SIOG National Representatives SIOG 2018 Reports

AUSTRALIA NR: Christopher Steer The COSA geriatric oncology group continues its activities under the leadership of Professor Meera Agar.

1. Ongoing work on Geriatric Oncology Guidance document on a Wiki platform. These guidelines will enable evidence-based activity in an Australian context and help shape policy direction and resource allocation.

2. The group holds regular research concept development meetings. These are scheduled teleconferences designed to encourage the development of research ideas and nurture research activity Australia-wide. Research concepts are submitted prior to the meeting and then discussed by a panel of experts. Suggestions for protocol refinement are often made. A collaborative, collegiate approach is vital to the development of this field and these meetings held every 6 months provide a positive backbone for such activity.

3. The group continues to provide expertise at local and international meetings. • eg The Victorian Care of Older People Clinical Network 2017 Forum – Older People with Cancer. Friday

27th October at Deakin Edge, Federation Square, Melbourne. • Geriatric oncology sessions at MASCC18 in Vienna June 2018 including a combined SIOG/MASCC event. • Geriatric oncology and supportive care sessions planned at ESMO ASIA Singapore November 2018. • Geriatric oncology initiatives being undertaken by several COSA members were featured at the 2017

COSA ASM in November. Abstracts and conference proceedings are available in APJCO. a) Assessing Treatment Tolerability after Geriatric Assessment in the Senior Oncology Clinic at the Gold

Coast University Hospital. James Fletcher, Jasotha Sanmugarajah, Susan Caird, Michael Allen, Amanda Quennell, Michael Powell [abstract #165]

b) A Pilot Study to Evaluate the Clinical Utility of the Cancer and Aging Research Group (CARG) Prediction Tool for Treatment Related Toxicity in Patients Over 70 Years of Age Undergoing Systemic Therapy at St Vincent's Hospital, Melbourne. John Lai, Anthony Dowling, Melissa Moore, Genni Newnham, Chris hart, Sue-Anne McLachlan [abstract #173]

c) Predicting Chemotherapy Toxicity in Older Adults: Comparing the Value of the CARG Toxicity Score With Oncologists’ Estimates of Toxicity. Erin B. Moth, Belinda E. Kiely, Vasikaran Naganathan, Andrew Martin, Natalie Stefanic, Philip Beale, Peter Grimison, Prunella Blinman [abstract # 189]

4. COSA members in Sydney, Melbourne and Adelaide were very pleased to host Supriya Mohile on her Australian sabattical tour in June-July 2018. Supriya spoke at a number of centres in her Australian visit and these meetings were very well attended. Supriya’s visit was timed just after the release of the ASCO guidelines on the care of older adults with cancer and served as a catalyst to give evidence-based care of older adults increased prominence in Australia.

Other key Geriatric Oncology Activity

1. The development of EviQ Geriatric Oncology Education modules online – hosted by Cancer Institute NSW. These modules have been developed with collaboration between the Peter MacCallum Cancer Centre, The Royal Melbourne Hospital Queensland University of Technology (QUT) Western & Central Integrated Cancer Service (WCMICS), Western Health Consumer representatives, The Royal Women’s Hospital (Melbourne) and The University of Melbourne. This project has been funded by WCMICS in Melbourne and was generously supported by The Frances & Harold Abbott Foundation. https://education.eviq.org.au/courses/geriatric-oncology

2. The continued development of Cancer in the Older Adult clinical services in Perth, The Canberra Hospital, Monash Medical Centre in Melbourne, The Gold Coast Hospital, The Royal Adelaide Hospital, South Australia and Eastern Health in Melbourne.

Ongoing Research activity includes

1. Phase II (pilot) step wedge cluster randomised controlled trial of a nurse-led triage and assessment system to optimize outcomes for older people with cancer. A multicentre trial Led by Meera Agar at University of Technology Sydney.

2. Elderly Functional Index (ELFI) for assessment of functioning in patients with cancer: how does it measure up? Validation of composite HRQOL instruments led by Wee Kheng Soo.

3. Feasibility of the Electronic Rapid Fitness Assessment at a Regional Cancer Centre A collaboration between Armin Shahrokni at the Memorial Sloan Kettering Cancer Centre in New York and the Border Medical Oncology Research Unit at the Albury Wodonga Regional Cancer Centre. Led by Christopher Steer.

Australian GO publications in 2017-2018

1. To THM, Soo WK, Lane H, Khattak A, Steer C, Devitt B, Dhillon HM, Booms A, Phillips J: Utilisation of geriatric assessment in oncology - a survey of Australian medical oncologists. J Geriatr Oncol 10.1016/j.jgo.2018.07.004, 2018

2. Moth EB, Kiely BE, Stefanic N, Naganathan V, Martin A, Grimison P, Stockler MR, Beale P, Blinman P: Predicting chemotherapy toxicity in older adults: Comparing the predictive value of the CARG Toxicity Score with oncologists' estimates of toxicity based on clinical judgement. J Geriatr Oncol 10.1016/j.jgo.2018.08.010, 2018

3. Moth EB, Kiely BE, Naganathan V, Martin A, Blinman P: How do oncologists make decisions about chemotherapy for their older patients with cancer? A survey of Australian oncologists. Support Care Cancer 26:451-460, 2018

4. Lane HP, McLachlan S, Philip JAM: 'Pretty fit and healthy': The discussion of older people in cancer multidisciplinary meetings. J Geriatr Oncol 10.1016/j.jgo.2018.06.001, 2018

5. Iqbal MS, Dua D, Kelly C, Bossi P: Managing older patients with head and neck cancer: The non-surgical curative approach. J Geriatr Oncol 9:411-417, 2018

