Simulation of Interactions of Radiation with Biological Systems at the Cellular and DNA Level

Based on

Sponsored by Activity of

The concept of “dose” fails at cellular and DNA scales It is desirable to gain an understanding to the processes at all

levels (macroscopic vs. microscopic+cybernetic) Quantitative knowledge and strict user requirements

scientifically satisfying; may be used as feedback to experimentalists

Potential later connection to other than radiation-induced effects at the cellular and DNA level

Relevance for space: astronaut and airline pilot radiation hazards, biological experiments. Applications in radiotherapy, radiobiology, ...

Relevance

Solar flare electrons,protons, and heavy ions

Jovianelectrons

Solar flare neutronsand -rays

SolarX-rays

Galactic and extra-galacticcosmic rays

Induced emission

(Neutrinos)

Trapped particles

Anomalouscosmic rays

Relevance for space: astronaut and aircrew radiation hazards

Programme description

-based “sister” activity to the Geant4 Low-E e.m. Working Group. Follows rigorous software standards

ESA-sponsored + INFN official activity Simulation of nano-scale effects of radiation at the DNA level Multiple approaches (RBE parameterisation, detailed biochemical

processes, etc.) can be implemented with Geant4 Various scientific domains involved: medical, biology, genetics,

software engineering, high and low energy physics, space physics