required that I step up my focus, of course. Here’s the bottom line. I removed those growth-limiting numbers from my head, and started adding muscles to my body. And I started gaining muscle like never before. It’s freaky.”

He later called me and said, if you use that in your book, be sure to mention sweating. Let me quote him again. “When you train this way with HSP Active, you will be sweating like you just stepped out of the sauna, your arms will be shaking, you’ll walk like you’ve had one too many and you’ll be breathing like you just finished a marathon. But you’ll enter the growth zone.”

Well said.

There you have it. The real know-how on training for the results you want. Stick with these tech-niques and you’ll start seeing the results you want and more!

A word for anybody involved in a bodybuilding contest…

sTrICT pre-ConTesT Mode

The principles of training, I’ve given you here, along with the principles of nutrition (see part VII), serve as your “base” training program.

And with new HSPs working for you, you should see spectacular results. But there’s a special training discipline that you’ll use if you’re training for a contest. I’ve laid it all out for you in Part VIII “Strict Pre-Contest Training Mode” (see page 102).

By the way, it doesn’t have to be a competition you’re training for. If there’s a special day you need to look your absolute best for, just follow the same schedule. There you have it. The real know-how on training. Stick with these techniques and you’ll start seeing all the results – and more!

Okay. Now you’re training correctly. HSPs are at full steam. Your muscle-building machinery is cranking full speed ahead. There’s only one part left. Nutrition. So let’s go.

part vII

principles of nutrition

parT vII PRINCIPLES OF NUTRITION

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L et’s look at what we have so far. Your exercise program and HSP Active are working in “synch” to help maximize your results. HSPs have ramped up your body’s “adaptive response” mecha-

nisms. Now it’s time to start feeding the muscle-building machine we’ve put in motion!

Just like with exercise, when it comes to nutrition you can forget about good, better, and best and focus on the right versus the wrong nutrition. There’s no “middle ground” when you’re training for specific outcomes like gaining mass, losing fat, or zeroing in on contest day when every muscle fiber in your body has to be in “peak” condition at just the right moment on stage. Now let’s find out just what the right nutrition is for you.

A word before we begin. My purpose in writing this book was not to author the “Complete, Ev-erything-You-Ever-Wanted-to-Know-About-Nutrition Reference Guide.” There are lots of great books written about sports nutrition out there. You’ve seen them. The over-sized 400-plus page magnum opus filled with every last bit of information about every single nutrient molecule on this planet. They’re fun to flip through and a great help if you’re preparing to go on the Nutrient Quiz Show. But it’s a little too much information for what you’ll need here.

What you will find out, however, is how to give your body the proper fuel, energy, and building blocks it requires to carry out your total body transformation in the fastest way possible!

MaTChIng your nuTrITIon WITh your TraInIng goals

How many times have you asked yourself: “How many calories should I eat everyday?” Or, “what kind of foods are best for me?” Or, “what is the ideal nutrient ratio?” The answer depends on what training phase you’re in, Mass-Building, Fat Loss, or strict Pre-Contest.

esTablIshIng your daIly CalorIC InTake

The main point here is to get a good approximation, then fine tune as you go. I’m gonna give you two ways. One’s the “old school,” the other is the one that MRI established.

The “old sChool”

I say “old.” But what I really mean is prior to MRI’s technologically-advanced supplements. And I always had the impression it was for athletes in general, not hard-training bodybuilders with special requirements. Anyway, here’s how that “old school” method works. First, was to estimate your basal metabolic rate (BMR).

How many calories do you think you’d expend lying on your bed awake for 24 hours in your room with a comfortable temperature? Not that you’d ever want to do this, but that’s how you

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establish your basal metabolic rate. Here’s a quick formula that Dr. Fred Hatfield came up with to estimate your BMR - it’s as good as any I’ve seen.

BMR in calories = (your body weight in kilograms) x (24 hours). To get your body weight in kilograms multiply your weight in pounds by 0.45. For example, if you weigh 200 pounds convert it to kilograms. (200) x (0.45) = 90 kilograms. Then multiply kilograms by 24. (90) x (24) = 2160.

That means lying on your bed awake for 24 hours (I guess with the TV on), it would take 2160 calories to maintain your body weight (assuming you weigh 200 pounds). No gains. No losses. Now, to find your daily caloric intake, you would simply add the number of calories you need to carry out your day’s activity to the BMR. Fred’s got a pretty good system he uses, and it goes something like this.