6. Morris L, Thiruthaneeswaran N, Lehman M, Hasselburg G, Turner S: Are Future Radiation Oncologists Equipped With the Knowledge to Manage Elderly Patients With Cancer? Int J Radiat Oncol Biol Phys 98:743-747, 2017

7. Lum C, Steer CB: Targeted Therapies in the Management of Ovarian Cancer: A Focus on Older Patients. Drugs Aging 34:821-831, 2017

8. Turner JP, Shakib S, Bell JS: Is my older cancer patient on too many medications? J Geriatr Oncol 8:77-81, 2017

BELGIUM NR: Lore Decoster Research activities

1. Publications - Decoster L, Schallier D. Treatment of older patients with advanced non-small cell lung cancer: A challenge. J

Geriatr Oncol 2018; doi: 10.1016/j.jgo.2018.09.008 - Kenis C, Baitar A, Decoster L, De Grève J, Lobelle JP, Flamaing J, et al. The added value of geriatric screening

and assessment for predicting overall survival in older patients with cancer. Cancer 2018; doi: 10.1002/cncr.31581

- Baitar A, Kenis C, Decoster L, De Grève J, Lobelle JP, Flamaing J, et al. The prognostic value of 3 commonly measured blood parameters and geriatric assessment to predict overall survival in addition to clinical information in older patients with cancer. Cancer 2018; doi: 10.1002/cncr.31580

- Kenis C, Decoster L, Flamaing J, Debruyne PR, De Groof I, Focan C, et al. Adherence to geriatric assessment-based recommendations in older patients with cancer: a multicenter prospective cohort study in Belgium. Ann Oncol 2018;29:1987-1994

- Decoster L, Fontaine C, Vanacker L, Schallier D, De Grève J. Docetaxel/cyclophosphamide chemotherapy in older patients with breast cancer. Breast J 2018;24:695-697

- Decoster L, Kenis C, Naessens B, Houbier G, De Man M, Lambrecht G, et al. Integrating geriatric assessment in the first line chemotherapy treatment in older patients with metastatic colorectal cancer: results of a prospective observational cohort study (AVAPLUS). J Geriatr Oncol 2018;9:93-101

2. Oral presentations - Kenis C, Baitar A, Decoster L, De Grève J, Lobelle J-P, Flamaing J, et al. The added value of geriatric

screening and assessment to predict overall survival in older patients with cancer.. 41ste Wintermeeting Belgische Vereniging voor Gerontologie en Geriatrie (BVGG). Oostende, België (February, 2018).

- Decoster L, Quinten C, Kenis C, Flamaing J, Debruyne PR, Degroof I, et al. Quality of life (QoL) in older patients (pts) with cancer and prognostic factors for QoL decline. Journal of Clinical Oncology. 2018;36:suppl;abstr 10010. 54th Annual Meeting of the American Society of Clinical Oncology (ASCO). Chicago, IL, Verenigde Staten van Amerika (June, 2018).

- Kenis C, Decoster L, Flamaing J, Debruyne PR, De Groof I, et al. Unplanned readmissions in older patients with cancer: a multicenter prospective cohort study in Belgium focusing on incidence and risk factors. 18th Meeting of the International Society of Geriatric Oncology. Amsterdam, Nederland (November, 2018).

3. Poster presentations - S Bröker, S Joris, F Bustin, K Pat, L Jacqmin, H Kalantari, W Demey, T Pieters, A Sibille, F Clinckart, JL Canon,

JC Goeminne, V Surmont, S Holbrechts, M Lambrechts, D Schallier, L Decoster . Real life safety and efficacy of nivolumab in older patients with non-small cell lung cancer: preliminary results. 18th Meeting of the International Society of Geriatric Oncology. Amsterdam, Nederland (November, 2018).

- Kenis C, Decoster L, Flamaing J, Debruyne P.R., De Groof I, Focan C., et al. Adherence to geriatric assessment (GA)-based recommendations in older patients (pts) with cancer. 41ste Wintermeeting Belgische Vereniging voor Gerontologie en Geriatrie (BVGG). Oostende, België (February, 2018).

- Kenis C, Baitar A, Decoster L, Degrève J, Lobelle J-P, Flamaing J, et al. The prognostic value of three commonly measured blood parameters and geriatric assessment to predict overall survival in addition to clinical information in older patients with cancer. 41ste Wintermeeting Belgische Vereniging voor Gerontologie en Geriatrie (BVGG). Oostende, België (February, 2018).

Promotion of geriatric oncology

- Report on SIOG Annual Meeting 2017 in the Belgian Journal of Geriatric Oncology entitled 'Geriatric Oncology: from research to practice: incorporating geriatric oncology into patient care' 0 (see appendix). In this report I also encouraged readers to attend the SIOG Treviso course and the SIOG annual meeting 2018.

- Presentation on geriatric oncology for the yearly congress of oncology and radiotherapy nurses: 'Oncogeriatrie en multidisciplinaire aanpak van ouderen met kanker'. VVRO Jaarcongres 18/11/2017

- Presentation on geriatric oncology for the Seminars in Oncology of the UZ Brussel: 'Geriatric oncology: focus on the older patient with cancer'. Seminars Oncology UZ Brussel 21/12/2017

- Currently finalizing my PhD thesis in geriatric oncology - Advertisements for SIOG Treviso course and SIOG annual meeting were circulated multiple times to all

members of the Belgian Society of Oncology (BSMO) via email and to the members of the Belgian society og gerontology and geriatrics (BVVG) via their website. In addition the advertisements were published in the Belgian Journal of Medical Oncology, which is distributed to all medical oncologists, gastroenterology oncologists and pneumology oncologists in Belgium.

