scopus - irep.iium.edu.myirep.iium.edu.my/63090/2/63090_the need for restructuring the... · scopus...

Scopus

Document details

1 of 1

The Need for Restructuring the Disordered Science of Amorphous Drug Formulations (Review) (Open Access)

, ,

Department of Pharmacy, Uppsala University, Uppsala Biomedical Centre, P.O. Box 580, Uppsala, SwedenKulliyyah of Pharmacy, International Islamic University Malaysia, Jalan Istana, Bandar Indera Mahkota, Pahang,

Malaysia

AbstractThe alarming numbers of poorly soluble discovery compounds have centered the efforts towards finding strategies toimprove the solubility. One of the attractive approaches to enhance solubility is via amorphization despite the stability

issue associated with it. Although the number of amorphous-based research reports has increased tremendously after

year 2000, little is known on the current research practice in designing amorphous formulation and how it has

changed after the concept of solid dispersion was first introduced decades ago. In this review we try to answer the

following questions: What model compounds and excipients have been used in amorphous-based research? How

were these two components selected and prepared? What methods have been used to assess the performance of

amorphous formulation? What methodology have evolved and/or been standardized since amorphous-based

formulation was first introduced and to what extent have we embraced on new methods? Is the extent of research

mirrored in the number of marketed amorphous drug products? We have summarized the history and evolution of

amorphous formulation and discuss the current status of amorphous formulation-related research practice. We also

explore the potential uses of old experimental methods and how they can be used in tandem with computational tools

in designing amorphous formulation more efficiently than the traditional trial-and-error approach. © 2017, The

Author(s).

Reaxys Database Information

Author keywordsamorphous solid dispersion computational tools crystallization dissolution stability

Indexed keywords

EMTREE drug terms: excipient

EMTREE medicalterms:

dispersion drug formulation drug research drug solubility drug storage

drug synthesis medical literature methodology priority journal Review simulation

Funding details

Funding number Funding sponsor Acronym Funding opportunities

Funding number Funding sponsor Acronym Funding opportunities

638965 European Research Council ERC

3309 Vetenskapsrådet VR

◅ Back to results

Export Download Print E-mail Save to PDF ⋆ Add to List ▻More...

View at Publisher

Pharmaceutical ResearchVolume 34, Issue 9, 1 September 2017, Pages 1754-1772

Edueng, K.ab Mahlin, D.a Bergström, C.A.S.a

a

b

View references (191)

⬈See opportunities by ERC

⬈See opportunities by VR

PlumX MetricsUsage, Captures, Mentions,Social Media and Citationsbeyond Scopus.

Metrics

4 Citations in Scopus

80th Percentile

1.21 Field-Weighted

Citation Impact

Cited by 4 documents

, (2018) International Journal ofPharmaceutics

, ,

(2018) Molecular Pharmaceutics

, ,

(2018) Journal of PharmaceuticalSciences

Inform me when this documentis cited in Scopus:

Related documents

▻View all metrics

Computational prediction ofdrug solubility in water-basedsystems: Qualitative andquantitative approaches used inthe current drug discovery anddevelopment setting

Bergström, C.A.S. Larsson, P.

Investigation of Drug-ExcipientInteractions in BiclotymolAmorphous Solid Dispersions

Schammé, B. Couvrat, N.Tognetti, V.

Development of a NovelAmorphous AgomelatineFormulation With ImprovedStorage Stability and EnhancedBioavailability

Barmpalexis, P. Grypioti, A.Vardaka, E.

View all 4 citing documents

▻Set citation alert

▻Set citation feed

https://www.scopus.com/home.uri?zone=header&origin=searchbasic

https://www.scopus.com/results/results.uri?sort=plf-f&src=s&st1=The+Need+for+Restructuring+the+Disordered+Science+of+Amorphous+Drug+Formulations&st2=&sid=088bcfe5d952f3ba87ef989e352f8991&sot=b&sdt=b&sl=95&s=TITLE-ABS-KEY%28The+Need+for+Restructuring+the+Disordered+Science+of+Amorphous+Drug+Formulations%29&offset=1&origin=recordpage

https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1007%2fs11095-017-2174-7&locationID=1&categoryID=4&eid=2-s2.0-85019909487&issn=07248741&linkType=TemplateLinking&year=2017&zone=outwardlinks&origin=recordpage&dig=64374a42b1b41f7a7d7329445c6f20e4&recordRank=

https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1007%2fs11095-017-2174-7&locationID=1&categoryID=4&eid=2-s2.0-85019909487&issn=07248741&linkType=ViewAtPublisher&year=2017&origin=recordpage&dig=0ebad7420b42e7c4add1da7123c3ed2d&recordRank=

https://www.scopus.com/sourceid/21123?origin=recordpage

https://www.scopus.com/authid/detail.uri?authorId=56017477300&eid=2-s2.0-85019909487



mailto:[email protected]

https://www.reaxys.com/sc-linking/xs/citations/71742179?view=substances&md5=e74cb0e0b2a867a02786087b7ec88113

https://www.mendeley.com/research-funding/501100000781/opportunities?dgcid=scopus_referral_fundingacknowledgement

https://www.mendeley.com/research-funding/501100004359/opportunities?dgcid=scopus_referral_fundingacknowledgement

https://www.scopus.com/standard/help.uri?topic=12031

https://www.scopus.com/record/display.uri?origin=citedby&eid=2-s2.0-85042213543&citeCnt=4&noHighlight=false&sort=plf-f&src=s&st1=The+Need+for+Restructuring+the+Disordered+Science+of+Amorphous+Drug+Formulations&st2=&sid=088bcfe5d952f3ba87ef989e352f8991&sot=b&sdt=b&sl=95&s=TITLE-ABS-KEY%28The+Need+for+Restructuring+the+Disordered+Science+of+Amorphous+Drug+Formulations%29&relpos=0

https://www.scopus.com/authid/detail.uri?origin=citedby&authorId=7004918607&zone=










https://www.scopus.com/search/submit/citedby.uri?eid=2-s2.0-85019909487&src=s&origin=recordpage

https://www.scopus.com/alert/form/document.uri?eid=2-s2.0-85019909487&ATP=document&discoveryEngineID=scopusdoccite&discoveryEventID=NEW&mode=C&AID=NEW&origin=recordpage&view=extended

https://www.scopus.com/results/rss/handler.uri?citeEid=2-s2.0-85019909487

References (191)

Funding textThis work was supported by the European Research Council Grant 638965 and the Swedish Research Council Grant2014?3309.

Simonelli, A.P., Mehta, S.C., Higuchi, W.I.

(1969) Journal of Pharmaceutical Sciences, 58 (5), pp. 538-549. . doi: 10.1002/jps.2600580503

Mayersohn, M., Gibaldi, M.


Bates, T.R.

(1969) Journal of Pharmacy and Pharmacology, 21 (10), pp. 710-712. . doi: 10.1111/j.2042-7158.1969.tb08159.x

Goldberg, A.H., Gibaldi, M., Kanig, J.L., Mayersohn, M.


MULLINS, J.D., MACEK, T.J.

(1960) Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 49, pp.245-248. .

Sekiguchi, K., Obi, N.

