senile purpura: multiple purpuric macules idiopathic thrombocytopenic purpura: multiple petechiae on...

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Page 1: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm
Page 2: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm
Page 3: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm
Page 4: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm

Senile purpura:

Multiple purpuric macules

Page 5: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm
Page 6: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm

Idiopathic thrombocytopenic purpura:

Multiple petechiae on the arm

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Page 8: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm

Disseminated intravascular coagulation:

Extensive geographic cutaneous infarction on the forearm

Page 9: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm

Disseminated intravascular coagulation:

Extensive deep purple ecchymoses with

hemorragic blister formation

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Page 11: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm

Henoch-Schonlein purpura:

Multiple palpable deep purple macules on the extensor side of lower extremities and buttocks

Page 12: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm

Henoch-Schonlein purpura:

Small venules show fibrinoid necrosis with considerable red cell extravasation.

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Henoch-Schonlein purpura:

The DIF of IgA shows granular depositions at the papillary dermis.

Page 15: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm
Page 16: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm

Pityriasis lichenoides et varioliformis acuta :

Multiple erythematous papules on the back and buttocks

Page 17: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm

Pityriasis lichenoides et varioliformis acuta :

Multiple erythematous papules with necrotic and crusted lesions on the buttocks

Page 18: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm

Pityriasis lichenoides et varioliformis acuta :

Multiple erythematous papules with necrotic and crusted lesions on the buttocks

Page 19: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm

Pityriasis lichenoides et varioliformis acuta :

This view shows basal cell hydropic degeneration, moderate lymphohistiocytic infiltrate at the upper dermis and red cell extravasation.

Page 20: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm

Pityriasis lichenoides et varioliformis acuta :

This view shows mild spongiosis, basal cell hydropic degeneration, moderate lymphohistiocytic infiltrate at the upper dermis and red cell extravasation.

Page 21: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm
Page 22: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm

Pityriasis lichenoides chronica :

Multiple brownish-to-red scaly papules with and crusted lesions

Page 23: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm
Page 24: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm

Erythema elevatum diutinum :

Multiple erythematous nodules present on the back of the hand.

Page 25: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm

Erythema elevatum diutinum :

Multiple erythematous nodules present on the back of the hand.

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Erythema elevatum diutinum :

Multiple erythematous nodules present on the palm and fingers.

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Erythema elevatum diutinum :

Multiple erythematous nodules present on the palm and fingers.

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Sweet’s syndrome :

Erythematous, edematous plaques on the periorbital area with superficial tiny pustules .

Page 30: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm

Sweet’s syndrome :

Erythematous, edematous plaques on the neck with pustules and crusted lesions .

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Sweet’s syndrome :

The epidermis shows subcorneal pustulation. There are diffuse mixed cell infiltrates in the dermis.

Page 32: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm

Sweet’s syndrome :

The infiltrate consisted largely of neutrophils.

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Polyarteritis nodosa:

Several dermal and subcutaneous nodules on the back of the foot.

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Polyarteritis nodosa:

Several erythematous dermal and subcutaneous nodules with ulceration on the foot.

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Polyarteritis nodosa:

Necrotizing vasculitis is seen within the subcutaneous fat.

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Polyarteritis nodosa:

Necrotizing vasculitis is seen within the subcutaneous fat.

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Page 39: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm

Wegener’s granulomatosis:

Several erythematous-dark red ulcerating plaques and nodules on the foot.

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Wegener’s granulomatosis:

One erythematous-dark red ulcerating plaque with blister formation.

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Wegener’s granulomatosis:

Extensive necrotizing vasculitis is seen within the dermis with red cell extravasation.

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Wegener’s granulomatosis:

Close-up view shows necrotizing vasculitis with red cell extravasation.

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Wegener’s granulomatosis:

Nasal mucosa biopsy shows necrotizing vasculitis

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Page 46: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm

Wegener’s granulomatosis:

Transbronchial biopsy shows necrotizing vasculitis with extravascular granuloma formation.

