shanmuganathan r, et al. proteomic signature of ... · shanmuganathan r, et al. proteomic signature...
TRANSCRIPT
Proteomic Signature of Intervertebral DiscsShanmuganathan R, et al.
https://doi.org/10.14245/ns.2040056.028www.e-neurospine.org
Supp
lem
enta
ry T
able
2. D
etai
led
list o
f 105
enric
hed
path
way
s fro
m S
TRIN
G (S
earc
h To
ol fo
r the
Ret
rieva
l of I
nter
actin
g G
enes
/Pro
tein
s) d
atab
ase
No.
Enric
hed
path
way
sTo
tal n
umbe
r of
pro
tein
s in
volv
edp-
valu
eG
ene s
ymbo
ls
1Ex
trac
ellu
lar m
atrix
org
aniz
atio
n37
8.90
E-24
A2M
, ACA
N, A
SPN
, BG
N, C
D47
, CO
L10A
1, C
OL1
1A2,
CO
L14A
1, C
OL1
5A1,
CO
L1A
1, C
OL1
A2,
CO
L2A
1, C
O-
L6A
1, C
OL6
A2,
CO
L6A
3, C
OM
P, D
CN, F
GA
, FG
B, F
GG
, FM
OD
, GD
F5, H
APL
N1,
HSP
G2,
HTR
A1,
LO
X, L
UM
, M
MP1
0, P
COLC
E, P
COLC
E2, P
PIB,
TH
BS1,
TIM
P1, T
NC,
TTR
, VCA
N, V
TN 2
ECM
pro
teog
lyca
ns18
9.26
E-16
ACA
N, A
SPN
, BG
N, C
OL1
A1,
CO
L1A
2, C
OL2
A1,
CO
L6A
1, C
OL6
A2,
CO
L6A
3, C
OM
P, D
CN, F
MO
D, H
APL
N1,
H
SPG
2, L
UM
, TN
C, V
CAN
, VTN
3In
tegr
in ce
ll su
rfac
e int
erac
tions
176.
49E-
14CD
47, C
OL1
0A1,
CO
L1A
1, C
OL1
A2,
CO
L2A
1, C
OL6
A1,
CO
L6A
2, C
OL6
A3,
CO
MP,
FGA
, FG
B, F
GG
, HSP
G2,
LU
M, T
HBS
1, T
NC,
VTN
4C
olla
gen
bios
ynth
esis
and
mod
ify-
ing
enzy
mes
131.
63E-
10CO
L10A
1, C
OL1
1A2,
CO
L14A
1, C
OL1
5A1,
CO
L1A
1, C
OL1
A2,
CO
L2A
1, C
OL6
A1,
CO
L6A
2, C
OL6
A3,
PCO
LCE,
PC
OLC
E2, P
PIB
5C
olla
gen
form
atio
n14
2.61
E-10
COL1
0A1,
CO
L11A
2, C
OL1
4A1,
CO
L15A
1, C
OL1
A1,
CO
L1A
2, C
OL2
A1,
CO
L6A
1, C
OL6
A2,
CO
L6A
3, L
OX,
PC
OLC
E, P
COLC
E2, P
PIB
6G
lyco
sam
inog
lyca
n m
etab
olism
124.
88E-
07AC
AN
, B3G
NT7
, BG
N, D
CN, F
MO
D, H
SPG
2, L
UM
, OG
N, O
MD
, PRE
LP, V
CAN
, XYL
T1 7
Kera
tan
sulfa
te d
egra
datio
n6
5.80
E-07
ACA
N, F
MO
D, L
UM
, OG
N, O
MD
, PRE
LP 8
Glu
cone
ogen
esis
50.
0005
4EN
O1,
GA
PDH
, PG
AM
2, P
GK1
, TPI
1 9
Form
atio
n of
the c
orni
fied
enve
lope
291.
66E-
24CD
SN, D
SG1,
DSP
, JU
P, KR
T1, K
RT10
, KRT
14, K
RT15
, KRT
16, K
RT17
, KRT
19, K
RT2,
KRT
33A
, KRT
4, K
RT5,
KR
T6A
, KRT
6B, K
RT6C
, KRT
72, K
RT73
, KRT
76, K
RT77
, KRT
78, K
RT79
, KRT
8, K
RT80
, KRT
84, K
RT9,
TG
M5
10Pl
atel
et d
egra
nula
tion
221.
