MORPHOLOGY CHANGES OF SERTOLI
EFFECTS OF DECREASE SERTOLI CELL COUNT ON
SPERMATOGENESIS
CONCLUSION
 
medical science. Humans age because during their
biological evolution, nature has relied more on
reproduction. Male fertility and the process of
spermatogenesis are dependent upon the somatic
Sertoli cells. Sertoli cells are the somatic cells of the
testis that are essential for testis formation and
 located within the seminiferous tubules
 far less numerous than the spermatogenic cells and are evenly distributed
 shape is highly irregular – columnar
 nuclues is ovoid, large and lightly stained and contains a large nucleolus
 A fold in the nuclear membrane is characteristic for sertoli cell
 interconnected by tight junctions
 
 
altering rates of spermatozoa produced
 called the "mother" or "nurse" cell
  protection of the developing germ cells, secretion of
factors that nurture germ cells and orchestration of
temporal and spatial control of apoptosis, mitosis and
meiosis during the complex process of spermatogenesis
 Act as phagocytes
 
 Sertoli cell is in morphological and functional contact
with a defined numer of sperm   !n men we oserve aout # germ cells or $%
spermatozoa per each Sertoli cell   numer of Sertoli cells in men increases until the
%th year of life  Sertoli cell proliferation is activated when exposed to
gonadotropin activity
 
 
 
 
COUNT ON SPERMATOGENESIS
 
maintenance of testicular homeostasis and male
reproductive viability. he Sertoli cells play a major role
in regulation of spermatogenesis and altering rates of
spermato/oa produced. he decrease of Sertoli cell
numbers such as that produced by an antimitotic
substance leads to a reduction of testicular volume and
sperm production which occurs in elderly. 3n elderly,
sertoli cell count will be decrease, and therefore causes
abnormality in spermatogenesis. As a result, there is
insufficiency to produce normal sperm count .