(1961) Chemical and Pharmaceutical Bulletin, 9 (11), pp. 866-872. . doi: 10.1248/cpb.9.866

ISSN: 07248741CODEN: PHREESource Type: JournalOriginal language: English

DOI: 10.1007/s11095-017-2174-7Document Type: ReviewPublisher: Springer New York LLC

▻View in search results format

All Export Print E-mail Save to PDF Create bibliography

View all 191 references

1

Dissolution Rates of High Energy Polyvinylpyrrolidone (PVP)‐SulfathiazoleCoprecipitates

Cited 244 times

View at Publisher

2

New method of solid‐state dispersion for increasing dissolution rates

Cited 77 times

View at Publisher

3

Dissolution characteristics of reserpine‐polyvinylpyrrolidone co‐precipitates

Cited 35 times

View at Publisher

4

Increasing dissolution rates and gastrointestinal absorption of drugs via solid solutionsand eutectic mixtures IV: Chloramphenicol—urea system

Cited 95 times

View at Publisher

5

Some pharmaceutical properties of novobiocin.

Cited 87 times

View at Publisher

6

Studies on Absorption of Eutectic Mixture. I. A Comparison of the Behavior of EutecticMixture of Sulfathiazole and that of Ordinary Sulfathiazole in Man

Cited 507 times

View at Publisher

, (2017) European Journal ofPharmaceutics andBiopharmaceutics

(2017) Journal of PharmaceuticalSciences

, ,

(2015) International Journal ofPharmaceutics

Find more related documents inScopus based on:

Glass-forming ability ofcompounds in marketedamorphous drug products

Wyttenbach, N. Kuentz, M.

Predicting the CrystallizationPropensity of Drug-LikeMolecules

Hancock, B.C.

Physical stability of drugs afterstorage above and below theglass transition temperature:Relationship to glass-formingability

Alhalaweh, A. Alzghoul, A.Mahlin, D.

View all related documents basedon references

▻Authors ▻Keywords

https://www.scopus.com/search/submit/references.uri?sort=plf-f&src=r&imp=t&sid=2e7cff686eef93ce6df25b0925341116&sot=rec&sdt=citedreferences&sl=23&s=EID%282-s2.0-85019909487%29&origin=recordpage&citeCnt=1&citingId=2-s2.0-85019909487

https://www.scopus.com/search/submit/references.uri?sort=plf-f&src=r&imp=t&sid=2e7cff686eef93ce6df25b0925341116&sot=rec&sdt=citedreferences&sl=23&s=EID%282-s2.0-85019909487%29&origin=recordpage&citeCnt=1&citingId=2-s2.0-85019909487

https://www.scopus.com/record/display.uri?eid=2-s2.0-0014515660&origin=reflist&sort=plf-f&src=s&st1=The+Need+for+Restructuring+the+Disordered+Science+of+Amorphous+Drug+Formulations&st2=&sid=088bcfe5d952f3ba87ef989e352f8991&sot=b&sdt=b&sl=95&s=TITLE-ABS-KEY%28The+Need+for+Restructuring+the+Disordered+Science+of+Amorphous+Drug+Formulations%29&recordRank=

https://www.scopus.com/search/submit/citedby.uri?eid=2-s2.0-85019909487&refeid=2-s2.0-0014515660&src=s&origin=reflist&refstat=core

https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1002%2fjps.2600580503&locationID=3&categoryID=4&eid=2-s2.0-0014515660&issn=15206017&linkType=ViewAtPublisher&year=1969&origin=reflist&dig=193680d568eb75f38bad8d6ce52d1d74&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1002%2fjps.2600551138&locationID=3&categoryID=4&eid=2-s2.0-0013966747&issn=15206017&linkType=ViewAtPublisher&year=1966&origin=reflist&dig=b63dcb20a5bdcb0fd99eb06604aa0be7&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1111%2fj.2042-7158.1969.tb08159.x&locationID=3&categoryID=4&eid=2-s2.0-0014592643&issn=20427158&linkType=ViewAtPublisher&year=1969&origin=reflist&dig=15dbe3615dae57c95c45bd3680d53780&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1002%2fjps.2600550610&locationID=3&categoryID=4&eid=2-s2.0-0013920636&issn=15206017&linkType=ViewAtPublisher&year=1966&origin=reflist&dig=ba5c81d0b9804d8ce21ad372d520f973&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=http%3a%2f%2fdx.doi.org%2f10.1002%2fjps.3030490417&locationID=3&categoryID=4&eid=2-s2.0-0000829230&issn=&linkType=ViewAtPublisher&year=1960&origin=reflist&dig=5b17fabcee7f580fd371b16bc5f3683f&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1248%2fcpb.9.866&locationID=3&categoryID=4&eid=2-s2.0-85008071016&issn=13475223&linkType=ViewAtPublisher&year=1961&origin=reflist&dig=94f6f7d251c499c0e84b21940d480664&recordRank=

https://www.scopus.com/record/display.uri?origin=recordpage&zone=relatedDocuments&eid=2-s2.0-84999122184&citeCnt=4&noHighlight=false&sort=plf-f&src=s&st1=The+Need+for+Restructuring+the+Disordered+Science+of+Amorphous+Drug+Formulations&st2=&sid=088bcfe5d952f3ba87ef989e352f8991&sot=b&sdt=b&sl=95&s=TITLE-ABS-KEY%28The+Need+for+Restructuring+the+Disordered+Science+of+Amorphous+Drug+Formulations%29&relpos=0

https://www.scopus.com/authid/detail.uri?origin=recordpage&authorId=56635689300&zone=relatedDocuments








https://www.scopus.com/search/submit/mlt.uri?eid=2-s2.0-85019909487&src=s&all=true&origin=recordpage&method=ref&zone=relatedDocuments

https://www.scopus.com/search/submit/mlt.uri?eid=2-s2.0-85019909487&src=s&all=true&origin=recordpage&method=aut&zone=relatedDocuments

https://www.scopus.com/search/submit/mlt.uri?eid=2-s2.0-85019909487&src=s&all=true&origin=recordpage&method=key&zone=relatedDocuments

Chiou, W.L., Riegelman, S.


Chiou, W.L., Riegelman, S.


Forster, A., Hempenstall, J., Rades, T.

(2001) Journal of Pharmacy and Pharmacology, 53 (3), pp. 303-315. . doi: 10.1211/0022357011775532

Forster, A., Hempenstall, J., Tucker, I., Rades, T.

(2001) International Journal of Pharmaceutics, 226 (1-2), pp. 147-161. . doi: 10.1016/S0378-5173(01)00801-8

Forster, A., Hempenstall, J., Rades, T.

(2003) Pharmazie, 58 (11), pp. 838-839. .

Allesø, M., Chieng, N., Rehder, S., Rantanen, J., Rades, T., Aaltonen, J.

(2009) Journal of Controlled Release, 136 (1), pp. 45-53. . doi: 10.1016/j.jconrel.2009.01.027

Laitinen, R., Lobm̈ann, K., Strachan, C.J., Grohganz, H., Rades, T.