Page 47: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm

Wegener’s granulomatosis:

Chest films shows cavitation on the right upper lobs.

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Dego’s syndrome:

Small white papules with central depression and white fine scaling.

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Dego’s syndrome:

There is hyperkeratosis with epidermal atrophy

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Dego’s syndrome:

There is hyperkeratosis with epidermal atrophy with ectatic vessels.

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Dego’s syndrome:

There is hyperkeratosis with epidermal atrophy. Note the ectatic vessels.

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Livedo reticularis:

A mottled violaceous discoloration of the skin in a net-like pattern.

Page 55: Senile purpura: Multiple purpuric macules Idiopathic thrombocytopenic purpura: Multiple petechiae on the arm

Livedo reticularis:

A mottled erythematous discoloration of the skin in a net-like pattern.

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Livedoid vasculitis: Multiple purpuric macules

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Livedoid vasculitis: Multiple purpuric macules

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Livedoid vasculitis: Punched-out ulcers are seen on the ankle

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Lymphomatoid granulomatosis: Multiple erythematous macules

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Lymphomatoid granulomatosis: Nodular to ulcerative cutaneous lesions

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Lymphomatoid granulomatosis: Nodular to ulcerative cutaneous lesions

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Lymphomatoid granulomatosis: Nodular lymphoid and/or granulomatous infiltration surrounding the vessels

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Lymphomatoid granulomatosis: Nodular lymphoid infiltration surrounding the vessles

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Purpura pigmentosa chronica: Multiple erythematous patches on the lower leg

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Purpura pigmentosa chronica: Scaly petechial or purpuric macules

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Acne vulgaris: Multiple erythematous papules and pustules

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Acne vulgaris: Multiple erythematous papules and pustules

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Steroid acne: Multiple erythematous papules and pustules

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Steroid acne: Multiple erythematous papules and pustules

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Neonatal: Multiple erythematous papules and pustules on a neonate

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Rosacea: Swollen nose with sebaceous gland hyperplasia and fibrosis

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Rosacea: Telangiectasia and erythema.

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Androgenic alopecia: Alopecia with the typical M-shape pattern

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Follicular muconosis: Acute form. Boggy plaques on the face.

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Follicular muconosis: Acute form. Boggy plaques on the face.

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Follicular muconosis: Mucin deposition in the follicles. Interfollicular cell infiltrate

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Follicular muconosis: Mucin deposition in the follicles. Interfollicular cell infiltrate

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Follicular muconosis: Mucin deposition in the follicles. Interfollicular cell infiltrate

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Relapsing polychondritis: Erythema, swelling, and pain of the cartilaginous portion of the ear

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Relapsing polychondritis: Loss of basophilic staining and breakdown of lacunar structure of the cartilage

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Relapsing polychondritis: Loss of basophilic staining and breakdown of lacunar structure of the cartilage

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Relapsing polychondritis: Breakdown of lacunar structure of the cartilage

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Eosinophilic pustular folliculitis: Erythematous plaque with superimposed coalescent pustules

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Eosinophilic pustular folliculitis: Erythematous plaque with superimposed coalescent pustules

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Eosinophilic pustular folliculitis: Microabscess composed of eosinophils

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Pityrosporum folliculitis: Pruritic eryhematous papules and pustules, primarily on the back, chest, and shoulders

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Pityrosporum folliculitis: Pruritic eryhematous papules and pustules, primarily on the back, chest, and shoulders

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Eosinophilic cellulitis: Recurrent painful or pruiritic plaques

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Eosinophilic cellulitis: Recurrent painful or pruiritic plaques with bullae

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Eosinophilic cellulitis: Recurrent painful or pruiritic plaques with bullae

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Eosinophilic cellulitis: Diffuse eosinophilic infiltrate throughout the dermis

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Eosinophilic cellulitis: Diffuse eosinophilic infiltrate throughout the dermis. Flame figures can be seen.