REVERSE PHARMACOGNOSY

PRESENTED BY,

GIRIJA MAGANTI

MPHARM(PHARMACOLOGY)

G.PULLAREDDY COLLEGE OF PHARMACY

INTRODUCTION

Normally we start from the plant and get the useful molecule. Here we start with knowing which molecule would affect a key enzyme, and finding which plants could be a source of that particular molecule .

Development is much faster than conventional

screening. We just need to test one molecule, where

in the traditional way, they looked at 10,000.

SELENERGY

• Inverse docking software predicts interaction between ligand and protein.

• It is database of 7000 proteins structures with annotated biological property

• Provides the estimation of synergy that molecule have on set of proteins.

Ligand finding synergy with proteins

STUDY ON ε-VINIFERIN

• Using this inverse docking software biological targets of ε-viniferin are get identified

• Among 400 screened proteins two targets are retained

• It shows selectivity for PDE4 and DR,other PDE subtypes(1,2,3,5,6)are not retained.

• This selectivity was confirmed by evaluation of TNFα and IL-8 secretion.

STUDY ON LIMNOCITRUSS

• Another study on identification of binding site targets of meranzin using selenergy

• Among 400 screened proteins 3 targets were selected(cox1,cox2,PPARgamma)

STUDY ON TOFISOPAM

• The racemic form of drug is used to treat anxiety in olden days.

• By applying drug reposition strategy to tofisopam using selenergy revealed that the isomers are able to fit with PDE4.

ADVANTAGES

• Accelerate drug discovery and development shortens the time and cost of R&D(finds new appplications of new plants)

• Drug reposition(target hoping)• Decreases plant usage.

REFERENCES

• current drug discovery technologies.• Greenpharma sas, 3 allée du titane 45100

orléans, france.• curr pharm des. 2010 may;16(15):1682-96 pub

med.

THANK YOU