- Announcements for SIOG meetings were also mentioned in all presentations by L Decoster and C Kenis - A non profit organization 'Kom op tegen Kanker' has initiated a working group on 'older patients with cancer' of

which Cindy Kenis, Lore Decoster and Hans Wildiers are members. This non-profit organization is currently running a pilot project which investigates how the social network of older patients with cancer can be enforced and is working on a report on 'Cancer in nursing homes'

- Geriatric oncology will be part of the course 'advanced practice nursing' at the UCCV Gent

Future projects: - UZ Leuven (Hans Wildiers and Cindy Kenis) and UZ Brussel (Lore Decoster) received a grant from a non profit

organization 'Kom op tegen kanker': randomized controlled trial on geriatric assessment and patient participation. - The Belgian Cancer Register in collaboration with UZ Leuven en UZ Brussel received a grant from a non-profit

organization 'Kom op tegen Kanker': observational study to investigate the effect of geriatric screening and assessment on different aspects on the long term.

Appendix 1

BRAZIL NR: Manuela Zereu In 2017-2018 we had little but very strong progress in the field of Geriatric Oncology: study groups in geriatric and geriatric oncology have regular meetings not only with physicians and medical students but also with multidisciplinary team. This group published a book to help the understanding of allied aspects of geriatrics. The chapter of geriatric oncology was written by me with the help of some medical students. Next year we will have the permanent participation of geriatric fellows in the program of clinical oncology!

CYPRUS NR: Demetris Papamichael

Promoting SIOG Promotional slide used for SIOG annual meeting 2018 during all my presentations. Publications relevant to Geriatric Oncology

1. Personalized management of elderly patients with rectal cancer: Expert recommendations of the European Society of Surgical Oncology, European Society of Coloproctology, International Society of Geriatric Oncology, and American College of Surgeons Commission on Cancer. Montroni I, Ugolini G, Saur NM, Spinelli A, Rostoft S, Millan M, Wolthuis A, Daniels IR, Hompes R, Penna M, Fürst A, Papamichael D, Desai AM, Cascinu S, Gèrard JP, Myint AS, Lemmens VEPP, Berho M, Lawler M, De Liguori Carino N, Potenti F, Nanni O, Altini M, Beets G, Rutten H, Winchester D, Wexner SD, Audisio RA. Eur J Surg Oncol. 2018 Aug 15. pii: S0748-7983(18)31272-1. doi: 10.1016/j.ejso.2018.08.003. [Epub ahead of print]

2. Optimal management of localized rectal cancer in older patients.

Bujko K, Glynne-Jones R, Papamichael D, Rutten HJT. J Geriatr Oncol. 2018 Aug 24. pii: S1879-4068(18)30225-X. doi: 10.1016/j.jgo.2018.08.001. [Epub ahead of print]

3. Identifying patients who may benefit from oxaliplatin-containing perioperative chemo(radio)therapy for rectal cancer. Papamichael D, Glynne-Jones R. Ann Oncol. 2018 Aug 1;29(8):1616-1618. doi: 10.1093/annonc/mdy230. No abstract available.

Ongoing and future project Study to Estimate the Toxicity, Dose-Intensity, and Benefit of anti-EGFR-Based Treatment in Patients with Advanced Colon Cancer according to age Update of SIOG guidelines (adjuvant) based on the IDEA Collaborators results and the ACCENT database. Will be presenting and discussing a proposal during the next IDEA meeting during ASCO GI 2019. Education Two presentations during the ESMO Preceptorship Programme in Colorectal Cancer Valencia, Spain 18-19 May 2018

Adjuvant treatment for elderly patients: how to address it

How to deal with elderly patients or individuals with co-morbidities

FRANCE NR: Rabia Boulahssass

PROMOTION OF SIOG (SIOG invitation at the end of each presentations)

COURS DE SAINT PAUL « metastatic breast cancers » 01/2017, Nice, France, oral presentation (OP)

MONACO AGE ONCOLOGIE, Monaco, ORAL THERAPIES 03/2017, 2 Other Oral Presentations in this meeting

SFNT French national congress (nephrology), Cognitive disorders Nice, Oral Presentation, 05/2017

Mini WorkShop on lung diseases, Lung cancer and older Adults Oral presentation, Nice, 05/2017

IAGG World Congress of Gerontology and Geriatric: cancer related morbidity and mortality issues San Francisco: chairman and oral presentation, 07/2017

EUGMS: International Congress of the European union geriatric medicine society, Fatigue and cancer, AWARD OF THE BEST ORAL COMMUNICATION, Nice 09/2017

SOFOG French National Congress GO, cancer and fatigue Oral presentation , 09/2018

FHU OncoAge Workshop Clinical Studies dedicated to elderly patients (PACA Est Cohort), Nice oral presentation,10/2017

SYMPOSIUM (oral presentations)

Amgen ethics and geriatric oncology, Nice 05/2017

MasterClass supporters, Nice 05/2017

Amgen ethics and geriatric oncology, Paris 10/2017

Roche Breast cancers and geriatric oncology, Cannes 10/2017

BMS Immunotherapy and older adults, Nice, 09/2017 RESEARCH LAST PUBLICATIONS PUBMED

Boulahssass R, Gonfrier S, Ferrero JM, Sanchez M, Mari V, Moranne O, RambaudC, Auben F, Hannoun Levi JM, Bereder JM, Bereder I, Baque P, Turpin JM, Frin AC, Ouvrier D, Borchiellini D, Largillier R, Sacco G, Delotte J, Arlaud C, Benchimol D, Durand M, Evesque L, Mahamat A, Poissonnet G, Mouroux J, Barriere J, BenizriE, Piche T, Guigay J, Francois E, Guerin O. Predicting early death in older adults with cancer. Eur J Cancer. 2018 Sep;100:65-74. Impact factor 7,19

