Side effects of anti-TB medications HREZ

Isoniazid• Isoniazid-induced hepatitis-most common major

toxic effect• Peripheral neuropathy• CNS toxicity-memory loss, psychosis,seizures• Fever and skin rashes• Drug-induced SLE• Hematologic abnormalities• Provocation of pyridoxine deficiency anemia• Tinnitus• Gastrointestinal discomfort

Katzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 773

Rifampicin

• Orange urine, sweat and tears• Rashes• Thrombocytopenia• Nephritis• Light-chain proteinuria• Flu-like sydrome(fever, chills, myalgia, anemia

and thrombocytopenia)

Katzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 774

Ethambutol

• Retrobulbar neuritismost common serious adverse eventLoss of visual acuity and red-green color blindness

• Hypersensitivity syndrome consisting of cutaneous reaction (such as rash or exfoliative dermatitis)

• Fever and lymphadenopathy

http://www.drugs.com/sfx/ethambutol-side-effects.html

Katzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 774

Pyrazinamide

• Hepatotoxicity-major adverse effect• Nausea• Vomiting• Fever• hyperuricemia

Katzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 775

*Streptomycin

• Vertigo and hearing loss• nausea, vomiting• paresthesia of face• rash• fever• Urticaria• angioneurotic edema• eosinophilia

Katzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 775http://www.drugs.com/sfx/streptomycin-side-effects.html