research and technology transfer at the bio/nano/electronic interface applied biotechnology...

RESEARCH AND TECHNOLOGY

TRANSFER AT THE

BIO/NANO/ELECTRONIC INTERFACE

Applied Biotechnology Innovation Centre

Ioanis KatakisOctoner 25, 2004

Tarragona


WHO ARE WE?

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PhD

Technicians

BBCAT

Evolution

of membership


HOW WE FINANCE OUR WORK?

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HOW WE WORK?

Knowledge Creation• Biosensors• Bioelectronics• Nanotechnology• Microsystems• (Photo)catalysis• Biotechnology

Technology Transfer• Clinical & veterinary diagnostics• Biomedical applications• Food & Agriculture• Pharmaceutical & Fine Chemicals• Chemical Industry• Renewable energies

Innovation• Spin off companies• New educational/vocational

models


OUR SECOND RESEARCH PLAN

MICROSYSTEMSMICROSYSTEMS

Enzyme (NAD) BIOELECTRONICSBIOELECTRONICS

NANOTECHNOLOGYNANOTECHNOLOGY

BIOSENSORSBIOSENSORS

NEW AREASNEW AREAS

APPLIED RESEARCHAPPLIED RESEARCH

Immunosensors

DNA Biofuel cells Neuron chip

Directed deposition Nanocatalysts

Screen printed Microreactors Aptamers

Bioreactors

Solar Cells

Making immuno strips and systems


FROM SUB MOLECULAR TO MACRO

GENESGENES

PROTEINSPROTEINS

CELLSCELLS

TISSUESTISSUES

ORGANSORGANS

ORGANISMSORGANISMS

ECOSYSTEMSECOSYSTEMS

NANOTECHNOLOGYNANOTECHNOLOGY

BIOSENSORSBIOSENSORS

BIOELECTRONICSBIOELECTRONICS

TISSUE ENGINEERINGTISSUE ENGINEERING

IN VITRO SYSTEMSIN VITRO SYSTEMS

MICROSYSTEMSMICROSYSTEMS

MULTI MICRO BIOREACTORSMULTI MICRO BIOREACTORS

ENVIRONMENTAL BIOTECHNOLOGYENVIRONMENTAL BIOTECHNOLOGY

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SOME RESEARCH LINES (1/4)

MODULE 1

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MODULE 2

++ + MODULE 3

-- -

MODULE 4

Os

Os Os+ +

MODULE 5

MODULE 6...

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-+

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+

Os

Os

Os

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SELF ASSEMBLY FOR THE ULTIMATE (BIO)CHEMICAL CATALYTIC FLEXIBILITY

• Narváez et al. Biosens Bioelectr 15:43-52 (2000)

• Narváez et al. J Electroanal Chem 430:227-33 (1997)



SUPRAMOLECULAR ARCHITECTURES FOR COMPLEX BIOSENSING, AMPLIFICATION, AND

CATALYSIS TASKS

• Popescu et al. J Electroanal Chem 464:208-14 (1999) (+2 in preparation)

• V. Pavlov Thesis (2005) on biosensors, K. Horton DEA (2003) liposomes

Sonicate, extrude



• Campàs & Katakis Int J Env Anal (in press), PCT&US pat. Appl (2002)

• M. Campàs PhD Thesis (2003), S. Dondapati DEA Thesis (2004)

gold colloidoligonucleotide

colloidal gold-oligonucleotideselective deposition

deposition

conjugation

NANOCOLLOID SYNTHESIS AND MODIFICATION FOR NANOPATTERNING AND ARTIFICIAL

INTELLIGENCE



Os+Os+

Os+Os+

Os+Os+

Os+Os+

Os+Os+

Os+Os+

- - --- -

+ + +++ +- - --

- - }N1

+ + +++ +

+ + +++ + }N2

- - --- -

Glucose oxidase produces H2O2

Peroxidase uses H2O2 and consumes electrons at E2

Glucose oxidase produces electrons at E1

e-

e-

• P. Pescador DEA thesis (2004) Biofuel cells

TOWARDS THE ULTIMATE NANOMACHINE(?): SELF POWERED, SELF PROPELLED, SELF PROPAGATING


BBG/DINAMIC MOST VALUABLE RESOURCE

• Magda Constanti (Lector, Microbiology)

• Teresa Hechevarria (Torres Quevedo, Chemical

Engineering)

• Ioanis Katakis (Associate professor, Chemical

Engineering)

• Petros Lenas (Ramon y Cajal, Tissue Engineering)

• Przemyslaw Los (Visiting Professor, Physical

Chemistry)

•Josep Ma Montornés (Post doctoral fellow, Org.

Synthesis)

• Susana Rodríguez (Ramon y Cajal, Bioprocess

Engineering)

• Jose Luis Toca-Herrera (Ramon y Cajal,

Nanotechnology)

SENIOR MEMBERS AND PROJECT MANAGERS


BBG/DINAMIC MOST VALUABLE RESOURCE

PERMANENT TECHNICIANS AND SUPPORT

• Barbara Vastenavond (Administration)• Lea Gragert (Administration and accounting)• Mònica Mir (Technician, Electrochemistry)• Joaquim Solana (Marketing, Project support)• Diego Bejarano (Technician, Chemical & Process Engineering)• Marta Jimenez (Technician, microbiology)• MireiaMassanell (Technician, Immunology)• Cristina Sanz (Technician, Analytical techniques)• Xavier Roch (IT Technician)


BBG/DINAMIC MOST VALUABLE RESOURCE GRADUATE STUDENTS AND TRAINEES

• Mònica Mir (PhD Student, Bioelectrochemistry)• Srujan Dondapati (PhD Student, Bioelectrochemistry)• Paula Pescador (PhD Student, Molecular biology/fuel cells)• Veronica Saravia (PhD Student, Tissue engineering)• Viviana Duarte (PhD Student, Immunosensors)• Frank Jeyson (PhD Student, Biofuel cells)• Kelly Briceño (PhD Student, Bioelectrochemistry)• Peter Pfeiffer (PhD Student, Biomolecular interactions)• Rory McNally (MS trainee, Microbiology)• Denise Hogan (MS trainee, Microbiology)• Antoni Montseny (Undergraduate trainee)• David Romero (Undergraduate trainee)• Josep Pamies (Undergraduate trainee)


OUR PRODUCTIVITY IN PERSPECTIVE

• PhD Theses: 2,0 (1995-2004)• DEA Theses: 9,0 (1995-2004)• Publications/PDI/year: 2,5 (ISI 1990-1999) • Citations/PDI/year: 21,0 (ISI 1990-1999)

DATA BBG

DATA Catalunya (all areas)• Citations/article/year: 1,7 (1994-1998)

DATA USA (Chemical Engineering source: NRC 1990-94)• Citations/PDI/year: 23,44 (rank #1 U of Minnesota)20,78 (rank #2 Stanford U)

• Publications/PDI/year: 4,6 (rank #1 U of Minnesota)

2,5 (rank #13 SUNY, Buffalo)1,7 (rank #72 U of Tulsa)


ACKNOWLEDGEMENTS

Our work is financed by:

• INNOCUOUS (Immunostrips for TCA detection)

• MICROPROTEIN (Patterning and arraying)

• HEALTHY AIMS (Fuel cells)

• CIDEM and our Clients

• URV, DURSI, MECD

research and technology transfer at the bio/nano/electronic interface applied biotechnology...

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