Hannoun-Lévi JM, Cham Kee DL, Gal J, Schiappa R, Hannoun A, Gautier M,Boulahssass R, Peyrottes I, Barranger E, Ferrero JM, Chand ME, Doyen J. Accelerated partial breast irradiation for suitable elderly women

using a single fraction of multicatheter interstitial high-dose-rate brachytherapy: Earlyresults of the Single-Fraction Elderly Breast Irradiation (SiFEBI) Phase I/IItrial. Brachytherapy. 2018 Mar - Apr;17(2):407-414

Crétel-Durand E, Nouguerède E, Le Caer H, Rousseau F, Retornaz F, Guillem O,Couderc AL, Greillier L, Norguet E, Cécile M, Boulahssass R, Le Caer F, Tournier S, Butaud C, Guillet P, Nahon S, Poudens L, Kirscher S, Loubière S, Diaz N,Dhorne J, Auquier P, Baumstarck K. PREDOMOS study, impact of a social intervention program for socially isolated elderly cancer patients: studyprotocol for a randomized controlled trial. Trials. 2017 Apr 12;18(1):174

RESEARCH

PI of the PACA East Prospective cohort with>3800 elderly cancer patients enrolled

Copil Member of GERICO (national research group for geriatric oncology in France

Scientific committee group of the SOFOG (French Oncogeriatric Association)

ASRO research group which promote the research in geriatric oncology in south east of France

Participation at several multicentric French studies and toxicity committee for research

Member of ONCOAGE: Hospital federation for research performed in 2016. Consortium of high level skills from several fields (clinicians, bio pathologist, immunologist, researchers, bioinformatician, mathematician, economists and social researchers) : it aims to improve research in lung and head and neck cancers.

PROMOTE EDUCATION (GERIATRIC ONCOLOGY) ! In France there are 5 post-graduate teaching trainings in geriatric oncology for geriatricians and oncologists. In the Southeast of France, we have this training since 2012 chaired by Olivier Guerin (Scientific responsibility) and Rabia Boulahssass (pedagogic responsibility) INCREASE PUBLIC AWARNENES IN THE ELDERLY POPULATION! Organization with every year in our area several meetings for older adults (with several French organizations fighting against cancer and media) to promote individual screening for colon and breast cancer. (“Mars bleu” Octobre Rose”) MAKING BRIDGES WITH YOUNG GERIATRIANS In 2017, Lisa Cooper from Tel Aviv and Costanza Bartolotti from Chili came to our hospital to perform their knowledge to set up a geriatric program in their countries. They will attend the congress of the SIOG 2018. Each year, we propose an invitation to a young French geriatrician for the SIOG: last year Sebastien Gonfrier and this year Noemie Champigny. ORGANIZATION NATIONAL COMMITTEE CONGRESS Monaco Age Oncologie (geriatric oncology) >500 attendees SOFOG French national association (geriatric oncology) >250 attendees EDITORIAL NATIONAL BOARD

Journal d’oncogeriatrie Revue de Geriatrie DRIVING SPECIFIC PROGRAMS for elderly patients with cancers From 2014, we run a specific physical activity program for hospitalized elderly patients with cancers (more than 200 patients) with the support of a charity (COGs for cancer) CARELINE program from 2014, “taking care” by calling by phone very frailty patients (homebound with cancers) ( >50 patients)

IRELAND NR: Anne Horgan CLINICAL

- It is anticipated that a National Clinical Lead in Geriatric Oncology will be appointed through the National Cancer Control Programme in the last quarter of 2018 / first quarter of 2019. This will result in a co-ordinated development of geriatric oncology services nationally

- The Geriatric Oncology Clinic in the South East Cancer Centre, University Hospital Waterford (Dr Anne Horgan) continues to expand. It recently received a National Hospital Professional Award for Innovation and Service Development 2018.

- This clinic has also been shortlisted for the National Healthcare Awards to be awarded in October 2018 EDUCATION

- Fourth Irish Geriatric Oncology Meeting held in April 2018 (Chair: Anne Horgan. Committee: Anita O’Donovan, Shane O’Hanlon). This meeting was again run under the auspices of SIOG with the president and a number of other SIOG members both in attendance and presenting.

- Annual meeting is mandatory for trainees in Medical Oncology and Geriatric Medicine to attend - Funding for a preceptorship for 2 trainees, one each in medical oncology and geriatric medicine, secured for

2018 (Anne Horgan). This is the second year of such a programme, and offers the opportunity for trainees to visit a centre of excellence in geriatric oncology internationally.

- Dr Shane O’Hanlon and Anita O’Donovan– part of faculty at Treviso course 2018 RESEARCH

Oral presentations - Anita O’Donovan presented at ESTRO course in Brussels October 2018: Multidisciplinary Management of Non-

Melanoma Skin Cancer in older patients - A. O'Donovan, Age Attuned Radiotherapy, European SocieTy for Radiotherapy and Oncology (ESTRO)

37, Barcelona, Spain, 20th-24th April , 2018Invited Talk, 2018 - Shane O’Hanlon presented on behalf of SIOG at ECOP-4 (European Conference of Oncology Pharmacy) in

Nantes October 2018

- Geriatric Oncology; Drug Safety Research Unit, London, 2018 (Shane O’Hanlon) - Frailty screening in older adults with cancer; EUGMS, Berlin 2018 (Shane O’Hanlon) - Debate: “This house believes we should not operate on the frail older patient”; Age Anaesthesia/POPS

