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1 Secrets and Features of major products in COTDE (Cosmeceutical To Dermatologists) 2006 THE INFORMATION PRESENTED IN THIS PLAN IS CONFIDENTIAL AND REMAINS THE EXCLUSIVE PROPERTY OF COTDE InC. THE INFORMATION CONTAINED HEREIN SHALL NOT BE COPIED, REPRODUCED, OR VERBALLY SHARED WITHOUT WRITTEN AUTHORIZATION FROM COTDE Inc.

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Page 1: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

1

Secrets and Features of major products

in COTDE(Cosmeceutical To Dermatologists)

2006

THE INFORMATION PRESENTED IN THIS PLAN IS CONFIDENTIAL AND REMAINS THE EXCLUSIVE PROPERTY OF COTDE InC. THE INFORMATION CONTAINED HEREIN SHALL NOT BE COPIED, REPRODUCED, OR VERBALLY SHARED WITHOUT WRITTEN AUTHORIZATION FROM COTDE Inc.

Page 2: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

2

1. ZYMOGEN DUAL ACTIVE C-SERUM- Anti-wrinkle & Whitening Serum

2. ZYMOGEN SPOT SERUM - Anti-Pigmentation

Page 3: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

3

ZYMOGENDual Active C-Serum

“Anti-wrinkle & Whitening Serum”

2x15ml/2x0.5FL.OZ

Bioconversion System

Sole & Perfect Solutionfor Vitamin-C

Page 4: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

4

ZYMOGEN Dual Anti-wrinkle & Whitening Serum

• Anti-wrinkle• Whitening effect• Rejuvenation of skin

Cosmetic Effects of Vitamin CBefore After 1 Year

Before After 1 Year

Page 5: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

5

ZYMOGEN Dual Anti-wrinkle & Whitening Serum

Issues of Vitamin C• Topical vitamin C must be in

the form of L-ascorbic acid to be useful to the body and skin. L-ascobic acid is unstable and tends to break down rapidly, that’s why it is so difficult to produce for cosmetic preparations.

Ascorbic acid-2-glucoside(AA2G)

Ascorbic acid (Vitamin-C)

AA-2G AA

StableReductive powerSkin penetration

No reductive powerNo skin penetration

Very Unstable

Page 6: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

6

ZYMOGEN Core Mechanism of “Int’l Patent”Bioconversion System (Patent # 100447533, 04-08-27)

( 15 ㎖ x 2 separate bottles with nozzles)

α-glucosidaseAscorbic acid-2-glucoside

(AA2G)

Mixing α-glucosidaseAA2G Cut Glucoside

Ascorbic acid (Vitamin-C)

Page 7: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

7

ZYMOGEN Core Mechanism of “Int’l Patent”

• The mutual bio-mechanism between AA2G as substrate and glucosidase as enzyme are activating each other to maximize the efficacy of Vitamin-C.

• Zymogen Dual Active C-Serum is the world 1st revitalization system product which is maximizing the efficacy of Vitamin-C.

• Gold Medal in Alternative Medicine Field at INPEX 2005 (Global Patent Exibition)

Page 8: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

8

ZYMOGEN Core Mechanism of AA2GCondition for Skin Penetration.

SizeHydrophobic-Hydrophilic Balance

Best Balance

AA-2G Vitamin C Glucose

Molecular weight 338.27 176.1 180.16

• Ref : Glucose is Hydrophilic

AA-2G has a glycosidic linkage at C2 of Vitamin-C. AA2G is a Vitamin-C analogue which linked with a glucose at C2-OH (Hydroxyl group of C2).

AA2G is produced by transferring a glucose from starch to a hydroxyl group of C2. A hydroxyl group of C2 is a functional group of Vitamin-C.

Page 9: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

9

Test Report for “AA2G to Ascorbic Acid (Vitamin-C)

Subject : Test of Bio-Conversion for AA2G to Ascorbic Acid.

Purpose : AA2G to Ascorbic Acid by “Glucose Enzyme”Test Institute : Korea Research Institute of

Bioscience and Biotechnology (KRIBB)Applicant : COTDE Inc.Date : December, 2004Test Method :

AsA Analysis : UV Detection by HPLCEnzyme Solution : measured AsA by HPLC for Enzyme ReactionConditions : under 33℃, 30 minutes after mixing

AA2G 2% with appropriate Enzyme.

Page 10: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

10

CONCLUSION of Test Report

KRIBB certified that More than 80% of AsA Bio-Conversion was confirmed after reaction of 2% AA2G with Amigase (Powder Enzyme).

