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NJ Department of Health
Role of the NJ State Lab in Assuring the Health & Safety of Cannabis Patients
Z. Tina Fan, Ph.D.
Program Manager, CT Lab New Jersey Department of Health
Getting into the Weeds: PHLs and Cannabis TestingAPHL Annual Conference
Albuquerque, NMJune 8, 2016
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NJ Department of Health
Introduction
• No federal guidance for cannabis testing in US.• The NJ Department of Health (NJDOH) Medicinal
Marijuana Program was established to implement the law, develop and enforce the regulations.
• Medical cannabis has been approved for use in a number of states, including NJ.• The NJ Compassionate Use Medical Marijuana Act (Senate
Bill, No. 119, the Act, N.J.S.A. 26:6I-1 et seq) was signed into law on January 18, 2010.
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NJ Department of Health
Role Of The NJ State Lab in MMP
To assure: • Potency compliance: < 10 %
Delta-9-Tetrahydrocannabinol (Δ-9-THC) in the raw plant material
• Free from pesticides, toxic heavy metals, and mycotoxins
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NJ Department of Health
Specific Activities Conducted by the NJ State Lab
Perform testing for cannabis, heavy metals, pesticides and mycotoxins.
Collect samples from the growing centers for testing.
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NJ Department of Health
Analysis of Marijuana for Cannabinoids Using HPLC-DAD* Method
Target Analytes
• Cannabidiol (CBD)• Cannabidiolic acid (CBDA)• Cannabigerollic acid (CBGA)• Cannabigerol (CBG)• Cannabinol (CBN)• Delta-8-terahydrocannabinol (Δ-8-THC)• Delta-9-Tetrahydrocannabinol (Δ-9-THC)• Tetrahydocannabinolic acid (THCA)
*High Pressure Liquid Chromatography – Diode Array Detector
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NJ Department of Health
Elemental Analysis on Medicinal Cannabis by ICP-MS
Target AnalytesArsenicCadmiumChromiumIronLeadManganeseMercuryNickelSeleniumZinc
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NJ Department of Health
Analysis of Pesticides in MM by GC-MSChemical Class Example Pesticides Use
Organophosphates Diazinon, Insecticide
Phosmet Insecticide
Dichlorovos Insecticide
Pyrethroids Resmethrin Insecticide, Repellent
Pyrethrin Insecticide, RepellentAllethrin Insecticide, Repellent
Carbamates Terbucarb InsecticideFenunucarb Insecticide
Avermectins Abamectin (Avid ) Insecticide , AnthelminticThiabendazoles Thiabendazole ParasiticideMiscellaneous Atrazine Herbicide
Bifenazate AcaricideBromocil HerbicideChlorpropham Growth RegulatorFenarimol FungicidePyrimethanil FungicideMetribuzin Fungicide
*Note: A total of 83 commonly used pesticides were tested but currently 56 are incorporated into method. These analytes are selected based on EPA pesticide testing method and commonly used pesticides.
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NJ Department of Health
• NJDA cooperates with NJ Department of Health to perform Mycotoxins analyses for medical marijuana plant materials
• The tests are aflatoxins (B1, B2, G1, and G2) and Ochratoxin A
• High Performance Liquid Chromatograph with Fluorescence Detection
8
Mycotoxin Analysis in MM by HPLC-Fluorescence Detection
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NJ Department of Health
Summary Results of Cannabis Analysis(October 2012 – April 2016)
• Total number of samples: 635• Total cultivars: 111• Total strain types: 65• All of the products tested are in
compliance with the regulations.
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NJ Department of Health
What’s New?• New types of cannabis
products have been proposed by a growing center in NJ.
• Testing plan proposed by the grower• Testing at their own lab• Other testing in the labs in other states• Sharing testing plan, results and any
related documents with NJDOH Hightimes.com
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NJ Department of Health
What Is the Role of NJDOH for the New MM Products?
• In discussion: Oversight role only ?• Should all of the target analytes tested for the
plant material be required for testing for the new products?
• Should we conduct QA tests??• Should we establish and validate the methods for
the new products?• Do we have enough resources for conducting the
new tests?
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NJ Department of Health
AcknowledgementsPHEL-NJDOHChristopher RinnOnesia Bishop, Ph.D.Bahman Parsa, Ph.D.Sherman Hom, Ph.D.--CT LabFloyd Genicola (retired)Bhupendra Patel, Ph.D.Daniel Wene--Inorganic labDouglas R HaltmeierShawn O’Leary Eric Bind
NJDA, Plant IndustryCarl Schulze (retired)Yong Pu, Ph.D.Grace McMackinMarcello Mangano
NJDOH MM Program OfficeJohn O’Brien (retired)Jim BaraciaKevin HealeyDave HodgesFredrick Loblein
PHEL-NJDOH--Data ManagementRobert Servis--QAEvan Cadoff (retired)Sharon RobinsonMartha Smith
Email: [email protected]: (609) 530-2803