04E-
16A
1BG
, A2M
, ALB
, AN
XA5,
APO
A1,
CD
109,
CLE
C3B,
CLU
, F13
A1,
FG
A, F
GB,
FG
G, H
RG, I
TIH
4, Q
SOX1
, SER
-PI
NA
1, S
ERPI
NG
1, T
F, TH
BS1,
TIM
P1, T
IMP3
, TTN
11Pl
atel
et ac
tivat
ion,
sign
allin
g an
d ag
greg
atio
n25
6.50
E-14
A1B
G, A
2M, A
LB, A
NXA
5, A
POA
1, C
D10
9, C
LEC3
B, C
LU, C
OL1
A1,
CO
L1A
2, F
13A
1, F
GA
, FG
B, F
GG
, HRG
, IT
IH4,
QSO
X1, R
ASG
RP2,
SER
PIN
A1,
SER
PIN
G1,
TF,
THBS
1, T
IMP1
, TIM
P3, T
TN12
Inna
te im
mun
e sys
tem
452.
71E-
13A
1BG
, ACT
G1,
AN
XA2,
ARG
1, C
1S, C
3, C
9, C
ALM
L5, C
ASP8
, CD
47, C
FB, C
FI, C
HI3
L1, C
LU, D
CD, D
SG1,
DSP
, FA
BP5,
FG
A, F
GB,
FG
G, F
LG2,
FTL
, GSN
, HBB
, HP,
HRN
R, JU
P, KR
T1, L
TF, L
YZ, M
IF, P
KM, P
LA2G
2A,
QSO
X1, R
ASG
RP2,
S10
0A1,
S10
0A8,
S10
0A9,
SER
PIN
A1,
SER
PIN
B1, S
ERPI
NG
1, T
NFA
IP6,
TTR
, VTN
13H
emos
tasis
341.
31E-
12A
1BG
, A2M
, ALB
, AN
XA2,
AN
XA5,
APO
A1,
CD
109,
CD
47, C
LEC3
B, C
LU, C
OL1
A1,
CO
L1A
2, F
13A
1, F
GA
, FG
B, F
GG
, HBB
, HBD
, HRG
, ITI
H4,
KIF
1B, M
IF, Q
SOX1
, RAS
GRP
2, S
ERPI
NA
1, S
ERPI
NA
5, S
ERPI
NC1
, SER
-PI
NE2
, SER
PIN
G1,
TF,
THBS
1, T
IMP1
, TIM
P3, T
TN14
Neu
troph
il de
gran
ulat
ion
291.
53E-
11A
1BG
, AN
XA2,
ARG
1, C
3, C
ALM
L5, C
D47
, CH
I3L1
, DSG
1, D
SP, F
ABP
5, F
LG2,
FTL
, GSN
, HBB
, HP,
HRN
R, JU
P, KR
T1, L
TF, L
YZ, M
IF, P
KM, Q
SOX1
, S10
0A8,
S10
0A9,
SER
PIN
A1,
SER
PIN
B1, T
NFA
IP6,
TTR
15D
egra
datio
n of
the e
xtra
cellu
lar m
a-tr
ix17
7.17
E-11
A2M
, ACA
N, C
OL1
0A1,
CO
L11A
2, C
OL1
4A1,
CO
L15A
1, C
OL1
A1,
CO
L1A
2, C
OL2
A1,
CO
L6A
1, C
OL6
A2,
CO
-L6
A3,
DCN
, HSP
G2,
HTR
A1,
MM
P10,
TIM
P116
Post-
tran
slatio
nal p
rote
in p
hos-
phor
ylat
ion
151.
94E-
10A
LB, A
POA
1, C
3, C
P, FG
A, F
GG
, MFG
E8, M
FI2,
QSO
X1, S
ERPI
NA
1, S
ERPI
NC1
, TF,
TIM
P1, T
NC,
VCA
N
17Im
mun
e sys
tem
573.