KRIBB certified that More than 80% of AsA Bio-Conversion was confirmed after reaction of 2% AA2G with 7.5% Liquid Amigase (Liquid Enzyme).

Page 11: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

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CONCLUSION of Test Report (with Powder Enzyme)

0

10

20

30

40

50

60

70

80

90

100

1% 1.25% 1.50% 1.75% 2% 2.25% 2.50%

enzyme concentration(%)

Prod

uctio

n of

vit

C (%

) .

Page 12: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

12

CONCLUSION of Test Report (with Liquid Enzyme)

0

20

40

60

80

100

7.5% 10.0%Enzyme concentration (%)

Prod

uctio

n of

vit

C (%

) .

Page 13: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

13

Percutaneous Absorption of Vitamin-C (Previously Reported)Time (h) Whole Skin (㎍/㎠) Stripped Skin (㎍/㎠)

0 0 0

2 0 100

4 22 500

12 50 4100

24 150 7700

48 430 10300

72 1420 -

Vitamin-C 1.3% ConcentrationpH : About 2.8~3Vitamin-C is reported as good percutaneous absorption materials.

The absorption of Vitamin-C reach to Steady State after 4 hour’s lag.After 40 hours, percutaneousabsorption is very sharply increased because Horny Layer is changed by Vitamin-C.

Whole Skin Profile

0

200

400

600

800

1000

1200

1400

1600

0 20 40 60 80

Time (h)

Q (

㎍/㎠

)

Page 14: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

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ZYMOGEN Dual Anti-wrinkle & Whitening Serum

• Active ascorbic acid (AA; vitamin C) by enzymatic bioconversion from ascorbic acid-2-glucoside(AA-2G) : Over 80% conversion in 30 minute.

• Stable in the form of AA-2G during storage• Patented proprietary technology (The only enzymatic bioconversion cosmetics)• Dual action of vitamin C for anti-wrinkle and whitening effect• Synergic anti-wrinkle effect of vitamin and adenosine• Dramatic diminish of wrinkle line• Enhanced efficacy by the combination with patches, packs, or iontophoretic system• Registered as functional cosmetics by KFDA• No skin irritation : can be used after peeling or laser therapy• No preservatives• No pigment• Usage : 1~2 times per day (For daytime use, sun-cream is essential.)

Features & Secrets

Page 15: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

15

ZYMOGEN Dual Anti-wrinkle & Whitening Serum

Features• An innovative & unique revitalization system (two

components : Substrate + Enzyme) for anti-wrinkle and whitening skin which have his own international patent.

• They are separated in two different airless cells before use, inone cell in active form of substrates, in the other cell, Enzymeactivator. When they contact each other after pumping out, Actives are created directly on the skin by enzymes and then penetrate into the skin more easily, do work more effectively.

• Sole and perfect solution to solve the existing Vitamin-C’s weak points by taking advantage of AA2G’s strong points.( 15 ㎖ x 2 )

Page 16: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

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ZYMOGEN Dual Anti-wrinkle & Whitening Serum

( 15 ㎖ x 2 )

EfficacyAnti-wrinkle and Whitening skin & face

IngredientsAscorbyl glucosidase, Arbutin, Adenosine, Amyloglucosidaseand and etc.

How to use• Use evening daily. Apply to wrinkle or hyper-pigmented lesions

after mixing two thoroughly on your palm.

• Avoid direct contact with eyes. Store refrigerated.

Page 17: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

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Comparisons with Competitors in the world

Item Obagi SkinCeuticals SkinMedica Laroche Posay COTDE

Price $120~$150 $150~$250 $100~$200 $100~$200 To be determined

Main Market Dermatology, Esthetics

Dermatology, Esthetics

Dermatology, Esthetics Dermatology No restrictions

Discoloration generally generally generally generally Absolutely Not

Preservatives Yes Yes Yes Yes No

Skin Penetration High High High High Very High

Effective Ingredients

Vitamin A, CHydroquinone

Vitamin C, ECollagen

Vitamin A, C, E Vitamin C AA2G>Vitamin C, Arbutin>HQ

Core Technology N/S N/S N/S N/S Bio-Conversion

MechanismPatent No No No No Yes

Stability No No No No Yes

Irritation Yes Yes Yes Yes No

* N/S : Nothing Special

Page 18: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

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ZYMOGENSpot Serum“Whitening Serum”

2x15ml/2x0.5FL.OZ

Bioconversion System

Innovative Ideal Solution for Whitening

Page 19: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

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ZYMOGEN SPOT SERUM : Anti-Pigmentation

Features• An innovative & unique revitalization system (two

components : Substrate + Enzyme) for whitening skin which has been registered as a internationally patented article (Patent number is 100389983)

• They are separated in two different airless cells before use, inone cell in active form of substrates, in the other cell, Enzymeactivator. When they contact each other after pumping out, Actives are created directly on the skin by enzymes and then penetrate into the skin more easily, do work more effectively.

