suppl. fig. 1 ab hpde panc1 suit028 suit007capani patu 8988t monomac 6 tgf actin
TRANSCRIPT
Suppl. Fig. 1
A B
HP
DE
PA
NC
1
Su
it02
8
Su
it00
7
Ca
pa
nI
Pa
Tu
89
88
t
Mo
no
Ma
c 6
TGF
Actin
A
Suppl. Fig. 2
empt
y ve
ctor
CU
X1
CUX1
β-Actin
ED
CUX1
β-Actin
un
tre
ate
d
Ctr
l siR
NA
CU
X1
siR
NA
#1
CU
X1
siR
NA
#2
CU
X1
siR
NA
#3
B CCXCL10 CCL5
NFkB p65
0 2 4 24 0 2 4 24 LV CUX1
CUX1
STAT1
β-Actin
STAT3
STAT6
NFkB p50
Phospho Stat3 (Ser727)
phosphoNFkBp65 (Ser536)
A
Suppl. Fig. 3
TNF (incubation time in hours)
β-Actin
STAT1
STAT3
STAT6
LV-
LV+
CUX-
CUX+ LV-
LV+
CUX-
CUX+
Nucleus Cytoplasma
CUX1
MEK1
ORC2
B
Suppl. Fig. 3
Suppl. Fig. 4
human
mouse -200 ACCTCACTCGTTAAAAATTAAAAGGAGCACAAGAGGGG-AGAGGGAAATTCC--AAGTTCATGGGTCACAATAAACACAAGCAATGCCCTCG-GTTT---ACAGGGGACTTCCCTCGGGT
-212 ACCTAATTCACTATTACCAAAAA--------------AAGAGGAGCAGAGGGAAATTCCGTAACTTGGAGGCT-ACAATAAATA------ATACCTTCGAGTCTGCAACATGGGACTTCCCCAGGA----
human
mouse -------T-GC--GGAGCCTT-GCTGAGTCATCTCCAAAGTC---AGCCAATCAGGACTCAGGGAGGGAAACT--CTTTGCAGATAAATA---CTC -10
ACAGCCAGCAGGTTTTGCTAAGTCAACTGTAATGCCCTTATCCAATCAGAATT-AGGGAGGGAAAATGGCTTTGCAGATAAATATGGCAC -18
CXCL10 CXCL10-1 for CXCL10-1 rev
CXCL10-2 for CXCL10-2 rev
Oligo-1
Oligo-2
Oligo-2
Green: putative CUX1 binding siteRed: putative NF-kB binding sitesSolid lines: qPCR primer for ChIPDashed lines: Oligonucleotides for DNA-pulldown
Suppl. Fig. 5
A
*
B C
merge
DAPI
Granzyme B
CD8