score: sum of three nuclear features (each 0 or · nuclear score: sum of three nuclear features...
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Nuclear features:
Nuclear score: Sum of three nuclear features (each 0 or 1)Thus, total score will vary between 0 and 3
Absent/insufficiently expressed (0) Present/Sufficient (1)
Slight changes not sufficient to call “present”
1) Size and Shape• Enlargement• Elongation• Overlapping
2) Membrane Irregularities• Irregular contours• Grooves• Intranuclear cytoplasmic
inclusions
3) Chromatin Features• Chromatin clearing• Margination to nuclear
membrane• Glassy nuclei
Criteria and examples for scoring nuclear features
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Case A8
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Case A26
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Case A27
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Case A29
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Case A35
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Case A36
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Case A37
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Case A38
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Case A41
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Case A43
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Case A46
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Case A47
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Case A52
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Case A56
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Case A58
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Case A59
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Case A60
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Case A62
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Case A73
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Case A79
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Case A80
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Case A102
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Case A111
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Case A120
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Case A121
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Case A126
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Case A127
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Case A128
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Case A134
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Case A136