( 15 ㎖ x 2 )

Page 20: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

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ZYMOGEN SPOT SERUM : Anti-Pigmentation

EfficacyWhitening skin and face

IngredientsArbutin, Amyloglucosidase, CM-5complexs, Retinyl palmitate, Lactic acid, Glycyrrhizic acid and etc.

How to use• After cleansing, push the nozzle part down to make two fluids to

be pumped out separately on the palm or on the back of the hand,mix them to bring one (substrate) into contact with the other (enzyme) and then apply as a thin layer on the pigmented region.

• This may be applied night and day. If applied it during the day time, follow with a sun protection skin care (SPF 15 or greater) or make-up product.

( 15 ㎖ x 2 )

Page 21: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

21

ZYMOGEN SPOT SERUM (ZSS) for Whitening

Issues of Hydroquinone• More than 4% concentration should require a prescription from Medical Doctor

in the U.S. market• Any concentration is prohibited as cosmetic preparations in Korea.• Very unstable and easy to discoloration.• High irritation

Arbutin Hydroquinone

Strong Points

Weak Points

Stable Very Effective

No so very effectiveVery UnstableDiscolorationIrritation

• No irritation by Time-Lag Bio Conversion System (80% within 30 minutes)

Page 22: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

22

ZYMOGEN Core Bio-Mechanism of “Int’l Patent”Bioconversion System (Patent # 100389983, 03-06-20)

( 15 ㎖ x 2 separate bottles with nozzles)

β-glucosidaseArbutin

Mixing β-glucosidaseArbutinCut Glucoside

Hydroquinone

Page 23: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

23

ZYMOGEN Core Bio-Mechanism of “Int’l Patent”

• Zymogen Spot Serum is the world 1st

revitalization system product which is maximizing the efficacy of whitening skin.

• The mutual bio-mechanism between arbutin as substrate and glucosidase as enzyme are activating each other to maximize whitening skin.

Page 24: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

24

Introduction of COTDE

(Cosmeceutical To Dermatologists)

2006

THE INFORMATION PRESENTED IN THIS PLAN IS CONFIDENTIAL AND REMAINS THE EXCLUSIVE PROPERTY OF COTDE Inc. THE INFORMATION CONTAINED HEREIN SHALL NOT BE COPIED, REPRODUCED, OR VERBALLY SHARED WITHOUT WRITTEN AUTHORIZATION FROM COTDE Inc.

Page 25: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

25

Business Domain

Active Ingredients

Cosmeceuticals

Page 26: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

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Introduction

• Since 2000, COTDE has produced functional cosmetics;

- Anti-Pigmentaion- Anti-Aging- Anti-Atopy- Anti-Acne- Anti-irritation products.- Anti-Dandruff- Sun-Protection- Hair Care

• COTDE has created brands for each distribution channel;

- Zymogen- Atoma- Gatz- Gluric- Ciracle- Zymex and so on

Page 27: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

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Characteristics of COTDE Products

Cosmeceutical & Pharmaceutical products

Products containing clinically proven ingredients with test data

No adverse side-effects

Bio-compatible products

55

Page 28: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

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Company History (1)

2006• Feb Patent of ‘Anti-Viral and Composition of it’ in Korea (#0552462, 06-02-08)• Jan Patent of Anti-Pigmentation in China (# ZL 01 8 20075.3, 2006-1-11).

2005• Oct Start to supply L/RRFF for Leucocide (Anti-bacterial & Anti-viral Feed

Supplements)• Jun Gold Medal in INPEX 2005 (Int’l Patent Exibition – USA).

Registered ‘Leuconostoc / Radish Root Ferment Filtrate (L/RRFF)’ from Kimchiin CTFA as cosmetic ingredients for natural preservatives.

• May Appointed as Special Export Company by Chung-Nam Provincial Government.• Apr New “Ciaracle” market to Hyundai Home Shopping Channel• Mar KFDA Approval for “Ciracle”• Jan Contract with Korean Military for Supply of Cosmetics

2004• Sep ISO9001 (#DKQ-5178) 1st Cosmeceuticals company in Korea • Jul Asia sole licensing & manufacturing agreement with Dr. Niwa (Japan) Products • Jan Selected in Components & Materials Project by Ministry of

Commerce, Industry and Energy (MOCIE) for natural preservatives.

