stanley m. crain, ph.d. - - pondera®...

CURRICULUM VITAE

Stanley M. Crain, Ph.D. HOME 2472 Pinehurst Court State College, PA 16803 814-867-8609 [email protected] BUSINESS Professor of Neuroscience, Emeritus Albert Einstein College of Medicine Bronx, NY (1974-present) Chief Scientific Officer, Pondera Pharmaceuticals, Inc. Pownal, Maine (2009-present) EDUCATION College Bachelor of Arts

City College of New York New York, NY 1940-1943

Graduate School Ph.D. Biophysics Columbia University New York, NY 1950-1954 FACULTY/RESEARCH POSITIONS

Research Associate: Columbia University, 1954-1957 Section Head: Abbot Laboratory, Chicago, 1957-1961 Assistant Professor: Columbia University, 1961-1965 Associate Professor: Columbia University, 1965-1969 Professor of Neuroscience, Albert Einstein College of Medicine, 1969-present OTHER PROFESSIONAL POSITIONS J. Neurobiology—Associate Editor, 1971-1986 Developmental Neuroscience – Editorial Board, 1977-1986 Developmental Brain Research—Editorial Board, 1980-94 Dysautonomia Foundation—Medical Advisory, 1974-1989 Opioid Antagonist Project – Director, 1987-present National Institute For Drug Abuse – Conferences, 1995 Pain Therapeutics, Inc. – Scientific Consultant, 1998-2006 Open Pain Journal—Editor, 2007-present Pondera Pharmaceuticals, Inc. – Chief Scientific Officer, 2009-present HONORS Grass Fellowship, Marine Biological Lab., Woods Hole 1957 Research Career Development, NINDB, 1961-1965 Kennedy Foundation Scholar Award, 1995-1975

mailto:[email protected]

Stanley Crain Patents:

Exclusively Licensed to Pondera Pharmaceuticals, Inc.

by Albert Einstein College of Medicine

(WO 2008/060381) Method for treating pain or opioid dependence using a specific type of

non-opioid agent in combination with a selective excitatory-opioid-

receptor inactivator (Filed in the US 4/27/09).

(W02002/076388) Methods for increasing analgesic potency and attenuating adverse

excitatory effects of bimodally-acting opioid agonists by inhibiting gm1-

ganglioside (Granted EU, pending US)

6,765,010 Compositions and methods for enhancing analgesic potency of tramadol and

attenuating its adverse side effects (US Only)

7,026,329 Method of simultaneously enhancing analgesic potency and attenuating

dependence liability caused by morphine and other bimodally-acting opioid

agonists

6,194,382 Method and composition for treating irritable bowel syndrome using low doses of

opioid receptor antagonists



agonists

RE36,547 Method of simultaneously enhancing analgesic potency and attenuating

dependence liability caused by exogenous and endogenous opioid agonists



agonists

5,624,932 Method for identification of low/non-addictive opioid analgesics and the use of

said analgesics for treatment of opioid addiction

5,585,348 Use of excitatory opioid receptor antagonists to prevent growth factor-induced

hyperalgesia



agonists


dependence liability caused by exogenous and endogenous opiod agonists


dependence liability caused by morphine and other opioid agonists

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Stanley M. Crain, PhD.

Publications List

1: Low doses of cyclic AMP-phosphodiesterase inhibitors rapidly evoke opioid receptor-

mediated thermal hyperalgesia in naïve mice which is converted to prominent analgesia by

cotreatment with ultra-low-dose naltrexone.

Crain SM, Shen KF.

Brain Res. 2008 Sep 22;1231:16-24. Epub 2008 Jul 12.

PMID: 18656459 [PubMed - indexed for MEDLINE]

Related Articles

2: Naloxone rapidly evokes endogenous kappa opioid receptor-mediated hyperalgesia in naïve

mice pretreated briefly with GM1 ganglioside or in chronic morphine-dependent mice.

Crain SM, Shen KF.

Brain Res. 2007 Sep 5;1167:31-41. Epub 2007 Jul 14.


Related Articles

3: Neuraminidase inhibitor, oseltamivir blocks GM1 ganglioside-regulated excitatory opioid

receptor-mediated hyperalgesia, enhances opioid analgesia and attenuates tolerance in mice.

Crain SM, Shen KF.

Brain Res. 2004 Jan 9;995(2):260-6.


Related Articles

4: Cholera toxin-B subunit blocks excitatory opioid receptor-mediated hyperalgesic effects in

mice, thereby unmasking potent opioid analgesia and attenuating opioid

tolerance/dependence.

Shen KF, Crain SM.

Brain Res. 2001 Nov 16;919(1):20-30.


Related Articles

5: Acute thermal hyperalgesia elicited by low-dose morphine in normal mice is blocked by

ultra-low-dose naltrexone, unmasking potent opioid analgesia.

Crain SM, Shen KF.

Brain Res. 2001 Jan 5;888(1):75-82.