For “light” expenditure days, multiply your BMR by 1.30 to come up with your “baseline” caloric intake for that day. In the example we’ve been using we’d multiply 2160 by 1.30 and rounding it off, come up with 2800 calories. For “heavy” expenditure days Fred uses a multiplier of 2.30. And then there’s everything in-between. Personally, I think it’s a little too complicated. And it doesn’t take into account the HSP Active factor. Here’s what we do at MRI.

MrI’s baselIne CalorIC InTake

I believe this way is lot easier, and it establishes a baseline caloric intake you can use every day. And it’s a “goal-driven” system. We’ll start with mass-building caloric intake (MBCI).

Mass-buIldIng CalorIC InTake (MbCI)

We start with Baseline Factor of 14.25 and adjust upwards, or downwards, if necessary. This, of course, takes into account the energy requirements necessary to complete the training routines I’ve given you in Part VI.

For example: If you weigh 200 pounds. Take 200 times 14.25. That comes to 2850. It’s that simple. So you start by taking in 2850 calories a day. That’s your MBCI. Stay on this caloric intake for two weeks. If you’re training properly and not gaining, bump up the baseline calories by 10%. Multiply 2850 by 1.10. That comes to 3135, your new MBCI.


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IMporTanT: If you have a high metabolism, try starting at an initial Baseline Factor of 15 times your body weight and adjust up or down by 10%. Conversely, if you have a slow metabolism, start at an initial Base-line Factor of 14.0 and adjust up or down by 10%. keep in mind, make no adjustments to your MBCI until you’ve been on a specific caloric intake for at least 2 full weeks.

faT loss CalorIC InTake

You want to lose fat weight, not muscle weight. So the real goal with fat loss is to maintain your muscle mass while you get rid of the fat. Although it’s impossible to make huge gains in mass and lose significant amounts of body fat at the same time. It’s a delicate balancing act, any changes we make to either exercise or nutrition will be by small steps not by large leaps.

sTep 1:

Here’s your first step in fat loss: do nothing. Don’t change your MBCI. From the example above, that would mean maintaining the 2850 calories a day.

Only after you try step 1 should you go to step 2.

sTep 2:

Remember what I said before: with relatively well-trained people, fat loss can be accomplished through high-intensity interval training alone. Here again, you won’t change your MBCI. Using the example above, you’d keep it at 2850 calories a day. But you would add 20 minutes of high-intensity cardio to your workout on training days #2 and #5 (see Part VI: Exercise: Cardio Technique, page 85). If necessary, add additional cardio to training day #4 and off-day #6. Remember, do your cardio AFTER your weight training not before.

sTep 3:

If steps 1 and 2 have not done the trick - then and only then - initiate step 3. But realize if you lose more than 1 or 2 pounds of body fat a week, you’re likely to put your existing muscle mass in jeopardy. Most bodybuilders can only handle 1 pound a week. So monitor your fat loss closely.

Start by lowering your caloric intake by 100 calories per day for 5 consecutive days. If you start feeling a little tired, take 100 calories off every other day for 10 days. Your goal is to get a total of 500 calories off your MBCI. In our example that would mean going from 2850 - 2750 - 2650

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- 2550 - 2450 - 2350. Your fat loss caloric intake would be 2350. (Note, if 500 calories represents more than 33% of your original MBCI, then your fat loss caloric intake should be limited to 67% of your original MBCI.)

When you reach the goal of “minus 500” calories, switch your nutrient ratio from 50-30-20 (carbs-protein-fat) to 55-35-10 and replace any starchy carbs with high fiber low glycemic index carbs (see carb chart on page 97). You can also try 2 days with no starchy carbs followed by 1 day on.

Now this is very important. Train with weights as normal. That means use the same amount of weight through the same routines. You may get tired because even though we raised the ratio of carbs to 55%, you’re still getting fewer total daily carbs than you did before. But do NOT decrease the “load” (amount of weight you use) when you train. Cut back on the amount of sets if you have to. Remember, your body perceives load when considering whether to maintain muscle mass.

