role of atorvastatin
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Role of atorvastatin,Role of atorvastatin, atrovastatin, statin, journal, pharmd, vels, Facebook, Diabetes mellitus, Diabetes mellitus type 2,TRANSCRIPT
ROLE OF ATORVASTATIN ON
C – REACTIVE PROTEIN LEVELSaini NK et al
Source Journal: Inventi Rapid: Pharmacy Practice Vol.2011, Issue 2
Introduction
C-reactive protein plays a role in the expression of different adhesion molecules on endothelial cells and the protein is able to activate human complement within the plaque.
It has been proven that an elevated CRP level is associated with an increased risk of occlusive arterial disease.
C-Reactive protein
C-reactive protein is an acute phase protein, the levels of which rise in response to inflammation, microbial infection.
CRP serves as a critical component of the innate immune system by enhancing the uptake of microbes by phagocytic cells of the immune system.
Normal CRP levels
C-Reactive protein normal: 0-1.0mg/dl (or) 10mg/L (SI Units) The hs-CRP test measures the risk for cardiovascular problems.
It may be done to find out an increased chance of having a sudden heart problem, such as a heart attack.
High-sensitivity C-reactive protein (hs-CRP) levels
Less than 1.0mg/L Lowest risk
1.0-3.0mg/L Average risk
More than 3.0mg/L Highest risk
Atorvastatin
Atorvastatin is a synthetic HMG-CoA reductase inhibitor with a great potency to lower both cholesterol and triglyceride concentrations.
Controlled studies with various groups of hyperlipidemic patients showed reduction of LDL cholesterol by up to 60% and triglyceride by up to 50%.
Mechanism of action: Inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the
rate limiting enzyme in cholesterol synthesis.
Mechanism of action of Atorvastatin
Pleiotropy of statins
Statins have been shown to decrease ROS production and VSMC proliferation, enhances eNOS levels exhibit anti-thrombotic and anti-inflammatory effects thereby, attenuate artherosclerotic plaques.
Trials using different statins, including pravastatin, simvastatin and atorvastatin have all demonstrated favourable reductions in C-reactive protein level.
VSMC-Vascular Smooth Muscle Cell
Role of Atorvastatin on CRP level
Atorvastatin improves endothelium dependent vasodilatation and a lowering of plasma CRP concentrations.
It has been demonstrated that statins have an effect on markers of inflammation, particularly C-reactive protein, independent of their lipid lowering effect.
Novel route of plaque attenuation: Artherosclerotic plaque growth may be attenuated with therapy aimed at minimizing inflammation.
Artherosclerotic plaque attenuatuion through CRP level reduction
Increased levels of C-reactive protein have associated with arterial wall inflammation.
Thus reduction in CRP levels may reduce the extent of endothelial-cell opsonisation, macrophage recruitment and blunting of nitric oxide release.
Prevention of vasoconstriction by attenuating the pro-inflammatory process and preserving vasodilatation may allow sufficient perfusion to prevent myocardial ischemia.
Suppression of expression of inflammatory parameters by Atorvastatin
Reduction in C-reactive protein level.
Reduction of endothelial cell opsonisation.
Increase in nitric oxide release
Vasodilation
Vasodilation
Increase in perfusion
Sufficient blood supply to the cardiac
tissue in need
Prevention of myocardial ischemia
Clinical trialsName of the study Type Drug % Reduction in
CRP level
MIRACL Randomized controlled trial
Atorvastatin 83%
CURVES Comparative dose efficacy study
Pravastatin, Simvastatin, Atorvastatin
Significant
TexCAPS Randomized placebo controlled trial
Lovastatin 14.8%
PRINCE trial Antiinflammatory effects
Pravastatin 16.9%
REVERSAL AtorvastatinPravastatin
36.4%5.2%
Inference
The use of statins may prevent ischemia by both inhibiting deposition of lipids and decreasing inflammation.
Atorvastatin also lowers plasma LDL cholesterol and C-reactive protein in type-2 diabetic patients, therefore could be a useful medication for the prevention of cardiovascular diseases in diabetic patients.
Doses of commonly used statins
Statin Dose Brand name Manufacturer
Lovastatin 10mg, 20mg ROVACOR, AZTATIN, LOVAMEG
Ranbaxy, Sun Pharma
Simvastatin 5mg, 10mg, 20mg SIMVOTIN, SIMCARD
Ranbaxy(Stancare)
Pravastatin 10mg, 20mg PRAVATOR Ranbaxy(Solus)
Atorvastatin 5mg, 10mg, 20mg AZTOR, ATORVA, ATORLIP, LIPITOR
Zydus Cadilla, Pfizer.
Rosuvastatin 5mg, 10mg, 20mg ROSUVAS, ROSYN Ranbaxy
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