Conference, London, 2018 (Shane O’Hanlon) - Geriatric Oncology; ATOM Conference, The Christie, Manchester, 2018 (Shane O’Hanlon) - Assessing Older People with Cancer; Royal College of Physicians and Surgeons of Glasgow, 2018 (Shane

O’Hanlon) - Oral presentation the Irish Geriatric Society Annual Meeting, October 2018. Integrating Principles of Geriatric

Care into Oncology : A Collaborative Approach to Managing Older Patients with Cancer, 2018 (Presenter: Dr AR Farooq; Lead: Anne Horgan)

- Oral presentation, Irish Society Medical Oncology (ISMO) Annual Meeting Feb 2018 Social Integration in Oncology Patients with a focus on the older population (Presenter Dr D Bracken-Clarke; Lead: Anne Horgan) Bursary awarded

- Geriatric Oncology and Bone Health, Bone Health in Cancer 2018 meeting, Ireland. October 2018 (Anne Horgan)

Publications:

- O’Hanlon S, Rechner J. Editorial: Optimising pre-operative assessment for older people Anaesthesia 73(11), June 2018.

- Lund CM, O’Hanlon S. The SIOG Treviso Course: Students’ Perspective - Corrigan LR, Bracken-Clarke DM, Horgan AM. The Challenge of treating older patients with pancreaticobiliary

malignancies. Curr Probl Cancer. 2018 Jan- Feb;42(1):59-72. - Bracken-Clarke D, Farooq AR, Horgan AM. Management of Locally advanced and Metastatic Esophageal

cancer in the older population. In press - Current Oncology Reports (Volume 21) - Shóna Whelehan, Orlaith Lynch, Niall Treacy, Ciara Gleeson, Andrea Oates, Anita O'Donovan, Optimising

Clinical Trial Design in Older Cancer Patients, Geriatrics, 2018 - Horgan, S. and O'Donovan, A., The Impact of Exercise during Radiation Therapy for Prostate Cancer on

Fatigue and Quality of Life: A Systematic Review and Meta-analysis, Journal of Medical Imaging and Radiation Sciences, 2018

Book Chapters

- O’Hanlon S, Gosney M. Epidemiology of Cancer in Older People. In: Oxford Textbook of Geriatric Medicine (2018) OUP

- O’Hanlon S. Management of delirium on the surgical ward. - In: Cognitive Changes After Surgery in Clinical Practice (2018) Springer - Horgan AM, Alibhai SMH. Screening for Cancer; In: Oxford Textbook of Geriatric Medicine (2018) OUP - O'Donovan A et al Radiotherapy in the Elderly in, editor(s)Maria Jose Molina Garrido , Textbook on Geriatric

Oncology, 2018

MEXICO NR: Enrique Soto Perez de Célis

Clinical Activities: 1. Expansion of the Cancer Care in the Elderly Clinic (CICAM) from six patients per week to 20 patients per week. 2. Establishment of a rotation for Medical Oncology Fellows in Geriatric Oncology at the National Institute of Medical Science and Nutrition in Mexico City. Educational Activities 1. Planning and development of the 13th International Geriatrics Meeting which will be focused on Geriatric Oncology. This meeting has SIOG auspices and will feature international speakers and will be held at the National Institute of Medical Sciences and Nutrition in Mexico City from November 28 to December 1st 2018. The meeting also has the

auspices of the Mexican Society of Oncology and the Mexican Geriatrics Society and provides CME credits for the Mexican Council of Oncology. 2. Presentation of a Symposium and Webcast on Geriatric Oncology in Breast Cancer for the Mexican Society of Mastology. 3. Presentation on mobile technology for older adults at the Geriatrics Symposium for patients held at the National Institute of Medical Sciences and Nutrition in Mexico City. Service to Profession and Participation in Committees 1. Associate Editor of the Journal of Geriatric Oncology 2. 2017-2020 ASCO Professional Development Committee 3. 2017-2020 ASCO Health Equity Committee 4. 2018-2020 International Society of Geriatric Oncology (SIOG) Science & Education Committee 5. 2018 SIOG Annual Meeting Planning Committee 6. 2018 ASCO Workforce Diversity Strategic Plan Task Force 7. 2018 ASCO Addressing Disparities in Older Adults Work Group 8. 2017-2018 Conquer Cancer Foundation Global Oncology Young Investigator Award Committee Active Grants 07/01/17 - current Global Cancer Institute Grant Global Cancer Institute Grant A Patient Navigation Program to Access Early Palliative and Supportive Care for Patients with Advanced Cancer (NCT03293849). Role: PI 10/01/17 - current Fundación Miguel Alemán Medical Research Grant Fundación Miguel Alemán Validation of a self-reported geriatric assessment using an electronic Tablet for older adults with cancer in Mexico Role: PI Meeting Presentations 1. Soto-Perez-de-Celis E, Li D, Sun CL et al. Patient-defined goals and preferences among older adults with cancer starting chemotherapy (CT). Oral Abstract Presentation. 2018 ASCO Annual Meeting. Chicago, USA. 2. Cao Y, Li, D, Charles K, Soto-Perez-de-Celis E et al. Association between participation in religious activities and depression and anxiety in older patients with cancer. 2018 ASCO Annual Meeting. Chicago, USA. 3. Verduzco Aguirre HC, Navarrete-Reyes AP, Reyes-Martinez NI…Soto-Perez de Celis E. The effect of a geriatric oncology (GO) evaluation on treatment (Tx) decisions for older patients (pts) with cancer in Mexico. 2018 ASCO Annual Meeting. Chicago, USA. Publications related to Geriatric Oncology 1. Bastiaannet E, Battisti N, Loh KP, de Glas N, Soto-Perez-de-Celis E, Baldini C, Kapiteijn E, Lichtman S. Immunotherapy and targeted therapies in older patients with advanced melanoma; Young International Society of Geriatric Oncology review paper. J Geriatr Oncol. 2018 Jul 16. doi: 10.1016/j.jgo.2018.06.009. 2. Soto-Perez-de-Celis E, Loh KP. Perspectives on Geriatric Oncology Research presented at the 2018 American Society of Clinical Oncology Annual Meeting. J Geriatr Oncol 2018 DOI: 10.1016/j.jgo.2018.06.013. 3. Fallahzadeh R, Ali-Rokni S, Ghasemzadeh H, Soto-Perez-de-Celis E, Shahrokni A. Digital Health for Geriatric Oncology. JCO Clinical Cancer Informatics 2018 :2, 1-12 4. Soto-Perez-de-Celis E, Li D, Yuan Y, Yat-Ming L, Hurria A. Functional versus chronological age: using the Geriatric Assessment to guide decision-making in older adults with cancer. Lancet Oncol. 2018 Jun;19(6):e305-e316. 5. Soto-Perez-de-Celis E, Sun CL, Tew WP, Mohile SG, Gajra A, Klepin HD, Owusu C, Gross CP, Muss HB, Lichtman SM, Chapman AE, Cohen HJ, Dale W, Kim H, Fernandes S, Katheria V, Hurria A. Association between patient-reported hearing and visual impairments and functional, psychological, and cognitive status among older adults with cancer. Cancer. 2018 May 24. doi: 10.1002/cncr.31540. 6. Soto-Pérez de Celis E, Baez-Bagattela JA, Lira-Huerta E, Herrera de la Luz A, Parra-Cabrera S, Orihuela-Espina F, Pérez de Celis-Herrero MC. [Sensor-based mobile system for the promotion and real-time monitoring of physical activity]. Salud Publica Mex. 2018 Mar-Apr;60(2):119-120.