Related Articles

6: Enhanced analgesic potency and reduced tolerance of morphine in 129/SvEv mice: evidence

for a deficiency in GM1 ganglioside-regulated excitatory opioid receptor functions.

Crain SM, Shen K.

Brain Res. 2000 Feb 21;856(1-2):227-35.


Related Articles

7: Antagonists of excitatory opioid receptor functions enhance morphine's analgesic potency

and attenuate opioid tolerance/dependence liability.

http://www.ncbi.nlm.nih.gov/pubmed/18656459?ordinalpos=1&itool=Email.EmailReport.Pubmed_ReportSelector.Pubmed_RVDocSum



http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=link&linkname=pubmed_pubmed&uid=18656459&ordinalpos=1:



















Crain SM, Shen KF.

Pain. 2000 Feb;84(2-3):121-31. Review.


Related Articles

8: Development of specific synaptic network functions in organotypic central nervous system

(CNS) cultures: implications for transplantation of CNS neural cells in vivo.

Crain SM.

Methods. 1998 Nov;16(3):228-38. Review.


Related Articles

9: Modulation of opioid analgesia, tolerance and dependence by Gs-coupled, GM1 ganglioside-

regulated opioid receptor functions.

Crain SM, Shen KF.

Trends Pharmacol Sci. 1998 Sep;19(9):358-65.


Related Articles

10: GM1 ganglioside-induced modulation of opioid receptor-mediated functions.

Crain SM, Shen KF.

Ann N Y Acad Sci. 1998 Jun 19;845:106-25. Review.


Related Articles

11: Ultra-low doses of naltrexone or etorphine increase morphine's antinociceptive potency and

attenuate tolerance/dependence in mice.

Shen KF, Crain SM.

Brain Res. 1997 May 23;757(2):176-90.


Related Articles

12: Barium elicits reversal of low-concentration etorphine-induced decrease of potassium

conductance in cultures of dissociated dorsal root ganglion neurons.

Fan S, Crain SM.

Brain Res. 1997 Apr 18;754(1-2):303-6.


Related Articles

13: Etorphine elicits anomalous excitatory opioid effects on sensory neurons treated with GM1

ganglioside or pertussis toxin in contrast to its potent inhibitory effects on naive or chronic

morphine-treated cells.

Crain SM, Shen KF.

Brain Res. 1996 Nov 25;741(1-2):275-83.


Related Articles

14: Modulatory effects of Gs-coupled excitatory opioid receptor functions on opioid analgesia,

tolerance, and dependence.

Crain SM, Shen KF.

Neurochem Res. 1996 Nov;21(11):1347-51. Review.


Related Articles

15: Biphalin, an enkephalin analog with unexpectedly high antinociceptive potency and low
























dependence liability in vivo, selectively antagonizes excitatory opioid receptor functions of

sensory neurons in culture.

Shen KF, Crain SM.

Brain Res. 1995 Dec 1;701(1-2):158-66.


Related Articles

16: Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine

on sensory neurons, thereby increasing its antinociceptive potency and attenuating

tolerance/dependence during chronic cotreatment.

Crain SM, Shen KF.

Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10540-4.


Related Articles Free article in PMC

17: Chronic opioid treatment of neuroblastoma x dorsal root ganglion neuron hybrid F11 cells

results in elevated GM1 ganglioside and cyclic adenosine monophosphate levels and onset

of naloxone-evoked decreases in membrane K+ currents.

Wu G, Fan SF, Lu ZH, Ledeen RW, Crain SM.

J Neurosci Res. 1995 Nov 1;42(4):493-503.


Related Articles

18: Dual regulation by mu, delta and kappa opioid receptor agonists of K+ conductance of DRG

neurons and neuroblastoma X DRG neuron hybrid F11 cells.

Fan SF, Crain SM.

Brain Res. 1995 Oct 23;696(1-2):97-105.


Related Articles

19: Chronic morphine-treated sensory ganglion neurons remain supersensitive to the excitatory

effects of naloxone for months after return to normal culture medium: an in vitro model of

'protracted opioid dependence'.

Crain SM, Shen KF.

Brain Res. 1995 Oct 2;694(1-2):103-10.


Related Articles

20: Specific N- or C-terminus modified dynorphin and beta-endorphin peptides can selectively

block excitatory opioid receptor functions in sensory neurons and unmask potent inhibitory

effects of opioid agonists.

Shen KF, Crain SM.

Brain Res. 1995 Feb 27;673(1):30-8.


Related Articles

21: Etorphine elicits unique inhibitory-agonist and excitatory-antagonist actions at opioid

receptors on sensory neurons: new rationale for improved clinical analgesia and treatment

of opiate addiction.

Crain SM, Shen KF.

NIDA Res Monogr. 1995;147:234-68. Review. No abstract available.


Related Articles






http://www.ncbi.nlm.nih.gov/pubmed/7479836?ordinalpos=16&itool=Email.EmailReport.Pubmed_ReportSelector.Pubmed_RVDocSum&log$=freepmc




















22: Neurotrophic factors in diabetic neuropathy.

Crain SM.