IMporTanT: If you’re interested in the strict pre-contest mode of train-ing, where you pick a “target day” to be in the best shape of your life, flip over to Part VIII).

nuTrIenT raTIos

Optimum gains were made with the 50-30-20 ratio, carbs-protein-fat, with some small adjust-ments made for metabolism. For third and fourth stage fat loss, there are some adjustments to the 50-30-20 as you saw above.

nuTrIenT raTIo CalCulaTor

Here’s the way to convert caloric ratios to grams of food. Say you need 2850 calories. And the nutrient ratio is 50-30-20. You know that 1 gram of carbs = 4 calories, 1 gram of protein = 4 calories, and 1 gram of fat = 9 calories. Here are the calculations:

Carbs (2850) x (0.50) = 1425 calories = 356 grams

protein (2850) x (0.30) = 855 calories = 214 grams

fat (2850) x (0.20) = 570 calories = 63 grams

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Carbs - your energy sourCe and More

Don’t forget, nutrition is all about growth and energy. And carbohydrates are your muscle’s best energy source. They provide the muscle glycogen that powers your workouts. Did you know you can completely deplete the muscle glycogen from both liver and exercised muscle in less than 2 hours! (A situation you want to avoid at all costs.) That’s why it’s so important to get the right amount of carbohydrates in every meal. They’re especially important to your recovery.

In addition, carbs help spare your muscle protein. Although the main role of protein is to build muscle tissue, your body will breakdown existing protein to use as energy if muscle glycogen stores are depleted. But there’s one very important part of the carb equation that you have to get right - the glycemic index.

geTTIng The glyCeMIC Index rIghT — MaxIMuM-energy InpuT

Not all carbohydrates are digested and absorbed at the same rate. The Glycemic Index is the rela-tive measure of the increase in blood sugar after eating 50 grams of carbohydrates. The “stan-dard” for the measure is pure glucose which is given a value of 100.

Now, here’s the rule: Whenever possible, eat low and medium glycemic-index carbs.

IMporTanT: you get one “cheat day” a week, that’s when you can reach for the high glycemic carbs! (See chart below.)!

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SUGARS High Medium Low

esotcurF esoculGSucrose Honey

Cane Syrup Maple Syrup Corn Syrup

VEGETABLES/LEGUMES High Medium Low

White Potato Sweet Potato Cauliflower Peas Carrots Green Peas Asparagus Lentil Beans

snaeB yendiK snaeB gnirtS spinsraPKale Broccoli

Lettuce FRUIT

High Medium Low

Raisin Oranges Apple Banana Grapes Peach

Watermelon Pear Plums Fig Cherries

DAIRY High Medium Low

Yogurt Milk

GRAINSHigh Medium Low

White Rice Whole Grain Bread Barley Cornflakes Spaghetti Wheaties ® Oatmeal

White Bread Brown Rice

proTeIn — building new Muscle, fasTer!

Remember, the purpose of nutrition is to “feed the machine” we’ve put into motion. That ma-chine is you! Carbs supply the energy. But it’s protein that gives your body the building blocks it needs to grow new muscle. Now I realize that is not news. But what is news is the way HSPs

“fold” proteins that are derived from the breaking down of dietary protein into aminos and reas-sembled into intracellular protein strands.


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You see, only when your body gets sufficient energy from the carbs you eat, can it use the dietary protein to build muscle.

What’s the best dietary protein?

CoMpleTe proTeIn

In case you haven’t heard it a million times before, I’ll say it one more time: only complete protein builds muscle. And complete proteins contain all the aminos, including the 8 “essential” aminos that your body can not make by itself.

After choosing only complete proteins, I think variety and taste are what count most. As body-builders, we’re on such a “structured” diet, that if we don’t enjoy the food we eat, we are likely to

“cheat” more than the one day a week we’re entitled to.

Here’s a hint: put every last gram of your daily fat allowance - what’s not already in the food you eat - into great-tasting sauces! That way you’ll avoid the weekend “pleasure mode” binges, and won’t be tempted to try to “undo” what you’ve done by going on one of those ketogenic-type diets. Here are my choices for dietary protein.

“off-season” proTeIns

By “off-season” I mean when you’re not training for a competition. In other words, all the time except during that 14-week Pre-Contest exercise and nutrition schedule. Even if you don’t com-pete, you might be training to “peak” at a specific and important date - like your wedding day - in which case that would, in essence, be training for a competition!