58E-
10A
1BG
, ACT
G1,
AN
XA1,
AN
XA2,
ARG
1, B
LMH
, C1S
, C3,
C9,
CA
1, C
ALM
L5, C
ASP8
, CD
47, C
FB, C
FI, C
HI3
L1,
CLU,
CO
L1A
1, C
OL1
A2,
CO
L2A
1, C
SF3R
, DCD
, DSG
1, D
SP, F
13A
1, F
ABP
5, F
GA
, FG
B, F
GG
, FLG
2, F
TL, G
SN,
HBB
, HP,
HRN
R, JU
P, KR
T1, L
TF, L
YZ, M
IF, M
SN, P
KM, P
LA2G
2A, Q
SOX1
, RAS
GRP
2, S
100A
1, S
100A
8,
S100
A9,
SER
PIN
A1,
SER
PIN
B1, S
ERPI
NG
1, T
IMP1
, TN
FAIP
6, T
NFR
SF11
B, T
TR, V
IM, V
TN
(Con
tinue
d to
the n
ext p
age)
Proteomic Signature of Intervertebral DiscsShanmuganathan R, et al.
https://doi.org/10.14245/ns.2040056.028 www.e-neurospine.org
No.
Enric
hed
path
way
sTo
tal n
umbe
r of
pro
tein
s in
volv
edp-
valu
eG
ene s
ymbo
ls
18A
ssem
bly
of co
llage
n fib
rils a
nd
othe
r mul
timer
ic st
ruct
ures
126.
15E-
10CO
L10A
1, C
OL1
1A2,
CO
L14A
1, C
OL1
5A1,
CO
L1A
1, C
OL1
A2,
CO
L2A
1, C
OL6
A1,
CO
L6A
2, C
OL6
A3,
LO
X,
PCO
LCE
19re
gula
tion
of in
sulin
-like
gro
wth
fa
ctor
tran
spor
t and
upt
ake b
y in
-su
lin-li
ke g
row
th fa
ctor
bin
ding
pr
otei
ns
151.
03E-
09A
LB, A
POA
1, C
3, C
P, FG
A, F
GG
, MFG
E8, M
FI2,
QSO
X1, S
ERPI
NA
1, S
ERPI
NC1
, TF,
TIM
P1, T
NC,
VCA
N
20D
iseas
es as
soci
ated
with
gly
cosa
mi-
nogl
ycan
met
abol
ism10
3.96
E-09
ACA
N, B
GN
, DCN
, FM
OD
, HSP
G2,
LU
M, O
GN
, OM
D, P
RELP
, VCA
N
21C
olla
gen
chai
n tr
imer
izat
ion
108.
43E-
09CO
L10A
1, C
OL1
1A2,
CO
L14A
1, C
OL1
5A1,
CO
L1A
1, C
OL1
A2,
CO
L2A
1, C
OL6
A1,
CO
L6A
2, C
OL6
A3
22D
evel
opm
enta
l bio
logy
371.
28E-
08AC
TG1,
AN
K2, C
DSN
, CO
L2A
1, C
OL6
A1,
CO
L6A
2, C
OL6
A3,
DSG
1, D
SP, H
2AFV
, JU
P, KR
T1, K
RT10
, KRT
14,
KRT1
5, K
RT16
, KRT
17, K
RT19
, KRT
2, K
RT33
A, K
RT4,
KRT
5, K
RT6A
, KRT
6B, K
RT6C
, KRT
72, K
RT73
, KRT
76,
KRT7
7, K
RT78
, KRT
79, K
RT8,
KRT
80, K
RT84
, KRT
9, M
SN, T
GM
523
Col
lage
n de
grad
atio
n11
1.37
E-08
COL1
0A1,
CO
L11A
2, C
OL1
4A1,
CO
L15A
1, C
OL1
A1,
CO
L1A
2, C
OL2
A1,
CO
L6A
1, C
OL6
A2,
CO
L6A
3, M
MP1
024
Form
atio
n of
fibr
in cl
ot (c
lotti
ng
casc
ade)
95.