Trends Neurosci. 1995 Jan;18(1):15-6. No abstract available.


Related Articles

23: Nerve growth factor rapidly prolongs the action potential of mature sensory ganglion

neurons in culture, and this effect requires activation of Gs-coupled excitatory kappa-opioid

receptors on these cells.

Shen KF, Crain SM.

J Neurosci. 1994 Sep;14(9):5570-9.


Related Articles Free article at journal site

24: Antagonists at excitatory opioid receptors on sensory neurons in culture increase potency

and specificity of opiate analgesics and attenuate development of tolerance/dependence.

Shen KF, Crain SM.

Brain Res. 1994 Feb 14;636(2):286-97.


Related Articles

25: Inhibition of the antianalgesic action of dynorphin A in mice by cholera toxin.

Arts KS, Fujimoto JM, Crain SM.

Pharmacol Biochem Behav. 1993 Nov;46(3):623-9.


Related Articles

26: Direct coupling of opioid receptors to both stimulatory and inhibitory guanine nucleotide-

binding proteins in F-11 neuroblastoma-sensory neuron hybrid cells.

Cruciani RA, Dvorkin B, Morris SA, Crain SM, Makman MH.

Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):3019-23.



27: mu and delta opioid agonists at low concentrations decrease voltage-dependent K+ currents

in F11 neuroblastoma x DRG neuron hybrid cells via cholera toxin-sensitive receptors.

Fan SF, Shen KF, Crain SM.

Brain Res. 1993 Mar 12;605(2):214-20.


Related Articles

28: Chronic selective activation of excitatory opioid receptor functions in sensory neurons

results in opioid 'dependence' without tolerance.

Shen KF, Crain SM.

Brain Res. 1992 Nov 27;597(1):74-83.


Related Articles

29: F11 neuroblastoma x DRG neuron hybrid cells express inhibitory mu- and delta-opioid

receptors which increase voltage-dependent K+ currents upon activation.

Fan SF, Shen KF, Scheideler MA, Crain SM.

Brain Res. 1992 Sep 11;590(1-2):329-33.


Related Articles







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30: After chronic opioid exposure sensory neurons become supersensitive to the excitatory

effects of opioid agonists and antagonists as occurs after acute elevation of GM1

ganglioside.

Crain SM, Shen KF.

Brain Res. 1992 Mar 13;575(1):13-24.


Related Articles

31: After GM1 ganglioside treatment of sensory neurons naloxone paradoxically prolongs the

action potential but still antagonizes opioid inhibition.

Crain SM, Shen KF.

J Pharmacol Exp Ther. 1992 Jan;260(1):182-6.


Related Articles

32: Brief treatment of sensory ganglion neurons with GM1 ganglioside enhances the efficacy of

opioid excitatory effects on the action potential.

Shen KF, Crain SM, Ledeen RW.

Brain Res. 1991 Sep 13;559(1):130-8.


Related Articles

33: Opioids at low concentration decrease openings of K+ channels in sensory ganglion

neurons.

Fan SF, Shen KF, Crain SM.

Brain Res. 1991 Aug 30;558(1):166-70.


Related Articles

34: A general role for adaptations in G-proteins and the cyclic AMP system in mediating the

chronic actions of morphine and cocaine on neuronal function.

Terwilliger RZ, Beitner-Johnson D, Sevarino KA, Crain SM, Nestler EJ.

Brain Res. 1991 May 10;548(1-2):100-10.


Related Articles

35: Cholera toxin-B subunit blocks excitatory effects of opioids on sensory neuron action

potentials indicating that GM1 ganglioside may regulate Gs-linked opioid receptor

functions.

Shen KF, Crain SM.

Brain Res. 1990 Oct 29;531(1-2):1-7.


Related Articles

36: Cholera toxin-A subunit blocks opioid excitatory effects on sensory neuron action potentials

indicating mediation by Gs-linked opioid receptors.

Shen KF, Crain SM.

Brain Res. 1990 Aug 20;525(2):225-31.


Related Articles

37: Dynorphin prolongs the action potential of mouse sensory ganglion neurons by decreasing a

potassium conductance whereas another specific kappa opioid does so by increasing a


























calcium conductance.

Shen KF, Crain SM.

Neuropharmacology. 1990 Apr;29(4):343-9.


Related Articles

38: Opioids can evoke direct receptor-mediated excitatory effects on sensory neurons.

Crain SM, Shen KF.

Trends Pharmacol Sci. 1990 Feb;11(2):77-81. Review.


Related Articles

39: Opioids can evoke direct receptor-mediated excitatory as well as inhibitory effects on

sensory neuron action potentials.

Crain SM, Shen KF.



Related Articles

40: Dynorphin prolongs the action potential duration of mouse sensory ganglion neurons by

decreasing a K+ conductance whereas the specific kappa opioid, U-50,488H does so by

increasing a Ca2+ conductance.

Shen KF, Crain SM.

Prog Clin Biol Res. 1990;328:343-6. No abstract available.