(2013) International Journal of Pharmaceutics, 453 (1), pp. 65-79. .

doi: 10.1016/j.ijpharm.2012.04.066

7

Pharmaceutical applications of solid dispersion systems

Cited 1319 times

View at Publisher

8

Preparation and dissolution characteristics of several fast‐release solid dispersions ofgriseofulvin

Cited 229 times

View at Publisher

9

Characterization of glass solutions of poorly water-soluble drugs produced by meltextrusion with hydrophilic amorphous polymers

Cited 145 times

View at Publisher

10

Selection of excipients for melt extrusion with two poorly water-soluble drugs bysolubility parameter calculation and thermal analysis

Cited 219 times

View at Publisher

11

Comparison of the Gordon-Taylor and Couchman-Karasz equations for prediction ofthe glass transition temperature of glass solutions of drug and polyvinylpyrrolidoneprepared by melt extrusion

Cited 8 times

12

Enhanced dissolution rate and synchronized release of drugs in binary systemsthrough formulation: Amorphous naproxen-cimetidine mixtures prepared bymechanical activation

Cited 106 times

View at Publisher

13

Emerging trends in the stabilization of amorphous drugs

Cited 152 timeswww.elsevier.com/locate/ijpharm

View at Publisher



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1002%2fjps.2600600902&locationID=3&categoryID=4&eid=2-s2.0-0015124656&issn=15206017&linkType=ViewAtPublisher&year=1971&origin=reflist&dig=3c0556a7fe7cbfeb809cd2867430b7dd&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1002%2fjps.2600581218&locationID=3&categoryID=4&eid=2-s2.0-0014628768&issn=15206017&linkType=ViewAtPublisher&year=1969&origin=reflist&dig=2d7b40622f36ec27c02fe6666c888abc&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1211%2f0022357011775532&locationID=3&categoryID=4&eid=2-s2.0-0035095847&issn=00223573&linkType=ViewAtPublisher&year=2001&origin=reflist&dig=79e2d24afcc89b6c414bef343867525e&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1016%2fS0378-5173%2801%2900801-8&locationID=3&categoryID=4&eid=2-s2.0-0035845751&issn=03785173&linkType=ViewAtPublisher&year=2001&origin=reflist&dig=d8fc05a1828c96aa819c5a3487019b6e&recordRank=





https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1016%2fj.jconrel.2009.01.027&locationID=3&categoryID=4&eid=2-s2.0-67349087395&issn=01683659&linkType=ViewAtPublisher&year=2009&origin=reflist&dig=2f0a3a6f912e8b5a545d9ed7e35df4f2&recordRank=



https://www.scopus.com/record/www.elsevier.com/locate/ijpharm

https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1016%2fj.ijpharm.2012.04.066&locationID=3&categoryID=4&eid=2-s2.0-84884160394&issn=18733476&linkType=ViewAtPublisher&year=2013&origin=reflist&dig=23feefe84fe7dec6f01e05597a8ea111&recordRank=

Löbmann, K., Strachan, C., Grohganz, H., Rades, T., Korhonen, O., Laitinen, R.

(2012) European Journal of Pharmaceutics and Biopharmaceutics, 81 (1), pp. 159-169. . doi: 10.1016/j.ejpb.2012.02.004

Doherty, C., York, P.


El-Hinnawi, M.A., Najib, N.M.

(1987) International Journal of Pharmaceutics, 37 (1-2), pp. 175-177. . doi: 10.1016/0378-5173(87)90024-X

Taylor, L.S., Zografi, G.

(1997) Pharmaceutical Research, 14 (12), pp. 1691-1698. . doi: 10.1023/A:1012167410376

Yoshioka, M., Hancock, B.C., Zografi, G.


Andronis, V., Zografi, G.


Oksanen, C.A., Zografi, G.

(1990) Pharmaceutical Research: An Official Journal of the American Association of PharmaceuticalScientists, 7 (6), pp. 654-657. . doi: 10.1023/A:1015834715152

14

Co-amorphous simvastatin and glipizide combinations show improved physicalstability without evidence of intermolecular interactions

Cited 81 times

View at Publisher

15

Evidence for solid‐ and liquid‐state interactions in a furosemide‐polyvinylpyrrolidonesolid dispersion

Cited 68 times

View at Publisher

16

Ibuprofen-polyvinylpyrrolidone dispersions. Proton nuclear magnetic resonance andinfrared studies

Cited 25 times

View at Publisher

17

Spectroscopic characterization of interactions between PVP and indomethacin inamorphous molecular dispersions

Cited 611 times

View at Publisher

18

Crystallization of indomethacin from the amorphous state below and above its glasstransition temperature

Cited 315 times

View at Publisher

19

The molecular mobility of supercooled amorphous indomethacin as a function oftemperature and relative humidity

Cited 125 times

View at Publisher

20

The Relationship Between the Glass Transition Temperature and Water VaporAbsorption by Poly(vinylpyrrolidone)

Cited 171 times

View at Publisher



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1016%2fj.ejpb.2012.02.004&locationID=3&categoryID=4&eid=2-s2.0-84861092839&issn=09396411&linkType=ViewAtPublisher&year=2012&origin=reflist&dig=80b03b6feb185b25088d7c9a088b14f7&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1002%2fjps.2600760912&locationID=3&categoryID=4&eid=2-s2.0-0023600719&issn=15206017&linkType=ViewAtPublisher&year=1987&origin=reflist&dig=9fa0617eac4d52e79fb934e12638966e&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1016%2f0378-5173%2887%2990024-X&locationID=3&categoryID=4&eid=2-s2.0-0023195586&issn=03785173&linkType=ViewAtPublisher&year=1987&origin=reflist&dig=2209b4c99c7785e40eac5f4e9a616ef1&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1023%2fA%3a1012167410376&locationID=3&categoryID=4&eid=2-s2.0-0031423468&issn=07248741&linkType=ViewAtPublisher&year=1997&origin=reflist&dig=f9ea1419a4992b72c7fb4630197dec39&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1002%2fjps.2600831211&locationID=3&categoryID=4&eid=2-s2.0-0028597539&issn=15206017&linkType=ViewAtPublisher&year=1994&origin=reflist&dig=ae7f0afb2ae95681bf6a7af72634615c&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1023%2fA%3a1011960112116&locationID=3&categoryID=4&eid=2-s2.0-0031782493&issn=07248741&linkType=ViewAtPublisher&year=1998&origin=reflist&dig=e1de9095e90ae03b84cd0eb93cc02168&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1023%2fA%3a1015834715152&locationID=3&categoryID=4&eid=2-s2.0-0025039869&issn=1573904X&linkType=ViewAtPublisher&year=1990&origin=reflist&dig=ff6621689dc04df867e4f3269d74c93b&recordRank=

Hancock, B.C., Zografi, G.


Hancock, B.C., Shamblin, S.L., Zografi, G.


Duddu, S.P., Dal Monte, P.R.


Hancock, B.C., Shamblin, S.L.

(2001) Thermochimica Acta, 380 (2), pp. 95-107. . doi: 10.1016/S0040-6031(01)00663-3

Correia, N.T., Moura Ramos, J.J., Descamps, M., Collins, G.


Six, K., Verreck, G., Peeters, J., Augustijns, P., Kinget, R., Van Den Mooter, G.

(2001) International Journal of Pharmaceutics, 213 (1-2), pp. 163-173. . doi: 10.1016/S0378-5173(00)00662-1

Aso, Y., Yoshioka, S., Kojima, S.