04E-
08A
2M, F
13A
1, F
GA
, FG
B, F
GG
, SER
PIN
A5,
SER
PIN
C1, S
ERPI
NE2
, SER
PIN
G1
25D
efec
tive S
T3G
AL3
caus
es M
CT1
2 an
d EI
EE15
65.
33E-
08AC
AN
, FM
OD
, LU
M, O
GN
, OM
D, P
RELP
26Bi
ndin
g an
d up
take
of l
igan
ds b
y sc
aven
ger r
ecep
tors
95.
63E-
08A
LB, A
POA
1, C
OL1
A1,
CO
L1A
2, F
TL, H
BA1,
HBB
, HP,
HPX
27N
onin
tegr
in m
embr
ane-
ECM
inte
r-ac
tions
106.
87E-
08CO
L10A
1, C
OL1
1A2,
CO
L1A
1, C
OL1
A2,
CO
L2A
1, H
SPG
2, T
HBS
1, T
NC,
TTR
, VTN
28A
myl
oid
fiber
form
atio
n11
7.28
E-08
APC
S, A
POA
1, A
POA
4, F
GA
, GSN
, HSP
G2,
LTF
, LYZ
, MFG
E8, T
GFB
I, TT
R29
Def
ectiv
e CH
ST6
caus
es M
CD
C1
67.
93E-
08AC
AN
, FM
OD
, LU
M, O
GN
, OM
D, P
RELP
30D
efec
tive B
4GA
LT1
caus
es
B4G
ALT
1-C
DG
(CD
G-2
d)6
7.93
E-08
ACA
N, F
MO
D, L
UM
, OG
N, O
MD
, PRE
LP
31M
etab
olism
of c
arbo
hydr
ates
173.
11E-
07AC
AN
, B3G
NT7
, BG
N, D
CN, E
NO
1, F
MO
D, G
APD
H, H
SPG
2, L
UM
, OG
N, O
MD
, PG
AM
2, P
GK1
, PRE
LP, T
PI1,
VC
AN
, XYL
T132
Com
mon
pat
hway
of f
ibrin
clot
for-
mat
ion
73.
54E-
07F1
3A1,
FG
A, F
GB,
FG
G, S
ERPI
NA
5, S
ERPI
NC1
, SER
PIN
E2
33Sc
aven
ging
of h
eme f
rom
pla
sma
65.
80E-
07A
LB, A
POA
1, H
BA1,
HBB
, HP,
HPX
34Ke
rata
n su
lfate
bio
synt
hesis
71.
03E-
06AC
AN
, B3G
NT7
, FM
OD
, LU
M, O
GN
, OM
D, P
RELP
35Re
gula
tion
of co
mpl
emen
t cas
cade
82.
02E-
06C1
S, C
3, C
9, C
FB, C
FI, C
LU, S
ERPI
NG
1, V
TN36
Regu
latio
n of
TLR
by
endo
geno
us
ligan
d6
3.19
E-06
FGA
, FG
B, F
GG
, S10
0A1,
S10
0A8,
S10
0A9
37D
iseas
es o
f gly
cosy
latio
n11
9.04
E-06
ACA
N, B
GN
, DCN
, FM
OD
, HSP
G2,
LU
M, O
GN
, OM
D, P
RELP
, TH
BS1,
VCA
N
Supp
lem
enta
ry T
able
2. C
ontin
ued
(Con
tinue
d to
the n
ext p
age)
Proteomic Signature of Intervertebral DiscsShanmuganathan R, et al.
https://doi.org/10.14245/ns.2040056.028www.e-neurospine.org
No.
Enric
hed
path
way
sTo
tal n
umbe
r of
pro
tein
s in
volv
edp-
valu
eG
ene s
ymbo
ls
38Er
ythr
ocyt
es ta
ke u
p ox
ygen
and
re-
leas
e car
bon
diox
ide
47.
48E-
05CA
1, C
A2,
HBA
1, H
BB
39Pl
atel
et ag
greg
atio
n (p
lug
form
a-tio
n)6
8.18
E-05
COL1
A1,
CO
L1A
2, F
GA
, FG
B, F
GG
, RAS
GRP
2
40In
trin
sic p
athw
ay o
f fib
rin cl
ot fo
r-m
atio
n5
0.00
011
A2M
, SER
PIN
A5,
SER
PIN
C1, S
ERPI
NE2
, SER
PIN
G1
41A
tetr
asac
char
ide l
inke
r seq
uenc
e is
requ
ired
for G
AG
synt
hesis
50.