Related Articles

41: Dual opioid modulation of the action potential duration of mouse dorsal root ganglion

neurons in culture.

Shen KF, Crain SM.

Brain Res. 1989 Jul 10;491(2):227-42.


Related Articles

42: Embryonic spinal cord neurons develop preferential cholinergic projections to sympathetic

ganglia explanted from appropriate levels of the neuraxis.

Chalazonitis A, Crain SM, Kessler JA.

Brain Res. 1989 Apr 17;485(1):115-24.


Related Articles

43: Inhibitor of cyclic AMP-dependent protein kinase blocks opioid-induced prolongation of

the action potential of mouse sensory ganglion neurons in dissociated cell cultures.

Chen GG, Chalazonitis A, Shen KF, Crain SM.

Brain Res. 1988 Oct 18;462(2):372-7.


Related Articles

44: Preferential cholinergic projections by embryonic spinal cord neurons within cocultured

mouse superior cervical ganglia.

Chalazonitis A, Crain SM, Kessler JA.

Brain Res. 1988 Aug 23;458(2):231-48.


Related Articles























45: Opioids excite rather than inhibit sensory neurons after chronic opioid exposure of spinal

cord-ganglion cultures.

Crain SM, Shen KF, Chalazonitis A.

Brain Res. 1988 Jul 5;455(1):99-109.


Related Articles

46: Modulation of adenylate cyclase activity of mouse spinal cord-ganglion explants by

opioids, serotonin and pertussis toxin.

Makman MH, Dvorkin B, Crain SM.

Brain Res. 1988 Apr 5;445(2):303-13.


Related Articles

47: Electrophysiologic responses and adenylate cyclase activities of mouse spinal cord-dorsal

root ganglion explants rendered tolerant by chronic exposure to morphine or pertussis toxin.

Crain SM, Makman MH.

Adv Exp Med Biol. 1987;221:331-44. No abstract available.


Related Articles

48: CNS tissue culture analyses of trophic mechanisms in brain transplantation.

Crain SM.

Ann N Y Acad Sci. 1987;495:103-7. No abstract available.


Related Articles

49: Pertussis toxin blocks depressant effects of opioid, monoaminergic and muscarinic agonists

on dorsal-horn network responses in spinal cord-ganglion cultures.

Crain SM, Crain B, Makman MH.

Brain Res. 1987 Jan 1;400(1):185-90.


Related Articles

50: Nerve growth factor regulates the action potential duration of mature sensory neurons.

Chalazonitis A, Peterson ER, Crain SM.

Proc Natl Acad Sci U S A. 1987 Jan;84(1):289-93.



51: Duchenne dystrophic muscle develops lesions in long-term coculture with mouse spinal

cord.

Peterson ER, Masurovsky EB, Spiro AJ, Crain SM.

Muscle Nerve. 1986 Nov-Dec;9(9):787-808.


Related Articles

52: Sustained hyperexcitability elicited by repetitive electric stimulation of organotypic

hippocampal explants.

Fowler J, Bornstein MB, Crain SM.

Brain Res. 1986 Jul 23;378(2):398-404.


Related Articles
























53: Chemical neurotoxicity: detection and analysis in organotypic cultures of sensory and motor

systems.

Spencer PS, Crain SM, Bornstein MB, Peterson ER, Van de Water T.

Food Chem Toxicol. 1986 Jun-Jul;24(6-7):539-44. Review.


Related Articles

54: Cyclic AMP or forskolin rapidly attenuates the depressant effects of opioids on sensory-

evoked dorsal-horn responses in mouse spinal cord-ganglion explants.

Crain SM, Crain B, Peterson ER.

Brain Res. 1986 Apr 2;370(1):61-72.


Related Articles

55: Maturation of opioid sensitivity of fetal mouse dorsal root ganglion neuron perikarya in

organotypic cultures: regulation by spinal cord.

Chalazonitis A, Crain SM.

Neuroscience. 1986 Apr;17(4):1181-98.


Related Articles

56: Dendritic patterns of granule cells in organotypic explants of fetal and neonatal mouse

hippocampal formation.

Fowler J, Crain SM.

Brain Res. 1986 Mar 12;368(1):148-53.


Related Articles

57: Antagonist-induced opiate receptor upregulation in cultures of fetal mouse spinal cord-

ganglion explants.

Tempel A, Crain SM, Peterson ER, Simon EJ, Zukin RS.

Brain Res. 1986 Mar;390(2):287-91.


Related Articles

58: Pertussis toxin treatment results in tolerance to the depressant effects of opioid,

monoaminergic, and muscarinic agonists on dorsal-horn network responses in mouse spinal

cord-ganglion cultures.

Crain SM, Crain B, Makman MH.

NIDA Res Monogr. 1986;75:137-40.


Related Articles

59: Taxol effects on glia in organotypic mouse spinal cord-DRG cultures.

Masurovsky EB, Peterson ER, Crain SM, Horwitz SB.

Cell Biol Int Rep. 1985 Jun;9(6):539-46.


Related Articles

60: Systemic pseudallescheriasis in a patient with acute myelocytic leukemia.