7. Cabrera-Galeana P, Soto-Perez-de-Celis E, Reynoso-Noverón N, Villarreal-Garza C, Arce-Salinas C, Matus-Santos J, Ramírez-Ugalde MT, Alvarado-Miranda A, Meneses-García A, Lara-Medina F, Torres-Dominguez J, Bargalló-Rocha E, Mohar A. Clinical characteristics and outcomes of older women with breast cancer in Mexico. J Geriatr Oncol. 2018 Apr 21. pii: S1879-4068(18)30149-8. doi: 10.1016/j.jgo.2018.04.003. *Co-first author status. 8. Soto-Perez-de-Celis E, Perez-Montessoro V, Rojo-Castillo P, Chavarri-Guerra Y. Health-Related Information-Seeking Behaviors and Preferences Among Mexican Patients with Cancer. J Cancer Educ. 2018 Jun;33(3):505-509. 9. Soto-Perez-De-Celis E, Kim H, Rojo-Castillo MP, Sun CL, Chavarri-Guerra Y, Navarrete-Reyes AP, Waisman JR, Avila-Funes JA, Aguayo Á, Hurria A. A pilot study of an accelerometer-equipped smartphone to monitor older adults with cancer receiving chemotherapy in Mexico. J Geriatr Oncol. 2018 Mar;9(2):145-151. 10. Loh KP, Soto-Perez-de-Celis E, Hsu T, de Glas NA, Battisti NML, Baldini C, Rodrigues M, Lichtman SM, Wildiers H. What Every Oncologist Should Know About Geriatric Assessment for Older Patients With Cancer: Young International Society of Geriatric Oncology Position Paper. J Oncol Pract. 2018 Feb;14(2):85-94. 11. Soto-Perez-de-Celis E, Cordoba R, Gironés R, Karnakis T, Paredero I, Chavarri-Guerra Y, Navarrete-Reyes AP, Avila-Funes JA. Cancer and aging in Ibero-America. Clin Transl Oncol. 2018 Feb 12. doi: 10.1007/s12094-018-1844-1.

NETHERLANDS NR: Johann Portielje

Research An increasing number of research groups in the country address cancer in elderly patients. All university hospitals now have team members that are involved in this research field. Several national scientific societies listed cancer and aging among their research priorities, which enables funding from governmental sources such as ZonMW. Leiden University and Maastricht University have instituted a chair in Geriatric Oncology within the field of medical oncology and epidemiology respectively. Nationally at least 10 PhD students wrote a thesis on cancer in elderly patients in the past year. Within the National breast cancer consortium the TOP (tailored treatment of older patients) consortium has initiated a prospective study of omission of radiotherapy in elderly patients with low risk breast cancer. The study has very good accrual. Prospective national studies in lung cancer (Eldapt study: Deciding through geriatric assessment on the optimal treatment strategy), colon cancer (Aspirin study: Adjuvant treatment (stages 2-3) with aspirin) and breast cancer (Climb study: prospective cohort study in early breast cancer). The national cancer foundation(KWF) and ZonMW have provided funds for studies of predictive geriatric markers in breast cancer (Portret study) and ovarian cancer(Gersoc study) Education Many educational conferences on cancer or cancer treatment have had geriatric oncology in the program. On the other hand, educational conferences on geriatrics often hold sessions on cancer. November 2017: the 7th National Symposium on Geriatric Oncology was organized by the foundation for Geriatric Oncology in the Netherlands (Gerionne) with 300 participants. Members of Gerionne contributed to many national symposia on cancer as well as programs of the national congress for oncology nurses. The institution of chairs in geriatric oncology in Leiden and Maastricht enables further development of courses in geriatric oncology in the medical studies and allied studies. Care Geriatric screening has been introduced nationwide in colorectal cancer care. Geriatric teams increasingly contribute in the multidisciplinary oncology teams and within geriatric teams, specialization on oncology gains popularity. In several hospitals treatment plans for frail elderly cancer patients are now made by dedicated geriatric oncology teams. At a national level several governmental and hospital organizations cooperate to improve individual treatment decisions in daily practice with the implementation of a care pathway that merges cancer pathways, geriatric and general health characteristic and shared decision making.