0002
2BG
N, D
CN, H
SPG
2, V
CAN
, XYL
T1
42Sy
ndec
an in
tera
ctio
ns5
0.00
022
COL1
A1,
CO
L1A
2, T
HBS
1, T
NC,
VTN
43Er
ythr
ocyt
es ta
ke u
p ca
rbon
dio
xide
an
d re
leas
e oxy
gen
40.
0002
4CA
1, C
A2,
HBA
1, H
BB
44Ap
opto
tic ex
ecut
ion
phas
e6
0.00
037
CASP
8, D
SG1,
DSP
, GSN
, HIS
T1H
1C, V
IM45
Sign
alin
g by
PD
GF
60.
0005
4CO
L2A
1, C
OL6
A1,
CO
L6A
2, C
OL6
A3,
TH
BS1,
TH
BS3
46A
ntim
icro
bial
pep
tides
70.
0007
6CL
U, D
CD, L
TF, L
YZ, P
LA2G
2A, S
100A
8, S
100A
947
Cro
sslin
king
of c
olla
gen
fibril
s4
0.00
08CO
L1A
1, C
OL1
A2,
LO
X, P
COLC
E48
Scav
engi
ng b
y cl
ass A
rece
ptor
s4
0.00
08A
POA
1, C
OL1
A1,
CO
L1A
2, F
TL49
Apop
totic
clea
vage
of c
ellu
lar p
ro-
tein
s5
0.00
082
CASP
8, D
SG1,
DSP
, GSN
, VIM
50M
etal
sequ
estr
atio
n by
antim
icro
bial
pr
otei
ns3
0.00
088
LTF,
S100
A8,
S10
0A9
51D
efec
tive B
4GA
LT7
caus
es E
DS,
pr
oger
oid
type
40.
0011
BGN
, DCN
, HSP
G2,
VCA
N
52D
efec
tive B
3GAT
3 ca
uses
JDSS
D-
HD
40.
0011
BGN
, DCN
, HSP
G2,
VCA
N
53D
efec
tive B
3GA
LT6
caus
es E
DSP
2 an
d SE
MD
JL1
40.
0011
BGN
, DCN
, HSP
G2,
VCA
N
54Si
gnal
ing
by re
cept
or ty
rosin
e ki-
nase
s15
0.00
13AC
TG1,
CIL
P, CO
L11A
2, C
OL1
A1,
CO
L1A
2, C
OL2
A1,
CO
L6A
1, C
OL6
A2,
CO
L6A
3, F
GFB
P2, H
SPB1
, JU
P, M
ST1,
TH
BS1,
TH
BS3
55D
efec
tive C
HST
3 ca
uses
SED
CJD
30.
0016
BGN
, DCN
, VCA
N56
Def
ectiv
e CH
ST14
caus
es E
DS,
m
uscu
loco
ntra
ctur
al ty
pe3
0.00
16BG
N, D
CN, V
CAN
57D
efec
tive C
HSY
1 ca
uses
TPB
S3
0.00
16BG
N, D
CN, V
CAN
58Re
tinoi
d m
etab
olism
and
tran
spor
t5
0.00
16A
POA
1, A
POA
4, H
SPG
2, R
BP4,
TTR
59In
tegr
in al
phaI
Ib b
eta3
sign
alin
g4
0.00
2FG
A, F
GB,
FG
G, R
ASG
RP2
Supp
lem
enta
ry T
able
2. C
ontin
ued
(Con
tinue
d to
the n
ext p
age)
Proteomic Signature of Intervertebral DiscsShanmuganathan R, et al.
https://doi.org/10.14245/ns.2040056.028 www.e-neurospine.org
No.
Enric
hed
path
way
sTo
tal n
umbe
r of
pro
tein
s in
volv
edp-
valu
eG
ene s
ymbo
ls
60D
erm
atan
sulfa
te b
iosy
nthe
sis3
0.00
29BG
N, D
CN, V
CAN
61M
ET ac
tivat
es P
TK2
signa
ling
40.