(2001) Journal of Pharmaceutical Sciences, 90 (6), pp. 798-806. .

doi: 10.1002/jps.1033

21

The Relationship Between the Glass Transition Temperature and the Water Content ofAmorphous Pharmaceutical Solids

Cited 425 times

View at Publisher

22

Molecular Mobility of Amorphous Pharmaceutical Solids Below Their Glass TransitionTemperatures

Cited 579 times

View at Publisher

23

Effect of glass transition temperature on the stability of lyophilized formulationscontaining a chimeric therapeutic monoclonal antibody

Cited 100 times

View at Publisher

24

Molecular mobility of amorphous pharmaceuticals determined using differentialscanning calorimetry

Cited 91 times

View at Publisher

25

Molecular mobility and fragility in indomethacin: A thermally stimulateddepolarization current study

Cited 88 times

View at Publisher

26

Characterization of glassy itraconazole: A comparative study of its molecular mobilitybelow T with that of structural analogues using MTDSCg

Cited 56 times

View at Publisher

27

Explanation of the crystallization rate of amorphous nifedipine and phenobarbital fromtheir molecular mobility as measured by c nuclear magnetic resonance relaxationtime and the relaxation time obtained from the heating rate dependence of the glasstransition temperature

13

Cited 56 timeswww.interscience.wiley.com/jpages/0022-3549

View at Publisher



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1023%2fA%3a1018941810744&locationID=3&categoryID=4&eid=2-s2.0-0028268210&issn=1573904X&linkType=ViewAtPublisher&year=1994&origin=reflist&dig=07965735921f10b5a5e923b5f6ba6f88&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1023%2fA%3a1016292416526&locationID=3&categoryID=4&eid=2-s2.0-0029015405&issn=1573904X&linkType=ViewAtPublisher&year=1995&origin=reflist&dig=078c9908f7e32705cac5381afb99957e&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1023%2fA%3a1012144810067&locationID=3&categoryID=4&eid=2-s2.0-0030961777&issn=07248741&linkType=ViewAtPublisher&year=1997&origin=reflist&dig=61585469ce1ff0a9b316be7bcf22345f&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1016%2fS0040-6031%2801%2900663-3&locationID=3&categoryID=4&eid=2-s2.0-0035861398&issn=00406031&linkType=ViewAtPublisher&year=2001&origin=reflist&dig=592c68eabc4f1b57f9952124c6ee498f&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1023%2fA%3a1013339017070&locationID=3&categoryID=4&eid=2-s2.0-0035663168&issn=07248741&linkType=ViewAtPublisher&year=2001&origin=reflist&dig=064e509542ac83b98511e3cf9ecc41e9&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1016%2fS0378-5173%2800%2900662-1&locationID=3&categoryID=4&eid=2-s2.0-0035253402&issn=03785173&linkType=ViewAtPublisher&year=2001&origin=reflist&dig=e37df387939cd46a166c7e100ba98406&recordRank=



https://www.scopus.com/record/www.interscience.wiley.com/jpages/0022-3549

https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1002%2fjps.1033&locationID=3&categoryID=4&eid=2-s2.0-0034965340&issn=00223549&linkType=ViewAtPublisher&year=2001&origin=reflist&dig=d86fdcfdb44700d8d47b7ee464ac5ba5&recordRank=

Hancock, B.C., Parks, M.


Loftsson, T., Brewster, M.E.

(2010) Journal of Pharmacy and Pharmacology, 62 (11), pp. 1607-1621. . doi: 10.1111/j.2042-7158.2010.01030.x

Bergström, C.A.S., Charman, W.N., Porter, C.J.H. Computational prediction of formulation strategies for beyond-rule-of-5 compounds (2016) Adv Drug Deliv Rev, 101, pp. 6-21. . PID: 26928657

Leeson, P.D., St-Gallay, S.A.

(2011) Nature Reviews Drug Discovery, 10 (10), pp. 749-765. . doi: 10.1038/nrd3552

Leeson, P.D., Springthorpe, B.

(2007) Nature Reviews Drug Discovery, 6 (11), pp. 881-890. . doi: 10.1038/nrd2445

Morphy, R.

(2006) Journal of Medicinal Chemistry, 49 (10), pp. 2969-2978. . doi: 10.1021/jm0512185

Wang, H., Chen, J., Hollister, K., Sowers, L.C., Forman, B.M.

(1999) Molecular Cell, 3 (5), pp. 543-553. .

doi: 10.1016/S1097-2765(00)80348-2

Fu, X., Menke, J.G., Chen, Y., Zhou, G., MacNaul, K.L., Wright, S.D., Sparrow, C.P., (...), Lund, E.G.

(2001) Journal of Biological Chemistry, 276 (42), pp. 38378-38387. . doi: 10.1074/jbc.M105805200

28

What is the true solubility advantage for amorphous pharmaceuticals?

Cited 772 times

View at Publisher

29

Pharmaceutical applications of cyclodextrins: Basic science and product development

Cited 240 times

View at Publisher

30

Cited 9 times

31

The influence of the 'organizational factor' on compound quality in drug discovery

Cited 96 times

View at Publisher

32

The influence of drug-like concepts on decision-making in medicinal chemistry

Cited 1181 times

View at Publisher

33

The influence of target family and functional activity on the physicochemical propertiesof pre-clinical compounds

Cited 88 times

View at Publisher

34

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

Cited 907 timeswww.molecule.org

View at Publisher

35

27-Hydroxycholesterol Is an Endogenous Ligand for Liver X Receptor in Cholesterol-loaded Cells

Cited 370 times

View at Publisher



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1023%2fA%3a1007516718048&locationID=3&categoryID=4&eid=2-s2.0-1142303337&issn=07248741&linkType=ViewAtPublisher&year=2000&origin=reflist&dig=6b773b18c5900971316790fdb7703d06&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1111%2fj.2042-7158.2010.01030.x&locationID=3&categoryID=4&eid=2-s2.0-78649654159&issn=00223573&linkType=ViewAtPublisher&year=2010&origin=reflist&dig=f1a158abb894a118c6b5850833203543&recordRank=

https://www.scopus.com/search/submit/citedby.uri?eid=2-s2.0-85019909487&refeid=2-s2.0-84983643290&src=s&origin=reflist&refstat=dummy



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1038%2fnrd3552&locationID=3&categoryID=4&eid=2-s2.0-80053471789&issn=14741776&linkType=ViewAtPublisher&year=2011&origin=reflist&dig=194ec03a658818a846aab89b730cc62a&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1038%2fnrd2445&locationID=3&categoryID=4&eid=2-s2.0-35748934487&issn=14741776&linkType=ViewAtPublisher&year=2007&origin=reflist&dig=a25db2e521ac0df36f8e20c19ec93bdc&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1021%2fjm0512185&locationID=3&categoryID=4&eid=2-s2.0-33646715920&issn=00222623&linkType=ViewAtPublisher&year=2006&origin=reflist&dig=f27f127510a4509d59b38fb0f3e61a20&recordRank=



https://www.scopus.com/record/www.molecule.org

https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1016%2fS1097-2765%2800%2980348-2&locationID=3&categoryID=4&eid=2-s2.0-0033026760&issn=10972765&linkType=ViewAtPublisher&year=1999&origin=reflist&dig=de801848a25c94f1e5633dfdb179f1c1&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1074%2fjbc.M105805200&locationID=3&categoryID=4&eid=2-s2.0-0035914330&issn=00219258&linkType=ViewAtPublisher&year=2001&origin=reflist&dig=139ecb094567ff3764fee804580fe9f5&recordRank=

Bergström, C.A.S., Wassvik, C.M., Johansson, K., Hubatsch, I.


Wassvik, C.M., Holmén, A.G., Draheim, R., Artursson, P., Bergström, C.A.S.

(2008) Journal of Medicinal Chemistry, 51 (10), pp. 3035-3039. . doi: 10.1021/jm701587d

Zakowiecki, D., Cal, K., Kaminski, K., Adrjanowicz, K., Swinder, L., Kaminska, E., Garbacz, G.

(2015) AAPS PharmSciTech, 16 (4), pp. 922-933. .

doi: 10.1208/s12249-015-0285-1

Jensen, K.T., Löbmann, K., Rades, T., Grohganz, H.