Smith AG, Crain SM, Dejongh C, Thomas GM, Vigorito RD.

Mycopathologia. 1985 May;90(2):85-9.


Related Articles
























61: Projections of growth-cone-bearing fibers of retinal ganglion cells within co-cultured tectal

explants: early branching depends on age of target tissue.

Friedlander DR, Crain SM.

Brain Res. 1985 Feb;350(1-2):231-40.


Related Articles

62: The possible role of "sibling neurite bias" in the coordination of neurite extension,

branching, and survival.

Smalheiser NR, Crain SM.

J Neurobiol. 1984 Nov;15(6):517-29. Review.


Related Articles

63: Phase II trial of bisantrene in advanced epidermoid carcinoma of the head and neck.

Forastiere AA, Crain SM, Garbino C, Tipping SJ, Perry DJ, Kasdorf H, Van Echo DA.

Cancer Treat Rep. 1984 Apr;68(4):687-8. No abstract available.


Related Articles

64: Radiosensitivity and differentiation of ganglion cells within fetal mouse retinal explants in

vitro.


Brain Res. 1984 Mar;315(1):159-63.


Related Articles

65: Development of Met-enkephalin immunoreactivity in organotypic explants of fetal mouse

spinal cord and attached dorsal root ganglia.

Chalazonitis A, Groth J, Hiller JM, Simon EJ, Crain SM.

Brain Res. 1984 Feb;314(2):183-9.


Related Articles

66: Laminin as a substrate for retinal axons in vitro.

Smalheiser NR, Crain SM, Reid LM.

Brain Res. 1984 Jan;314(1):136-40.


Related Articles

67: Spinal cord tissue culture models for analyses of opioid analgesia, tolerance and plasticity.

Crain SM.



Related Articles

68: Hyperexcitability in organotypic mouse hippocampal explants.

Fowler J, Crain SM.

Prog Neuropsychopharmacol Biol Psychiatry. 1984;8(4-6):507-14.


Related Articles

69: Morphological alterations in dorsal root ganglion neurons and supporting cells of

organotypic mouse spinal cord-ganglion cultures exposed to taxol.
























Neuroscience. 1983 Oct;10(2):491-509.


Related Articles

70: Phase II trial of mitoguazone in patients with advanced squamous cell carcinoma of the

head and neck.

Perry DJ, Crain SM, Weltz MD, Wilson JP, Davis RK, Woolley PV, Forastiere AA, Taylor HG, Weiss RB.

Cancer Treat Rep. 1983 Jan;67(1):91-2.


Related Articles

71: Phase II trial of aziridinylbenzoquinone (AZQ) in head and neck cancer.

Forastiere AA, Crain SM, Callahan K, Van Echo D, Mattox D, Thant M, Von Hoff DD, Wiernik PH.

Cancer Treat Rep. 1982 Dec;66(12):2097-8. No abstract available.


Related Articles

72: Destructive osteolytic bone lesions in chronic granulocytic leukemia.

Crain SM, Choudhury AM, Molnar Z, Jablokow VR.

IMJ Ill Med J. 1982 Sep;162(3):213-7. No abstract available.


Related Articles

73: Nerve growth factor attenuates neurotoxic effects of taxol on spinal cord-ganglion explants

from fetal mice.

Peterson ER, Crain SM.

Science. 1982 Jul 23;217(4557):377-9.


Related Articles

74: Development of cross-tolerance to 5-hydroxytryptamine in organotypic cultures of mouse

spinal cord-ganglia during chronic exposure to morphine.

Crain SM, Crain B, Peterson ER.

Life Sci. 1982 Jul 19;31(3):241-7.


Related Articles

75: Exposure to 4-aminopyridine prevents depressant effects of opiates on sensory-evoked

dorsal-horn network responses in spinal cord cultures.

Crain SM, Crain B, Peterson ER, Hiller JM, Simon EJ.

Life Sci. 1982 Jul 19;31(3):235-40.


Related Articles

76: Preferential growth of neurites from isolated fetal mouse dorsal root ganglia in relation to

specific regions of co-cultured spinal cord explants.


Brain Res. 1981 Oct;254(3):363-82.


Related Articles

77: Selective innervation of target regions within fetal mouse spinal cord and medulla explants

by isolated dorsal root ganglia in organotypic co-cultures.























Crain SM, Peterson ER.

Brain Res. 1981 Oct;254(3):341-62.


Related Articles

78: Specific neuritic pathways and arborizations formed by fetal mouse dorsal root ganglion

cells within organized spinal cord explants in culture: a peroxidase-labeling study.

Smalheiser NR, Peterson ER, Crain SM.

Brain Res. 1981 Oct;254(3):383-95.


Related Articles

79: Thrombotic thrombocytopenic purpura. A reappraisal.

Crain SM, Choudhury AM.

JAMA. 1981 Sep 11;246(11):1243-6. No abstract available.


Related Articles

80: Microtubule arrays in taxol-treated mouse dorsal root ganglion-spinal cord cultures.