0031
COL1
1A2,
CO
L1A
1, C
OL1
A2,
CO
L2A
162
Cas
pase
-med
iate
d cle
avag
e of c
yto-
skel
etal
pro
tein
s3
0.00
35CA
SP8,
GSN
, VIM
63D
iseas
e24
0.00
39AC
AN
, ACT
G1,
ALB
, BG
N, C
P, D
CN, F
GA
, FG
B, F
GG
, FM
OD
, HSP
G2,
IPO
5, L
TF, L
UM
, OG
N, O
MD
, PRD
X1,
PRD
X2, P
RELP
, RBP
4, T
HBS
1, T
TR, V
CAN
, YW
HA
E64
GRB
2:SO
S pr
ovid
es li
nkag
e to
MA
PK si
gnal
ing
for I
nteg
rins
30.
0042
FGA
, FG
B, F
GG
65D
issol
utio
n of
fibr
in cl
ot3
0.00
42A
NXA
2, H
RG, S
ERPI
NE2
66C
ell-C
ell c
omm
unic
atio
n7
0.00
45AC
TG1,
AN
G, C
D47
, FLN
C, JU
P, KR
T14,
KRT
567
Cel
l jun
ctio
n or
gani
zatio
n6
0.00
45AC
TG1,
AN
G, F
LNC,
JUP,
KRT1
4, K
RT5
68C
S/D
S de
grad
atio
n3
0.00
47BG
N, D
CN, V
CAN
69p1
30C
as li
nkag
e to
MA
PK si
gnal
ing
for i
nteg
rins
30.
0047
FGA
, FG
B, F
GG
70Si
gnal
ing
by h
igh-
kina
se ac
tivity
BR
AF
mut
ants
40.
0051
ACTG
1, F
GA
, FG
B, F
GG
71Vi
sual
pho
totr
ansd
uctio
n6
0.00
55A
POA
1, A
POA
4, H
SPG
2, R
BP4,
RD
H8,
TTR
72G
lyco
lysis
50.
0064
ENO
1, G
APD
H, P
GA
M2,
PG
K1, T
PI1
73G
ene a
nd p
rote
in ex
pres
sion
by
JAK
-STA
T sig
nalin
g af
ter I
nter
leu-
kin-
12 st
imul
atio
n
40.
0065
AN
XA2,
CA
1, M
IF, M
SN
74M
AP2
K an
d M
APK
activ
atio
n4
0.00
7AC
TG1,
FG
A, F
GB,
FG
G75
Sign
alin
g by
mod
erat
e kin
ase a
ctiv
i-ty
BRA
F m
utan
ts4
0.00
7AC
TG1,
FG
A, F
GB,
FG
G
76Pa
rado
xica
l act
ivat
ion
of R
AF
sig-
nalin
g by
kin
ase i
nact
ive B
RAF
40.
007
ACTG
1, F
GA
, FG
B, F
GG
77Pl
asm
a lip
opro
tein
asse
mbl
y3
0.00
8A
2M, A
POA
1, A
POA
478
NC
AM
1 in
tera
ctio
ns4
0.00
85CO
L2A
1, C
OL6
A1,
CO
L6A
2, C
OL6
A3
79C
hond
roiti
n su
lfate
bio
synt
hesis
30.
0089
BGN
, DCN
, VCA
N80
TLR
casc
ades
70.
0099
CASP
8, F
GA
, FG
B, F
GG
, S10
0A1,
S10
0A8,
S10
0A9
81In
itial
trig
gerin
g of
com
plem
ent
30.
0113
C1S,
C3,
CFB
82A
ltern
ativ
e com
plem
ent a
ctiv
atio
n2
0.01
2C3
, CFB
Supp
lem
enta
ry T
able
2. C
ontin
ued
(Con
tinue
d to
the n
ext p
age)
Proteomic Signature of Intervertebral DiscsShanmuganathan R, et al.
https://doi.org/10.14245/ns.2040056.028www.e-neurospine.org
No.