(2014) Pharmaceutics, 6 (3), pp. 416-435. .

doi: 10.3390/pharmaceutics6030416

Wairkar, S., Gaud, R.


doi: 10.1208/s12249-015-0371-4

Onoue, S., Kojo, Y., Aoki, Y., Kawabata, Y., Yamauchi, Y., Yamada, S.

(2012) Drug Metabolism and Pharmacokinetics, 27 (4), pp. 379-387. .

doi: 10.2133/dmpk.DMPK-11-RG-101

Choi, J.-S., Park, J.-S.

(2017) European Journal of Pharmaceutical Sciences, 97, pp. 269-276. .

doi: 10.1016/j.ejps.2016.11.030

36

Poorly soluble marketed drugs display solvation limited solubility

Cited 88 times

View at Publisher

37

Molecular characteristics for solid-state limited solubility

Cited 53 times

View at Publisher

38

The Improvement of the Dissolution Rate of Ziprasidone Free Base from Solid OralFormulations

Cited 2 timeshttp://www.springerlink.com/content/1530-9932/

View at Publisher

39

Improving co-amorphous drug formulations by the addition of the highly watersoluble amino acid, Proline

Cited 25 timeshttp://www.mdpi.com/1999-4923/6/3/416/pdf

View at Publisher

40

Co-Amorphous Combination of Nateglinide-Metformin Hydrochloride for DissolutionEnhancement


View at Publisher

41

Physicochemical and Pharmacokinetic characterization of amorphous solid dispersionof tranilast with enhanced solubility in gastric fluid and improved oral bioavailability

Cited 20 timeshttps://www.jstage.jst.go.jp/article/dmpk/27/4/27_DMPK-11-RG-101/_pdf

View at Publisher

42

Design of PVP/VA S-630 based tadalafil solid dispersion to enhance the dissolutionrate

Cited 7 timeswww.elsevier.com/locate/ejps

View at Publisher



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1021%2fjm0706416&locationID=3&categoryID=4&eid=2-s2.0-36148933709&issn=00222623&linkType=ViewAtPublisher&year=2007&origin=reflist&dig=a059616cea7dd876bf184bb605283507&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1021%2fjm701587d&locationID=3&categoryID=4&eid=2-s2.0-43949104093&issn=00222623&linkType=ViewAtPublisher&year=2008&origin=reflist&dig=a42d75b1a228b83f98946d1bb85559c8&recordRank=



http://www.springerlink.com/content/1530-9932/

https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1208%2fs12249-015-0285-1&locationID=3&categoryID=4&eid=2-s2.0-84937815964&issn=15309932&linkType=ViewAtPublisher&year=2015&origin=reflist&dig=5577a4a0e8405d1c4bf9ed410875d2f4&recordRank=



http://www.mdpi.com/1999-4923/6/3/416/pdf

https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.3390%2fpharmaceutics6030416&locationID=3&categoryID=4&eid=2-s2.0-84904310486&issn=19994923&linkType=ViewAtPublisher&year=2014&origin=reflist&dig=b6154f6ddc4da6361250cc9ce9153d13&recordRank=




https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1208%2fs12249-015-0371-4&locationID=3&categoryID=4&eid=2-s2.0-84940094015&issn=15309932&linkType=ViewAtPublisher&year=2016&origin=reflist&dig=62b647829c4e5a5c9476df12f32444ff&recordRank=



https://www.jstage.jst.go.jp/article/dmpk/27/4/27_DMPK-11-RG-101/_pdf

https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.2133%2fdmpk.DMPK-11-RG-101&locationID=3&categoryID=4&eid=2-s2.0-84865398523&issn=18800920&linkType=ViewAtPublisher&year=2012&origin=reflist&dig=de0c01819475ce34b3568c90d5174484&recordRank=



https://www.scopus.com/record/www.elsevier.com/locate/ejps

https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1016%2fj.ejps.2016.11.030&locationID=3&categoryID=4&eid=2-s2.0-85006761770&issn=18790720&linkType=ViewAtPublisher&year=2017&origin=reflist&dig=2b1270013caec5ffa375d18a0b433327&recordRank=

Wei, Q., Keck, C.M., Müller, R.H.

(2017) International Journal of Pharmaceutics, 518 (1-2), pp. 253-263. .

doi: 10.1016/j.ijpharm.2016.11.005

Tehler, U., Fagerberg, J.H., Svensson, R., Larhed, M., Artursson, P., Bergström, C.A.S.

(2013) Journal of Medicinal Chemistry, 56 (6), pp. 2690-2694. . doi: 10.1021/jm301721e

Iwata, K., Karashima, M., Ikeda, Y.

(2016) Crystal Growth and Design, 16 (8), pp. 4599-4606. .

doi: 10.1021/acs.cgd.6b00691

Duggirala, N.K., Perry, M.L., Almarsson, Ö., Zaworotko, M.J.

(2016) Chemical Communications, 52 (4), pp. 640-655. .

doi: 10.1039/c5cc08216a

Seo, J.H., Park, J.B., Choi, W.-K., Park, S., Sung, Y.J., Oh, E., Bae, S.K.

(2015) Drug Design, Development and Therapy, 9, pp. 3961-3968. .

doi: 10.2147/DDDT.S87687

Varia, S.A., Stella, V.J.


Kumar, S., Jog, R., Shen, J., Zolnik, B., Sadrieh, N., Burgess, D.J.


doi: 10.1002/jps.24155

43

Oral hesperidin—Amorphization and improved dissolution properties by controlledloading onto porous silica


View at Publisher

44

Optimizing solubility and permeability of a biopharmaceutics classification system(BCS) class 4 antibiotic drug using lipophilic fragments disturbing the crystal lattice

Cited 13 times

View at Publisher

45

Cocrystallization Enhanced TAK-441 Aqueous Solubility and Suppressed HighSolvatomorphism

Cited 3 timeshttp://pubs.acs.org/journal/cgdefu

View at Publisher

46

Pharmaceutical cocrystals: Along the path to improved medicines

Cited 145 timeswww.rsc.org/chemcomm

View at Publisher

47

Improved oral absorption of cilostazol via sulfonate salt formation with mesylate andbesylate

Cited 6 timeshttp://www.dovepress.com/getfile.php?fileID=26216

View at Publisher

48

Phenytoin prodrugs V: In Vivo evaluation of some water‐soluble phenytoin prodrugs indogs

Cited 42 times

View at Publisher

49

In Vitro and in Vivo Performance of Different Sized Spray-Dried CrystallineItraconazole


View at Publisher




https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1016%2fj.ijpharm.2016.11.005&locationID=3&categoryID=4&eid=2-s2.0-85008712430&issn=18733476&linkType=ViewAtPublisher&year=2017&origin=reflist&dig=ec3fb72bb74286f603523eb4f53d8204&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1021%2fjm301721e&locationID=3&categoryID=4&eid=2-s2.0-84875739359&issn=00222623&linkType=ViewAtPublisher&year=2013&origin=reflist&dig=299c2c41eb0e4f269c444556def09aa4&recordRank=



http://pubs.acs.org/journal/cgdefu

https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1021%2facs.cgd.6b00691&locationID=3&categoryID=4&eid=2-s2.0-84982747958&issn=15287505&linkType=ViewAtPublisher&year=2016&origin=reflist&dig=5cd6221dd7c8c942e56a24772b5c58d5&recordRank=



https://www.scopus.com/record/www.rsc.org/chemcomm

https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1039%2fc5cc08216a&locationID=3&categoryID=4&eid=2-s2.0-84953290764&issn=1364548X&linkType=ViewAtPublisher&year=2016&origin=reflist&dig=8315e58b7b70afed3bcbdb49fd7cceb5&recordRank=



http://www.dovepress.com/getfile.php?fileID=26216

https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.2147%2fDDDT.S87687&locationID=3&categoryID=4&eid=2-s2.0-84938322805&issn=11778881&linkType=ViewAtPublisher&year=2015&origin=reflist&dig=6b8d4eea27b72451a1afff0705b0d53c&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1002%2fjps.2600730814&locationID=3&categoryID=4&eid=2-s2.0-0021134891&issn=15206017&linkType=ViewAtPublisher&year=1984&origin=reflist&dig=98033747b2d428e8b81537a7f343d378&recordRank=




https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1002%2fjps.24155&locationID=3&categoryID=4&eid=2-s2.0-84939251925&issn=15206017&linkType=ViewAtPublisher&year=2015&origin=reflist&dig=048543517b95db9ecee31175490db959&recordRank=

Junghanns, J.-U.A.H., Müller, R.H.