NEW ZEALAND NR: Cristian Hartopeanu

In saying that though I would like to inform everyone that here in NZ the following are happening:

At the annual RANZCR College meeting in August, GO will have prime time on agenda and there is a will for forming a national network; I will keep the group informed on the outcome;

In August as well, our first clinician that went overseas for a formal fellowship combining oncology and geriatrics will return to work with us.

He will attend the conference in Amsterdam.

SPAIN NR: Raul Cordoba

The Spanish Group of Geriatric Hematology (GEHEG) celebrated two meetings along the year, with one session slot to discuss about our participation in SIOG.

This year 2018, we are giving a travel grant to one GEHEG member to attend SIOG annual meeting after reviewing the abstracts sent for SIOG18.

We organized the 2nd Day of Geriatric Oncology & Hematology, with a final slide of SIOG.

R Cordoba (NR Spain) has included SIOG guidelines and SAVE THE DATE for SIOG18 in all his talks along 2018, including ASCO18 (June 2018), SEHH18 (October 2018) and Saudi Lymphoma Group Annual Meeting (September 2018).

R Cordoba organized a Preceptorship in Lymphoma at Fundacion Jimenez Diaz University Hospital, with a track fully dedicated to Geriatric Hematology, where SIOG guidelines were reviewed and workshops on CGA were conducted.

Members of the GEHEG are working in a book chapter on Geriatric Hematology, highlighting SIOG guidelines and recommendations.

SPAIN NR: Regina Girones

MEMBERS: The number of members ascribed to our group has increased from 50 at the end of 2017 to 74 actually I have tried to increase the number of Spanish SIOG members, although this is information that I do not have I have stimulated the attendant to TREVISO course, although it is really difficult to find financing. Although, I know that at least 3 persons had attended the course. I hope the participation on the next SIOG event 2018 for Spanish members will increase, as I have stimulate member to send abstracts for the meeting PUBLICATIONS:

1. Gironés Sarrió R1, Antonio Rebollo M2, Molina Garrido MJ3, Guillén-Ponce C4, Blanco R5, Gonzalez Flores E6, Saldaña J2; Spanish Working Group on Geriatric Oncology of the Spanish Society of Medical Oncology (SEOM). General recommendations paper on the management of older patients with cancer: the SEOM geriatric oncology task force's position statement. Clin Transl Oncol. 2018 Oct;20(10):1246-1251. doi: 10.1007/s12094-018-1856-x. Epub 2018 Apr 9.

2. Gironés R1, Morilla I2, Guillen-Ponce C3, Torregrosa MD4, Paredero I4, Bustamante E5, Del Barco S6, Soler G2, Losada B7, Visa L8, Llabrés E9, Fox B10, Firvida JL11, Blanco R12, Antonio M2, Aparisi F13, Pi-Figueras M8, Gonzalez-Flores E14, Molina-Garrido MJ15, Saldaña J2; Spanish Working Group on Geriatric Oncology of the Spanish Society of Medical Oncology (SEOM). Geriatric oncology in Spain: survey results and analysis of

the current situation. Clin Transl Oncol. 2018 Aug;20(8):1087-1092. doi: 10.1007/s12094-017-1813-0. Epub 2017 Dec 11.

3. Molina-Garrido MJ1, Guillén-Ponce C2, Blanco R3, Saldaña J4, Feliú J5, Antonio M6, López-Mongil R7, Ramos Cordero P8, Gironés R9; Working Group on Oncogeriatrics of the Spanish Society of Medical Oncology (SEOM). Delphi consensus of an expert committee in oncogeriatrics regarding comprehensive geriatric assessment in seniors with cancer in Spain. J Geriatr Oncol. 2018 Jul;9(4):337-345. doi: 10.1016/j.jgo.2017.11.012. Epub 2017 Dec 13.

4. Feliu J1, Heredia-Soto V2, Gironés R3, Jiménez-Munarriz B4, Saldaña J5, Guillén-Ponce C6, Molina-Garrido MJ7. Can we avoid the toxicity of chemotherapy in elderly cancer patients?. Crit Rev Oncol Hematol. 2018 Nov;131:16-23. doi: 10.1016/j.critrevonc.2018.08.008. Epub 2018 Aug 28.

5. Soto-Perez-de-Celis E1, Cordoba R2, Gironés R3, Karnakis T4, Paredero I5, Chavarri-Guerra Y6, Navarrete-Reyes AP7, Avila-Funes JA7,8. Cancer and aging in Ibero-America. Clin Transl Oncol. 2018 Sep;20(9):1117-1126. doi: 10.1007/s12094-018-1844-1. Epub 2018 Feb 12.

MEETINGS:

- II SPANISH NATIONAL EVENT ON GERIATRIC ONCOLOGY Valencia, 18th May 2018 - SPANISH SOCIETY OF MEDICAL ONCOLOGY MADRID: 25th -28th SEPTEMBER 2018:

- Oncogeriatric session - Meeting with the members of the Spanish Working Group on Geriatric Oncology

- XXX ADVANCED COURSE OF MEDICAL ONCOLOGY FOR FELLOWSHIPS: Madrid 15th July 2018 Elderly cancer patients: Is it worthy to treat them?

- 60 GERIATRICS AND GERONTOLOGY SPANISH SOCIETY MEETING Gran Canaria 12th-13th July 2018: Screening for elderly people: until when, for whom?