Brain Res. 1981 Aug 3;217(2):392-8.


Related Articles

81: Neurites from mouse retina and dorsal root ganglion explants show specific behavior within

co-cultured tectum or spinal cord.

Smalheiser NR, Peterson ER, Crain SM.

Brain Res. 1981 Mar 16;208(2):499-505.


Related Articles

82: Development of ganglion cells and their axons in organized cultures of fetal mouse retinal

explants.

Smalheiser NR, Crain SM, Bornstein MB.

Brain Res. 1981 Jan 5;204(1):159-78.


Related Articles

83: Presence of leucine-enkephalin in organotypic explants of fetal mouse spinal cord.

Naftchi NE, Abrahams SJ, Crain SM, Peterson ER, Hiller JM, Simon EJ.

Peptides. 1981;2 Suppl 1:57-60.


Related Articles

84: Introducing a core basal series through simplified media.

Crain SM.

Am Ann Deaf. 1980 Sep;125(6):814-6. No abstract available.


Related Articles

85: Failure of nerve growth factor to affect fetal mouse brain stem catecholaminergic neurons in

culture.

Dreyfus CF, Peterson ER, Crain SM.

Brain Res. 1980 Aug 4;194(2):540-7. No abstract available.






















Related Articles

86: Thrombotic thrombocytopenic purpura in a splenectomized patient with Hodgkin's disease.

Crain SM, Choudhury AM.

Am J Med Sci. 1980 Jul-Aug;280(1):35-40.


Related Articles

87: Recent studies on interaction between opioid peptides and their receptors.

Simon EJ, Bonnet KA, Crain SM, Groth J, Hiller JM, Smith JR.

Adv Biochem Psychopharmacol. 1980;22:335-46. Review. No abstract available.


Related Articles

88: Development of specific synaptic networks in organotypic CNS tissue cultures.

Crain SM.

Curr Top Dev Biol. 1980;16:87-115. Review. No abstract available.


Related Articles

89: Dependence on nerve growth factor of early human fetal dorsal root ganglion neurons in

organotypic cultures.

Crain SM, Peterson ER, Leibman M, Schulman H.

Exp Neurol. 1980 Jan;67(1):205-14. No abstract available.


Related Articles

90: Development of tolerance to opiates and opioid peptides in organotypic cultures of mouse

spinal cord.

Crain SM, Crain B, Finnigan T, Simon EJ.

Life Sci. 1979 Nov 19;25(21):1797-802. No abstract available.


Related Articles

91: Innervation of hippocampal explants by central catecholaminergic neurons in co-cultured

fetal mouse brain stem explants.

Dreyfus CF, Gershon MD, Crain SM.

Brain Res. 1979 Feb 9;161(3):431-45.


Related Articles

92: Selective depression by opiates and opioid peptides of sensory evoked dorsal horn network

responses in organized fetal mouse spinal cord cultures.

Crain SM, Crain B, Peterson ER, Simon EJ.

Proc West Pharmacol Soc. 1979;22:375-8. No abstract available.


Related Articles

93: Selective depression by opioid peptides of sensory-evoked dorsal-horn network responses

in organized spinal cord cultures.

Crain SM, Crain B, Peterson ER, Simon EJ.

Brain Res. 1978 Nov 17;157(1):196-201. No abstract available.


Related Articles























94: Formation of functional retinotectal connections in co-cultures of fetal mouse explants.


Brain Res. 1978 Jun 16;148(2):484-92. No abstract available.


Related Articles

95: Opiate receptors in cultures of fetal mouse dorsal root ganglia (DRG) and spinal cord:

predominance in DRG neurites.

Hiller JM, Simon EJ, Crain SM, Peterson ER.

Brain Res. 1978 Apr 28;145(2):396-400. No abstract available.


Related Articles

96: Regional localization of patterned spontaneous discharges during maturation in culture of

fetal mouse medulla and spinal cord explants.

Tarrade T, Crain SM.

Dev Neurosci. 1978;1(3-4):119-32.


Related Articles

97: Selective opiate depression of sensory-evoked synaptic networks in dorsal horn regions of

spinal cord cultures.

Crain SM, Peterson ER, Crain B, Simon EJ.

Brain Res. 1977 Sep 9;133(1):162-6. No abstract available.


Related Articles

98: Nonfunctional retroperitoneal extra-adrenal paraganglioma. Case report.

Crain SM, Mukhopadhyay D.

IMJ Ill Med J. 1977 Apr;151(4):257-60. No abstract available.


Related Articles

99: Electrophysiological studies of fetal mouse olifactory bulb explants during development of

synaptic functions in culture.

Corrigall WA, Crain SM, Bornstein MB.

J Neurobiol. 1976 Nov;7(6):521-36.


Related Articles

100: Depression of complex bioelectric discharges in cerebral tissue cultures by thermolabile

complement-dependent serum factors.

Crain SM, Bornstein MB.

Exp Neurol. 1975 Oct;49(1 Pt 1):330-5. No abstract available.