(2008) International Journal of Nanomedicine, 3 (3), pp. 295-309. .

Jog, R., Kumar, S., Shen, J., Jugade, N., Thiam Tan, D.C., Gokhale, R., Burgess, D.J.


doi: 10.1016/j.ijpharm.2015.12.033

Dong, B., Hadinoto, K.

(2017) Drug Development and Industrial Pharmacy, 43 (6), pp. 996-1002. .

doi: 10.1080/03639045.2017.1287721

Maniruzzaman, M., Nair, A., Renault, M., Nandi, U., Scoutaris, N., Farnish, R., Bradley,M.S.A., (...), Douroumis, D.

(2015) International Journal of Pharmaceutics, 496 (1), pp. 52-62. .

doi: 10.1016/j.ijpharm.2015.09.025

Waring, M.J., Arrowsmith, J., Leach, A.R., Leeson, P.D., Mandrell, S., Owen, R.M., Pairaudeau, G., (...), Weir,A.

(2015) Nature Reviews Drug Discovery, 14 (7), pp. 475-486. .

doi: 10.1038/nrd4609

Alhalaweh, A., Alzghoul, A., Kaialy, W., Mahlin, D., Bergström, C.A.S.

(2014) Molecular Pharmaceutics, 11 (9), pp. 3123-3132. .

doi: 10.1021/mp500303a

Baird, J.A., Van Eerdenbrugh, B., Taylor, L.S.


doi: 10.1002/jps.22197

50

Nanocrystal technology, drug delivery and clinical applications

Cited 414 times

51

Formulation design and evaluation of amorphous ABT-102 nanoparticles


View at Publisher

52

Amorphous nanoparticle complex of perphenazine and dextran sulfate as a newsolubility enhancement strategy of antipsychotic perphenazine

Cited 5 timeshttp://www.tandfonline.com/loi/iddi20#.Vmuk8Lfovcs

View at Publisher

53

Continuous twin-screw granulation for enhancing the dissolution of poorly watersoluble drug


View at Publisher

54

An analysis of the attrition of drug candidates from four major pharmaceuticalcompanies

Cited 188 timeshttp://www.nature.com/nrd/index.html

View at Publisher

55

Computational predictions of glass-forming ability and crystallization tendency ofdrug molecules

Cited 24 timeshttp://pubs.acs.org/journal/mpohbp

View at Publisher

56

A classification system to assess the crystallization tendency of organic molecules fromundercooled melts

Cited 227 timeshttp://onlinelibrary.wiley.com/doi/10.1002/jps.22197/pdf

View at Publisher






https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1016%2fj.ijpharm.2015.12.033&locationID=3&categoryID=4&eid=2-s2.0-84951063374&issn=18733476&linkType=ViewAtPublisher&year=2016&origin=reflist&dig=2b903c75bb8ed260aff0f0944df1689b&recordRank=



http://www.tandfonline.com/loi/iddi20#.Vmuk8Lfovcs

https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1080%2f03639045.2017.1287721&locationID=3&categoryID=4&eid=2-s2.0-85012924775&issn=15205762&linkType=ViewAtPublisher&year=2017&origin=reflist&dig=6d108869837d777f1b936cfbfedb7d56&recordRank=




https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1016%2fj.ijpharm.2015.09.025&locationID=3&categoryID=4&eid=2-s2.0-84961121067&issn=18733476&linkType=ViewAtPublisher&year=2015&origin=reflist&dig=c1de8481cc3be8135c5658e71c9cf5ab&recordRank=



http://www.nature.com/nrd/index.html

https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1038%2fnrd4609&locationID=3&categoryID=4&eid=2-s2.0-84934439985&issn=14741784&linkType=ViewAtPublisher&year=2015&origin=reflist&dig=0948b25acd55cae145085bd0a5bdf6ca&recordRank=



http://pubs.acs.org/journal/mpohbp

https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1021%2fmp500303a&locationID=3&categoryID=4&eid=2-s2.0-84906898071&issn=15438392&linkType=ViewAtPublisher&year=2014&origin=reflist&dig=f93f4da4cb259ba5ca6fd2efc823c26c&recordRank=



http://onlinelibrary.wiley.com/doi/10.1002/jps.22197/pdf

https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1002%2fjps.22197&locationID=3&categoryID=4&eid=2-s2.0-77955232982&issn=15206017&linkType=ViewAtPublisher&year=2010&origin=reflist&dig=5cd0df535395f0aeec2c40484f864fc2&recordRank=

Van Eerdenbrugh, B., Baird, J.A., Taylor, L.S.


doi: 10.1002/jps.22214

Kawakami, K., Harada, T., Yoshihashi, Y., Yonemochi, E., Terada, K., Moriyama, H.

(2015) Journal of Physical Chemistry B, 119 (14), pp. 4873-4880. .

doi: 10.1021/jp509646z

Jog, R., Gokhale, R., Burgess, D.J.


doi: 10.1016/j.ijpharm.2016.05.068

Alhalaweh, A., Alzghoul, A., Kaialy, W., Mahlin, D., Bergström, C.A.S.


doi: 10.1021/mp500303a

Wyttenbach, N., Kirchmeyer, W., Alsenz, J., Kuentz, M.


doi: 10.1021/acs.molpharmaceut.5b00688

Nurzyńska, K., Booth, J., Roberts, C.J., McCabe, J., Dryden, I., Fischer, P.M.


doi: 10.1021/acs.molpharmaceut.5b00409

Alhalaweh, A., Alzghoul, A., Mahlin, D., Bergström, C.A.S.

