respiratory system. which lung is bigger? why is it bigger? which lung is bigger? why is it bigger?...
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Respiratory System Respiratory System
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Which lung is bigger? Why is it Which lung is bigger? Why is it bigger?bigger?
Why does breathing in cold air hurt?Why does breathing in cold air hurt?
Can you get sick from breathing in Can you get sick from breathing in cold air?cold air?
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FunctionFunction
Gas exchange for the Gas exchange for the bodybody
–Supply OSupply O2 2
–Remove CORemove CO22
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StructureStructure
Two major divisions:Two major divisions:
–Upper Respiratory TractUpper Respiratory Tract
–Lower Respiratory TractLower Respiratory Tract
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Upper Respiratory TractUpper Respiratory Tract
Think Think holes holes and tubesand tubes
Nasal/oral Nasal/oral cavitiescavities
PharynxPharynx LarynxLarynx TracheaTrachea
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Upper Respiratory TractUpper Respiratory Tract
Air is Air is –FilteredFiltered
–MoistenedMoistened
–WarmedWarmed
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Lower Respiratory TractLower Respiratory Tract
Think Think upside upside down treedown tree
BronchiBronchi
BronchioleBronchiole
AlveoliAlveoli
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Bronchus vs. BronchioleBronchus vs. Bronchiole
Bronchus – lots of cartilage – won’t Bronchus – lots of cartilage – won’t collapsecollapse
Bronchiole – more muscle – so can Bronchiole – more muscle – so can dilate and constrictdilate and constrict
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AlveoliAlveoli
300 million alveoli in each lung300 million alveoli in each lung Wall is single cell layer thickWall is single cell layer thick
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Where does Respiration Where does Respiration Occur?Occur?
Respiration:Respiration:
Gas exchange Gas exchange across a across a membranemembrane
Ventilation:Ventilation:
Conducting Conducting air in/outair in/out
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Which lung is bigger? Why is it Which lung is bigger? Why is it bigger?bigger?
Why does breathing in cold air hurt?Why does breathing in cold air hurt?
Can you get sick from breathing in Can you get sick from breathing in cold air?cold air?
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As Nate would say, “I don’t As Nate would say, “I don’t want to breathe anymore…”want to breathe anymore…”
Ciliated Ciliated epithelial epithelial cellscells in trachea in trachea (250 cilia/cell)(250 cilia/cell)
Goblet cellsGoblet cells located located between these between these cells produce ½ cells produce ½ cup of cup of mucus/daymucus/day
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Coughing and SneezingCoughing and Sneezing
the cilia beat about 1,000 the cilia beat about 1,000 1,500/minute, moving mucus up 1,500/minute, moving mucus up about 10-20 mm/min (1 mile/week) about 10-20 mm/min (1 mile/week)
You cough when nerve endings in the You cough when nerve endings in the larynx, trachea, or larger bronchi are larynx, trachea, or larger bronchi are irritated. irritated.
You sneeze when nerve endings at You sneeze when nerve endings at the back of the nasal cavity are the back of the nasal cavity are irritated. irritated.
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HOW do we breathe?HOW do we breathe?
What keeps your lungs from collapsing?What keeps your lungs from collapsing?
How MUCH do we breathe?How MUCH do we breathe?
How do we TRANSPORT what we How do we TRANSPORT what we breathe?breathe?
What makes us take the next breath?What makes us take the next breath?
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HOW do we breathe?HOW do we breathe?
What is the relationship between What is the relationship between pressure and volume?pressure and volume?
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HOW do we breathe? HOW do we breathe? Inhaling:Inhaling:
1.1. Diaphram and intercostal muscles Diaphram and intercostal muscles contract – thoracic cavity expandscontract – thoracic cavity expands
2.2. Lungs expand (adhered to walls) Lungs expand (adhered to walls)
3.3. Since Since intrapulmonary volumeintrapulmonary volume has increased, pressure has increased, pressure ____________.____________.
