sindrome isquemia reperfusion
DESCRIPTION
SIRTRANSCRIPT
7/21/2019 SINDROME ISQUEMIA REPERFUSION
http://slidepdf.com/reader/full/sindrome-isquemia-reperfusion 1/11
SINDROME ISQUEMIAREPERFUSION
LUISA FERNANDA BONILLA010150292008
JHON OXAL OLAYA 010150482007
7/21/2019 SINDROME ISQUEMIA REPERFUSION
http://slidepdf.com/reader/full/sindrome-isquemia-reperfusion 2/11
FISIOPATOLOGÍADE LA LESIÓNPOR ISQUEMIAREPERFUSIÓN
7/21/2019 SINDROME ISQUEMIA REPERFUSION
http://slidepdf.com/reader/full/sindrome-isquemia-reperfusion 3/11
7/21/2019 SINDROME ISQUEMIA REPERFUSION
http://slidepdf.com/reader/full/sindrome-isquemia-reperfusion 4/11
LA MITOCONDRIA Y LOS EFECTOS DELMETABOLISMO CELULAR DE LA ISQUEMIA
Y LA REPERFUSIÓN
PERIODOS DE ISQUEMIA
E !"#$!#" $% &#'() $*')&!+,
D% -) %-%&('#,%.)(!/!$)$%, -) &)$%,) $%%-%&('#,%"
,# )-(%')' -) % &)&!)),(!# !$),(%
RLO,%*(')-! )$#"
E !"#$!#" $% -)'.)
$*')&!+,D)3# %, "* *,!$)$ )') %-
(')," #'(% $% %-%&('#,%"
)& 6*-# $% "(%'%" $% A&%(!- C#A $!"6!,*&!+,
$%- P: !,(')&%-*-)' -! %')&!+, $% :!%''# ;%''#"#<F%=>? @ ;#'6)&!+, $% ')$!&)-%" -! '%" $% O2
:! # ),(!,)"Agotamiento deATP
7/21/2019 SINDROME ISQUEMIA REPERFUSION
http://slidepdf.com/reader/full/sindrome-isquemia-reperfusion 5/11
E" %&!%" $% # .%,# '%)&(!/#
E"(' " # !$)(!/#
%" %&!%" $% # .%,# '%)&(!/# <RLO?$%,('# $% -#" &*)-%" *,) $% -)" 6 " !6 #'(),(%"
%" %-SUPERÓXIDO
B) # O2 #' -) "* %'+ !$# $!"6!,*()")<SOD? '#$*&% %- 6 " %"() -% RLO %-
%'+ !$# $% :!$'+.%,# <H2O2?
$)3# %, -)" 6%6 '),)" &%-*-)'%" #'%'# !$)&!+,
$% -#" - !$#"
A&(!/)&!+, -%*&#&!()'!) @*!6!#() !"
7/21/2019 SINDROME ISQUEMIA REPERFUSION
http://slidepdf.com/reader/full/sindrome-isquemia-reperfusion 6/11
CITOQUINAS EICOSANOIDESACCION PRO INFLAMATORIA
IL 1 FNT P T LT
P E2
IL IL8
S%-%&(!,)" !,(%.'!,)"QQE78
*!6!#() !"
ICAM 1
RLO
APOPTOSISCELULAR
Proteínade !a eag"da#e$re%a&"e'ia(i)oten i*n%id A%%i*n o$re
+e"%o%ito
,a odi+ata%i*n
-ron%o%on tri%%i*n
FAP
7/21/2019 SINDROME ISQUEMIA REPERFUSION
http://slidepdf.com/reader/full/sindrome-isquemia-reperfusion 7/11
A'(%'!#-)" F')&)"# $% -)'%-) )&!+, $% -)
6*"&*-)(*') -!")NO<!,)&(!/)$#?
L%*&#&!(#")&(!/)$#"
)$:%'!$#"
C) !-)'%"!,&'%6%,(# $% -) -(')&!+, $% - *!$#:)&!) %- !,(%'"(!&!# @ $!"6!,*&!+, $%-) -* &) !-)' '#/#&)$) #' *,) !,)&!+, $% %$%6) $% -)" & -*-)"&) !-)'%" $% -) '%"!+, $% -#"-%*&#&!(#" )$:%'!$#" &#, # "!,
-) *%()" @ $%- )&*6*-# $% - *!$#!,(%'"(!&!)-G
,*-)" )$:%"!#,%" $% -%*&#&!(#" )- %,$#(%-!#@ "* 6!.')&!+, ('),"%,$#(%-!)-).'%.)&!+, $% -) *%()" -%*&#&!(#")&(!/)&!+, $% 6)"(#&!(#" @6)&'+;).#" % (')/)")&!+, $%)- 6!,) @ "# '%
(#$# "* %' '#$*&&!+, $% 6#- &*-)"# !$),(%"
7/21/2019 SINDROME ISQUEMIA REPERFUSION
http://slidepdf.com/reader/full/sindrome-isquemia-reperfusion 8/11
7/21/2019 SINDROME ISQUEMIA REPERFUSION
http://slidepdf.com/reader/full/sindrome-isquemia-reperfusion 9/11
7/21/2019 SINDROME ISQUEMIA REPERFUSION
http://slidepdf.com/reader/full/sindrome-isquemia-reperfusion 10/11
EL RESULTADO FINAL APOPTOSIS NECROSIS O AMBASK
E- " ,$'#6% $% '% %';*"!+, "% &)')&(%'! ) #' *,) ;#'6)
$% 6*%'(% &%-*-)'  !,)$) &)')&(%'! )$) #' -)"!6*-(),%!$)$ $% ,%&'#"!" @ ) # (#"!" %, %- &*)- &#% !"(%,*,) /)'!)$) .)6) $% %/%,(#" @ "%&*%-)" $%(%'6!,),(%" $%-) 6*%'(% &%-*-)'G
7/21/2019 SINDROME ISQUEMIA REPERFUSION
http://slidepdf.com/reader/full/sindrome-isquemia-reperfusion 11/11