Beef

Chicken - White meat

Turkey

Eggs

Bottom round trimmed 1 oz. 45 6.2 0.0 2.1 Bottom round untrimmed 1 oz. 64 5.7 0.0 4.4 Flank untrimmed 1 oz. 51 5.6 0.0 3.0 Tenderloin untrimmed 1 oz. 82 5.0 0.0 6.7 Top Sirloin untrimmed 1 oz. 44 6.0 0.0 2.0

�e “Whole” Egg 1 large 75 6.3 0.6 5.0

Dark meat 1 oz. 35 5.7 0.0 1.2 Light meat 1 oz. 33 6.7 0.0 0.4

Breast + skin 1 oz. 49 5.9 0.0 2.6 Breast only 1 oz. 31 6.5 0.0 0.4

FOOD Portion Calories Proteins Carbs Fat

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“on-season” proTeIns

When you’re training for a competition you’re looking for any advantage you can get, even if the only advantage is eliminating a few grams of fat from every meal. Except for your one “cheat” day, I’d use this list as a guideline.

Fish Cod 1 oz. 23 5.0 0.0 0.2

FOOD Portion Calories Proteins Carbs Fat

Tuna (canned in water) 1 oz. 35 7.5 0.0 0.5 Tuna (fresh) 1 oz. 41 6.6 0.0 1.4 Bass (fresh water) 1 oz. 32 5.3 0.0 1.0 Bass 1 oz. 27 5.2 0.0 0.6 Salmon 1 oz. 48 6.0 0.0 2.6

Egg white only 1 large 17 3.5 0.3 0.0 Eggs

a Word abouT faTs

Not all fats are bad for you. Some, in fact, are healthy.Let me give the final word on fat. There are three types of fats, with three completely different molecular structures. You’ve got Saturated, Polyunsaturated, and Monounsaturated.

saTuraTed faTs – no go

These are the harmful fats. They elevate cholesterol in the blood. They also lack the essential fatty acids you need! Here are examples of saturated fats:

butter

Cheese

Chocolate

egg yolks

Meat fat

dairy fat

shortening

palm oil

palm kernel oil

Coconut oil

Except for the “tropical” ones (palm, palm kernel, and coconut) you can easily recognize a satu-rated fat because it is solid at room temperature. In other words, if it keeps it’s shape, it’ll help you lose yours!


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Mono and poly unsaTuraTed faT – go!

Vegetable fats are mostly mono and poly unsaturated. And instead of raising blood cholesterol, they actually lower it. The contain the essential fatty acids (EFAs) such as omega 3s and omega 6s. Where do you find these friendly fats?

polyunsaturated:

fish

Walnuts

almonds

flax

some salad dressings

soybean oil

sunflower oil

safflower oil

Monounsaturated:

avocados

Cashews

peanuts

pecans

natural peanut butter

olive oil

I’m telling you about the good fats, because all too often bodybuilders cut them out completely in an attempt to lean out. But listen to this. EFAs are essential to improving insulin sensitivity, energy production, oxygen transfer, suppressing Cortisol, promoting growth and… burning fat!!!

hsp aCTIve and WaTer

Drink at least 64 ounces - even when you don’t feel thirsty! Because HSPs help accelerate muscle growth (and make you sweat more), your body needs more water to keep the system run-ning in peak condition.

part vIII

strict pre-Contest Training Mode!The grueling 14 weeks that get you into the best shape of your life!

parT vIII STRICT PRE-CONTEST TRAINING MODE!

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I t’s show time! It’s where you pick a specific day you want to be in the best shape of your life. You start 14 weeks out. An you do it!

The Pre-Contest routine has the most intricate interplay of exercise and nutrition. Aside from the more aggressive stages of fat loss, only the pre-contest routine involves substantially altering caloric intake. That’s why I’m including the Pre-Contest section twice, once here, and once in Part VII on Nutrition.

If you’re competing, you want to be as ripped and cut as possible on the day of the competition. That means you have to “wring your muscles out.” One common mistake (a dictate from the old school) was to carb-deplete 3 days before a show. That’s exactly what not to do. That’s when you should ramp up your carb level. The reality is, to be in absolute peak, peak, peak form for a com-petition, you start your preparation 14 weeks out. Except where indicated, keep your 50-30-20 ratio of carbs, protein, fat. It will give you maximum size with maximum cuts.