(2015) International Journal of Pharmaceutics, 495 (1), art. no. 15184, pp. 312-317. .

doi: 10.1016/j.ijpharm.2015.08.101

57

Crystallization tendency of active pharmaceutical ingredients following rapid solventevaporation - Classification and comparison with crystallization tendency fromundercooled melts

Cited 70 timeshttp://onlinelibrary.wiley.com/doi/10.1002/jps.22214/pdf

View at Publisher

58

Correlation between Glass-Forming Ability and Fragility of PharmaceuticalCompounds

Cited 18 timeshttp://pubs.acs.org/journal/jpcbfk

View at Publisher

59

Solid state drug-polymer miscibility studies using the model drug ABT-102


View at Publisher

60

Computational predictions of glass-forming ability and crystallization tendency ofdrug molecules


View at Publisher

61

Theoretical Considerations of the Prigogine-Defay Ratio with Regard to the Glass-Forming Ability of Drugs from Undercooled Melts


View at Publisher

62

Long-Term Amorphous Drug Stability Predictions Using Easily Calculated, Predicted,and Measured Parameters


View at Publisher

63

Physical stability of drugs after storage above and below the glass transitiontemperature: Relationship to glass-forming ability


View at Publisher



http://onlinelibrary.wiley.com/doi/10.1002/jps.22214/pdf

https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1002%2fjps.22214&locationID=3&categoryID=4&eid=2-s2.0-77955234073&issn=15206017&linkType=ViewAtPublisher&year=2010&origin=reflist&dig=20df5ead4adc659071e3800d8d0a88d7&recordRank=



http://pubs.acs.org/journal/jpcbfk

https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1021%2fjp509646z&locationID=3&categoryID=4&eid=2-s2.0-84927622461&issn=15205207&linkType=ViewAtPublisher&year=2015&origin=reflist&dig=9e03ce92a8588cedb553b5ca6a657a9e&recordRank=




https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1016%2fj.ijpharm.2016.05.068&locationID=3&categoryID=4&eid=2-s2.0-84974624153&issn=18733476&linkType=ViewAtPublisher&year=2016&origin=reflist&dig=d345eb51a038c5be4644f58ae27ab791&recordRank=




https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1021%2fmp500303a&locationID=3&categoryID=4&eid=2-s2.0-84906898071&issn=15438392&linkType=ViewAtPublisher&year=2014&origin=reflist&dig=f93f4da4cb259ba5ca6fd2efc823c26c&recordRank=




https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1021%2facs.molpharmaceut.5b00688&locationID=3&categoryID=4&eid=2-s2.0-84953410937&issn=15438392&linkType=ViewAtPublisher&year=2016&origin=reflist&dig=c9f198a6ff1e9d8a9dfd2521e67acf63&recordRank=




https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1021%2facs.molpharmaceut.5b00409&locationID=3&categoryID=4&eid=2-s2.0-84941114243&issn=15438392&linkType=ViewAtPublisher&year=2015&origin=reflist&dig=5ca3c5c461dba492f4771f258627e0ab&recordRank=




https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1016%2fj.ijpharm.2015.08.101&locationID=3&categoryID=4&eid=2-s2.0-84941104993&issn=18733476&linkType=ViewAtPublisher&year=2015&origin=reflist&dig=cbc8c6827ee7508f9c995ac0a09c1351&recordRank=

Mahlin, D., Ponnambalam, S., Heidarian Höckerfelt, M., Bergström, C.A.S.

(2011) Molecular Pharmaceutics, 8 (2), pp. 498-506. . doi: 10.1021/mp100339c

Mahlin, D., Bergström, C.A.S.

(2013) European Journal of Pharmaceutical Sciences, 49 (2), pp. 323-332. . doi: 10.1016/j.ejps.2013.03.016

Lipinski, C.A., Lombardo, F., Dominy, B.W., Feeney, P.J.

(1997) Advanced Drug Delivery Reviews, 23 (1-3), pp. 3-25. . doi: 10.1016/S0169-409X(96)00423-1

Veber, D.F., Johnson, S.R., Cheng, H.-Y., Smith, B.R., Ward, K.W., Kopple, K.D.

(2002) Journal of Medicinal Chemistry, 45 (12), pp. 2615-2623. . doi: 10.1021/jm020017n

Lu, J.J., Crimin, K., Goodwin, J.T., Crivori, P., Orrenius, C., Xing, L., Tandler, P.J., (...), Burton, P.S.


Jog, R., Burgess, D.J.


doi: 10.1016/j.xphs.2016.09.014

Council, I.P.E. The IPEC excipient composition guide (2009) International Pharmaceutical Excipients Council (IPEC)

Verma, S., Rudraraju, V.S.


doi: 10.1208/s12249-014-0281-x

64

Toward in silico prediction of glass-forming ability from molecular structure alone: Ascreening tool in early drug development

Cited 52 times

View at Publisher

65

Early drug development predictions of glass-forming ability and physical stability ofdrugs

Cited 33 times

View at Publisher

66

Experimental and computational approaches to estimate solubility and permeability indrug discovery and development settings

Cited 5140 times

View at Publisher

67

Molecular properties that influence the oral bioavailability of drug candidates

Cited 1960 times

View at Publisher

68

Influence of molecular flexibility and polar surface area metrics on oral bioavailabilityin the rat

Cited 110 times

View at Publisher

69

Pharmaceutical Amorphous Nanoparticles


View at Publisher

70

71

Wetting Kinetics: an Alternative Approach Towards Understanding the EnhancedDissolution Rate for Amorphous Solid Dispersion of a Poorly Soluble Drug


View at Publisher



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1021%2fmp100339c&locationID=3&categoryID=4&eid=2-s2.0-79953809533&issn=15438384&linkType=ViewAtPublisher&year=2011&origin=reflist&dig=521ae3717154a6b626ab6497ef85ac9a&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1016%2fj.ejps.2013.03.016&locationID=3&categoryID=4&eid=2-s2.0-84877037504&issn=09280987&linkType=ViewAtPublisher&year=2013&origin=reflist&dig=2a0885ea41435df9c0823aaaca85824e&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1016%2fS0169-409X%2896%2900423-1&locationID=3&categoryID=4&eid=2-s2.0-0031024171&issn=0169409X&linkType=ViewAtPublisher&year=1997&origin=reflist&dig=04ad9a80a3e90e3a0d7ee3f48f5c2a62&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1021%2fjm020017n&locationID=3&categoryID=4&eid=2-s2.0-0037030653&issn=00222623&linkType=ViewAtPublisher&year=2002&origin=reflist&dig=6db235f6f141037e7f60445f9b7f9ba7&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1021%2fjm0306529&locationID=3&categoryID=4&eid=2-s2.0-8644219619&issn=00222623&linkType=ViewAtPublisher&year=2004&origin=reflist&dig=12bb9fe3ffaac34436ea8bf65936781d&recordRank=




https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1016%2fj.xphs.2016.09.014&locationID=3&categoryID=4&eid=2-s2.0-85002564019&issn=15206017&linkType=ViewAtPublisher&year=2017&origin=reflist&dig=3838648e5da5d017b03370e65f6d7ce5&recordRank=




https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1208%2fs12249-014-0281-x&locationID=3&categoryID=4&eid=2-s2.0-84944516080&issn=15309932&linkType=ViewAtPublisher&year=2015&origin=reflist&dig=abeccb633ad12182eab507fb29f24c5e&recordRank=

Nagy, Z.K., Balogh, A., Démuth, B., Pataki, H., Vigh, T., Szabó, B., Molnár, K., (...), Brewster, M.E.


doi: 10.1016/j.ijpharm.2015.01.025

Ewing, A.V., Clarke, G.S., Kazarian, S.G.

(2014) European Journal of Pharmaceutical Sciences, 60, pp. 64-71. .

doi: 10.1016/j.ejps.2014.05.001

Balogh, A., Drávavölgyi, G., Faragó, K., Farkas, A., Vigh, T., Sóti, P.L., Wagner, I., (...), Nagy, Z.K.


doi: 10.1002/jps.23904

Mosquera-Giraldo, L.I., Trasi, N.S., Taylor, L.S.


doi: 10.1016/j.ijpharm.2013.11.057

Tian, Y., Caron, V., Jones, D.S., Healy, A.-M., Andrews, G.P.