Page 29: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

29

Company History (2)

2003• Oct Start sales of Anti-Pigmentation (Mela-X) at LG Home Shopping TV.• Jun Patent of Anti-Pigmentation in Korea. Applied in USA, EU, Japan & China• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA.

2002• Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer.

Start Export to Japan (Hydro Gel Products). • Aug Zymogen, Anti-Aging (Redox-C) to Market (Dermatology).

2001• Oct Anti-Atopy series to market (Dermatology and Pediatrics).• Jan Applied patent for natural Vitamin-C, Anti-Dandruff, Whitening Skin, • Apr Moisturizing using, Whitening Skin (Using Arbutin and Enzyme)

2000• Sep GATZ (for Acne), GLURIC (for Anti-Irritation) to Market (Dermatology).

Page 30: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

30

Business Model

R&D Expert and Patent Marketing(CRO : Contract Research Organization)

IntegrativeCosmeceuticals

Research & Company

InnovativeCosmeceuticalsProductsBusiness

New CreativeCosmeceuticals

MaterialBusiness

Page 31: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

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Products CategoryFinished Products

Raw MaterialsAnti-Pigmentation

[ZYMOGEN,…]

Anti-Acne[GATZ,…]

Anti-Atopy[ATOMA,…]

Anti-Aging[REDOX,…]

Anti-Irritation[GLURIC,…]

Anti-Dandruff[OVALIGY,…]

Sun Protection[Stosun,…]

Cosmeceuticals Hair Care[OVALYN,…]

Sun Protection[MELTIO,…]

Natural Preservatives[KIMCHISIN,…]

Page 32: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

32

Products Road Map

To MarketTo Market

• ZYMOGEN (Anti-Pigmentation,Anti-Aging, Sun-Block)

• REDOX-C (Anti-Aging)• COTDE ™ (Hydorogel Sheet)• ATOMA® (Anti-Atopy)• GATZ® (Anti-Acne)• GLURIC® (Anti-Irritation)• AROMAZYME®(Enzyme Cleanser)• Luecidal (Natural Preservatives)

DevelopingDeveloping

• Anti-Dandruff• Anti-Aging Ingredients

• Immunity Controller

• Tanning

PlanningPlanning

‘2004 at present

Page 33: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

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Competitive

R&D CapabilityBest researchers in Korea and Co-R&D system with Seoul National Univ.

Advanced TechnologyWorld 1st and International Patents (WO 02/05547A1)New creative & innovative products series

Quality GuaranteeMarket share #1 in Korean dermatologists Proved in quality as export to Japan

Price Competitiveness

Meet Clients’ All NeedsOEM/ODM/CRO/CMS to meet all customers’ needs

Page 34: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

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Target Market

I. Dermatological ClinicsIn KOREA[ 2001~ ]

Active Ingredients[2000 ~ ]

II. Homeshopping in KOREA [2003 ~ ]

Global Cosmetic Active Ingredients Market

[2005 ~ USA, Japan ]

III. Global Cosmeceuticals Market [2005 ~ Japan Market ]

Page 35: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

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Production Capability in House

Daily Production Capability- 10,000 bottles per 8 hours

Monthly Production Capability - 200,000 per 1 shift (20 working days basis) - Three shifts possible

Page 36: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

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Patents Status (1/2)

County Subject Date of Application Application #

Date of Registratio

nReg. #

USA Patents

Skin whitening composition containing arbutin and glucosidase as active ingredients

2003-05-09 10/416,311

EU Patents

Skin whitening composition containing arbutin and glucosidase as active ingredients

2003-07-14 1273212.9

EUPatents

Antibody against Pityrosprorum 2003-10-10 2718674.1

JapanPatents

ァルブンおよグルコシダ-ゼを有効成分としてする美白製

2003-06-09 PT2002-555783

ChinaPatents

Skin whitening composition containing arbutin and glucosidase as active ingredients

2003-06-05 1820075.3 206-01-11 ZL 01 8 20075.3

China Patents

Anti pityrosporum ovale igy and its uses

2003-10-14 2808231.1

Page 37: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

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Patents Status (2/2)County Subject Date of