- ROYAL MEDICAL ACADEMY OF VALENCIA: Special Session: Cancer and Aging Valencia, 1th February 2018

- XII SEOM COURSE OF SYMPTOM CONTROL FOR FELLOWSHIPS: Valencia, 20th of January 2018 Special Session: the Elderly Cancer Patient

- ASOCAM GERIATRIC ONCOLOGY MEETING Madrid, 5th February 2018 - III GERIATRIC ONCOLOGY MEETING: Madrid 28th September 2018. With the attending and participation of Dr

Enrique Soto - II REUNION OF MEDICAL ONCOLOGY, HAEMATOLOGY, RADIOTHERAPY AND GERIATRICS: Madrid 14th

November 2018 OTHER ACTIVITIES: There has been an increase on Medical Oncology physicians that are involved on Geriatric Oncology, creating new units inside their hospitals Postgraduate and doctoral thesis based on Geriatric Oncology are now on going INVESTIGATION: CLINICAL TRIAL: Pembrolizumab in Elderly Patients With Advanced Lung Cancer. ClinicalTrials.gov Identifier: NCT03293680. On going

UNITED KINGDOM NR: Kwok-Leung Cheung

PROMOTING SIOG Appeal to join SIOG membership and to attend Annual Meeting in Warsaw in November 2017

a) Formal invitations were sent to the following national, regional and local organisations (May 2018):

- Association of Breast Surgery - British Association of Cancer Surgery - Royal College of Radiologists

- Association of Cancer Physicians - British Geriatrics Society (BGS) - British Society for Haematology - Expert Reference Group for Older People with Cancer - Royal College of Surgeons of England - Royal College of Surgeons of Edinburgh - NHS England (Central Midlands) - Derby Teaching Hospitals NHS Foundation Trust (surgeons, oncologists, gynaecological oncologists, palliative care physicians, cancer lead clinicians, geriatricians; including their trainees and allied health professionals in the

teams) b) Personal promotion to research collaborators in Hong Kong during and after an investigators meeting (March 2018)

INFLUENCING NATIONAL STAKEHOLDERS 1. I continue to serve as a member of the Expert Reference Group on Older People with Cancer, representing SIOG. 2. In response to my appeal in ‘Promoting SIOG’, I was invited to contribute an article on the ‘Relevance of geriatric oncology and SIOG’ in the summer issue of the newsletter of the Association of Breast Surgery – https://associationofbreastsurgery.org.uk/newsletter-articles/relevance-of-geriatric-oncology-and-siog-by-kwok-leung-cheung/ 3. While attending SIOG’s Treviso Advanced Course in Geriatric Oncology as a faculty member (June 2018), I grasped hold of the opportunity to connect with the students from the UK to discuss future strategies to promote geriatric oncology and SIOG in the UK. We have arranged to meet initially at the Annual Conference in Amsterdam. EDUCATION 1. 5th Symposium on Primary Breast Cancer in Older Women, hosted by the University of Nottingham, under the auspices of SIOG – Preparation is underway to be held on 1st March 2019. Details are available from www.nottingham.ac.uk/medicine/breastmeetings. RESEARCH 1. Within my host institution (University of Nottingham), I continue to lead a research programme on ‘Primary breast cancer in older women’ with three streams: a) biology and clinical outcome; b) geriatric assessment and psychosocial aspects; and c) cost effectiveness of therapeutic strategies. 2. I continue to be a collaborator in a national multicentre study – ‘Bridging the Age Gap in Breast Cancer – Improving outcomes for older women’, funded by National Institute for Health Research (NIHR), UK. 3. As the Chief Investigator of a study looking at geriatric assessment and quality of life in older women with primary breast cancer, I have expanded the study to include a centre at the University of Hong Kong Medical Centre following initial discussion in March 2018. The site has since been activated and started recruiting patients. I have also invited the local Principal Investigator to attend the Annual Conference in Amsterdam. SERVICES AT SIOG In addition to my NR role, I continue to serve as:

- Chairperson, Membership and National Representatives Committee - Member, Board - Member, Executive Committee

USA NR: Vicki Morrison

1. I have been, and continue to be, a member of the Cancer in the Older Adult Committee, of the Alliance for Clinical Trials in Cancer

2. As part of the Alliance Cancer in the Older Adult Committee, my manuscript on the impact of weight-based dosing on toxicities (grade 3/4 hematologic and non-hematologic toxicities) and outcome in a CALGB trial of

adjuvant breast cancer chemotherapy (CALGB 44907) in women > 70 yrs of age was recently published in JGO.

3. A manuscript delineating practice patterns of CLL therapy in an elderly national Veterans Healthcare system database of CLL patients has been drafted, with anticipated submission to JGO in the near future.

4. Additional manuscripts in preparation focusing on the elderly population include: a. In conjunction with the Chronic Disease Research Group, based at Hennepin County Medical Center

(Mpls MN), examination of a 20% Medicare (US) data base (2007-14) for practice patterns in the following NHL histologies: DLBCL, MCL, MZL

b. Examination of a Truven data base to examine initial therapies for DLBCL, specifically to delineate what alternative non-RCHOP regimens are being utilized, and in what specific populations

5. Facilitate presentations on cancer in elderly patients for Medicine Grand Rounds and Medicine Research Conference at my site (University of Minnesota/Hennepin County Medical Ctr, Minneapolis, MN).

6. Mentorship of University of Minnesota Hem/Onc fellows with geriatric oncology career interests. 7. Continue to be a member of the Cancer and Aging Research Group (CARG). 8. Under the auspices of the Alliance Cancer in the Older Adult Committee, examine the toxicities of older vs

younger DLBCL patients treated on CALGB 50303 (RCHOP vs dose-adjusted R-EPOCH).