skin appearance benefits from a 3-product salycylic acid anti acne regimen
TRANSCRIPT
-
7/28/2019 Skin Appearance Benefits From a 3-Product Salycylic Acid Anti Acne Regimen
1/14
SKIN APPEARANCE BENEFITS FROM A3-PRODUCT SALICYLIC ACID ANTI-ACNE
REGIMEN
J . R. Kaczvinsky1, C. E. Mack1, L. L. Griffin1, J . Li1, R. A. Rose-Mansfield1,S. C. Weitz1, M. J . Marmor1, P. E. Grimes, MD2 and M. I. Perez, MD3
1The Procter & Gamble Company, Cincinnati, Ohio USA2UCLA Medical Center, Los Angeles, CA USA3Columbia University, New York, NY USA
Poster FC02-07
-
7/28/2019 Skin Appearance Benefits From a 3-Product Salycylic Acid Anti Acne Regimen
2/14
Background
Mild to moderate acne vulgaris can persist in somewomen well past adolescence
The periodic appearance of inflamed lesions can be asignificant source of psychological and emotional distress
Many acne treatment products are harsh and notcompatible with other skin needs of post-adolescentwomen, such as those related to aged appearance.
A multi-product regimen containing salicylic acid was
designed that addresses both the acne treatment andskin appearance needs of these women
-
7/28/2019 Skin Appearance Benefits From a 3-Product Salycylic Acid Anti Acne Regimen
3/14
Study Design Skin Benefit EndpointsObjective:
1. Compare the extent of beauty-related skin benefits for treatment with a 3-product
salicylic acid (SA) acne regimen versus a positive control regimen (2.5% benzoylperoxide; BP) and a placebo
Design:
Randomized, double-blind, placebo-controlled parallel group study
2 wks pre-conditioning, 12 wks treatment
~330 healthy post-adolescent females (aged 18-45)Mild to moderate acne (grades 2-3)Conducted at three separate (US) study sites
Measures:
Baseline and after 4, 8, and 12 weeks treatment
Skin texture by image analysis and subject self-assessmentEnlarged pores by image analysis and subject self-assessmentSkin barrier function (TEWL)
Skin hydration (capacitance)
-
7/28/2019 Skin Appearance Benefits From a 3-Product Salycylic Acid Anti Acne Regimen
4/14
StudyTimeline
Assess
Assess
Assess
Assess
Pre-ConditioningCleanse with mild liquid cleanser
AM, PM: Placebo Moistur izer w/3% glycerin/SPF15
Wk -2
Wk 0
Wk +4
Wk +8
Wk +12
~110 subjects
SA Regimen
AM
SA Cleanser
(1.8% salicylic acid)SA Treatment(1.5% salicylic acid)
AA Moisturizer(5% niacinamide)
Sunscreen(3%gly/SPF15)
PM
SA Cleanser
SA Treatment
AA Moisturizer
BP Regimen
AM
Cleanser
(non-acne)BP Treatment
(2.5% benzoyl peroxide)
Sunscreen(3% gly/SPF15)
PM
Cleanser
BP Treatment
3% gly Moisturizer
Placebo
AM
Cleanser
(non-acne)Sunscreen(3%gly/SPF15)
PM
Olay FFW
3%gly Moisturizer
~110 subjects ~110 subjects
-
7/28/2019 Skin Appearance Benefits From a 3-Product Salycylic Acid Anti Acne Regimen
5/14
Results Inflammatory Lesion Counts
Both BP and the SA regimens significantly reduced the number ofinflammatory lesions relative to the placebo treatment at all time points
Efficacy from the two test regimens was not significantly different
Mean 12-wk reductions were ~53% for the SA regimen and ~57% for BP
Data was logtransformedfor analysis
Reported datais backtransformed
There wassubstantialimprovementin the placebogroup
-
7/28/2019 Skin Appearance Benefits From a 3-Product Salycylic Acid Anti Acne Regimen
6/14
Texture and Pore Analysis
REAL 3.0 system
-
7/28/2019 Skin Appearance Benefits From a 3-Product Salycylic Acid Anti Acne Regimen
7/14
Results Skin Texture/Image Analysis
The SA regimen significantly improved facial skin texture comparedto the other two treatment regimens
BPs impact was negative but not significant compared to placebo
Texture
benefit notdriven byacne lesionresolution
-
7/28/2019 Skin Appearance Benefits From a 3-Product Salycylic Acid Anti Acne Regimen
8/14
Results Skin Texture Self-Assessments
Subjects using the SA regimen noticed an improvement in theirskin texture throughout the study
This may be driven in part by clearance of their acne lesions
Subjects gradedtheir skin texture
on a 0-10 ptcontinuous scale
Absolute gradeswere given ateach time point
Lower numbermeans lessuneven (moreeven) texture
Subjects could
calibrate to theirlast grade
-
7/28/2019 Skin Appearance Benefits From a 3-Product Salycylic Acid Anti Acne Regimen
9/14
Results Pore Area Image Analysis
Pore reduction
benefit notdriven by acnelesionresolution
The SA regimen significantly reduced the detectable pore area compared tothe other two treatment regimens
BP treatment increased pore area but not significantly compared to placebo
-
7/28/2019 Skin Appearance Benefits From a 3-Product Salycylic Acid Anti Acne Regimen
10/14
Results Pore Size/Visibility Self Assessment
Subjects graded theirpore size/visibility ona 0-10 pt continuousscale; poor toexcellent
Significant benefits after 8 wks with the SA regimen and after 12 wks for BP
Results not completely driven by improvements in acne lesions
-
7/28/2019 Skin Appearance Benefits From a 3-Product Salycylic Acid Anti Acne Regimen
11/14
Results Barrier Function (TEWL)
The SA regimen was similar to placebo with respect to barrier integrity
Possible balancing effect of niacinamide (known to provide barrierintegrity improvement) and salicylic acid
BP regimen treatment significantly compromised barrier
TEWL wasmeasured on thecheek with mostacne at baseline
Triplicate readingswere averaged
Vapometer
-
7/28/2019 Skin Appearance Benefits From a 3-Product Salycylic Acid Anti Acne Regimen
12/14
Results Skin Hydration (Corneometer)
Hydration wasmeasured via
Corneometeronthe cheek mostbroken out atbaseline
Triplicate readingswere averaged
SA regimen treatment provided a significant hydration benefit early oncompared to placebo and BP; the comparative benefit and change vs.baseline was reduced over time
BP treatment had a negative effect, which improved over time
-
7/28/2019 Skin Appearance Benefits From a 3-Product Salycylic Acid Anti Acne Regimen
13/14
Conclusions
The SA regimen used in this study significantly reduced inflammatoryacne lesions starting at 4 weeks treatment, compared to placebo
The acne benefits from the SA regimen were comparable to thoseachieved with twice daily use of 2.5% benzoyl peroxide.
The SA regimen improved skin texture as well as or better than both
2.5% benzoyl peroxide and placebo after 4 weeks treatment.
Four or more weeks treatment with the SA regimen significantlyreduced the area of enlarged pores and made them less visible
The SA regimen was more hydrating and less damaging to the skin
than 2.5% benzoyl peroxide and also provided additional skinbenefits.
The SA regimen provided both anti-acne efficacy and additionalbenefits for attributes related to skin aging. The latter benefits werenot achieved with a 2.5% BP regimen.
-
7/28/2019 Skin Appearance Benefits From a 3-Product Salycylic Acid Anti Acne Regimen
14/14
This work was funded by P&G Beauty & Grooming