Application Application #Date of

Registration

Reg. #

KoreaPatents

Anti-Viral and Composition of it 2005-06-28 10-2005-0065888 2006-02-08 0552462

KoreaPatents

Anti-Aging with Skin whitening 2003-05-30 10-2003-0034873 2004-08-27 100447533

KoreaPatents

Sample Packaging 2003-04-01 10-2003-0020339 2005-03-14 100478424

KoreaPatents

Natural preservatives – Kimchisin 2004-02-21 10-2004-0011695

KoreaPatents

New sun-protection with new manufacturing process

2003-03-29 10-2003-0019787

KoreaPatents

Anti-Dandruff using antibody of dandruff 2001-04-14 10-2001-0020004 2004-08-24 100446856

KoreaPatents

Skin whitening composition containing arbutin and glucosidase as active ingredients

2001-01-10 10-2001-0001236 2003-06-20 100389983

New Design PT

Sample Packaging 2003-03-31 20-2003-0009602 2003-09-23 200328666

KoreaPatents

Skin immunizing products inc. extracts of new catabolism

2001-09-24 10-2001-0058922

KoreaPatents

Costmeceuticals using extracts from Ellipsoidea

2001-05-02 10-2001-0023640

KoreaPatents

External skin care products using malts 2001-04-02 10-2001-0017390

Page 38: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

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Government R&D Projects

# Leader Co. in R&D

ParticipantsR&D Co. Subjects Periods Amount

(USD) PJT Name

1 COTDEInc.

COTDE Inc., Seoul National University

Natural Preservativesusing Korean KimChi

2003.12.01 ~2006.11.30

648,000 Components & Materials Development PJTBy MOCIE

2 COTDEInc.

COTDE Inc. Cosmeceuticalssample vessel

2003.8.1 ~ 2004. 7. 31

117,000 New Tech & Innovation PJT By SMBA

3 COTDEInc.

COTDE Inc. Lee & Joe Inc.Biotech Inc.

Anti-Dandruff 2001.8.1 ~ 2002.7.31

158,000 Components & Materials Development PJTBy MOCIE

4 COTDEInc.

COTDE Inc. New Skin Whitening

2001.7.1 ~2002.6.30

119,000 New Tech Incubation PJT By MOCIE

5 TegoScience

Tego ScienceCOTDE Inc.BIoTherm

Skin cell mass production technologyfor In vitrouse

2001.11.1 ~2003.10.31

830,000 Components & Materials Development PJTBy MOCIE

Page 39: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

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ODM/OEM & Own Business-2006

55

Page 40: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

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ODM Case-A : Home Shopping TV

Brand : Mela-XProducts : Depigmenting Special program (10 Kinds) Client : Arumdaunnara Inc. ( www.anacli.co.kr )R&D and Patents : COTDE INC. (#100389983, 2003-06-20)Channel : Home Shopping TVRef : The Best Seller on GS Home Shopping since 2003.

Page 41: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

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ODM Case-B (1/2) : On-Line Mall

Brand : RojukissProducts : Special Treatment Program against Acne

and relatives (Cleanser, Peeling and …. 30 Kinds)Client : Rojukiss Inc. ( www.rojukiss.co.kr )R&D and Patents : COTDE INC.Channel : On-Line Shopping Mall specialized in CosmeceuticalsRef : The Biggest On-Line Mall in ACNE fields since 2002.

Special Treatment program against Acne

Page 42: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

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ODM Case-B (2/2) : On-Line Mall

Cleanser Peeling Moisturizing program

Soothing programDepigementing Antiaging Sun protection

Page 43: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

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ODM Case-C : Aesthetic Shop

Brand : OrjadeProducts : Special Skin Treatment Program

(Cleanser, Whitening, Soothing, Vitamin and …. 25 Kinds)Client : Aro Cosmetics Co. Ltd. ( www.aronet.co.kr )R&D and Patents : COTDE INC.Channel : Aesthetic Shop Ref : Market Share #1 in This Fields since 2005.

250 ml ~ 500 ml

Page 44: Secrets and Features of major products in COTDE• May Certified as Cosmeceuticals for Anti-Pigmentation by KFDA. 2002 • Dec Set-Up Cheonan-Factory and registered as Cosmetics Manufacturer

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OEM/ODM Case-etc : Distributors

Brand : Project Owner’s PB (Private Brand)Products : About 200 Kinds of CosmeceuticalsClient : Cosmetic Distributors, Dermatology and so on.R&D with Patents: COTDE INC.Channel : All Cosmeceuticals Market

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Own Brand : COTDE

Brand : Zymogen, Atoma, GATZ, GLURIC 등Products : Depimenting, Anti-Aging, Anti-Atopy, Anti-Acne,

Anti-IrritationClient : Our Own Channel ( www.cotde.co.kr ) Channel : Dermatology R&D and Patents : COTDE INC.Ref : Market Share #1 in This Fields since 2003.