Enric
hed
path
way
sTo
tal n
umbe
r of
pro
tein
s in
volv
edp-
valu
eG
ene s
ymbo
ls
83D
ereg
ulat
ed C
DK
5 tr
igge
rs m
ultip
le
neur
odeg
ener
ativ
e pat
hway
s in
Alz
heim
er d
iseas
e mod
els
30.
0123
PRD
X1, P
RDX2
, YW
HA
E
84Ap
opto
sis7
0.01
35CA
SP8,
DSG
1, D
SP, G
SN, H
IST1
H1C
, VIM
, YW
HA
E85
The c
anon
ical
retin
oid
cycle
in ro
ds
(twili
ght v
ision
)3
0.01
35RB
P4, R
DH
8, T
TR
86Si
gnal
ing
by R
AS
mut
ants
40.
0155
ACTG
1, F
GA
, FG
B, F
GG
87A
ctiv
atio
n of
C3
and
C5
20.
0185
C3, C
FB88
HD
L as
sem
bly
20.
0185
A2M
, APO
A1
89Te
rmin
al p
athw
ay o
f com
plem
ent
20.
0222
C9, C
LU90
Sign
alin
g by
BRA
F an
d RA
F fu
sions
40.
0225
ACTG
1, F
GA
, FG
B, F
GG
91Pl
asm
a lip
opro
tein
rem
odel
ing
30.
024
ALB
, APO
A1,
APO
A4
92H
DL
rem
odel
ing
20.
026
ALB
, APO
A1
93A
dher
ens j
unct
ions
inte
ract
ions
30.
0278
ACTG
1, A
NG
, JU
P94
Chy
lom
icro
n as
sem
bly
20.
0304
APO
A1,
APO
A4
95C
hylo
mic
ron
rem
odel
ing
20.
0304
APO
A1,
APO
A4
96Ve
sicle
-med
iate
d tr
ansp
ort
150.
0308
ACTG
1, A
LB, A
NK2
, APO
A1,
CO
L1A
1, C
OL1
A2,
FTL
, HBA
1, H
BB, H
P, H
PX, K
IF1B
, SER
PIN
A1,
TF,
YWH
AE
97Pl
asm
a lip
opro
tein
asse
mbl
y, re
-m
odel
ing,
and
clear
ance
40.
0318
A2M
, ALB
, APO
A1,
APO
A4
98In
terle
ukin
-4 an
d In
terle
ukin
-13
signa
ling
50.
0318
AN
XA1,
CO
L1A
2, F
13A
1, T
IMP1
, VIM
99D
etox
ifica
tion
of re
activ
e oxy
gen
spec
ies
30.
0332
PRD
X1, P
RDX2
, SO
D3
100
Apop
totic
clea
vage
of c
ell a
dhes
ion
prot
eins
20.
0338
DSG
1, D
SP
101
GP1
b-IX
-V ac
tivat
ion
signa
lling
20.
0338
COL1
A1,
CO
L1A
210
2Ty
pe I
hem
ides
mos
ome a
ssem
bly
20.
0338
KRT1
4, K
RT5
103
Reve
rsib
le h
ydra
tion
of ca
rbon
di-
oxid
e2
0.03
82CA
1, C
A2
104
Retin
oid
cycle
dise
ase e
vent
s2
0.03
82RB
P4, T
TR10
5G
alph
a (i)
signa
lling
even
ts10
0.04
99AG
T, A
NXA
1, A
POA
1, A
POA
4, C
3, H
SPG
2, IN
SL5,
RBP
4, R
DH
8, T
TR
ECM
, ext
race
llula
r mat
rix; T
LR, T
oll-l
ike r
ecep
tor;
GA
G, g
lyco
sam
inog
lyca
ns; P
DG
F, pl
atel
et-d
eriv
ed g
row
th fa
ctor
; ED
S, E
hler
s–D
anlo
s syn
drom
e; TP
BS, t
emta
my
prea
xial
bra
chyd
ac-
tyly
synd
rom
e; PT
K2,
pro
tein
tyro
sine k
inas
e 2; M
APK
, mito
gen-
activ
ated
pro
tein
kin
ase;
HD
L, h
igh-
dens
ity li
popr
otei
n.
Supp
lem
enta
ry T
able
2. C
ontin
ued