Here’s an example of a 14-week Pre-Contest routine. Let’s say you have a competition on Satur-day, October 1st. Here are the precise steps to follow:

A word of caution. If the amount of fat you’re trying to lose is equal to 10% or more of your body weight, you should probably wait until the next competition.

IMporTanT: Cardio is vital if you want to get your body fat down to single digits. During Pre-Contest training, begin doing cardio, even if it’s not been part of your workout routine up till now. That means high-inten-sity cardio (see Cardio Technique on page 85).

sTep 1: sWap Carbs TypesSaturday, July 15th

Eliminate all high-glycemic carbs. Eat only low and medium-glycemic carbs. Especially the ones high in fiber.

sTep 2: reduCe CalorIesBegin Saturday, July 15th

At the same time you’re swapping carbs, begin to lower your caloric intake by 100 calories a day. The goal is to reach 67% of your mass-building caloric intake. For example, if you’re eating 2400 calories a day before July 15th, the goal would be to get to 1608. That should take you about 8

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weeks. If you’re dropping more than 2 pounds a week, add back 50 calories a day and continue dropping calories the rate of 50 a day.

Do this until you reach the 1608 mark. When you hit 1608, switch your nutrient ratio from 50-30-20 to 55-35-10 with 2 days off starch completely and one on. Remember, you’re involved in a delicate balancing act between maintaining muscle and stripping off fat so keep your water intake high.

IMporTanT: Continue to train at maximum intensity. That means tak-ing every set to failure. You’ll end up doing fewer sets because of the reduced caloric intake, but you MUST keep your muscles under “load” with maximum intensity training so you can keep every ounce of muscle.

By the way, until you reach 14 days out, you get one “cheat day” a week where you can eat any-thing you want.

Continue this 1608 calorie a day/low-medium glycemic carb routine until you reach 7 days before the competition.

sTep 3: Carb depleTe/CuT CardIoBegin Sunday, September 25th

From Sunday morning, September 25th until Wednesday afternoon September 28, ditch the 55-35-10 ratio. About 99% of your 1608 calories should be in the form of lean protein like skinless chicken breasts and non-fatty fish. Keep your fat to almost zero, and limit your carbs to 20 - 50 grams a day. It’s okay to eat lettuce salads. What you’re doing here is wringing out your body. That means depleting all your glycogen and glucose. I know that sounds opposite of what you want. But just wait 24 hours. Because as you’ll see, the next day you’ll carb load. And because your muscles are “starving” for glycogen and glucose, they’ll suck them up harder and faster. And that’s good because it’s the glucose and glycogen that help make your muscles appear big and full. During this time period, your water intake should be high.

Also during Step 3, cut all cardio.

sTep 4: Carb overload/sTop TraInIngBegin Wednesday (afternoon), September 28th

At this point (Wednesday afternoon) bump your calories back up to 87% of your mass building caloric intake. That would mean 87% of 2400, which comes to 2088. For simplicity, I round up

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to 2100. So you’d eat 7 small meals of 300 calories each. Change your nutrient ratio to 80-20-0. That’s 80% carbs, 20% protein, and no fat. Some good choices for carbs are rice, oatmeal and baked potatoes. The rice and oatmeal naturally contain water, so the amount of water you drink should be equal to the water you lose in urination.

In addition, stop all training. Do not go into the gym. Do not lift weights. This is a good time to practice your posing.

sTep 5: CuT proTeInStart Friday (afternoon) September 30th

I know this may be a little controversial, but it works. Beginning Friday afternoon, 90% of your caloric intake should be carbs (low glycemic). Take in very little protein and almost no fat. Drink as little water as possible.

sTep 6: CuT WaTerStart Friday (night) September 30th

By Friday night, your water should be limited to small sips. At this point I wouldn’t force food at all. Eat enough high-fiber, low-glycemic index carbs to stave off hunger. The truth is, the night before a competition, you don’t want a lot of food in your gut anyway.

sTep 7: pre-JudgIng MealStart Saturday (morning) October 1st.

Saturday - have a small cup of coffee and a light carbohydrate meal in the morning like a few pancakes. Keep sipping water. Enter the pre-judging part of the competition.

Now, you’re almost there. After the pre-judging, you could theoretically eat anything you want. But I wouldn’t. Your body is not ready for “regular food” like a hamburger right now. Chances are you could become bloated and gaseous. My advice is to get a muffin or a pastry. Good luck in the show!

Sounds complicated, I know. But it works!Now, I’ve inserted a special section for all you extremely busy guys, who may not have 3 or 4 days a week top devote to training. Just turn the page.

Training for the (very) busy Man!Help Has Arrived!

part Ix

parT Ix TRAINING FOR THE (VERY) BUSY MAN!

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S ound familiar? “I’d like to workout more. But I’ve only got a day or two every week. I work late most evenings. At business lunches, I tend to over-consume. I travel 10 days out of the

month. But I’d still like to look lean and toned. In fact, that’s why I work out in the first place. Not to look like Arnold Schwarzenegger. I’d still like to get a few ooh’s and aah’s from my wife, or girlfriend. Can you help me?” Yes!

WhaT To do When…you Can only TraIn 1 or 2 days a Week

You’ve set new goals, and you want to hit it hard. But… you can’t. Your job won’t allow it. Your girlfriend or wife rules it out. That’s it. You’ve got one or two days.

Now what?

Here’s a great new workout technique that will give you the same results in half as many work-outs. But be prepared, it’s intense.

The “High-Intensity Full-Body Workout”Also called the “Huff n’ Puff”

Here’s what you do...

for large body parts

Perform 1 exercise per body part Do 4 sets. 10 reps per set

for small body parts

Perform 1 exercise per body part Do 3 sets. 10 reps per set You can – and should - choose a different exercise for each training routine. Be sure change up order every few workouts. Give everybody part a chance to go first.

And you get almost no rest. It should take you no more than about 30 – 45 seconds between sets. Just enough to change the weight and move on. Huff n’ Puff workout. Use enough weight to take the every set – after the first set - to failure.

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Any cardio you do should not exceed 20 minutes. Make it high intensity cardio (see page 85) 20 on 10 off. 80% max or more. Remember: Do Cardio AFTER lifting.

big Muscles

Chest Back Leg Press

small Muscles

Shoulders Biceps Triceps Calves

Cardio

See Page 84

you’re reTunIng To WorkIng ouT afTer TIMe aWay

This applies to beginners too. Do the same “Huff n’ Puff” as above. Continue for the first 8 weeks. But only do 2 sets per exercise. That applies to both large and small muscle groups. Do NOT take sets to failure. Your emphasis should be on perfect form and motor coordination. What you’re doing is reconditioning your muscles, preparing them for the periodization exer-cises that will follow later on. My advice here is, be patient. Stick with this routine for the full 8 weeks. It’ll help prevent injury, and “set up” your muscles for a major period of growth.

you’re TravelIng – no gyM In your hoTel

Go out and get yourself some different bands. They make blue, green, red and have different “load equivalents. Roll ‘em up and put them in your carry on (in case your luggage arrives late.) They take up less room than a tie. And they’re a lot better than doing nothing.

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glossary of TerMsdefInITIons as They apply To TheIr use In ThIs book

Anabolic Pathway – The series of chemical reactions involving the synthesis of amino acids into proteins used for muscle growth and repair.

Androgen Receptor – AR is a receptor inside the cell regulated by a HSP Chaperonin Complex (made up of several HSPs). Once bound to the AR/hormone complex, it becomes ac-tive and can then bind to the DNA.

Cell Proliferation (Hyperplasia) – The increase of the number of cells involving satellite cells, known as hyperplasia.

Cell Signaling – The communication that governs cellular processes and activities.

Chaperone – Term used to describe HSPs involved with protein folding, protein stabilization and protein transport.

Chaperonin Complex – Two or more HSPs working together to perform a specific function.

Cortisol – A hormone that is also called the “stress hormone” is catabolic and can decrease amino acid uptake by muscle, and inhibit protein synthesis.

DNA – Located in the cell nucleus the DNA contains all genetic information of the cell.

Down Regulate/Up Regulate - Increases or decreases the activity of or the ability of (ex: receptor) to respond.

Estradiol – The most potent form of estrogen, estradiol can be formed when Testosterone is converted by the enzyme aromatase to estradiol.

Estrogen – A sex hormone. Excessive estrogen production can lead to gynecomastia (breast growth) in men.

Free Radical – A hippy walking the streets in the 1960s or a highly reactive compound that can have damaging effects on cells. Free radicals can be produced by workouts.