Depigmenting

Anti-Atopy Anti-IrritationAnti-Acne

Anti-Aging

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COTDE Brand in Details 2006( Our Own Brand)

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Anti-Aging & Anti-Wrinkle : Redox-C

Feature

Redox-C is pure Vitamin-C 10% stabilized products in the form of serum by our own hi-technology which is most suitable for the skin to maximize the effect of anti-aging, anti-wrinkle, anti-oxidation , whitening and skin-revitalization. This is manufactured to be hypoallergenic by ideally mixing-up with our own developed A-O Complex.

Efficacy

Anti-Wrinkle, Antioxidant, Whitening Skin and Skin Protection.

Ingredients

Vitamin C 10% ( L-Ascorbic acid), Retinol, Vitamin E (Tocopherol), Rose-extract and etc

How to use

Morning and Night, use the serum sufficiently on the part of the skin which you want to be anti-wrinkle and to be whitened.

( 20 ㎖ )

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Moisturizing and Atopy Products

Efficacy of AtomaEfficacy of Atoma Selection of Atoma

Supply Anti-Evapo possession

Continuance

Control

Soothing serum

Moisture

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Anti-Atopy : Atoma Soothing SerumFeature

The Atopy Soothing Serum is the optimum epoch-making products which alleviate the skin trouble such as flame red blazer, itching symptoms which is caused on the sensitive skin, dry skin and atopy skin.

Efficacy

Very effective and efficient to relax or pacify the trouble or the itching symptoms.

Ingredients

New Catabolism Extracts (Patent # 10-2001-0058922), Phytosphingosine, Beta-glucan , chamomile extract, Ursolic acid and etc

How to use

Use serum with pat on the skin after cleansing. You would better use it softly on the skin which has some serious trouble or itching symptoms in it. It is effective to use on the part of which is caused by using other cosmetics on the skin of trouble or itching symptoms.

( 60 ㎖ )

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Anti-Atopy : Atoma Essence

FeatureIt is the optimized skin-care essence which prevents the development of any atopy skin. It also alleviates any inflammation or any itching symptoms thanks to the addition of COTDE’s prescription for the immunity adjustment element and the optimization of the living organism which is stabilized among horny cells by the system of a surface active agent. The horny cell fat is nano-sized into the refreshing skin-care layout. It is truly fresh because any active agent is not used as an production material at all.

EfficacyVery effective and efficient in severe atopy skin.

IngredientsLecithin, Ceramide, Cholesterol, Phytosphingosine, Oleic acid, Rosehips oil, Lactic acid and etc

How to useEffect and efficiency by using the essence on the whole part of your face or on the specific part of troubled skin. Ingredients of ceramide is fast effective and efficient to cure or improve the skin of trouble

( 60 ㎖ )

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Anti-Atopy : Ceramide Cream

FeatureIt is the cream which revitalizes the cell wall of the atopy skin. It maintains an suitable moisture in the skin and also prevents any itching symptoms thanks to the addition of COTDE’s prescription for the immunity adjustment element and the optimization of the living organism which is stabilized among horny cells by the system of a surface active agent. Only the natural oils such as squalene and rose hips are used in the production of the cream.

EfficacyIt maintains the atopy skin or dry skin very moist and soft.

IngredientsSqualane, Vitamin E acetate, Lecithin, Ceramide and etc

How to useUse in spread with the suitable quantity of cream very softly and evenly. You will find it very effective and efficient to recover the skin of the atopy trouble if you use it constantly and continuously

( 60 ㎖ )

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Anti-Atopy : Ceramide Body Lotion

FeatureThis lotion includes the natural substances of natural horny cell fat, various natural moistening factor (NMF), skin fat ( Serum), natural oils such as squalene & rose hips. The lotion is used to maintain suitable moisture and to improve gradually the atopy skin thanks to the ingredients of the composition materials because the lotion includes the natural substance of horny cell to cell fat, various natural moistening factors, skin fat ( Serum), Natural oils such as squalene and rose hips.

EfficacyThe natural substance of squalene and rose hips oil keeps your skin soft and moist.

IngredientsLecithin, Ceramide, Sqalane, Vitamin E acetate and etc

How to useUse in spread and softly on your skin several times a day after having a shower and wiping your body cleanly. You can use it on your face just in the same way as you use other lotion. You can keep your skin soft and moist if you use it just before you use Atoma Ceramide.

