TBLI and HIV

30% of People infected with

HIV/AIDS and have latent TB

will eventually get active TB

(5 -10% /year).In HIV negative

5-10 % during their life.

It is known that treatment of

latent TB infection(LTBI) or

TB preventive therapy, helps

to prevent progression to

active disease

Isoniazid prevention therapy

(IPT ) 6-12 months

PREVALENCE OF ACTIVE

TB IN PEOPLE WITH HIV

WHO HAVE LATENT TB AND

TREATED WITH INH FOR 6

MONTHS FROM 2004 -2011S .mansuri M.HajiabdolbaghiM.Hasibi

Inclusion criteria

HIV positive who have been treated with INH

for 6 months and fallowed up for 1 year after

Exclusion criteria

Sputum AFB positive during INH prophylaxis

CxR or CT compatible with TB

Pathology compatible with TB

LTBI prophylaxis with other drug except INH

Results

Table - 1 TST result

Numbers Percent TST56.64 639 38.5 Positive

43.35 489 29.12 Negative

100 1138 67.18 TST was done

551 32.81 TST was not done

1679 100 Sum

In this study TST was

done in67.2% of all

HIV patients in our

center .

This rate in other

studies was between 50

%- 79%

TST number

Positive number

Percent

1128 (M.haji)

639 56.6

NA (mohraz)

NA 25%

NA(alavi) NA 54.5

NA (Alaee) NA 88%

NA(Shokoohi)

NA 39.4

In other studies

prevalence of TBLI in

HIV positive from

25% to 46% is reported.

TST Prophylaxis

 number percent

404 63.22 INH prophylaxis

229 35.83 No INH

prophylaxis6 .93 PZA ,RIF

prophylaxis

639 100 Sum 

In other studies( WHO .USA.

Brasilia) 25% ,46% 59.8%

HIV positive patient with

LTB have received IPT

Mean follow up period was 3.5

(1.5± 3.5 )

  PPD+  

PPD-  INH≥6m INH- INH<6m

Cases Number

230 229 80 489

TB cases6 53 18 22

TB% 2.6 23.1

4

22.5 4/49

TB cases in PPD+ and PPD-

Variable

Age 57/ 8± 39.75)

Sex M 264 (85%) F46 (15%)

CD4 10 -1124

ART yes 218(70/3%)

No 92 (29/7%)

76% of our cases had compliance to prophylaxis

Mean period of time

between IPT to

treatment of TB in 6 TB

cases was 24.7 months

1672PPD

-No

PPD

PPD+

489

632

551

22

INH+

397

INH-235

94

80

18

653

1 37

303

230

229Z+R6

134 TB cases

PPD - 22 16.41

No PPD 37 27.61

No IPT 53 39.55

PPD+

INH <6 mo

18 13.

Complete IPT

6 2.6

TB before HIV diagnosis

22 16.46

TB after HIV diagnosis

74 55.22

TB ,HIV same time 38 28,35

ART before TB diagnosis

29 21.64

ART after TB diagnosis

105 87.35

134 TB cases

TB after ARV

<3m 3-6m 6-12m 12-24m >24m

44.82%

6.90% 10.30%17.20%20.60%