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GNMK-IMC-1039-A
Gastrointestinal Pathogen Panel (GI)n Bacterial, viral, and parasitic targets
associated with gastrointestinal infections from a stool sample
HCV Genotyping Panel (HCVg)n Typing and subtyping of HCV 1a, 1b, 2a/c,
2b, 3, 4, 5, and 6 from plasma or serum
Central Nervous System Panel (CNS)n Bacterial, viral, and fungal targets associated
with central nervous system infections from a cerebrospinal fluid sample
Fungal Pathogen Panel (FP)n Fungal targets associated with bloodstream
infections from positive blood culture
Product in Development
Sample-to-Answer Multiplex Molecular Diagnostics
Electrowetting Technology
n Proprietary electronic fluid
movement technology
n Enables rapid thermal cycling
for fast turnaround time
Sample-to-Answer Solution
n Single use, self-contained cartridge
n Fully integrates nucleic acid extraction,
amplification, and detection
n No user-added reagents
CAPTURE PROBE
SIGNAL PROBE PATIENT DNA
FERROCENE LABEL
GOLD ELECTRODE
eSensor® Detection
n Proprietary electrochemical
detection technology
n Multiplexing with high sensitivity
and specificity
n Eliminates the need for routine
instrument maintenance
and calibration
GenMark is committed to providing patient-focused solutions to aid in the diagnosis of disease and the selection and dosing of therapies. Utilizing eSensor® detection technology, the ePlex™ sample-to-answer system
is being designed to support a broad range of multiplex molecular diagnostic panels.
CU
RR
EN
T N
AN
OA
MP
S
VOLTAGE
40
35
30
25
20
15
10
5
0-0.2 0.0 0.2 0.4 0.6
Ferrocene SignalBackground Current
nA
/m
m2
POTENTIAL (V)
180
170
160
150
110
130
100-0.2 0.0 0.2 0.4 0.6
Wild Type (WT)Mutant (MUT)Heterozygous (HET)
120110
Excellent Sensitivity and Specificity Demonstrated in Independent Studies
Scalable Configuration & Throughput
1 Pierce, V.M., Hodinka, R.L. 2012. Comparison of the GenMark Diagnostic eSensor Respiratory Viral Panel to Real-Time PCR for Detection of Respiratory Viruses in Children. Journal of Clinical Microbiology. doi:10.1128/JCM.01384-12. 2 Popowitch, E.B, O’Neill, S.S., Miller, M.B. Comparison of Four Multiplex Assays for the Detection of Respiratory Viruses: Biofire FilmArray RP, GenMark eSensor RVP, Luminex xTAG RVPv1 and Luminex xTAG RVP FAST. J. Clin. Microbiol.
13 March 2013, doi: 10.1128/JCM.03368-12.
Random and Continuous Access
Run any assay, any time
Flexible Design 1 to 4 towers to address testing
capacity requirements
192
144
96
48
1 2 3 4
Towers
Sample Throughput (6 samples per tower, based on 8-hour shift)
GenMark is committed to providing patient-focused solutions to aid in the diagnosis of disease and the selection and dosing of therapies. Utilizing eSensor® detection technology, the ePlex™ sample-to-answer system
is being designed to support a broad range of multiplex molecular diagnostic panels.
Author Comparator Method eSensor® XT-8 Performance
Popowitch1 Molecular Multiplex Tests 99.6% Overall Sensitivity*
Pierce2 PCR 99.2% Agreement
LIS
Bi-directional LIS Interface
Download test orders and upload results
Fast Turnaround
Sample to result in 60-90 minutes
*GenMark’s eSensor XT-8 RVP is designed to detect only Rhinovirus. The data presented is based on the removal of three Enterovirus specimens.
GNMK-IMC-1039-A
Respiratory Pathogen Panel (RP) n >20 viral and bacterial targets
associated with respiratory infections from a nasopharyngeal swab
Blood Culture Identification Gram-Positive Panel (BCID-GP)n >20 bacterial and resistance targets
associated with bloodstream infections from positive blood culture
Blood Culture Identification Gram-Negative Panel (BCID-GN)n >25 bacterial and resistance targets
associated with bloodstream infections from positive blood culture
Gastrointestinal Pathogen Panel (GI)n Bacterial, viral, and parasitic targets
associated with gastrointestinal infections from a stool sample
HCV Genotyping Panel (HCVg)n Typing and subtyping of HCV 1a, 1b, 2a/c,
2b, 3, 4, 5, and 6 from plasma or serum
Central Nervous System Panel (CNS)n Bacterial, viral, and fungal targets associated
with central nervous system infections from a cerebrospinal fluid sample
Fungal Pathogen Panel (FP)n Fungal targets associated with bloodstream
infections from positive blood culture
Comprehensive Multiplex Panels*
Solutions to aid diagnosis and accelerate treatment decisions
GenMark Diagnostics, Inc.5964 La Place CourtCarlsbad, CA 92008USA
[email protected] genmarkdx.com
*Product in Development. Not available for sale in the US. Panel targets and specifications subject to change.Copyright © 2014, GenMark Diagnostics. GenMark®, GenMark Dx®, eSensor®, ePlex™, and XT-8™ are trademarks of GenMark Diagnostics, Inc.
GenMark Diagnostics Europe GmbHGeneral-Guisan-Strasse 66303 ZugSwitzerland [email protected]
To learn more about the ePlex™ system, contact us at [email protected].