( 100 ㎖ )

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Anti-Acne : GATZ SolutionFeatureThis is the cosmetics to cure or improve the boring and pimpled skin because it contains the material of medicinal efficacy which is prescribed into the optimum concentration of coping with the primary pathological factors which have caused the breakout of the acne in the face. It restores your skin to the normal one thanks to its ability to secret and regulate the skin fat. ZN derivative and Licorice extracts are contained into the constituents of the cosmetics. These substances have the tendency to secrete and regulate the skin fat. Also, there is AHA, which is contained in it. This acts to remove the existing chitin and keratin and new one. You will get the normal skin back on the basis of the new chitin and keratin.It is also assigned to prevent any bacterial contamination and inflammation in itthanks to such the anti-pimple germs as Triclosan and tea tree oils and the anti-inflammation element, Scutellaria.

EfficacyThis is very efficacious in curing the pimples skin, boring head-skin and also improving the inflammation of spore bag of the skin cell.

IngredientsGlycolic acid, Salicylic acid, Dipotassium glycyrrhizinate, Licorice ext., Tea tree oil, Zinc PCA, Triclosan and etc

How to useUse it 1~2 times a day after washing your face. You are recommended to use UV sun protection cream when you go out doors.

( 20 ㎖ )

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Anti-Acne : GATZ EmulsionFeatureIt is a cosmetics to cure or improve tedious or pimpled skin because it contains the medicinally efficacious element. The prescription for the optimum concentration of the medicinal efficacy is done to cope with the primary pathological factors which are causing the breakout of the pimples in the face. It will cure your skin until you get the normal skin in your face back thanks to the ability of the substance to secrete and regulate the skin fat. ZN-derivative and Licorice extracts are used as the raw material of the cosmetics because they are very efficacious in treating the fat skin. Also, AHA is acting to produce new chitin and keratin after removing the existing one. This is why you will get back your normal skin after you use it continuously. Triclosan and tea tree oils are also used as the raw material of the cosmetics because they are working against the breakout of the pimple in the face and the extracts of Scutellaria is also contained to prevent any bacterial contamination and inflammation.

EfficacyIt is very efficacious against the occurrence of the pimple in the face. It also works against the tediousness and contamination of the skin.

IngredientsGlycolic acid, Azelaic acid, Retinyl palmitate, Licorice ext., Tea tree oil, Zinc PCA, Triclosanand etc

How to useYou may use it 1~2 times a day after you use the GATZ solution in advance.You should use UV Sun Protection Cream when you go out of doors.

( 20 ㎖ )

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Anti-Irritation : GLURIC Sol

FeatureThis has been developed as the results of the comparative analysis of the dryness and itchiness and the overview of the wide range of skin tranquilizing materials available. It is a good anti-inflammatory cosmetics which can replace the steroid inthe future. The cosmetics acts to tranquilize the skin in which you got some troubleafter you treated the pimple there or you took other medicine or cosmetics or youreceived a laser treatment there. You can tranquilize the skin by plastering theGLURIC on it continuously.

Efficacy1. The efficacy of curing the injury is proved2. The efficacy of anti-inflammation by Licorice acid and Ursolic acid3. The effect of alleviating the stimulus of skin and tranquilizing the allergy.

Ingredientsβ-1,3-Glucan, Chamomile ext., Ursolic acid, Dipotassium glycyrrhizinate and etc.

How to useUse it continuously several times a day. You may use it before having a makeup or you

can use it as the after-sun care. It is very efficacious in case of sensitive skin, skinstimulus, skin spasm, inflammation, skin dryness, inflammation caused by other cosmetics and the after-shaving flare. The effect of tranquilization is very good even when you use it after you received a laser treatment.

( 20 ㎖ )

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Anti-Irritation : GLURIC LotionFeatureThis is the anti-inflammation and anti-itching cosmetics which has been developed to replace steroid in the future according to the prescription for the medicinal material for the tranquilization of skin trouble. The tranquilizer material has been chosen on the basis of the results of both the analysis of skin dryness and itchiness and the wide ranged materials of tranquilizer. You can plaster it on the sensitive skin, the inflammated skin of atopic character, itchiness, the skin to skin contagious inflammation and other eczema such as stimulant inflammation. You can tranquilize the skin which is in trouble or alleviate a spasm or a stimulus which is occurred in the skin by plastering it on the relevant part of the skin when you have the trouble after having treated the pimples or when the keratin is appeared on the skin after you took medicine.