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101: Circulation and turnover of synaptic vesicle membrane in cultured fetal mammalian spinal

cord neurons.

Teichberg S, Holtzman E, Crain SM, Peterson ER.

J Cell Biol. 1975 Oct;67(1):215-30.


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http://www.ncbi.nlm.nih.gov/pubmed/1176531?ordinalpos=101&itool=Email.EmailReport.Pubmed_ReportSelector.Pubmed_RVDocSum&log$=freejrpmc

102: Regeneration in vitro of previously frozen adult mouse and human striated muscle coupled

with fetal spinal cord.

Liveson JA, Peterson ER, Crain SM, Borstein MB.

Exp Neurol. 1975 Sep;48(3 Pt 1):624-36. No abstract available.


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103: Early formation of synaptic networks in culture of fetal mouse cerebral neocortex and

hippocampus.

Crain SM, Raine CS, Bornstein MB.

J Neurobiol. 1975 May;6(3):329-36. No abstract available.


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104: Development of specific sensory-evoked synaptic networks in fetal mouse cord-brainstem

cultures.


Science. 1975 Apr 18;188(4185):275-8.


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105: Neuronal growth cone relationships and their role in synaptogenesis in the mammalian

central nervous system.

Pappas GD, Fox GQ, Masurovsky EB, Peterson ER, Crain SM.

Adv Neurol. 1975;12:163-80. No abstract available.


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106: Enhanced afferent synaptic functions in fetal mouse spinal cord-sensory ganglion explants

following NGF-induced ganglion hypertrophy.


Brain Res. 1974 Oct 11;79(1):145-52. No abstract available.


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107: Development of neural connections in culture.


Ann N Y Acad Sci. 1974 Mar 22;228(0):6-34. No abstract available.


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108: Early onset in inhibitory functions during synaptogenesis in fetal mouse brain cultures.


Brain Res. 1974 Mar 22;68(2):351-7. No abstract available.


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109: Directly evoked paroxysmal' depolarizations of mouse hippocampal neurons in

synaptically organized explants in long-term culture.

Zipser B, Crain SM, Bornstein MB.

Brain Res. 1973 Oct 12;60(2):489-95. No abstract available.


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110: Notes on synaptic vesicles and related structures, endoplasmic reticulum, lysosomes and

peroxisomes in nervous tissue and the adrenal medulla.

Holtzman E, Teichberg S, Abrahams SJ, Citkowitz E, Crain SM, Kawai N, Peterson ER.

J Histochem Cytochem. 1973 Apr;21(4):349-85. Review. No abstract available.


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111: Restorative effects of cyclic AMP on complex bioelectric activities of cultured fetal rodent

CNS tissues after acute CA++ deprivation.

Crain SM, Pollack ED.

J Neurobiol. 1973;4(4):321-42. No abstract available.


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112: In vitro studies of regeneration and innervation of muscle from dystrophic (dy2J) mutant

mice.

Hamburgh M, Bornstein MB, Peterson ER, Crain SM, Masurovsky EB, Kirk C.

Prog Brain Res. 1973;40(0):497-508. No abstract available.


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113: Tissue culture studies of central nervous system maturation.

Crain SM.

Res Publ Assoc Res Nerv Ment Dis. 1973;51:113-31. Review. No abstract available.


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114: Regeneration and innervation in cultures of adult mammalian skeletal muscle coupled with

fetal rodent spinal cord.


Exp Neurol. 1972 Jul;36(1):136-59. No abstract available.


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115: Organotypic bioelectric activity in cultured reaggregates of dissociated rodent brain cells.


Science. 1972 Apr 14;176(31):182-4.


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116: Patterns of spontaneous bioelectric activity during maturation in culture of fetal rodent

medulla and spinal cord tissues.

Corner MA, Crain SM.



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117: Development of motility in fish embryos in relation to release from early CNS Inhibition.

Pollack ED, Crain SM.



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118: Magnetically coupled micromanipulator for use within a sealed chamber.




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Baer SC, Crain SM.

J Appl Physiol. 1971 Dec;31(6):926-9. No abstract available.


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119: Electron microscopy of the in vitro development of mammalian motor end plates.

Pappas GD, Peterson ER, Masurovsky EB, Crain SM.

Ann N Y Acad Sci. 1971 Sep 15;183:33-45. No abstract available.


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120: Lack of correlation between changes in bioelectric functions and myelin in cultured CNS

tissues chronically exposed to sera from animals with EAE.

Bornstein MB, Crain SM.

J Neuropathol Exp Neurol. 1971 Jan;30(1):129. No abstract available.


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121: Bioelectric interactions between cultured fetal rodent spinal cord and skeletal muscle after

innervation in vitro.

Crain SM.

J Exp Zool. 1970 Apr;173(4):353-69. No abstract available.


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122: Neuromuscular transmission in cultures of adult human and rodent skeletal muscle after

innervation in vitro by fetal rodent spinal cord.

Crain SM, Alfei L, Peterson ER.



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123: Innervation in cultures of fetal rodent skeletal muscle by organotypic explants of spinal

cord from different animals.


Z Zellforsch Mikrosk Anat. 1970;106(1):1-21. No abstract available.


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124: The development of spontaneous bioelectric activities and strychnine sensitivity during

maturation in culture of embryonic chick and rodent central nervous tissues.


Arch Int Pharmacodyn Ther. 1969 Dec;182(2):404-6. No abstract available.


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125: Maturation of cultured embryonic CNS tissues during chronic exposure to agents which

prevent bioelectric activity.

Crain SM, Bornstein MB, Peterson ER.

Brain Res. 1968 May;8(2):363-72. No abstract available.


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126: Onset and development of functional interneuronal connections in explants of rat spinal

cord-ganglia during maturation in culture.

























Brain Res. 1967 Dec;6(4):750-62. No abstract available.


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127: Development of "organotypic" bioelectric activities in central nervous tissues during

maturation in culture.

Crain SM.

Int Rev Neurobiol. 1966;9:1-43. Review. No abstract available.


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128: Spontaneous contractions and bioelectric activity after differentiation in culture of

presumptive neuromuscular tissues of the early frog embryo.


Experientia. 1965 Jul 15;21(7):422-4. No abstract available.


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129: FUNCTIONAL STUDIES OF CULTURED BRAIN TISSUES AS RELATED TO

"DEMYELINATIVE DISORDERS".

BORNSTEIN MB, CRAIN SM.

Science. 1965 May 28;148:1242-4.

PMID: 14280011 [PubMed - OLDMEDLINE]

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130: DIFFERENTIATION AND PROLONGED MAINTENANCE OF BIOELECTRICALLY

ACTIVE SPINAL CORD CULTURES (RAT, CHICK AND HUMAN).

PETERSON ER, CRAIN SM, MURRAY MR.

Z Zellforsch Mikrosk Anat. 1965 Mar 25;66(1):130-54. No abstract available.


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131: BIOELECTRIC ACTIVITY OF NEONATAL MOUSE CEREBRAL CORTEX DURING

GROWTH AND DIFFERENTIATION IN TISSUE CULTURE.

CRAIN SM, BORNSTEIN MB.

Exp Neurol. 1964 Nov;10:425-50. No abstract available.


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132: SOME CYTOLOGIC EFFECTS OF SALIVARY NERVE-GROWTH FACTOR ON

TISSUE CULTURES OF PERIPHERAL GANGLIA.

CRAIN SM, BENITEZ H, VATTER AE.

Ann N Y Acad Sci. 1964 Oct 9;118:206-31. No abstract available.


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133: COMPLEX BIOELECTRIC ACTIVITY IN ORGANIZED TISSUE CULTURES OF

SPINAL CORD (HUMAN, RAT AND CHICK).

CRAIN SM, PETERSON ER.

J Cell Physiol. 1964 Aug;64:1-13. No abstract available.


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134: Bioelectric activity in long-term cultures of spinal cord tissues.
























CRAIN SM, PETERSON ER.

Science. 1963 Aug 2;141:427-9.


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135: DEVELOPMENT OF COMPLEX BIOELECTRIC ACTIVITY DURING GROWTH

AND DIFFERENTIATION OF CULTURED MOUSE CEREBRAL NEOCORTEX.

CRAIN SM.

Trans Am Neurol Assoc. 1963;88:19-21. No abstract available.


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136: Catecholamine levels of mouse sympathetic ganglia following hypertrophy produced by

salivary nerve-growth factor.

CRAIN SM, WIEGAND RG.

Proc Soc Exp Biol Med. 1961 Jul;107:663-5. No abstract available.


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137: Electrophysiology of supramedullary neurons in Spheroides maculatus. III. Organization

of the supramedullary neurons.

BENNETT MV, CRAIN SM, GRUNDFEST H.

J Gen Physiol. 1959 Sep;43:221-50. No abstract available.



138: Electrophysiology of supramedullary neurons in Spheroides maculatus. II. Properties of

the electrically excitable membrane.





139: Electrophysiology of supramedullary neurons in Spheroides maculatus. I. Orthodromic

and antidromic responses.





140: Resting and action potentials of cultured chick embryo spinal ganglion cells.

CRAIN SM.

J Comp Neurol. 1956 Apr;104(2):285-329. No abstract available.


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141: Electrical activity from tissue cultures of chick embryo spinal ganglia.

CRAIN SM, GRUNDFEST H, METTLER FA, FLINT TJ.

Trans Am Neurol Assoc. 1953;3(78th Meeting):236-9. No abstract available.


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142: Development of electrical activity in the cerebral cortex of the albino rat.

CRAIN SM.

Proc Soc Exp Biol Med. 1952 Oct;81(1):49-51. No abstract available.


























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143: Spontaneous electrical activity from tissue cultures.

METTLER FA, GRUNDFEST H, CRAIN SM, MURRAY MR.

Trans Am Neurol Assoc. 1952;56(77th Meeting):52-3. No abstract available.


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