Why are Zinc Oxide Sunscreens the best?

cyberdermthe  sunscreen  company

Thursday, February 23, 2012

DERMATOLOGIC FIRST PRINCIPLES

• Topical agents should act locally and not achieve tissue or blood levels by absorption

• Ideal topical therapy should have zero risk for photo-allergy or photo-contact dermatitis

cyberdermthe  sunscreen  company

Thursday, February 23, 2012

THE MEDICAL BASIS FOR A SAFE AND EFFECTIVE SUNSCREEN

• Safety

• Exclude all active ingredients that are absorbed, i.e. those with a molecular weight < 500 Daltons

• Efficacy

• Provide broad spectrum UVA and UVB protection with the minimum number of active ingredients

• All ingredients should be photo-stablecyberdermthe  sunscreen  company

Thursday, February 23, 2012

EXCLUSION FACTOR #1: ABSORPTION

cyberdermthe  sunscreen  company

0

175

350

525

700

Oxybenzone Octisalate Avobenzone Octinoxate Mexoryl XLMexoryl SX Tinosorb S Tinsorb M

Molecular Weight (Daltons) of Commercially Available Active Ingredients

Min. Molecular Weight of 500 Daltons

Thursday, February 23, 2012

EXCLUSION FACTOR #2: PHOTO-ALLERGIC/ALLERGIC

Photo-Allergic

• Oxybenzone

• PABA

• Avobenzone (Parsol)

• Homosalate

• Octinoxate (Non-Encapsulated)

• Octisalate

cyberdermthe  sunscreen  company

In descending order of frequencyLevel of risk less than 1%

Allergic• Oxybenzone• Octyl PABA• Octinoxate (Non-Encapsulated)• Avobenzone• Octisalate

Thursday, February 23, 2012

ACTIVE INGREDIENTS THAT MEET THE SAFETY CRITERIA

• Zinc Oxide and Titanium Dioxide

• Tinosorb S and Tinosorb M

• Proprietary to Johnson and Johnson, limited availability,

• Requires adjunctive agents that do not meet the criteria

• Mexoryl SX and Mexoryl XL

• Proprietary to L’Oreal, limited availability,

• Requires adjunctive agents that do not meet the criteria

cyberdermthe  sunscreen  company

Thursday, February 23, 2012

EFFICACY: BROAD SPECTRUM PROTECTION*

•

Sample Sunscreen with 18% Zinc Oxide, SPF 30 Sample Sunscreen with 3% Avobenzone, 6%

Oxybenzone, 15% Homosalate, 5% Octisalate, 10% Octocrylene, SPF 100

Sample Sunscreen with 2% Avobenzone, 3% Mexoryl SX, 10% Octocrylene, TiO2 5%, SPF 45

cyberdermthe  sunscreen  company

*Source: Environmental Working Group Skin Deep Database

Thursday, February 23, 2012

CYBERDERM SUNSCREENS:COMING SUMMER 2012

Every Morning Sun Whip SPF 25

• 15 % Zinc Oxide

• 7.5% Encapsulated Octinoxate

cyberdermthe  sunscreen  company

Simply Zinc Sun Whip SPF 30

• 22% Zinc Oxide

Thursday, February 23, 2012