Efficacy1. Efficacy to cure injury 2. Efficacy of anti-inflammation of Licorice and Ursolic acid 3. Glucan’s efficacy to alleviate stimulus of the skin and to tranquilize the allergy

Ingredientsβ-1,3-Glucan, Centella asiatica ext., Stearyl glycyrrhetinic acid , Ursolic acid, Bisabolol and etc

How to useUse it continuously several times a day. You may use it before having a makeup or you can use it as the after-sun care. It is very efficacious in case of sensitive skin, skin stimulus, skin spasm, inflammation, skin dryness, inflammation caused by other cosmetics and the after-shaving flare. The effect of tranquilization is very good even when you use it after you received a laser treatment.

( 20 ㎖ )

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Sun Screen – Oil-Free UV Protector

Extremely lightweight formula offers SPF30 protection from sun'sUVA/UVB rays.

High level, daily sun protection for all skins, especially acne skin.

No glossiness and stickiness.

Available for makeup-base.

With bacteria-killing Pine Pollen Extract, aloe extract and hyaluronic acidprotect irritated skin.

Oil-Free, non-acnegenic.

Type : Cream Container : Tube with individual paper caseCapacity : 60 ml Brand : Buyer’s Brand

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Clinic Hair Conditioner (1/2) – Feature

ClinicHair

Conditioner

Keep Water Effect Balancing Effect

Conditioning Effect

Protection Effect

Aroma Therapy

Clinic Hair Conditioner is to keeps water and to protect for damaged hair as it contains LPP ingredients which include plenty of natural Amino Acid.

Glossy and Elastic Hair by hair conditioning effect coming from including cation polymer, water soluble silicon and ceramide.

Balancing Effect to Hair & Head Skin by natural moisturizing ingredients.

Rest and Peace to Body & Spirit by aroma therapy coming from natural herb Lavender and musk woody flavor.

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Clinic Conditioner (2/2) – Major Ingredients

Oat Protein : To protect damaged hair by plenty of Amino Acid and Protein. Also acting as cleanser without soap makes hair clean and soft

Wheat Protein : Moisturizing and Softening hair by forming membrane in surface of hair. It also have lots of Amino Acid and Protein.

Lavender Oil : Rest and Peace to Body & Spirit by functioning ofanti-allergy, anti-inflammation, balancing, energy supplying andAnti- Irritation. It also is facilitating Cell-Growth and Restoration.

Ceramide : Cell Balancing Effect by deeply supplying various kinds of water with well-nourished factors to hair and skin in head. It effects to skin in head by cell protection membrane of Ceramide.

Type : CreamContainer : Tube with individual paper caseCapacity : 150 ml for individual / 240 ml for Shop

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TG Perm (1/2) – Feature

Forming Strong Curl and Wave

TGPerm Glossy and Elastic

Hair EffectAroma Therapy

Effect

TG Perm is Expert Wave Products with which you could finish the permanent in fast time. It is forming the strong Curl and Wave.

Attractive and Glossy Wave Forming by providing with natural moisturized factors and well-nourished ingredients by natural extracts such as Amino Acid which is similar in hair’s protein contents.

Rest and Peace to Body & Spirit by aroma therapy coming from natural herb Lavender and musk woody flavor.

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TG Perm (2/2) – Major Ingredients

Mono Ethanolamine : As non-volatile alkaline ingredients, its swelling is very strong but no smelling comparing with ammonia.

Oat Protein : To protect damaged hair by plenty of Amino Acid and Protein. Also acting as cleanser without soap makes hair clean andsoft

Wheat Protein : Moisturizing and Softening hair by forming membrane in surface of hair. It also have lots of Amino Acid and Protein.

Lavender Oil : Rest and Peace to Body & Spirit by functioning of anti-allergy, anti-inflammation, balancing, energy supplying and Anti-Irritation. It also is facilitating Cell-Growth and Restoration.

Type : I and II Container : Bottle Type without individual paper caseCapacity : I (400 ml) + II (400 g) Usage : For Beauty Shop

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Contact Points

Company Name : COTDE Inc.

Home Page : www.cotde.com

HQ/R&D Center / Factory : 2F Seangsankwan, CTP Cheonan-Valley,43-5, Sameun-Ri, Jiksan-Eup, Cheonan-City,Chungchengnam-Do 330-816, Korea Tel : 041-587-1365, 1375 / Fax : 041-587-1376E-Mail : [email protected]