(2014) Journal of Pharmacy and Pharmacology, 66 (2), pp. 256-274. . doi: 10.1111/jphp.12141

Lee, T.W.-Y., Boersen, N.A., Yang, G., Hui, H.-W.

(2014) Drug Development and Industrial Pharmacy, 40 (8), pp. 1072-1083. .

doi: 10.3109/03639045.2013.807279

Yadav, P.S., Kumar, V., Singh, U.P., Bhat, H.R., Mazumder, B.

(2013) Saudi Pharmaceutical Journal, 21 (1), pp. 77-84. . doi: 10.1016/j.jsps.2011.12.007

72

High speed electrospinning for scaled-up production of amorphous solid dispersion ofitraconazole


View at Publisher

73

Stability of indomethacin with relevance to the release from amorphous soliddispersions studied with ATR-FTIR spectroscopic imaging

Cited 25 timeswww.elsevier.com/locate/ejps

View at Publisher

74

Plasticized drug-loaded melt electrospun polymer mats: Characterization, thermaldegradation, and release kinetics


View at Publisher

75

Impact of surfactants on the crystal growth of amorphous celecoxib


View at Publisher

76

Using Flory-Huggins phase diagrams as a pre-formulation tool for the production ofamorphous solid dispersions: A comparison between hot-melt extrusion and spraydrying

Cited 25 times

View at Publisher

77

Evaluation of different screening methods to understand the dissolution behaviors ofamorphous solid dispersions

Cited 10 timeshttp://www.tandfonline.com/loi/iddi20#.Vmuk8Lfovcs

View at Publisher

78

Physicochemical characterization and in vitro dissolution studies of solid dispersions ofketoprofen with PVP K30 and d-mannitol

Cited 36 times

View at Publisher




https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1016%2fj.ijpharm.2015.01.025&locationID=3&categoryID=4&eid=2-s2.0-84921730384&issn=18733476&linkType=ViewAtPublisher&year=2015&origin=reflist&dig=184470d46c8cfa30544d3b8253e01f00&recordRank=



https://www.scopus.com/record/www.elsevier.com/locate/ejps

https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1016%2fj.ejps.2014.05.001&locationID=3&categoryID=4&eid=2-s2.0-84901927324&issn=18790720&linkType=ViewAtPublisher&year=2014&origin=reflist&dig=0b3f4da1686ff4cca0bc8ebe9ed9ba99&recordRank=




https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1002%2fjps.23904&locationID=3&categoryID=4&eid=2-s2.0-84896403118&issn=15206017&linkType=ViewAtPublisher&year=2014&origin=reflist&dig=d682b4dda5cd7fa3f98ef43fe98ff9dd&recordRank=




https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1016%2fj.ijpharm.2013.11.057&locationID=3&categoryID=4&eid=2-s2.0-84891513015&issn=18733476&linkType=ViewAtPublisher&year=2014&origin=reflist&dig=4da4dc1d53a6a9ddbc70794bbb663cdf&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1111%2fjphp.12141&locationID=3&categoryID=4&eid=2-s2.0-84892749014&issn=00223573&linkType=ViewAtPublisher&year=2014&origin=reflist&dig=2ed56c68852e1dc042842185b0485a63&recordRank=



http://www.tandfonline.com/loi/iddi20#.Vmuk8Lfovcs

https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.3109%2f03639045.2013.807279&locationID=3&categoryID=4&eid=2-s2.0-84905456922&issn=15205762&linkType=ViewAtPublisher&year=2014&origin=reflist&dig=fbc7c8def6b1c81b4fcab127cb0cc6c9&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1016%2fj.jsps.2011.12.007&locationID=3&categoryID=4&eid=2-s2.0-84871952081&issn=13190164&linkType=ViewAtPublisher&year=2013&origin=reflist&dig=37a4b976d987029bae18c0cc8dda318c&recordRank=

1 of 1

Priemel, P.A., Laitinen, R., Grohganz, H., Rades, T., Strachan, C.J.

(2013) European Journal of Pharmaceutics and Biopharmaceutics, 85 (3 PART B), pp. 1259-1265.

. doi: 10.1016/j.ejpb.2013.09.010

Ilevbare, G.A., Liu, H., Pereira, J., Edgar, K.J., Taylor, L.S.

(2013) Molecular Pharmaceutics, 10 (9), pp. 3392-3403. . doi: 10.1021/mp400228x

Bergström, C.A.S.; Department of Pharmacy, Uppsala University, Uppsala Biomedical Centre, P.O. Box 580,Uppsala, Sweden; email: © Copyright 2017 Elsevier B.V., All rights reserved.

79

In situ amorphisation of indomethacin with Eudragit® e during dissolution

Cited 19times

View at Publisher

80

Influence of additives on the properties of nanodroplets formed in highlysupersaturated aqueous solutions of ritonavir

Cited 37 times

View at Publisher

[email protected]

◅ Back to results Top of page

About Scopus

What is Scopus

Content coverage

Scopus blog

Scopus API

Privacy matters

Language

⽇本語に切り替える切换到简体中文

切換到繁體中文

Русский язык

Customer Service

Help

Contact us

Copyright © 2018 . All rights reserved. Scopus® is a registered trademark ofElsevier B.V. Cookies are set by this site. To decline them or learn more, visit our .

Terms and conditions Privacy policy

Elsevier B.V

Cookies page



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1016%2fj.ejpb.2013.09.010&locationID=3&categoryID=4&eid=2-s2.0-84888992981&issn=09396411&linkType=ViewAtPublisher&year=2013&origin=reflist&dig=7d8bff969a953341a92507200bfbf609&recordRank=



https://www.scopus.com/redirect/linking.uri?targetURL=https%3a%2f%2fdoi.org%2f10.1021%2fmp400228x&locationID=3&categoryID=4&eid=2-s2.0-84883573956&issn=15438384&linkType=ViewAtPublisher&year=2013&origin=reflist&dig=ed46275666d8335165dc0daf944cd3ed&recordRank=

mailto:[email protected]

https://www.scopus.com/results/results.uri?sort=plf-f&src=s&st1=The+Need+for+Restructuring+the+Disordered+Science+of+Amorphous+Drug+Formulations&st2=&sid=088bcfe5d952f3ba87ef989e352f8991&sot=b&sdt=b&sl=95&s=TITLE-ABS-KEY%28The+Need+for+Restructuring+the+Disordered+Science+of+Amorphous+Drug+Formulations%29&offset=1&origin=recordpage

https://www.elsevier.com/online-tools/scopus

https://www.elsevier.com/online-tools/scopus/content-overview/

https://blog.scopus.com/

https://dev.elsevier.com/

https://www.elsevier.com/legal/privacy-approach

https://www.scopus.com/personalization/switch/Japanese.uri?origin=recordpage&zone=footer&locale=ja_JP

https://www.scopus.com/personalization/switch/Chinese.uri?origin=recordpage&zone=footer&locale=zh_CN

https://www.scopus.com/personalization/switch/Chinese.uri?origin=recordpage&zone=footer&locale=zh_TW

https://www.scopus.com/personalization/switch/Russian.uri?origin=recordpage&zone=footer&locale=ru_RU

https://www.scopus.com/standard/contactUs.uri?pageOrigin=footer

https://www.scopus.com/standard/contactForm.uri?pageOrigin=footer

https://www.elsevier.com/

https://www.elsevier.com/locate/termsandconditions

https://www.elsevier.com/locate/privacypolicy

https://www.elsevier.com/

https://www.scopus.com/standard/help.uri?topic=11237

http://www.relx.com/