synthesis and hybridization property of novel 2′,5′-isodna mimic chiral peptide nucleic acids

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2003 Peptides Peptides U 0400 Synthesis and Hybridization Property of Novel 2',5'-isoDNA Mimic Chiral Pep- tide Nucleic Acids. — The synthesis of the title compounds (VI) from D- and L-aspar- tic acid and their incorporation in aminoethyleneglycine peptide nucleic acid thymine dodecamers are described. — (ABDEL-AZIZ, M.; YAMASAKI*, T.; OTSUKA, M.; Bioorg. Med. Chem. Lett. 13 (2003) 6, 1041-1043; Fac. Pharm. Sci., Kumamoto Univ., Oehon, Kumamoto 862, Japan; Eng.) — D. Singer 29- 151

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Page 1: Synthesis and Hybridization Property of Novel 2′,5′-isoDNA Mimic Chiral Peptide Nucleic Acids

2003 Peptides

PeptidesU 0400 Synthesis and Hybridization Property of Novel 2',5'-isoDNA Mimic Chiral Pep-

tide Nucleic Acids. — The synthesis of the title compounds (VI) from D- and L-aspar-tic acid and their incorporation in aminoethyleneglycine peptide nucleic acid thymine dodecamers are described. — (ABDEL-AZIZ, M.; YAMASAKI*, T.; OTSUKA, M.; Bioorg. Med. Chem. Lett. 13 (2003) 6, 1041-1043; Fac. Pharm. Sci., Kumamoto Univ., Oehon, Kumamoto 862, Japan; Eng.) — D. Singer

29- 151