Heat Shock Activator – A compound that triggers the elevation of HSPs through a sup-portive mechanism, most commonly by helping to elevate Heat Shock Factors. This is different than a reactive compound that achieves elevation of HSP levels by inducing a negative action that causes the body to elevate HSPs in response to the potentially damaging effects.

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glossary

Heat Shock Factor – Heat Shock Factors (HSF) are transcription factors that signal the growth of new HSPs when they are triggered by an intense workout. Tex-OE helps “pre-condi-tion” cells by elevating HSF so as soon as your workout begins, the HSF can elevate HSPs in as little as 6 minutes. Without Tex-OE, the body has to first create more HSF, then it can create more HSPs taking up to 2 hours or more.

Heat Shock Protein – Heat Shock Proteins (HSPs) facilitate the synthesis and folding of proteins throughout every cell. In addition, heat shock proteins have been shown to participate in protein assembly, protein stabilization, protein transport, damaged protein removal and dis-posal, cell growth regulation and the regulation of transcription factors.

Hormone – A chemical that is released by the body that acts as a chemical messenger deliver-ing a signal to another part of the body.

Hyperplasia (see “Cell Proliferation”)

Hypertrophy – The increase in the size of individual muscle cells.

Insulin – A hormone that allows amino acids to enter the muscle cell, which is necessary for HSP protein synthesis.

mRNA – Messenger RNA carries the instructions from the DNA to the ribosome.

Nascent Protein - A newly formed muscle protein produced by the ribosome, before it has been folded into a specific “perfect protein”.

Negative Feedback Loop - An example of down regulation in which actions of one chemical causes the opposite action to occur through a series of chemical reactions, which can lead to homeostasis. This is a mechanism of balancing for the body, like excessive stimulation leading to a response that causes the body to shut down or “crash”.

Oxidative Stress – This occurs when Reactive Oxygen Species (ROS) accumulates faster than the body can detoxify itself, which is often the case with intense exercise.

Perfect Protein – A protein that has been properly folded and is active and functional.

Protein Folding - A function of HSPs that form a protein into a very specific configuration which gives the protein its specific identity and makes it usable and active.

Ribosome – The ribosome pieces together the amino acids to form a protein under the in-structions of the mRNA.

glossary

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Satellite Cell – Cells found between muscle fibers which can fuse to existing cells or form completely new muscle cells (hyperplasia).

Standardized Extract – An extraction of a raw material (ex: herb) that has been treated so that a consistent percentage of a particular active compound(s) is present. An example: WAR contains an extract of schisandra fruit that has been standardized so that every gram contains >/= 10% schisandrins.

Steroid – A hormone such as Testosterone, estrogen and cortisol, that can be endogenous (naturally occurring in the body) or exogenous (synthetic compound introduced into the body).

Testosterone – A steroid hormone that initiates the anabolic process and is responsible for “giv-ing the orders” to build muscle to the DNA. Upon entering the cell, testosterone is received by the Androgen Receptor (AR) which is activated and regulated by an HSP Chaperonin Complex.

Tex-OE® – Tex-OE is a patented opuntia cactus fruit skin extract that rapidly accelerates the synthesis of HSPs.

Transcription – The “writing of instructions” from the DNA onto messenger (mRNA).

Translation - A ribosome translates the instruction from the mRNA into a specific protein.

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[1] Ritossa FA. A new puffing pattern induced by temperature shock and DNP in Drosophila. Experientia 1962;18:571-573.

[2] Tissières A, Mitchell HK, Tracy UM. Protein synthesis in salivary glands of Drosophila melanogaster: relation to chromosome puffs. J Mol Biol. 1974 Apr 15;84(3):389-98.

[3] Meyer RA. Aerobic performance and the function of myoglobin in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2004 Dec;287(6):R1304-5.

[4] Hoffman EP, Nader GA. Balancing muscle hypertrophy and atrophy. Nat Med. 2004 Jun;10(6):584-5.

[5] Wadekar SA, Li D, Sánchez ER. Agonist-activated glucocorticoid receptor inhibits binding of heat shock factor 1 to the heat shock protein 70 promoter in vivo. Mol Endocrinol. 2004 Mar;18(3):500-8.

the final step in anabolism… where new muscle is bornthe final step in anabolism… where new...

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