4.4. Air is sucked inAir is sucked in http://http://www.smm.org/heart/lungs/breathing.htmwww.smm.org/heart/lungs/breathing.htm
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How do we breathe? How do we breathe? ExhalingExhaling
1.1. Diaphram and intercostals relaxDiaphram and intercostals relax
2.2. Thoracic/intrapulmonary volume Thoracic/intrapulmonary volume decreasesdecreases
3.3. Intrapulmonary pressure is now Intrapulmonary pressure is now ____________
4.4. Gases flow outGases flow out
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So what keeps your lungs from So what keeps your lungs from collapsing?collapsing?
Intrapleural pressure is always negativeIntrapleural pressure is always negative
If it equalizes with atmospheric pressure (as in If it equalizes with atmospheric pressure (as in a chest wound), lungs immediately collapsea chest wound), lungs immediately collapse
Air in intrapleural Air in intrapleural space = space = pneumothoraxpneumothorax
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How MUCH do we breathe?How MUCH do we breathe?
Tidal volume – normal exhaled breathTidal volume – normal exhaled breath
Vital Capacity – largest exhaled breathVital Capacity – largest exhaled breath
Residual Volume - left over amt after Residual Volume - left over amt after VCVC
Total Lung Capacity – RV + VCTotal Lung Capacity – RV + VC
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How MUCH do we breathe?How MUCH do we breathe?
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How MUCH do we breathe?How MUCH do we breathe?
Tidal volume – 500 mlTidal volume – 500 ml
Vital Capacity – 4800 mlVital Capacity – 4800 ml
Residual Volume - 1200 mlResidual Volume - 1200 ml
Total Lung Capacity – 6000 mlTotal Lung Capacity – 6000 ml
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How do we TRANSPORT what How do we TRANSPORT what we breathe?we breathe?
OXYGEN: Transported by hemoglobin (Hb) OXYGEN: Transported by hemoglobin (Hb) as oxyhemoglobin (HbOas oxyhemoglobin (HbO22))
Each OEach O22 attaches to attaches to one Hemeone Heme
Each RBC has 250 Each RBC has 250 million hemoglobinsmillion hemoglobins
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How do we TRANSPORT what How do we TRANSPORT what we breathe?we breathe?
Carbon Dioxide: two Carbon Dioxide: two methodsmethods
1.1. On the globin of HbOn the globin of Hb
2.2. As bicarbonate:As bicarbonate:
COCO22 + H + H220 0 HH22COCO33 H H++ + HCO3 + HCO3- -
This occurs inside the RBC – but then the HCO3This occurs inside the RBC – but then the HCO3- -
goes back into the blood plasma. goes back into the blood plasma. WHY?WHY?
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Carbonic anhydraseCarbonic anhydrase
Oxyhemoglobin - Oxyhemoglobin - HbOHbO22
Carbaminohemoglobin - Carbaminohemoglobin - HbCOHbCO22
Bicarbonate - HCO3Bicarbonate - HCO3--
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What makes us take the next What makes us take the next breath?breath?
Too dangerous to wait for OToo dangerous to wait for O2 2 levels to droplevels to drop
The major stimulus for inspiration is a The major stimulus for inspiration is a slight increase in blood acidity:slight increase in blood acidity:
HH++ + HCO + HCO33-- normoventilationnormoventilation
respiratory control respiratory control
center in braincenter in brain
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What happens when you What happens when you hypoventilate?hypoventilate?
What happens when you What happens when you hyperventilate? hyperventilate?
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What Is Asthma?What Is Asthma?
Spasmodic contraction of bronchi Spasmodic contraction of bronchi
Bronchial swellingBronchial swelling
Increased production of mucusIncreased production of mucus
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What is bronchitis?What is bronchitis?
bronchi are inflamed and swollenbronchi are inflamed and swollen
mucus is hypersecretedmucus is hypersecreted
Why?Why?
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What is emphysema?What is emphysema?
Airways are permanently damagedAirways are permanently damaged
Alveoli are permanently damagedAlveoli are permanently damaged
Reduced ability to exchange gasesReduced ability to exchange gases
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DiphtheriaDiphtheria