r e p o r t - ucla molecular biology institute · 2018-11-20 · r e p o r t êèéï êèéð 8...
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ANNUAL REPORT
2017 -2018
Molecular Biology Institute
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m b i . u c l a . e d u
U C L A B o y e r H a l l
m b i a s s t @ l i f e s c i . u c l a . e d u
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MOLECULAR BIOLOGY INSTITUTE
REMEMBERING PAUL BOYER
MBI DIRECTOR’S REPORT MBI COMMITTEES
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MBI ADMINISTRATIVE SUPPORT STAFF ACTIVITIES Administrative Services Building Management
MBI PROGRAMS & EVENTS
The David S. Sigman Memorial Lectureship & Symposium The Audree Fowler Fellows in Protein Science The Jules Brenner Achievement Fellowship in Molecular Biology Boyer/Parvin Postdoctoral Research Awards Thursday Seminar Series MBI Interdisciplinary Faculty Seminars MBI Annual Retreat & Research Conference Biotechnology Edge Workshop Focus on Imaging Workshop Mouse Genome Informatics Workshop
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MBI FACULTY RESEARCH & PROFESSIONAL ACTIVITIES Newly Appointed Members Honors & Professional Awards Service on UCLA Committees Service on External Committees Patents Issued Visiting Faculty & Scholars
19 22 23 27 32 33
MBI PARTNERS IN BOYER HALL Institute for Quantitative & Computational Biology (QCBio) The QCBio Collaboratory UCLA-DOE Institute Fermentation Core Facility
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GRADUATE PROGRAMS Molecular Biology Interdepartmental Ph.D. Program (MBIDP) Whitcome Pre-doctoral Training Program
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MEMBER PUBLICATIONS MBI Faculty Publications
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PAUL D. BOYER 1918 - 2018
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REMEMBERING WITH GRATITUDE
PAUL D. BOYER 1918 - 2018
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DearColleagues,Thisyearwillbeforevermemorableinthehistoryof our Institute because itmarks the passing ofourbelovedPaulBoyer.Hismanyscientificandacademic accomplishments have beenhighlighted in several journals and it has beenwonderful to hear so many colleagues speakabouthowmuchDr.Boyermeanttothem.Wearegrateful for his vision, his collegiality, hiscommitment to scientific excellence and hisoptimisticspirit,allofwhichbecamepartofthecultureofourinstitute.Thankyou,Paul!ThelastyearwasalsomarkedbyseveralchangesintheMBIDPofficeandbuilding.TwonewSAOs,StephanieCuellarandAshleyTerHorst joinedourofficeandhavesmoothlytakenovertheadministrationoftheMBIDPandhavequicklybecome familiarwithourbodyof students and faculty.Anewadministrator assistant,AltagraciaAlvaradoisnowthefacebehindtheMBIemails,workshops,eventsandinteractionswithourbodyofstudents.BigkudostoHelenHouldsworthfor“fillingtheblanks”aswecompletedsearchesandrecruitedthisgreatteam.WealsowelcomeMikeKane,ournewbuildingmanagerwhohassoefficientlyadaptedtoUCLAandBoyerHallandcontinuedtotakecareoftheInstituteandBoyerHalloccupants.MuchofourattentionhasbeenplacedontherenovationsofBoyer159,ourpremierconferenceroom.ThemuchneededupgradewasonlypossiblebecauseofthecommitmentandsupportoftheDeansofLifeSciences,DGSOMandPhysicalSciencesaswellastheChairofChemistryandBiochemistry.Wecouldnothavedoneitwithoutyou!Thepatio adjacent to the conference roomwill also be renovatedby the endofNovember andwill provide anoutstanding space for events, meetings, student recruitment, informal discussions and celebrations. We areextremelyexcitedtohavethisgreatspaceavailableforalltheevents,thesisdefensesandscientificseminars.Thankyouallforyourpatienceandtrust.HighlightsofthepastyearfortheMBIincludedtheSigmanSymposiumhonoringProfessorYigongShiwhodeliveredamemorablelectureentitled“Mechanismofpre‐mRNAsplicingbytheSpliceosome”.Asinpreviousyears,thiswasawonderfuleventandImustacknowledgetheMBISigmanLectureshipCommitteethatincludesFengGuo,ReidJohnsonandJimBowie(chair).Thankyoufortheoutstandingselectionandyourcontinuouscommitmenttothisevent.Alongtheselines,theflagshipoftheinstitute,MBIThursdaySeminarSerieshasbroughtinfantastictalksandimpressivescientists.ThankyoutoMargotQuinlanandTracyJohnsonandtheircommitteefortheirhard,hard,hardworkonthisendeavor.AscanbeeasilynotedintheNewsletter,themembershipcontinuestothriveandthescientificcaliberofourfacultyisunquestionable.HereImusthighlightafewhonorsreceivedbyourmembers:theelectionofUtpalBanerjeetotheNationalAcademyofSciences,HHMIinvestigatorawardtoTamirGonen,theWilliamC.RoseAwardgivenbytheASBMBtoStevenClarke,thePaulSiglerPrizegivenbyYaleUniversitytoDavidEisenbergandtheAmericanHeartAssociationRusselRossMemorialLectureshiptoKarenReue.Congratulations!Ourgraduateprogramisexpanding,withatotalof145students.Wejustwelcomedourincomingclassof2018‐2019with23students.Duringthisacademicyear,14studentsreceivedtheirdoctoratesandcombinedtheyproduced119scientificpublications.Theyareour legacyandweare fullycommitted toconstantly improve their trainingandresearchexperience.Iwouldtaketheopportunitytothankourhomeareadirectors:FengGuo(BBSB),JeffLong(CDB),MichaelCarey(GREAT)andPeterBradley(IMMP)whohaveplacedalotofenergyintotherecruitmentoftheincomingclassandtheguidanceofcurrentstudents.Ourmissiontoreconnectwithourlargebodyofgraduateshascontinued,throughalumninewslettersandotheroptionstoconnectwiththeprogram.Duringthiscomingyear,alumnilocatedintheLAareawillbeinvitedtoattendtheupcomingMBIretreatwhichwillbeinLakeArrowhead.It
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hasbeennicetoreceivefeedbackfromsomeofthemstatinghowmuchtheinstitution,andtheMBIinparticular,meanttothematacriticaltimeintheircareers.ThroughthegenerosityofourdearAudreeFowler,theMBIhasbeenabletoawardfourAudreeFowlerFellowshipsin Protein Science this past year. This has become a wonderful tradition and our graduate students are veryappreciativefortheopportunitytocompeteforthisaward.Thisyear’sawardeesare:MichaelHughes(Eisenberglab),Kanishk Jain (Clarke lab),WilliamBarshop(Wohlschlegel lab)andYuxiLiu (Yeates lab).The JulesBrennerAchievement Fellowship in Molecular Biology went to Aimee Flores (Lowry lab). Congratulations to all theseoutstandinggraduatestudents!Finally,the18thannualBoyer‐Parvinrecognitionawardshavecontinuedtoprovideastand‐upsalutetoourbodyofpost‐doctoraltrainees.Thisyear,from9exceptionalnominees,3wereselected.ThewinnerswereFrancisMercer(PatriciaJohnson’slab),MarcusSeldin(JakeLusis’lab)andMichaelHicks(AprilPyle’slab).ThishasbeenaspecialsignatureoftheMBI,initiatedbyourfounder,andwearecommittedtoseekadditionalfundstocontinuethesupportofthisimportantevent.Asinpreviousyears,theImagingWorkshopandtheBiotechnologyWorkshopswereasuccesswithattendancetofullcapacity.WearepreparingsomeslightmodificationstotheImagingworkshoptobettersupportourcommunitywithmorestratificationintraining(beginner,intermediate,advanced).Hopetoseeyouatourevents,symposiaandseminars!Hastapronto.LuisaLuisaIruela‐Arispe,Ph.D.Director,MolecularBiologyInstitute
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EXECUTIVEADVISORYCOMMITTEEAmanderClark,CatherineClarke,AlexanderHoffmann,SiavashKurdistani,SabeehaMerchantand
JeromeZack
MBIMEMBERSHIPArnoldBerk(Chair),AlisonFrand,BennettNovitch,ThomasVondriskaandMeganMcEvoy
THURSDAYSEMINARSMargotQuinlan(co‐Chair),TracyJohnson(co‐Chair),DouglasBlack,HilaryColler,David
Eisenberg,SriKosuri,MichaelTeitellandTomVallim
SIGMANAWARDSELECTIONJamesBowie,FengGuo,LuisaIruela‐ArispeandReidJohnson
AUDREEFOWLERFELLOWSHIPINPROTEINSCIENCEJoseRodriguez,SiavashKurdistani,KathrinPlathandGregoryPayne
JULESBRENNERSCHOLAR’SACHIEVEMENTFELLOWSHIPINMOLECULARBIOLOGYJulesBrenner,AmanderClark,DonKohnandTimothyLane
PHILIPJ.WHITCOMEFELLOWSHIPFengGuo,JeffreyLong,PeterBradleyandMichaelCarey
BOYER/PARVINPOSTDOCTORALAWARDSKarenReue,JoseRodriguez,OliverFregosoandHilaryColler
MOLECULARBIOLOGYINTERDEPARTMENTALPH.D.PROGRAMLuisaIruela‐Arispe,PeterBradley,MichaelCarey,JeffreyLongandFengGuo
2017‐2018ANNUALRETREATGeoffreyProvonost(Chair),AaronVanLoon,BrendaMolgora,GuillaumeUrtecho,Samantha
Edwards,AlexSercelandJessicaOchoa
ANNUALRETREATPOSTERJUDGESPeterBradley,MichaelCarey,HilaryColler,AndrewGoldstein,FengGuo,LuisaIruela‐Arispe,
TracyJohnson,JeffreyLong,MargotQuinlanandMelissaSpence
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ADMINISTRATIVESERVICESHelenHouldsworth,BoyerHallManagementServicesOfficer
It’s a pleasure to update you on the administrative team thatmade the activities you read about in this reportpossible.I’mconsistentlyimpressedbytheenergytheybringtotheirroles,aswellastheircommitmenttoserveourFacultyandstudentsandtheteamworktheyshoweachother.InOctoberwewelcomedAltagraciaAlvaradoasournewOfficeCoordinator,replacingMeganWeitzelwhomovedontoanSAOpositioninnorthcampus.Altagracia(“Gracie”)isarecentgraduatefromUCLAandapassionateBruin.Althoughnewtothesouthcampussciencecommunityandtomanyofthetasksshewasfacedwith,shethrewherselfwhole‐heartedlyintolearningandadaptingtohernewrole.Shealsobroughthercreativeskillswhichhavegivenouradvertisingmaterials,websiteandsocialmediaamuchneededboost.She’smade thepositionherownandbecomeavaluedmemberoftheteam.Ataroundthesametime,wehiredStephanieCuellar,andshortlyafterthatAshleyTerHorstasnewSAO’sfortheMolecularBiologyIDP.(Yes,itwasabusyfallquarter!).Inaneworganizationalarrangementforus,Stephanienowtakesprimaryresponsibilityforstudentrecruitment,admissionsandalumnirelationsandAshleyisresponsibleforcontinuingstudentactivitiesandtime‐to‐degreeprogress.BothAshleyandStephaniejoinedusfromotherpositionsatUCLA,whichhelpedthemadapttotheirnewroles.Nevertheless,theyworkedtirelesslytobecomefamiliarwithourMBIcommunityandthenuancesofanIDP,atatimewhentheacademicquarterwasalreadyinfull‐swing.Theirwillingnesstosupporteachotherandworkasateamisahugebenefittotheprogramandgivesusagreatercapacitytosupportallaspectsofourstudents’education.IntheabsenceofanyMBIDPSAO’sduringthesummer,newBioinformaticsSAOMandyMcWeeneyhelddownthefortforbothprograms.Wecouldnothavesurvivedthishectictimewithouther!ShealsogenerouslysharedherknowledgeandexperiencewithStephanieandAshleywhentheyarrived,helpingthemgetuptospeed.As a final summer challenge in theGraduate Programs office,we decided to initiate a remodel, to improve theawkwardconfigurationandcreatethreeentirelyseparateandprivateofficesforourSAOs.TheworktookmuchlongerthanhopedandAshleywasconfinedtotemporaryofficespaceforseveralmonthsaftershestarted.However,I’mhappytoreportthatallthreeSAOsarenowinplaceandwehaveamuchmorefunctionalsuite!Long‐timeBuildingManager,ShawnLockard,retiredfromUCLAattheendof2018.ShawnhadalongandsuccessfulcareeratUCLAandadeepknowledgeofBoyerHall,boththepersonnelandtheinfrastructure.Heleftbigshoestofill.Afteranextensivesearchforhisreplacement,wewerefortunatetofindMichaelKane.MikecameonboardinlateJanuary,bringinghisexperienceinuniversitybuildingmanagementfromMITandabackgroundinconstructionprojectmanagementwhich isproving tobe invaluable inBoyerHall at this time (seehis firstmanagers’ reportbelow!).Mike’sattentiontodetail,enthusiasmtolearnaboutBoyerHallandhiseasy‐goingpersonalityhaveallbeengreatlyappreciatedbyouradminteamandtheFaculty.WealsoappreciatedOrenSaig,ourFacilitiesCoordinatorwhosteppedinasBuildingManageruntilMikewashired.OrencoveredforShawnwiththesameleveloffocusanddedicationhebringstohisownrole,makingsuretherewasminimalimpacttotheresearchersofBoyer.AsaresultwewerehappytorecommendhimforapromotiontoAssistantBuildingManager,arequestwhichwasapprovedrecently.OrenandMikehavedevelopedagreatworkingrelationshipandtheoccupantsofBoyerarefortunatetohavebothofthesededicatedguysintheBuildingManagementoffice.IwouldberemissatthispointtonotmentionLuzTorres,whohaskeptourfinancesonanevenkeelthroughouttheyear.LuzsuccessfullymanagesinternalandexternalfundsfortheMBI,MBIDP,QCBioandBioinformatics,whichrepresents hundreds of payments, reimbursements, transfers and overall budgeting oversight. Luz also plays aleadingroleintrainingjunioradministratorsinfinancialtransactionsandansweringtheirquestionsastheybecomefamiliarwiththeUCLAsystems.ThishasbeenaverybusyyearforLuzandweappreciatehercalmleadershipandoversightofallofouroperations.Luzwillbeinevenhigherdemandnextyear,astheMBIofficemovesintointer‐departmentalgrantssubmissions.Webelievethisisamuch‐neededservicetoourmembersandoneweareuniquelyplacedtoprovide.Moreonthisinnextyear’sreport!
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Finally, a note about QCBio, which continues to grow and evolve. BIG summer, the undergraduate program tointroduceyoungstudentstobioinformaticswelcomedaround40participantsthisyear,fromacrossthecountry.QCBioProgrammanagerJessicaJimenezhastakentheleadinthisinnovativeprogramand,duetoafamilymove,she’snowhandingoverthereinstoLanaMartin.LanajoinedusattheendofJulyandwilltakeoverbothBIGSummerandtheQCBiocollaboratorypostdoctoralteachingprogram.QCBioadministratorMarieGrossettspentalargepartofheryearplanningandrunningtheInternationalSystemsBiologyofHumanDiseasesConference,whichwashosted atUCLA this year.Marie arranged all the conferencelogistics,meals,accommodationandguestspeakers.TheconferencewasabigsuccessandMarie’swarm,hospitableapproachwascommentedonbymanyoftheguests.Asyoucansee,wehadaveryfullyearwithlotsofchanges!We’lllookforwardtoseeingwhatthenewacademicyearbringsourway.
BUILDINGMANAGEMENTMichaelKane,BoyerHallBuildingManager
ProjectsWehadtwoprojectscommenceduringthe2017‐2018academicyearinBoyerHall.(1)LabRenovationinBoyer332forDr.Allard(ISGDept),whichwascompletedinJune,and(2)ConferenceRoomRenovationinBoyer159,whichwillbecompletedbyFallQuarter2018.Thefollowingprojectsareinthedesigndevelopmentphases,andwilllikelybecompletedinthe2018‐2019academicyear:
ElevatorUpgrades–BothBoyerHallelevatorswillhavetheirmechanicalsystemsreplacedandbothcabswillreceiveinteriorrefreshes.ItlookslikeourelevatorupgradewillcommenceintheFallQuarterof2018.Staytuned…
BoyerHallPatioRefresh–Wewillbesprucingupthepationowtheconferenceroomprovidesmoreaccessandvisibility.Improvementswillincludenewfurnitureandlandscapingfeatures.
QCBioWallRelocation–Weareinthedesignphaseforthiswallrelocationproject.Thisminorrenovationwillhelpopenupthecorridoronthe5thfloorandcreatemoreofacollaborativespaceforthe5thfloorlabs.
NewFacultyWeareexcitedtowelcomeDr.PatrickAllardfromTheInstituteforSocietyandGenetics.Dr.AllardjustcompletedhismovefromCHStoBoyerHallinJuneof2018.Dr.AllardandhislabgroupnowresideinBoyerHallRoom332wheretheyresearchenvironmentalimpactsongeneexpressionandtheirrelevancetohealth.BuildingPersonnelChangesIwashiredonasBuildingManagerlateJanuaryof2018.Ithasbeengreatgettingtoknoweveryoneinthebuilding,andIlookforwardtoservingtheBoyerHallresidents.IwouldalsoliketocongratulateOrenSaigonhiswell‐deservedpromotiontoAssistantBuildingManager.OrenhasbeenanexemplaryemployeefromthetimeI’veknownhimandwe’reexcitedtoseehimgrowintohisnewrole.BuildingServicesTherefrigerationunittocoldroom324wasreplaced,thiswasa$20,000maintenanceproject.Wearecurrentlylookingtoadda–20toourfreezerbackupprogramlocatedinthebasementofBoyerHall.BuildingMaintenanceWearecurrentlyworkingwithAssociateViceChancellor,KellySchmader,tomodernizethegeneraluseareasinBoyerHall.Wearehopingtomakeaestheticimprovementstogeneralbuildingareas(corridors,smallconferencerooms,andrestrooms).WearealsoseekingdeferredmaintenancefundsfromthestatetoupgradeDIwaterand
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buildinglabwastelines.Inadditiontothesedeferredmaintenanceprojects,weareworkingtosetupapreventativemaintenanceprogramforthegeneral/sharedareasofBoyerHall.ThiswouldincludeactivitiessuchasregularlyscheduledstrippingandwaxingofthecorridorfloorsandtouchuppaintingthroughoutthesharedspacesofBoyerHall.
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DAVIDS.SIGMANMEMORIALLECTUREThursday,October19,2017
DavidS.SigmanProfessor,BiologicalChemistryandChemistry&BiochemistryThe SigmanLectureshipAwardwas established in2002 tohonor thememory ofDavidSigman,ProfessorintheDepartmentsofBiologicalChemistryandChemistry&Biochemistry,andafoundingmemberandformerAssociateDirectoroftheMBI.Hewasa leader in the fieldofchemicalbiologyatUCLAanddiscoveredchemicalnucleases in a career that illuminated the molecular mechanisms of catalysis. Apermanentlyendowedfundwasmadepossiblebycontributionsfromover200ofProfessor Sigman’s colleagues, friends, and family, as well as corporate donorsincluding theAmgenFoundation,EliLillyandCompany, theBristol‐MyersSquibbFoundation,andRaytheonSystemsCompany.
2017SigmanLectureshipHonoreeYigongShi,Ph.D.VicePresident,TsinghuaUniversityDean,SchoolofLifeSciences,TsinghuaUniversityCo‐Director,Tsinghua‐PekingJointCenterforLifeSciences,BeijingKeynotePresentation“Mechanismofpre‐mRNASplicingbytheSplicesome”AbstractPrecursormessengerRNA(pre‐mRNA)splicing,discovered40yearsago,isanessentialstepintheinformationflowfromDNAtoproteininall eukaryotes.Research efforts of thepast fourdecadeshave led tomoleculardelineationof thesplicingpathway, includingdiscoveryofthenatureandspecificsofthesplicingreaction,definitionofthespliceosomeandidentificationofitscomponents,andbiochemicalanalysisofthevarioussplicingcomplexesandtheirregulation.Structuralinformationiscentraltomechanistic understanding of pre‐mRNA splicing by the spliceosome. X‐ray crystallography of the spliceosomalcomponentsandsubcomplexesiscomplementedbyelectronmicroscopy(EM)oftheintactspliceosome.Inthepasttwoyears,aburstofatomicstructuresontheintactspliceosomeatdifferentstagesofthesplicingcyclehasrevealedunprecedentedmechanisticinsightsintopre‐mRNAsplicing,corroboratingandexplainingalargebodyofgeneticandbiochemicaldata.Thespliceosomeisproventobeaprotein‐directedmetalloribozyme.Inthispresentation,Iwillsummarizemechanisticrevelationsfromrecentstructuraladvancesontheyeastandhumanspliceosomes.Atalunchtimeevent,thefollowingtraineespresentedtheirresearchtoDr.Shi:Presenter PI/Mentor TitleofPresentation
MimiHo PascalEgea/JasmineZhou
“InteractionsandepitopemappinginHumanCytomegalovirusgH/gLPentamercomplex”
DuyoungMin
JimBowie “HowCLCchloridetransporterfolds”
YuxiLiu ToddYeates “ASymmetricMolecularScaffoldforProteinImagingbyCryo‐ElectronMicroscopy”
YiYing DougBlack “SplicingactivationbyanRbfoxproteinrequiresself‐aggregationthroughitstyrosine‐richdomain”
KevinMurray
DavidEisenberg “ComputationalDesignofAmyloidFibril Inhibitors
Honoree Yigong Shi with Sigman Chair Jim Bowie
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AUDREEFOWLERFELLOWHIPSINPROTEINSCIENCE
Dr.AudreeV.FowlerhasbeenadedicatedBruinformorethan60years.Astrongsupporterofthebasicsciences,theperformingarts,andmedicineatUCLA,sherecentlydemonstratedherdevotiontotheCollegeofLettersand Science again by establishing the Audree V. Fowler GraduateFellowshipinProteinScience,tobeadministeredbytheMolecularBiologyInstitute.Since2008,30talentedgraduatestudentshavereceivedthesefellowships.AudreereceivedherB.S.inchemistryfromUCLAin1956andwentontoearn a Ph.D. in biochemistry in 1963, when that field was almostexclusivelymale. She served as aNIHpostdoctoral fellow at theAlbert
EinsteinCollegeofMedicine inNewYorkand inUCLA’sDepartmentofBiologicalChemistrybeforebecomingaresearchbiologicalchemistintheDavidGeffenSchoolofMedicineatUCLA.Shebuiltaneminentresearchcareerwhich includesover80publications. Shealsobuilt strong connectionswith theMolecularBiology Institute, theDepartment of Biological Chemistry in theDavidGeffen School ofMedicine, theUCLAProteinMicrosequencingFacility—wheresheservedasdirectorfor15years—andtheJonssonComprehensiveCancerCenter.SheisoneoffivefoundingmembersoftheAssociationofBiomolecularResourceFacilities(ABRF),whichisnowaninternationalorganizationof1,100members.Shewasnamedthefirstlifetimememberoftheorganizationin2008.AlthoughsheretiredfromUCLAin1999,Fowlerisdeterminedtoremainactive.SheisanavidBruin,maintainingher emeritimembership in theMolecular Biology Institute and serving on the board of directors ofWomen&Philanthropy.ShealsoisontheexecutiveboardofDesignforSharingandtheIrisCantorUCLAWomen’sHealthCenter,andshevolunteeredattheSantaMonicaPierAquarium—formerlytheUCLAOceanDiscoveryCenter.SheexpandedherinvolvementbygivingtoursofthePalisadesParkhostedbytheSantaMonicaconservancyandoftheMarionDaviesBeachHouse.The Audree V. Fowler Graduate Fellowships in Protein Science serves as a fitting testament to Dr. Fowler’scommitmentanddedicationtoherresearchandtoUCLA.ThefellowshipsareawardedtopromisingPh.D.candidatesworkinginproteinscience.ThecrucialresourcesprovidebytheawardadvancetheeducationoftheFowlerFellowsbyenablingthemtoconcentrateontheirinnovativeresearch.
“ThesciencesgavemeagreatlifeandnowIwanttohelpotherstohavethesameopportunitiesIenjoyed.”2017‐18Recipients
Michael Hughes (Eisenberg Lab) “Structural insights into low-complexity domains & non-membrane bound organelles”
KanishkJain(ClarkeLab)“Understandingproteinargininemethyltransferasesandtheirbiochemicalmechanisms”
WilliamBarshop(WohlschlegelLab)“MilkyWay:AProteomeBioinformaticsPlatform,anditsApplicationinDevelopmentofProteolyticDigestionResistantAffinityPurificationBeads”
YuxiLiu(YeatesLab)“CharacterizationofNaturalandEngineeredSymmetricProteinOligomers”Moreinformationaboutthisyear’srecipientsandtheirresearchcanbefoundwww.mbi.ucla.edu/fowler‐fellows.
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JULESBRENNERACHIEVEMENTFELLOWSHIPINMOLECULARBIOLOGY
Jules Brenner has worked in thecinematography division of themotionpictureindustryfromtheendofhismilitaryservicein1959totheday of his retirement in 1996,startingasacameraassistant/loaderat Warner Bros up to Director ofPhotography(1968‐1991)withsuchfilm credits as Dalton Trumbo's“Johnny Got His Gun,” John Milius’“Dillinger,”twoearlyepisodesoftheMacGyverTVseriesandthecultfave,“TheReturnoftheLivingDead.”(Hisfullcredit list isavailableonIMDB).He is a voting member of theAcademyofMotionPictureArts&Sciences(AMPAS)andservesasajudgeintheirNichollFellowshipScreenwritingCompetition.Since retirement he has been active as a motion picture and book reviewer, accredited by theMotion PictureAssociationofAmerica(MPAA)asaprintandonlinefreelancejournalist.HisreviewshavebeenpublishedinprintpublicationssuchasMysterySceneMagazine,andallaroundthewebonsuchsitesas filmcritic.com,Paste.com,About.com,andothers inaddition tohisownsites,CinemaSignalsandCriticalMysteryTour.HisreviewblurbsappearonRottenTomato.HehaslecturedonScreenwritingforColumbiaCollegeofChicago,StudioCitycampus.HewritescodeinHTML,VisualBasicandASMandlovesswimming,scubadiving,andweighttraining.Hisaddictionsaremoviesandreadingandhehasanintenseinterest,strictlyasalayman,inthesciences.
Awardees (L-R) Michael Hughes, Yuxi Liu, Kanishk Jain and William Barshop, with Dr Fowler.
Past and present Brenner Fellows: Lulan Wang (2016), Courtney Young (2017) and Aimee Flores (2018) with Mr. Brenner
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Mr. Brenner believes that Molecular Biology is where thefuture lies and has provided a gift to recognize oneoutstanding student that has advanced the discipline. Theawardee was selected by a committee of distinguishedfacultyandbyMr.Brenner,whoalsointroducedtheawardin a video presentation at the Annual MBI Retreat, April,2017.2018Recipient AimeeFlores(LowryLab)
BOYER/PARVINPOSTDOCTORALRESEARCHAWARDSMBIFoundingDirectorPaulBoyerhadadeepregardforpostdoctoralresearchers.Heappreciatedthededication,intellectandskilltheybringandtheimpactoftheirresearchonscientificprogress.ItwasinthisspiritthatDrBoyerdonatedaportionofhis1997NobelPrizetoestablishthePostdoctoralAwards.Additionalsupportfromhislong‐timecolleagueJamesPeter,fromPhyllisParvinonbehalfoftheParvinFoundationandfromAmgenInc.createdanopportunitytorecognizeover100exceptionalresearchersinChemistry,BiochemistryandMolecularBiology,forthepast16years.TheParvinFoundationhasbeenatirelesssupporterofmolecularbiologyresearchsincethegiftof$1millionmadetheMolecularBiologyBuilding(nowPaulD.BoyerHall)possible.FoundationPresidentPhyllisParvincontinuestobeanavidsupporterofthepostdoctoralawards.ThankstotheParvinFoundation,AmgenIncandindividualdonorswho believe in the value of postdoctoral research, we are able to continue the tradition of recognizing theseexceptionalscientists.
Therecipientsofthesethreeawardswere:
FrancisMercer,Ph.D.Mentor:Prof.PatriciaJohnson;Microbiology,Immunology&
MolecularGenetics
MarcusSeldin,Ph.D.Mentor:Prof.A.JakeLusis;Cardiology
MichaelHicks,Ph.D.
Mentor:Prof.AprilPyle;Microbiology,Immunology&MolecularGenetics
ThanksgotothemembersoftheSelectionCommittee,KarenReue,JoseRodriguez,OliverFregosoandHilary
Coller,fortheirextensiveeffortsinselectingthewinners.
Aimee receiving her award from Mr. Brenner
(L-R) Awardees Marcus Seldin, Francis Mercer and Michael Hicks
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RESEARCHSEMINARSERIES
ThisseminarseriescontinuestobeafocalpointofMBIactivities.The2017‐2018scheduleincludednationalandinternationallyrenownedspeakers,invitedandhostedbyMBIFacultyandstudentsfromtheMBIDPprogram.
Date Speaker Institution(s) Title Host
10/5/2017 LianaLareau,Ph.D. CaliforniaInstituteforQuantitativeBiology,UniversityofCalifornia,
Berkeley
“RibosomeDynamicsCapturedbyDeepSequencingandDeepLearning”
MBIDPstudents(GREATHomeArea)
10/12/2017 ElcinUnal,Ph.D. UniversityofCalifornia,Berkeley
“MeioticDifferentiation:UncoveringUniqueModesofGeneRegulationand
OrganelleRemodeling”
SriKosuri
10/19/2017 YigongShi,Ph.D. TsinghuaUniversity,Beijing
"Mechanismofpre‐mRNASplicingbytheSpliceosome"
JimBowie/ReidJohnson
10/26/17 RaymondDeshaies,Ph.D.
AmgenandCaliforniaInstituteof
Technology
"TheAdaptiveExchangeHypothesis:DynamicSpecificationoftheSCFUbiquitinLigaseRepertoireby
Substrate"
SteveYoung
11/2/2017 PeterJackson,Ph.D.
StanfordUniversitySchoolofMedicine
"Reformulatingadipogenesis:CilarytraffickingofafattyacidGPCRactivatescAMP‐dependent
differentiationofmesenchymalstemcells"
JorgeTorres
11/9/2017 LeonardZon,M.D. Children'sHospitalBoston,HarvardMedicalSchool
HowardHughesInvestigator
"Pathwaysregulatinghematopoieticstemcellself‐renewalandmigration"
CarlaKoehler
11/16/2017 TamirGonen,Ph.D. Investigator,HowardHughesMedicalInstituteDepartmentofBiological
Chemistry
"MicroEDopensaneweraforbiologicalstructuredetermination"
DougBlack
11/30/2017 RaymondStevens,Ph.D.
UniversityofSouthernCalifornia
"Anewapproachtowardsdiabetesstructurebaseddrugdiscovery"
RonKaback
12/7/2017 ChristopherLima,Ph.D.
MemorialSloanKetteringCancerCenter
"NuclearqualitycontrolandtheRNAexosome"
TracyJohnson&DougBlack
1/11/2018 DavidRawlings,M.D.
SeattleChildren'sHospitalUniversityofWashington
"Engineeringhumanlymphoidcellsfornovelclinicalapplications"
MBIDPstudents(IMMPHomeArea)
1/18/2018 KarenAdelman,Ph.D.
HarvardMedicalSchool "TranscriptionasaCentralHallmarkofActiveEnhancers"
TracyJohnson
1/25/2018 VamsiMootha,M.D.
HarvardMedicalSchool,
"GenomicsApproachestoMitochondrialBioenergetics"
SteveYoung&SabeehaMerchant
2/1/2018 ScottKeeney,Ph.D. HHMIMemorialSloanKetteringCancerCenter
HowardHughesInvestigator
"BreakingPar:SexChromosomeRecombinationinMaleMeiosis"
TracyJohnson
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2/8/2018 MichelGoedert,M.D.,Ph.D.
MedicalResearchCouncil,UniversityofCambridge
"SynucleinopathiesandTauopathies" DavidEisenberg
2/22/2018 WilliamA.PetriJr.,M.D.,Ph.D.
UniversityofVirginia
"RoleofHumanGenetics,environmentandmicrobiomeinsusceptibilityto
amebiccolitis"
PatriciaJohnson
3/1/2018 EmanuelaGussoni,Ph.D.
HarvardMedicalSchool "TetraspaninCD82inMuscleStemCellsandMuscularDystrophy"
MBIDPstudents
(CDBHomeArea)
3/8/2018 OlgaBoudker,Ph.D.
CornellUniversity "GlutamateTransporterDynamics:HowFastCanItGo?"
JimBowie
3/15/2018 StevenBoxer,Ph.D. StanfordUniversity "Reactions,Interactions,DynamicsandMassSpecImagineinModelBiological
Membranes:VirusesandRafts"
SteveYoung
4/12/2018 SophieDumont,Ph.D.
UniversityofCalifornia,SanFrancisco
"CellDivision:MechanicalIntegritywithDynamicParts"
MargotQuinlan
4/19/2018 HanaElSamad,Ph.D.
UniversityofCalifornia,SanFranciscoSchoolof
Medicine
"CellularFeedbackControl‐WhatDoAlltheLoopsDo?"
MargotQuinlan(MBI)&
VanSavage(QCB)
4/26/2018 RoyParker,Ph.D. UniversityofColorado,Boulder
"RNPGranulesinHealthandDisease" MingGuo
5/3/2018 GregoryAlushin,Ph.D.
TheRockefellerUniversity "Cytoskeletalstructuralplasticityinforcegenerationandmechanosensation"
HilaryColler
5/10/2018 PhotiniSinnis,M.D. JohnsHopkinsBloombergSchoolofPublicHealth
"Establishment ofMalariaInfection:ParasiteBottleneck&Pointfor
Intervention
PeterBradley
5/17/2018 TimStearns,Ph.D. StanfordUniversity "CentrosomesandCilia:FromSingleMoleculestoNewModelOrganisms"
MargotQuinlan
5/24/2018 JayKeasling,Ph.D. UniversityofCalifornia,Berkeley
"EngineeringMicroorganismsforProductionofIsoprenoidNaturalProductsandSomeNot‐So‐Natural
Products"
MBIDPstudents(BBSBHomeArea)
5/29/2018 AngeliqueBordey,Ph.D.
YaleSchoolofMedicine "UnderstandingHowMTORHyperactivityLeadstoEpilepsyand
BehavioralDeficits"
YeZhang(MBI)&
ChrisEvans(BRI)
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FACULTYRESEARCHSEMINARSERIES
Theseinformalpresentationscontributetoourscientificprogressandenableourmembershiptokeepup‐to‐dateoncurrentresearchdevelopmentsbytheMBIfaculty.
Date MBIFacultyMember Department Title
10/3/2017 LuisaIruela‐Arispe,Ph.D.
MCDB "StateoftheMBI2017:Agrowingmembership,newstaff,facilityrenovationsandmore..."
10/10/17 PatrickAllard,Ph.D. InstituteforSocietyandGenetics
"MechanismsoftransgenerationalinheritanceofenvironmentalexposuresinC.elegans"
10/17/17 ManishButte,Ph.D. PedAllergy/Immunology
"PullingouttheStopsinT‐cells"
10/24/2017 DonPuppione,Ph.D. EmeritusProfessor "CombiningproteomicswithgenomicstolookattheevolutionofmammalianapoC‐I"
10/31/2017 GeraldLipshutz,M.D.,D.D.S.
Surgery,Endocrinology,DiabetesandHypertension,
Molecular&MedicalPharmacology
"TrialsandTribulationswithArginase:ProgressinGeneandCellTherapyforitsDeficiencyandDefiningitsPossibleCellAutonomousRolein
NeuronalDevelopment"
11/7/2017 AliceSoragni,Ph.D. Hematology‐Oncology "Proteinaggregationincancer:p53andbeyond"
11/14/2017 MatteoPellegrini,Ph.D. MCDB "WhatcanDNAmethylationtellusaboutmetabolicsyndrome?"
11/28/2017 JoseRodriguez,Ph.D. Chemistry&Biochemistry
"StructuresofMammalianPrion"
12/05/2017 BrigetteGomperts,M.D.
Pediatrics,Hem/Onc "MaintainingMucociliaryClearance‐ theCriticalRoleofAirwayBasalStemCells"
1/9/2018 GraceAldrovandi,M.D. Pediatrics‐InfectiousDiseases
"Moms,MilkandMicrobes:HowtoBuildHealthyBabies"
1/30/2018 HongZhou,Ph.D. MIMG "StructuralstudiesofHumanHerpesViruses"
2/6/2018 MargotQuinlan,Ph.D. Chemistry&Biochemistry
"CytoskeletalControlofCellPolarityintheDrosophilaOocyteandOtherActinNews"
2/13/2018 AmanderClark,Ph.D. MCDB "MolecularRegulationofHumanGermCellFormation"
2/20/2018 FengGuo,Ph.D. BiologicalChemistry "RNAStructuresandmicroRNABiogenesis"
2/27/2018 LilyWu,M.D.,Ph.D. Molecular&MedPharmacology
"Tumorheterogeneityandmetastaticprogressioninrenalcellcarcinoma"
3/6/2018 ToddYeates,Ph.D. Chemistry&Biochemistry
"GiantProteinAssembliesinNatureandByDesign"
3/13/2018 YousangGwack,Ph.D. Physiology "CalciumSignalingComponentsinInnateImmunity"
3/20/2018 LouisBouchard,Ph.D. Chemistry&Biochemistry
"TechnologyDevelopmentforPreciseModulationofT‐CellsFate,TissueEngineering,Mechanosensing
andOtherStories"4/3/2018 ElissaHallem,Ph.D. MIMG "Host‐SeekingBehaviorsofParasiticNematodes"
4/10/2018 SriKosuri,Ph.D. Chemistry&Biochemistry
"SyntheticApproachesforUnderstandingBiology"
4/17/2018 LuisaIruela‐Arispe,Ph.D.
MCDB "MBIDPUpdate‐ReporttotheFaculty"
4/24/2018 RenSun,Ph.D. Molecular&MedPharmacology
"RationalVaccineDesignEnabledbyHighResolutionGeneticMapsofViralGenomes"
5/1/2018 JosephLoo,Ph.D. Chemistry&Biochemistry
"Pushing(andImaging)theBoundariesofProteinMassSpectrometryBeyondSequencingtoStructural
Biology"5/8/2018 JeromeZack,Ph.D. Hem‐ Onc/MIMG "DevelopinganApproachtoPurgeHIVReservoirs"
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5/15/2018 PeterTontonoz,M.D.,Ph,D.
Path&LabMed "LipidTransportPathwaysinPhysiologyandDisease"
5/22/2018 MichaelCarey,Ph.D. BiologicalChemistry "GeneUnitSub‐Tads:HowESCellEnhancersInteractwithPromoterswithinthe3DGenome"
MBIANNUALRETREAT&RESEARCHCONFERENCE
The MBI Retreat is organized each year bystudent representatives from the MolecularBiology Interdepartmental Ph.D. Program, theCellular&MolecularBiologyTrainingProgramand the Cell‐Biology Interface TrainingProgram. The program offers the opportunityfortheMBIcommunity;students,postdocsandfaculty, to gather together to celebrate thediversityof intellectualpursuits thatcomprisemodernmolecularbiologyatUCLA.The40thMBIAnnualretreatwasheldonMarch17‐18,2017theCrownePlazaVenturaBeach.169peopleattendedtheretreat,including146graduatestudentsand23facultymembers.44students presented posters and 10 studentsgaveoralpresentations.Oneofthehighlightsofthisyear’sretreatwasthepresentationbyourKeynote Speaker, Dr. Michael Snyder from
StanfordUniversity.Anotherhighlightof theretreatwastheCareerPanel,whereprofessionals fromacademiaandindustryoutlinedtheircareerpathsandgaveprofessionaldevelopmentadvicetothestudents.
Panelists with student host Jessica Ochoa
Thepaneliststhisyearwere:
EdwinSaada(SandiaNationalLaboratories) JenniferLovick(SAGEPublishing) DavidLeibly(ADRx)
Retreat Committee Chair Geoff Pronovost talks to fellow students at the retreat poster session.
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EmilyLowe(KitePharma/Gilead)
Theretreatprogramalsoincludedtimetorelaxandenjoythebeautifullocation.TheHomeArea“HouseCup”wasextremelypopular,which includedagameof tug‐o‐waronthebeach,withGeneRegandIMMPtyingtoendtheevents.We were grateful for the financial support of several UCLA Departments: Biological Chemistry; Chemistry andBiochemistry;MCDB;MIMG;PathologyandLaboratoryMedicine,andtheDavidGeffenSchoolofMedicine,BroadStemCellResearchInstitute,andJonssonComprehensiveCancerCenter,whomadethisretreatpossible.Also, avery specialTHANKYOU toourbenefactorsDr.AudreeFowler,Dr.GarryMiyadaand JulesBrenner, forbelievingthatinvestingingraduateeducationisthepathtoabetterfutureforall.
RETREATSCHEDULE
Saturday,March17,2018KeynoteAddressIntroduction
GuillaumeUrtecho
1:30–2:30PM MichaelSnyder,Ph.D.StanfordUniversity”BigDataandHealth”
SessionIChair:ManishButte,M.D.,Ph.D.2:30–2:50PM AanandPatel(QuinlanLab)2:50–3:10PM AdewunmiAdeleja(HoffmannLab)3:10–3:40PM DonaldKohn,M.D.CareerPanelModerator:JessicaOchoa4–5PM Q&AwithPanelists:
EmilyLowe(KitePharma/Gilead)EdwinSaada(SandiaNationalLaboratories)DavidLeibly(ADRx)JenniferLovick(SAGEPublishing)
5:30–7PM DinnerandPresentationofStudentAwards7–8:30PM PosterSession8:30–11PM PubTrivia
Sunday,March18,2018SessionIIChair:AndrewGoldstein,Ph.D.9:30–9:50AM GuillaumeUrtecho(KosuriLab)9:50–10:10AM ThangNguyen(TeitellLab)10:10–10:40AM SiavashKurdistani,Ph.D.SessionIIIChair:OliverFregoso,Ph.D.10:50–11:10AM JaspreetSandhu(TontonozLab)11:10–11:40AM StephanieDemarco(HillLab)
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11:40–12:10PM MargotQuinlan,Ph.D.GraduateStudentAwards1:30PM PosterAwardPresentationsFowlerFellowshipAwardPresentationsIntroduction AudreeFowler
1:40–2PM MichaelHughes(EisenbergLab)2–2:20PM KanishkJain(S.ClarkeLab)2:20–2:40PM WilliamBarshop(WohlschlegelLab)2:40–3:00PM YuxiLiu(YeatesLab)3–3:30PM KathrinPlath,Ph.D.
ClosingRemarks DirectorLuisaIruela‐Arispe,Ph.D.
MB‐IDPHouseCup3:40–4:45PM WaterBalloonToss,TugofWar,FlagTag,
Cornhole
BIOTECHNOLOGYEDGEWORKSHOPMBI&AmgenInc.
March26th‐30th,2018theMBIcollaboratedwithresearchersatAmgentoholdthe3rdAnnual“BiotechnologyEdge”Workshop. Theworkshop provided an opportunity to learn firsthand about the biotechnology industry,
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includingallaspectsofthedrugdiscoveryprocessandthewaysinwhichtraineescanprepareforacareerintheprivatesector.Duringthefirstfourdays,seniorAmgenscientistscametoUCLAtogivepresentationsonvariousaspectsofdrugdesignandtesting.Theyalsospoketotheaudienceaboutpreparingforcareersinbiotechnology.OnthelastdayoftheworkshopthetraineestraveledtoThousandOakstotourAmgenlabstointeractwithdirectlygroupleadersandjuniorresearchersandseefirst‐handhowthelatesttechnologiesarebeingusedtomovepotentialtherapeutics through the pipeline. The entire workshop was extremely popular and only 30 trainees could beaccommodatedduetospacelimitationsontheAmgentour.
FOCUSINIMAGINGWORKSHOPMBI,CNSI,CarlZeissMicroscopy&Bitplane
HeldAugust1stthrough4th,the“FocusonImagining”workshop,providedessentialhands‐ontraininginthebasicprinciplesofmicroscopy,confocal,electronmicroscopyandImaris3D/4Dvisualizationandanalysis.ThiswasthethirdworkshoporganizedincollaborationwithpartnersatZeissandBitplane,whoprovideequipmentandexperttrainingpersonnel.Eachsessionwas2hourslongandwasofferedonmultipledaysandtimestoaccommodateasmanyaspossible.BitplaneSpecialistLynseyHamilton,Ph.D,gaveanintroductoryseminarfortheIMARISTrainingonthefinalday.55traineesandfacultyattended.
TRAININGSESSIONSCHEDULE
Tuesday–August1stPrinciplesofMicroscopy1pmand3:30pmConfocalMicroscopy1pmand3:30pmElectronMicroscopy1pmand3:30pmWednesday–August2ndPrinciplesofMicroscopy9:30am,1pmand3:30pmConfocalMicroscopy9:30am,1pmand3:30pmElectronMicroscopy9:30am,1pmand3:30pmThursday–August3rdPrinciplesofMicroscopy9.30am,1pmand3.30pmConfocalMicroscopy9.30am,1pmand3.30pmElectronMicroscopy9.30am,1pmand3.30pmFriday–August4thBoyerHall130IntroductorySeminar 10am“Exploreyour3DdatawithImaris”LynseyHamilton,Ph.D.BitplaneSpecialistIMARISTrainingSessionsIntroductorySessionsFridayAugust4th1pm–2pm:Imaris3Drendering&animationsFridayAugust4th2pm–3pm:ImarisAutomatedobjectdetection,countingandvolumetricstatistics
AdvancedSessionsFridayAugust4th3.30pm–4.30pm:ImarisColocalizationanalysistechniquesFridayAugust4th4.30pm–5.30pm:ImarisNeuronTracing,Q&A
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MOUSEGENOMEINFORMATICSWORKSHOP
Afterashorthiatus,theMBIreconveneditspopularmousegeneticsandgenomeinformaticsworkshop.The2hourworkshopwasheldonTuesdayMarch20,2018andleadbyDr.MeiyeeLaw,OutreachCoordinatoratJacksonLabs.Dr.Lawbeganbycoveringbasicconceptsofmousegenetics,datastructures,pagenavigationintheMGIdatabase(www.informatics.jax.org)andbatchdatamining/analysis.Inthesecondhalfoftheworkshop,sheleadparticipantsthroughpracticalexamples todemonstratehowtheMGIdatabasecouldbeused toanswerbiologicalquestions.Attendeesalsoreceivedone‐on‐oneassistancewithanalyzingtheirowndata.Theworkshopwasextremelypopularandregistrationreachedtheroomcapacityof60,withawaitinglistforopenspots.Giventheinterestinthisarea,andwiththesupportofJacksonLabswehopetoofferthisworkshopannually.
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NEWMBIMEMBERS
JustineC.Lee,MD,Ph.D.,FACSAssociateProfessor,PlasticandReconstructiveSurgerywww.uclahealth.org/JustineLeeDr.Leeisacraniofacialsurgeon‐scientist.Herresearchprogramincludesabasicscienceandclinicalcomponentfocusedoncraniofacialreconstructionandinvestigatingpracticalsolutionsfordefectsofthecraniofacialskeleton.Herbasicworkisfocusedonunderstandinganddevelopingmaterials‐basedcalvarialboneregenerationstrategiesforrapidtranslation.Herclinicalworkisfocusedonoutcomesofcraniofacialsurgerywithaparticularemphasisonpediatriccongenitalanomalies.SheisfundedbytheJeanPerkinsFoundation,theBernardG.SarnatEndowment,thePlasticSurgeryFoundation,andtheUSDepartmentofVeteransAffairs.Dr.LeegraduatedsummacumlaudefromUCLAwitha
BachelorsofScienceinMolecular,Cell,andDevelopmentalBiology.Subsequently,shereceivedherMDandPhDfromtheUniversityofChicago.ShecompletedherplasticandreconstructivesurgeryresidencyattheUniversityofChicagoandreturnedtoUCLAforhercraniofacialsurgeryfellowship.SheistheBernardG.SarnatEndowedChairforCraniofacialBiology.InadditiontoherworkatUCLA,sheishighlyactiveinbothnationalandinternationalreconstructivesurgeryorganizations.SheservesasAssociateEditorforAnnalsofPlasticSurgery,SectionEditorinCraniofacialSurgeryfortheCleftPalate‐CraniofacialJournal,andSectionEditorinPlasticandReconstructiveSurgeryfortheCleftPalate‐CraniofacialJournal.
MelodyLi,Ph.D.AssistantProfessor,Microbiology,ImmunologyandMolecularGeneticswww.melodylilab.orgDr.Liisamolecularvirologistandherlaboratorystudieshostdefensestrategiesthatcontrolinfectionswitharthropod‐borneviruses(arboviruses),whichhavecauseddevastatingoutbreaksinrecentyears.Viralinfectionstimulatestheproductionofinterferon,resultingintheexpressionofalargeanddiverserepertoireofinterferon‐stimulatedgenes.However,mostofthesegeneshavenotbeencharacterized.Ingraduateschool,Dr.LielucidatedthefunctionalconsequencesofhumanpolymorphismsintheAPOBEC3Hgene.Herworkwasamongthefirststudiestoestablishananti‐HIV‐1roleforhumanAPOBEC3Hinvivo.Herpostdoctoralworkontwointerferon‐inducedproteins,ZAPandIRF2,
advancesourunderstandingofhostmechanismsthatinhibitviraltranslationandpromoteclearanceinthecentralnervoussystem.Herlaboratoryiscurrentlyinvestigatingthemechanismandregulationofbroad‐spectrumantiviralfactorswiththehopethattheywillinformdevelopmentofnoveltherapeuticsagainstre‐emergingarboviruses.Dr.LireceivedherPhDinMicrobiologyfromUniversityofWashington,Seattlein2011.ShesubsequentlycompletedherpostdoctoralworkatRockefellerUniversityin2017andstartedherowngroupatUCLAinthefallof2017.
TheodorosKelesidis,M.D.,Ph.D.,M.Sc.AssistantProfessor,Medicine–InfectiousDiseaseshttps://www.uclahealth.org/theodoros‐kelesidisDr.Kelesidisisatranslationalphysician‐scientistfocusingonimmunopathogenesisofinfectiousdiseases.HislaboratoryusesavarietyofinvitroandinvivomodelstoinvestigatenovelmechanismsofHIV‐relatedinflammationandimmunedysfunctionandhowtheydriveendorgandiseasesuchasatherosclerosis.InadditiontoHIV,Dr.Kelesidis’researchinterestsincludeinfectionsinimmunocompromisedpatientsandantimicrobialresistance.Dr.KelesidisreceivedhisMDfromUniversityinAthens,GreeceandhisPhDfromUniversityofCaliforniaLosAngeleswherehealsodidhisfellowshipininfectiousdiseases.HehasalsoreceivedanM.ScintranslationalresearchfromUCLA.Heis
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currentlyanAssistantProfessorofMedicineattheDepartmentofMedicine,DivisionofInfectiousDiseasesatUCLA.
SiobhanABraybrook,Ph.D.AssistantProfessor,Molecular,Cell,andDevelopmentalBiologyhttps://www.mcdb.ucla.edu/faculty/siobhanbDr. Braybrook is a developmental biologist who specializes in themechanicalproperties of cells and tissues as they relate to growth. She collaborateswithmathematicians, computer modellers, and engineers in order to addressthephysicalbiologyofgrowth.Hermajorstudysystemsareplantsandbrownalgae,with recent forays into immunology and cancer. The lab currently focuses onmechanisms of pH‐induced growthmechanics, anisotropic cell elongation, thebiomechanics of biological gels, andmorphometric analysis of cell shapes. Dr.BraybrookreceivedherPh.D.fromUCDavis.ShecompletedaresearchfellowshipattheUniversityofBern(CH)beforestartingaresearchgroupatTheUniversity
ofCambridge(UK).In2017,thelabmovedtoUCLA.
TamirGonen,Ph.D.Professor,BiologicalChemistryhttps://cryoem.ucla.edu/Dr.GonenisanexpertinelectroncrystallographyandcryoEM.Hedeterminedthe1.9Åresolutionstructureofthewaterchannelaquaporin‐0byelectroncrystallography,thehighestresolutionforanyproteindeterminedbycryoEMtechniquesatthetime.DrGonenestablishedhisownlaboratoryattheUniversityofWashingtonin2005togetherwiththeveryfirstcryoEMlaboratoryinthePacificNorthwest,aresourcethatcontinuestobenefitmanyresearchersattheUWSchoolofMedicineandbeyond.MorerecentlyDrGonenwashonoredwithaCareerDevelopmentawardfromtheAmericanDiabetesAssociation,becameaMemberoftheRoyalSocietyofNewZealand,aswellasbeingchosenoneofonly50HowardHughesMedicalInstituteEarlyCareer
Scientistsaroundthecountry.In2011DrGonenacceptedapositionasaGroupLeaderattheHHMIJaneliaResearchCampuswherehebegandevelopingMicroEDasanewmethodforstructuralbiology.WiththismethodDrGonenhaspushedtheboundariesofcryoEManddeterminedseveralpreviouslyunknownstructuresatresolutionscloseto1Å.In2017DrGonenmovedhislaboratorytotheDavidGeffenSchoolofMedicineoftheUniversityofCalifornia,LosAngelesasanInvestigatoroftheHowardHughesMedicalInstituteandaProfessorofBiologicalChemistryandPhysiology,wherehecontinuesstudyingmembraneproteinstructureandfunctionusingcryoEMandMicroED.DrGonenauthoredmorethan100publicationsandseveralofhispasttraineesarenowfacultyaroundtheworldattopuniversities.
TimO’Sullivan,Ph.D.AssistantProfessor,Microbiology,Immunology,andMolecularGeneticshttp://www.mbi.ucla.edu/faculty/tim‐osullivan/Dr. O’Sullivan is an Assistant Professor of Microbiology, Immunology, andMolecular Genetics. He received his Bachelors of Science Degree (B.S.) fromCornell University and his Doctor of Philosophy Degree (Ph.D.) in BiomedicalSciencefromtheUniversityofCaliforniaSanDiego.Dr.O’Sullivan’sthesisworkfocusedontheinteractionsbetweentheinnateimmunesystemandcancer.Dr.O’Sullivan subsequently completed his American Cancer Society postdoctoralfellowshipatMemorialSloanKetteringCancerCenterwherehestudiedtheroleofcirculatingandtissue‐residentinnatelymphoidcells(ILC)duringviralinfectionanddiet‐inducedobesity.Dr.O’SullivanestablishedhisownlaboratoryatUCLA
in2017.TheO’Sullivanlabisdedicatedtounderstandingthemolecularmechanismsresponsibleforprotectiveorpathologicimmuneresponsesduringcancer,viralinfection,andobesity.
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TamerSallam,MDPh.D.AssistantProfessor,MedicineDr.Sallamisacardiovascularphysician‐scientistinvestigatingtherelationshipbetweengeneticdiversityandcommoncardiovascularproblemssuchasdyslipidemia,obesityandheartdisease.Dr.Sallam’spreviousworkhasprovidedfundamentalinsightsintomechanismscontrollingcholesterollevelsandphysiologicrolesofnewlyrecognizedgenesknownaslongnon‐codingRNAincardiovasculardisease.ThroughmultipleindependentgrantshislabiscurrentlyinvestigatingthecontributionsoflongnoncodingRNAsincardiovascularriskfactorsanddisease.Dr.SallamcompletedresidencyandchiefresidencytrainingatYale,followedbycardiologyfellowshiptrainingatUCLA.Dr.SallamgraduatedfromtheSTARprogramatUCLAearningaPhDintheLab
ofPeterTontonoz.Dr.SallamhasbeenawardedtheLaurenB.LeichtmanandArthurE.LevineinvestigatorshipatUCLA.HeistherecipientoftheAmericanCollegeofCardiologyPresidentialCareerDevelopmentAward,BurroughsWellcomeFundCareerAwardforMedicalScientists,andAmericanSocietyforClinicalInvestigationYoungInvestigatorAward.Dr.Sallamcurrentlyservesasco‐directoroftheUCLAcenterforCholesterolManagementandAssistantDirectoroftheUCLASpecialtyTrainingandAdvancedResearch(STAR)Program.
JesseZamudio,Ph.D.AssistantProfessor,Molecular,Cell,andDevelopmentalBiologyJesse Zamudio received his bachelor's degree from UCLA in Chemistry &Biochemistry. He received his Ph.D. from UCLA in the Department ofMicrobiology,ImmunologyandMolecularGeneticsworkinginthelaboratoryofDr.DavidCampbellandDr.NancySturm.Forhisthesiswork,hecharacterizedthe first eukaryotic messenger RNA (mRNA) ribose cap methyltransferases.AlthoughpresentinboththeuniquemRNAcapstructureofhumanpathogenicKinetoplastidprotozoaandhumanmRNA,theproteinsresponsibleforeachhadnot been discovered. Based on evolutionary sequence conservation to knownviral proteins, they were able to characterize a conserved eukaryotic proteinfamily responsible for thesemodifications and determine their role inmRNAbiogenesisandproteintranslationinkinetoplastids.Thesestudieshaveaidedthe
investigation of the human cap ribose methyltransferases implicated in early development. Jesse pursued hispostdoctoral research in the laboratory of Dr. Phil Sharp at the MIT Cancer Center. His research focused onquantitativeapproachestocharacterizeRegulatoryRNAsinembryonicandadultstemcells.HeaimedtoconfidentlyassayregulationbythemammalianRNAinterference(RNAi)pathwayandindoingsodiscoverednewclassesofmammaliansmallRNAsandprinciplesdeterminingregulatoryactivity.Currentresearchinthelabis focusedoncharacterizingfunctionalRNAsinthecontrolofcellstatetransitionsduringdevelopmentandcancerprogression.
De‐ChenLin,Ph.D.AssistantProfessor,Cedars‐SinaiMedicalCenterAdjunctAssistantProfessor,UCLASchoolofMedicineDr.Linhasabroadbackgroundincancergeneticsandbiology,withspecifictrainingandexpertiseinfunctionalgenomicstudyaswellastranscriptionalregulation.Themajorfocusofhisworkisidentifyingkeygenomicandepigenomicabnormalitiesinhumanmalignanciesandtranslatingthesefindingsintonovelclinicalmanagements.Tofacilitatethisresearch,hehasestablishedanddevelopedavarietyoffunctionalgenomicapproachesaswellascomputationalalgorithms.Withthesetoolsandcomprehensivebiologicalstudies,Dr.Linuncoveredimportantgenomicandepigenomicaberrationswhichpromotemalignantphenotypes.
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MBIFACULTYHONORS&PROFESSIONALAWARDS
Bannerjee,Utpal ElectedMember,NationalAcademyofSciences
Bitan,Gal UCLAInauguralUndergraduateResearchWeekFacultyMentorAward
Bowie,James ElectedFellowoftheBiophysicalSociety,AcademiaSinicaChohHaoLiMemorialLecture
Clarke,Steven WilliamC.RoseAwardoftheAmericanSocietyofBiochemistryandMolecularBiology
Coller,Hilary CancerResearchInstituteClinicalandLaboratoryIntegrationProgramAwardDepartmentalNomineeforUCLADistinguishedTeacherAwardAnna‐MariaandStephenKellenFoundation‐MelanomaResearchAllianceTeamScienceAwardUCLAUndergraduateResearchFacultyMentorAward
DeRobertis,Edward 50thAnniversaryLectureoftheJapaneseSocietyofDevelopmentalBiology90thAnniversaryLectureforInstitutoClementeEstable
Eisenberg,David PaulSiglerPrize,YaleUniversity
Ernst,Jason NIH/NIDAAvenirAward, RoseHillFoundationInnovatorAward
Goldstein,Andrew AmericanCancerSociety2018GiantsofScienceHopeAward
Gonen,Tamir HHMIInvestigator
Guo,Ming GlennFoundationforMedicalResearchAward
Hoffmann,Alexander KeynoteSpeaker,InternationalConferenceonIntelligentBiologyandMedicine
Iruela‐Arispe,Luisa NIH/NHLBIOutstandingInvestigatorAward(R35)
Johnson,Tracy Chair,KeithandCeciliaTerasakiEndowed;LifeSciencesAwardforExcellenceinPromotingDiversityandInclusionThroughService,Teaching,MentoringandResearch
Kohn,Donald LifetimeAchievementAward,thePediatricBlood&MarrowTransplantConsortium
Kurdistani,Siavash W.M.KeckFoundationAward
Lipshutz,Gerald EndowedChair
Novitch,Bennett EthelScheibelChairinNeuroscience;AblonScholarsAward(JCCC/BSCRC)
Pyle,April AblonAward
Quinlan,Margot UndergraduateResearchWeekFacultyMentorAward
Reue,Karen AmericanHeartAssociationRussellRossMemorialLecture
Rodriguez,Jose PewBiomedicalScholar
Sallam,Tamer BurroughsWellcomeFundCareerAwardforMedicalScientistsFellowofAmericanCollegeofCardiology
Soragni,Alice Lynda'sFundPilotStudyAward
Spencer,Melissa GoldenTestTubeAward,UCLADept.ofNeurology
Tarling,Elizabeth IrvineH.PageYoungInvestigatorResearchAwardPromotedtoAssociateProfessorinResidence
Teitell,Michael AppointedDirector,UCLAJonssonComprehensiveCancerCenterPresident,JonssonCancerCenterFoundationDirector,DGSOMCancerResearchThemeLydaandHarrisonLattaEndowedChairinPathologyJeromeB.BlockMemorialLecture,LABioMed
Torres,Jorge 2019RuthKirschsteinDiversityinScienceAwardAmericanSocietyforBiochemistryandMolecularBiology
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Yeaman,Michael SpiritofInnovationAward(LABioMed);GlobalTechnologyCommunity(CNSDiseases)DistinguishedPrimaryInvestigator(U.S.DepartmentofDefense)Chair,SummitonImmuneTolerizationVaticanCouncilonMedicine&Society
MBIFACULTYSERVICEONUCLACOMMITTEES
Adams,John MemberandAdvisor,CTSIKL2GrantProgram
Chair,UCLA‐UCIAlphaStemCellClinicInternalAdvisoryBoardChair,UCLAScientificReviewCommitteeMember,ExecutiveOversightCommmittee,ClinicalandTranslationalScienceInstituteMember,OperationsCommitteeandExecutiveActionCommittee,ClinicalandTranslationalScienceInstitute,DavidGeffenSchoolofMedicineatUCLAMember,UCLAClinicalandTranslationalScienceInstituteProgramAreaLeaderCommitteeMember,ExecutiveAcademicActionsCommittee,OrthopaedicSurgeryMember,CTSIInstitutionalSteeringCommitteeMember,CTSISeminar(formerlyIMED)CommitteeMember,ClinicalResearchGovernanceCommitteeDGSOMSeedGrantReviewCommitteeDGSOMOppenheimGrantReviewCommittee
Allard,Patrick LifeScienceDiversityAdvisoryCommitteeUCLAFacultyGrantProgramCommittee
Ardehali,Reza Co‐DirectoroftheUCLAVascularBiologyTrainingGrantMember,DGSOMScholarshipSelectionCommitteeMember,UCLAMedicalinstitutionalReviewBoard
Berk,Arnold Chair,MBIMembershipCommittee
Bitan,Gal Judge,UndergraduateResearchPosterDayDean'sPrizeBBSBPh.D.HomeAreaAdmissionsCommitteeJudge,CollinsDayPosterSession(Neurobiology)
Black,Douglas MIMGViceChairforAcademicPersonnelChair,MIMGMeritReviewCommitteeMember,SpecialCommitteeforViceChancellorforResearchMember,MBISeminarCommitteeChair,HonorsandAwardsCommitteeofUndergraduateCouncil
Bowie,James UCLACouncilofAdvisors;SigmanLectureCommittee
Bradley,Peter IMMPCurriculumandAdmissionsCommitteeIntercollegiateAthleticsCommittee
Braun,Jonathan UCLAHealthSystemExecutiveCommitteeUCLAHealthSciencesDataStrategyandGovernanceCommittee
Braybrook,Siobhan Member,MCDBFacultyRecruitmentCommittee(PlantBiology)Member,LifeSciencesDiversityAdvisoryCommittee
Butler,Samantha Member,NeurobiologyAcademicReviewCommitteeReviewer,UCLAInnovationFund(DGSOM)Member,MCDBPlantJobSearchCommittee
Butte,Manish Co‐DirectorofI3T:Immunity/Inflamation/Infection/TransplantationCo‐DirectorofCancerNanoThemeoftheJonssonComprehensiveCancerCenter
Chen,Irvin Member,UCLADualUseReviewEntityMember,AdHOCPromotionCommitteeChair
Chen,Jau‐Nian Member,UCLAAcademicSenateCouncilonResearch
Chow,Samson Chair,InstitutionalBiosafetyCommitteeMember,EmbryonicStemCellResearchOversightCommittee
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Clarke,Catherine Member,UndergraduateStudyandCurriculumCommittee(Chem&Biochem)Member,DiversityandLeadershipCommittee(Chem&Biochem)Member,DevelopmentCommittee(Chem&Biochem)
Colicelli,John UCLASPOREinProstateCancerInternalAdvisoryCommitteeFacultyAdvisoryCommittee,MinorinBiomedicalResearchDiversityOversightCommittee,SchoolofMedicineDGSoMMedicalEducationCommitteeJCCCIntramuralReviewCommittee
Coller,Hilary Chair,AdHOCCommitteetoReviewDissertationYearFellowshipinBiologicalChemistryReviewer,DavidGeffenMetabolismThemeSeedFundsApplicationsMember,MBISeminarCommitteeExecutiveCommitteeMember,DermatologyT32Reviewer,MetabolismThemeAwardsMember,FacultySearchCommittee(MCDB)Member,MCDBPromotionReviewMember,FacultySearchCommittee(Biomathematician)Member,JonssonComprehensiveCancerCenterInternalReviewCommitteeMember,BroadStemCellCenterPredoctoralFellowReviewCommitteeReviewer,IrisCantorWoman'sHealthCenterReviewer,JonssonComprehensiveCancerCenterSeedGrantsReviewer,UCLAInnovationFundGrantApplicationsMember,MBIBoyer/ParvinPostdoctoralFellowAwardCommittee
DeRobertis,Edward Chair,HonorsCommittee(SchoolofMedicine)
Eisenberg,David MBISeminarCommitteeChair,Chem&BiochemistryPostdoctoralResearchAwardsDevelopmentCommittee,Chemistry&BiochemistryDepartmentDistinguishedLectureCommittee(Chem&Biochem)FianniFellowsInterviewCommittee
Ernst,Jason Chair,UCLABioinformaticsSeminarCommitteeMember,UCLABioinformaticsAdmissionsCommitteeMember,UCLABioinformaticsExecutiveCommitteeMember,UCLABioinformaticsWrittenQualifyingExamEvaluationCommitteeReviewer,UCLAStemCellTrainingGrantsReviewer,UCLAInnovationFund
Faull,Kym DepartmentalRepresentative,LegislativeAssemblyoftheUCLAAcademicSenateMember,BoardofGovernors,UCLAFacultyCenterMember,PersonnelSub‐Committee,BoardofGovernors,UCLAFacultyCenterUCLARepresentative,LegislativeAssemblyoftheUCAcademicSenateMember,DepartmentofPsychiatryandBiobehavioralSciencesAppointmentsandAdvancementsCommittee
Fregoso,Oliver Member,LifeSciencesDiversityAdvisoryCommitteeMember,MARCCommittee;Boyer/ParvinPostdoctoralAwardsCommittee
Gelbart,William UCLAGlennT.SeaborgMedalistandSymposiumHonoree
Gonen,Tamir ExecutiveCommittee,DepartmentofPhysiologyUCLA
Guo,Ming Member,SwitzerPrizeSelectionCommitteeChair,AcademicAdvisoryCouncil,SoundBodySoundMindCo‐Chair,WomeninScience&DoctorsofMedicineMember,Advancement&PromotionCommitteeintheDepartmentofNeurologySearchCommittee,FacultyAppointment,Neuroscience
Hallem,Elissa Member,LifeSciencesDiversityAdvisoryCommitteeMember,IMMPAdmissionsCommitteeMember,CommitteeforUCLANeuroscience
Hartenstein,Volker Member,NeuroscienceIDPParentCommitteeMember,MCDBMastersProgramCommittee
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Hevener,Andrea MEDCAP;Chair,AcademicSenateCommitteeonDevelopmentEndocrinologyChief,SearchCommittee
Hirsch,Ann AdHOCMember,BiosafetyCommittee
Hoffmann,Alexander Member,TaskforceonComputationalBiology,GenomicsandMedicine
Iruela‐Arispe,Luisa Member,UCLASearchCommitteeforAcademicPersonnelVice‐ChancellorMember,UCLAUndergraduateResearchScholarProgramReview
Jacobsen,Steven Director,BroadStemCellResearchCenterSequencingFacilityMCDBPrizeandAwardCommitteeUCLABenGurionCommittee(LeshinFund)PersonnelActionCommittees
Johnson,Tracy UCLACenterfortheStudyofWomenAdvisoryCommitteeUCLAMorenoImplementationCommitteeChair,LifeSciencesDiversityAdvisoryCommitteeCMBTrainingGrantAdvisoryCommittee;Dean,UndergraduateEducationReviewCommitteeUCLAHumanPluripotentStemCellResearchOversight
Kaufman,Daniel DepartmentofMolecular&MedicalPharmacologyMeritReviewCommittee
Koehler,Carla Chair,IACCommitteeCo‐Director,CMBTrainingGrantMember,CBIAdvisoryCommitteeMember,StudentAthleteAdmissionsCommittee
Kohn,Donald Member,JCCCDataSafetyMonitoringCommitteeChair,DataSafetyMonitoringBoardfor"GeneCorrectionofAutologousHematopoieticStemCellsinArtemisDeficientSCIDUCLA‐UCIAlphaStemCellClinicInternalAdvisoryCommittee
Lazazzera,Beth Chair,AcademicSenateUndergraduateCouncilMember,AcademicSenateExecutiveBoard
Lee,Justine Member,UCLAHonors,AwardsandPrizesCommitteeMember,UCLAChildren'sSurgicalGroupCo‐Director,UCLAMulti‐DisciplinaryVascularBirthmarkClinic
Li,Melody Member,UCLAGraduateProgramsinBioscienceAdmissionsCommitteefortheIMMPHomeAreaMember,I3TCommunicationsCommittee
Lipshutz,Gerald Member,CASPP
Loo,Joseph Member,UCLA/DOELaboratoryforGenomicsandProteomicsMember,UCLAMolecularBiologyInstituteMember,Dept.ChemistryandBiochemistryInstrumentationCommitteeMember,Dept.ChemistryandBiochemistryDevelopmentCommitteeMember,AdvisoryCommittee,UCLAMolecularInstrumentationCenterMember,GraduateStudiesCommittee,DepartmentofChemistryandBiochemistryGraduateAdviser,AnalyticalChemistry/MeasurementSciencePh.D.Specialization,DepartmentofChemistryandBiochemistryMember,UCLAAcademicSenateCommitteeonDevelopmentMember,UCLAAcademicSenateGraduateCouncil
McEvoy,Megan Member,FacultySearchCommittee(MIMG)Member,AmgenFacultyReviewCommitteeMember,MBIMembershipReviewCommitteeMentor,RegentsScholarSociety
Morrison,Sherie Member,UCLACollegeCampaignCommittee
Nakano,Austin LegislativeAssembly,CardiovascularThemeResearchCommittee
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Novitch,Bennett Member,BroadCenterforRegenerativeMedicineandStemCellResearchSteeringCommitteeMember,UCLANeuroscienceInterdepartmentalGraduateProgramMembershipCommitteeMember,UCLAMolecularBiologyInstituteMembershipCommitteeMember,UCLAAnimalProgramforNeuralRepairMember,UCLAClinicalandTranslationalSciencesInstituteScientificReviewCommitteeMember,DavidGeffenSchoolofMedicineatUCLANeurosurgeryChairSearchCommittee
O'Sullivan,Timothy Member,I3TCommunicationsCommitteeMember,IMMPAdmissionsCommittee;Member,I3TSeminarSeriesCommittee
Pellegrini,Matteo Member,CommitteetoEvaluateComputationalBiology(Genomics&MedicineLandscapeUCLA)
Plath,Kathrin Chair,SwitzerPrizeCommitteeMember,DGSOM‐CTSIRecruitmentCommittee
Pyle,April Chair,LifeSciencesExcellenceinResearchAwardsCommitteeMember,UCLAAssistantProfessorMentorshipProgramLifeSciencesMentorshipFacultySearchCommitteeMember,LifeSciencesDiversityAdvisoryCommittee
Quinlan,Margot Co‐Chair,UCLAMBISeminarCommittee
Reddy,Srinvasa Member,CommitteeonTeachingMember,LegislativeAssembly
Reue,Karen MedicalScientistsTrainingProgramAdmissionsCommitteeMBIPost‐doctoralAwardSelectionCommitteeBoyer‐ParvinPostdoctoralAwardCommittee
Sallam,Tamer Member,CardiovascularThemeCommunicationsandDevelopmentCommitteeMember,STARProgramSelectionCommittee
Schweizer,Felix InterimDirector,BrainResearchInstituteChair,GraduateNeuroscienceInterdepartmentalProgram
Spencer,Melissa Member,ESCROCommitteeMember,AdvancementsandPromotionsCommittee(Neurology)NeuromuscularProgramDirectorCo‐Director,CenterforDuchenneMuscularDystrophy
Sun,Ren Co‐Director,UCLAFogartyAITRPprogramonAIDS‐associatedCancersCo‐Director,Co‐InfectionandMalignanciesProgram,UCLAAIDSInstituteDirector,MedicalPharmacologyTrackoftheMolecularandMedicalPharmacologyPharmacologyGraduateTrainingCommitteeUCLAOptimizeCareerServiceProvisionforGraduateandPostdoctoralStudentsCommitteeUCLAPostdoctoralScholarsAdvisoryCommitteeChair,UCLACross‐DisciplinaryTrainingCommitteeSteeringCommitteeofUCLAChinaInitiativesAdvisoryCommitteeofUCLAInternationalInstituteAdvisoryCommitteeofUCLAConfuciusInstituteUCLACTSIEducationCommittee
Teitell,Michael Co‐Director,NIHT32TumorImmunologyTrainingProgramAssociateDirector,UCLA‐CaltechMedicalScientistTrainingProgram(MSTP)SelectionCommittee,MBISeminarSeriesAdmissionsCommittee,IntercollegiateStudent‐AthletesTrainingGrantCommittee,CSUN‐CIRMBridgestoStemCellBiologyNCAAFacultyAthleticsRepresentative;UCLAIntercollegiateStudent‐AthletesAcademicSenateIntercollegiateAthleticsCommittee(IAC)
Tontonoz,Peter UCLARepresentativetotheUCSystem‐wideAcademicSenate
Torres,Jorge Chair,CommitteeonContinuingandCommunityEducationMember,GraduateCouncil/GraduateDivision,MentoringandEvaluationofGraduateAcademicProgressWorkgroupMember,UndergraduateCouncil'sHonors,Awards&PrizesCommitteeMember,DiversityCommitteefortheDivisionofPhysicalSciences
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Wang,Yibin DGSOMExecutiveResearchCommittee
Weiss,Shimon UCLAChemistryDepartmentDevelopmentCommitteeUCLAChemistryDepartmentInstrumentationCommitteeUCLACNSIMolecularScreeningSharedResourceAdvisoryBoard
Witte,Owen UCLASPOREinProstateCancerExecutiveCommitteeUCLAClinicalandTranslationalScienceInstituteAdvisoryCommitteeUCLADept.Chairs,MajorCenters&DirectorsCommitteeDGSOMJCCCDirector'sSearchCommitteeGeffenScholarshipSelectionCommittee;Chair,BelzerChairSearch
Xiao,Xinshu(Grace) FacultyMentor,RegentsScholarSocietyatUCLAFacultySearchCommitteeforMathematicalBiology,LifeSciences,UCLAPersonnelCommittee,DepartmentofIntegrativeBiologyandPhysiology,UCLAAdvisoryCommittee,InstituteforQuantitativeandComputationalBiology,UCLAAdvisoryCommittee,BioinformaticsIDP,UCLAAdvisoryCommittee,ComputationalandSystemsBiologyIDP,UCLA
Yang,X.William Member,UCLAMSTPAdmissionsCommitteeMember,FacultyAdvisoryCommitteetotheUCLAAccelerator
Yeaman,Michael Member,ExecutiveCommitteeUCLAI3TProgram
Zack,Jerome Chair,HighContainmentLabOversightCommitteeChair,DualUseResearchCommittee
Zhang,Ye Member,NSIDPAdmissionsCommittee
Zheng,Jie Member,UCLAAcademicSenateCommitteeonFacultyWelfare
MBIFACULTYSERVICEONEXTERNALCOMMITTEES
Adams,John MemberandFormerChair,ExternalAdvisoryPanelfortheMayoClinicNIAPPG"GonadalSteroids
andBone"Member,ExternalAdvisoryCommitteefortheMayoMedicalCenterT32"MusculoskeletalResearchTrainingProgram"Member,DataSafetyMonitoringBoard,NIDDK‐sponsored"VitaminDandType2Diabetes(D2d)"studyCharterMember,Arthritis,MusculoskeletalandSkin(AMS)StudySection,NIAMSNIHMemberandChair,ExternalAdvisoryBoard,JohnsHopkinsOrthopaedicSurgeryNIHT32Member,ExternalAdvisoryBoard,MayoClinicOrthopaedicSurgeryNIHT32Member,ExternalAdvisoryBoard,WashingtonUniversity,MusculoskeletalNIHT32Member,ExternalAdvisoryBoard,WashingtonUniversity,MusculoskeletalNIHP50Chair,ExternalAdvisoryPanelfortheHarbor‐UCLANIDDKT32"TraininginEndocrinologyandMetabolism"Chair,LosAngelesBioMedScientificAdvisoryBoardMember,CIRM‐AlphaStemCellClinicNetworkDirector'sSteeringCommittee
Allard,Patrick NIHSIEEStudySectionNIHIRAPStudySectionCalifornia'sDevelopmentalandReproductiveToxicantIdentificationCommittee
Bitan,Gal EditorialBoardMember,JournalofBiologicalChemistryEditorialBoardMember,ScientificReportsAdHOCMember,NIHSpecialEmphasisPanel/ScientificReviewGroupZRG1MDCN‐E(52),MDCN‐E(56),MDCN‐E(57),MDCN‐P(52)
Black,Douglas Member,NIGMSStudySectionforJuniorMIRAAwards
Bowie,James StockholmUniversitySearchCommitteeBiophysicalSocietyAwardsCommitteeChairofGordonConferenceonMembraneProteinFolding
Braun,Jonathan Chair,ExploratoryStudiesforDelineatingMicrobiome(ZDK1GRB‐6M2)
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Member,SEP/SRG2017/01ZCA1SRB‐J(J4)RMeetingChair,SAB,MilieuInterieurConsortium‐InstitutPasteur,Paris
Braybrook,Siobhan AcademicEditor,PlantDirectMember,ASPBDigitalFuturesCommittee
Butte,Manish NIHStudySection(NIAIDCMIA)NIHStudySection(NIAID2017/10ZAI1NVM‐I(S1))
Carey,Michael JBCandMCBEditorialBoards,AdHoc,NIHMGBStudySection
Chen,Jau‐Nian Member,CDDNIHStudySectionMember,ZRG1F10ANIHStudySectionMember,CardiovascularDevelopmentAHAStudySection
Chow,Samson Member,AMCBNIHStudySectionClubb,Robert Member,MSFCNIHStudySectionColicelli,John CancerResearchCoordinatingCommitteeColler,Hilary Reviewer,R35MaximizingInvestigators'ResearchAwardforEarlyStageInvestigatorsReviewer,
AustrianScienceFundReviewer,NationalScienceFoundationCareerProgramReviewer,ArthritisResearchUKReviewer,NationalCancerInstituteProvocativeQuestionsReviewer,MedicalResearchCouncilReviewer,JamesandEstherKingBiomedicalResearchProgramPeerReviewReviewer,NationalCancerInstituteP01Reviewer,IsraeliNationalScienceFoundationReviewer,FrenchNationalResearchAgencyReviewer,MarsdenFundReviewer,NCIProvocativeQuestions
DeRobertis,Edward BoardMember,LatinAmericanSocietyofDevelopmentalBiologistsScientificAdvisoryBoard,PewCharitableLatinAmericanFellowsProgramScientificCouncil,AvademicdeCienciasdeAmericaLatina
Eisenberg,David HARCCenterScientificAdvisoryBoardVisitingCommittee,CaltechBeckmanInstituteChair,ScientificAdvisoryBoard(ADRx)
Ernst,Jason TemporaryMember,GCATNIHStudySectionEditorialBoard,GenomeResearchCo‐organizer,ISMB‐RegSysCommunityofSpecialInterestGroupMeetingMember,ProgramCommitteeICML/IJCAIWorkshopinComputationalBiologyMember,ProgramCommitteeRECOMBGeneticsMember,ProgramCommitteeISMBMember,ProgramCommiteeRECOMB/ISCBRegulatoryandSystemsGenomicsConferencewithDREAMChallengesMember,ProgramCommitteeNIPSWorkshopinComputationalBiology
Faull,Kym Member,AdvisoryBoardoftheInternationalJournalofMedicalBiochemistryMember,EditorialBoardoftheSirirajMedicalJournal
Fregoso,Oliver Co‐Organizer,PalmSpringsMeetingonHIV/AIDSGelbart,William Chair,ChemistryGraduateStudiesCommitteeGera,Joseph Member,BenchTestingTherapeutic/IndicationPairingStrategies(UG3/UH3),NCATS,NIHStudy
SectionGoldstein,Andrew Member,2018ProstateCancerFoundationChallengeAwardGonen,Tamir Member,BBMNIHStudySectionGuo,Ming HongKongResearchGrantCouncil(RGC),MonitoringandAssessmentPanelCommitteeMember
AssessorPanelMember,Biology&MedicalSubgroupScientificSelectionCommitteeMember,McKnightNeuroscienceFoundationScientificAdvisoryCommitteeMember,A.P.GianniMedicalFoundationChan‐ZuckerbergInitativeThinkTank,WorkshoponNeurodegeneration
Gwack,Yousang AdHOCMember,CMIBandSpecialEmphasisPanel,NIHStudySectionHallem,Elissa AdHOCPanelist,NIHChemosensorySystemsStudySection
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Hartenstein,Volker Member,NIHNIMHBrainInitiativeStudyPanelSectionEditor,CellandTissueResearchSectionEditor,DevelopmentalNeurobiologySectionEditor,ArthropodStructureandDevelopment
Hevener,Andrea AmericanDiabetesAssociationScientificSessionsOrganizingCommitteeNIHSpecialEmphasisPanels
Hill,Kent ScientificAdvisoryCounciloftheArnoldandMabelBeckmanFoundationHirsch,Ann Member,ASPBFellowsAwardNominatingCommittee
Reviewer,EuropeanResearchCommissionAssociateEditor,PlantSignaling&BehaviorCommunicatingEditor,MolecularGeneticsandGenomics
Hoffmann,Alexander EditorialBoard,CellResearch,MolecularSystems Biology,MBCSystemsBiologyHouk,Kendall EditorialAdvisoryBoard,JournalofOrganichChemistry,OrganicLetters,
AccountsofChemicalResearchJournalofChemicalTheoryandComputation
Iruela‐Arispe,Luisa AssociateEditor,Atherosclerosis,ThrombosisandVascularBiologyJournalEditorialBoardMember,AngiogenesisJournalEditorialBoardMember,CancerBiologyandTherapyJournalEditorialBoardMember,CellBiologyJournalEditorialBoardMember,Atherosclerosis,ThrombosisandVascularBiologyEditorialBoardMember,CardiovascularPathologyEditorialBoardMember,CancerResearchEditorialBoardMember,JournalofExperimentalMedicineReviewer,ItalianAssociationforCancerResearch(AIRC)Member,NIH/NCI‐BoardofScientificCounselorsforBasicSciencesMember,NHLBIAdvisoryCouncilBoard
Jacobsen,Steven EditorialBoardMember,CurrentBiologyEditorialBoardMember,EpigenomicsEditorialBoardMember,GeneticsandEpigeneticsEditorialBoardMember,EpigeneticsandChromatinEditorialBoardMember,EpigenomesAdvisoryBoardMember,EPICEditorialBoardMember,Non‐GeneticInheritanceNationalAcademyofSciencesSectionLiason
Johnson,Reid NIHSpecialEmphasisReviewPanelJohnson,Tracy NationalCancerInstitute,BoardofScientificCounselorsforBasicResearchKaback,H.Ronald NHLBIBoardofScientificSiteVisitReviewKaufman,Daniel AdHOCReviewer,JuvenileDiabetesResearchFoundation
AdHOCReviewer,GenevaUniversityHospitals&FacultyofMedicineResearchFoundationAdHOCReviewer,NIHRFA‐DK‐003AdHOCReviewer,CysticFibrosisFoundationEditorialBoard,J.Clinical&CellularImmunologyScientificAdvisoryBoard,DiamydMedical
Kelesidis,Theodoros AdHOCReviewer,NIHNeuroAIDSandotherEnd‐organDiseasesStudySectionAdHOCReviewer,NIHAIDSClinicalStudiesandEpidemiologyStudySectionAdHOCReviewer,NIHAIDSSpecialEmphasisStudySection
Koehler,Carla Member,NOMDNIHStudySectionMember,AHAGrantReviewerPanelScientificandAdvisoryBoardofUnitedMitochondrialDiseaseFoundationScientificAdvisoryBoardofOxalosisandHyperoxaluriaFoundation
Kohn,Donald Member,ExternalAdvisoryBoard,SCID‐NETMember,Immuno‐andGeneTherapyCommitteeMember,2018AnnualMeetingOrganizingCommitteeMember,ReviewPanelfortheDorisDukeCharitableFoundation'sClinicalScientistDevelopmentAwardMember,ClinicalAdvisoryPanel
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Kurdistani,Siavash AdHOCMember,SpecialEmphasisPanel,NIHAdHOCMember,Fellowship:Genes,Genomes,andGenetics(ZRG1F08)StudySection,NIHAdHOCMember,CancerMolcularPathobiology(CAMP)StudySectionAdHOCMember,GrantReviewPanel,CancerResearch
Lazazzera,Beth Member,NIHTWD‐BStudySection;Member,NSFGeneExpressionPanelLee,Justine AssociateEditor,AnnalsofPlasticSurgery
SectionEditor,CleftPalateCraniofacialJournal(PlasticandReconstructiveSurgerySection)SectionEditor,CleftPalateCraniofacialJournal(CraniofacialSurgerySection)AnnualMeetingProgramandInstructionalCourseCommitteeASPS/PSFResearcherEducationCommitteeASPS/PSFResearchDevelopmentCommitteeASPS/PSFWomenPlasticSurgeonsSteeringCommitteeASPS/PSFCurriculumCommitteeMember,PlasticSurgeryResearchCouncilPSRCMentorshipCommitteeMember
Li,Melody Speaker,WomeninSTEMGloballyPanelDiscussion,AmericanAssociationofUniversityWomenLipshutz,Gerald GDDNIHStudySectionReviewerLoo,Joseph Editor‐in‐Chief,JournaloftheAmericanSocietyforMassSpectrometry
EditorialBoard,MassSpectrometryReviewsEditorialBoard,ClinicalProteomicsEditorialBoard,InternationalJournalofMassSpectrometryMember,USHUPOBoardofDirectorsMember,BoardofDirectors,ConsortiumforTop‐DownProteomicsMember,FoundingExecutiveBoard,LosAngelesMetropolitanMassSpectrometryDiscussionGroupCo‐Organizer,14thUppsalaConferenceonElectronCaptureandTransferDissociation
Lusis,Jake NIHStudySectionsAdHOCReviewer,AmericanHeartAssociationGrantsCommitteeonResearch,AmericanHeartAssociationExternalAdvisoryCommittee,NIHSABReCardiovascularDiseaseInitiativeBurroughs‐WellcomeTrainingPrograminMetabolicDiseasesAdvisoryBoardMember,BoardofScientificCounselors(NIH)BoardofDirectors,KernLipidConferenceReviewEditor,FrontiersinGeneticsofComplexTraitsWellcomeTrustCentreforHumanGenetics,InternationalScientificAdvisoryBoardScientificAdvisoryBoardMeetingSteeringCommittee,PharmacogeneticsResearchNetworkEditorialBoard,Arterisclerosis,ThrombosisandVascularBiologyAssociateEditor,JournalofLipidResearchEditorialBoard,CurrentCardiologyReviewsEditorialBoard,OpenAccessBioinformaticsReviewEditor,FrontiersinGeneticsofComplexTraitsAssociateEditor,JournalofSexDifferencesEditorialBoard,MammalianGenome;EditorialBoard,DiabesityAssociateEditor,SystemsBiologyandMedicine
McEvoy,Megan Member,TWD‐DNIHStudySectionMorrison,Sherie Member,CIINIHStudySection
Nakano,Austin CDDStudySection;PPGStudySectionNovitch,Bennett AdHOCMember,NIHNeurogenesisandCellFateStudySection
AdHOCMember,NIHMolecular,Cellular,andDevelopmentalNeuroscienceIntegratedReviewGroupAdHOCMember,MissouriSpinalCordInjury/DiseaseResearchProgram
Payne,Gregory ResearchGrantsCouncilAreasofExcellenceMonitoringandAssessmentPanel
Plath,Kathrin BoardofReviewingEditors,ScienceChair,PublicationsCommittee,ISSCRMember,InternationalCommittee,ISSCR
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Pyle,April AdHOC,MDAStudySectionAdHOC,SMEPNIHStudySection
Quinlan,Margot Member,NCSDNIHStudySectionReddy,Srinvasa NIHSpecialEmphasisPanel,VascularHematologyReue,Karen NHLBIInstitutionalTrainingMechanismReviewCommittee
NHLBIR03GrantStudySectionSchweizer,Felix Life‐Trustee,TheGrassFoundationSmale,Steven Member,NIHCMIAStudySection
Member,BlavatnikAwardsforYoungScientistsNationalJurySoragni,Alice BiOverlayAssociateEditor,BiorXivAffiliate
MemberNPISAdvisoryBoardSpencer,Melissa Chair,ScientificAdvisoryBoard,CoalitiontoCureCalpain3
Adhoc,SkeletalMuscle,ExercisePhysiologyStudySectionMember,ScientificAdvisoryCommitteeMuscularDystrophyAssociationMember,ScientificAdvisoryBoard,ParentProjectMuscularDystrophyReviewer,JesseJourneyFoundation;Organizer,FASEBSummerConferenceonCalpainsinHealthandDisease
Sun,Ren BoardofScientificCounselors,NationalCancerInstituteTamanoi,Fuyuhiko SeriesEditor,TheEnzymes,AcademicPress/ElsevierTang,Yi DOEBERReviewPanel,EditorialBoardofMetabolicEngineeringTarling,Elizabeth Member,VCMBandR03SEPNIH/NHLBIStudySections
Member,AHAFellowshipsLipids&ThrombosisPeerReviewCommittee,DeuelConferenceBoardMember,ATVBWomen'sLeadershipCommittee
Teitell,Michael NIH,CancerCenterSupportGrantReviewTeam,NCIOfficeofCancerCentersInternationalScientificCouncil,IsraelCancerResearchFoundationScientificAdvisoryBoard,TheMethodistResearchInstituteChair,MountainPacificSportsFederationAdministrativeCommitteeChair,Pac‐12ConferenceDiversityLeadershipCommitteeChair,Pac‐12ConferenceWomanoftheYearNominatingCommitteeChair,Pac‐12ConferenceNominatingCommitteeChair,Pac‐12ConferenceLegislativeCommittee
Tetradis,Sotirios AdHOCMember,ODCSStudySection,NIHTontonoz,Peter Editor‐In‐Chief,MolecularandCellularBiologyTorres,Jorge AdHOC,NIH‐NIGMSCellBiologyandRegulatorySystemsStudySectionWang,Yibin EditorialBoardMember,JBC,CirculationResearch,JournalofMolecularandCellularCardiology
Member,ScientificAdvisoryBoardofKeystoneSymposiumMember,ScientificAdvisoryBoardofAcademicaSinica
Weiss,Shimon ScientificAdvisoryBoard,MaxPlanckInstituteforMedicalResearch,Heidelberg,GermanyWhitelegge,Julain Member,EBITNIHStudySectionWilliams,David Beckman‐ArgyrosAwardExecutiveCommittee
GrantReviewer,FightforSight,UKFoundationforFightingBlindnessStudySectionGuestEditor,ProceedingsoftheNationalAcademyofSciences
Witte,Owen 2018Louis‐JeantetFoundationReviewCommitteePresident'sCancerPanelChildren'sResearchInstitute,UTSouthwesternMedicalCenter,ExternalAdvisoryBoardAndersonMoonShotsReviewCommitteeAACRNominatingCommitteeNationalAcademyofSciencesTemp.NominatingGroup,ClassIVCancerCellEditorialBoardProstateEditorialBoardProceedingsoftheNationalAcademyofSciencesUSAEditorialBoard
Wong,David CharteredMember,CancerBiomarkerStudySection,NIHCenterofScientificReviewXiao,Xinshu(Grace) NIHNCI2018/08Immuno‐OncologyTranslationNetworkStudySection,ZCA1SRB‐C(A1)R
AdHOC,NIHCSRSpecialEmphasisPanelAdHOC,IsraelScienceFoundation;Member,NIHBiodataManagementandAnalysisStudySection
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Yang,X.William CharteredMember,NIHCellularandMolecularBiologyofNeurodegenerationStudySectionScientificAdvisoryBoardMember,HereditaryDiseaseFoundationEditorialBoardMember,MolecularNeurodegenerationEditorialMember,JournalofHuntington'sDisease
Yeaman,Michael NIHStudySectionService:NIHZRG1EditorialBoardService:PLoSPathogensJournalReviewerService:InfectionandImmunity,JournalofInfectiousDiseases,AntimicrobialAgents&Chemotherapy,NewEnglandJournalofMedicine,Nature,JournalofLeukocyteBiology,Nature[Immunology],EukaryoticCell,JournalofBacteriology,Nature[Microbiology],PNAS
Zheng,Jie ScientificReviewer,Technology/TherapeuticDevelopmentAwardApplicationReviewCommitteeVisionResearchProgramMember,ProfessionalDevelopmentandEducationCommittee,AssociationforResearchinVisionandOphthalmologyEditorialBoard,CellCommunication&Signaling
Zhou,Hong AdHOC,NSFandNIHReviewCommittee
PATENTSISSUED2017‐2018
Member PatentName PatentNumber
Inventors
Clubb,Robert Methodsandcompositionstoincreasetherateoflitigationreactionscatalyzedbyasortaste
15164 R.Clubb,B.Amer
Eisenberg,David Structure‐basedPeptideInhibitorsofP53AggregationasaNewApproachtoCancerTherapeutics
9,873,718 A.Soragni,L.Jiang
Gelbart,William InVitroReconstitutedPlantVirusCapsidsforDeliveringRNAGenestoMammalianCells
183635 W.Gelbart,etal.
Kaufman,Daniel GabaAntagonistsintheTreatmentofDisordersAssociatedwithMetabolicSyndromeandGabaCombinationsinTreatmentorProphylaxisofTypeIDiabetes
9,820,955 D.Kaufman,J.Tian
Morrison,Sherie CD138‐Targetedinterferondemonstratedpotentapoptoticandanti‐tumoractivities.
9,803,021 S.Morrison
Nakano,Austin Metabolicinterventionsforpreventionofcongenitalheartdisease
A.Nakano,H.Nakano
Pyle,April Methodsforgeneratingandenrichingskeletalmuscleprogenitorcells
62/443,499 Hicks,A.Pyle
Soragni,Alice Structure‐basedPeptideInhibitorsofP53AggregationasaNewApproachtoCancerTherapeutics
9,873,718 D.Eisenberg,A.Soragni,L.Jiang
Spencer,Melissa CRISPR/CAS9MediatedGenome;DrugsThatIncreaseMuscleMass;NanoparticleDeliveryCRISPR;PolyrtaxaneNanoparticles;StemCellDelivery
Spencer,Melissa
Tang,Yi WeedControl 62/474,528 S.Jacobsen,Y.Tang,Y.Yan,Y.LiuTeitell,Michael UseofLiveCellInterferometrytoDetermine
ChangesinMassofMammalianCells9,810,683 J.Gimzewski,J.Reed,M.Teitell
Weiss,Shimon Electronicdisplaysusingopticallypumpedluminescentsemiconductornanocrystals;Semiconductornanocrystalprobesforbiologicalapplicationsandprocessformakingandusingsuchprobes
9,063,363;9,182,621;9,671,536;9,530,928
S.Weiss,Schlamp,M.C.,Alivisatos,A.P.;S.Weiss,M.Bruchez,Jr.,P.Alivisatos
Yang,X.William ACell‐BasedSeedingAssayforHuntingtonAggregation
62/571,433 X.W.Yang
Yeaman,Michael Peptidesandmethodsforinducingcelldeath 9,562,083 M.Yeaman,N.Y.Yount,E.P.BrassAnti‐infectivehydroxy‐phenylbenzoatesandmethodsofuse
9,585,897 M.Yeaman,A.S.Bayer
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Zack,Jerome Engineeringanti‐viralTcellimmunitythroughstemcellsandchimericantigenreceptors
9951118 S. Kitchen,J.Zack,O.O.Yang,I.Chen,M.Kamata
VISITINGFACULTY&SCHOLARS
Host Visitor HomeInstitution DatesatUCLA
Bitan,Gal
HudaAlalami CornellUniversity 6/19/17to9/8/2017
ZizihengLi UniversityofTokyo 12/1/17topresent
Black,Douglas
HidehitoKuroyanagi,PhD TokyoMedicalandDentalUniversity
9/17to6/18
ManuelAres,Ph.D. UniversityofCalifornia,SantaCruz
1/18to2/18
MelissaJurica,Ph.D. UniversityofCalifornia,SantaCruz
2/18to3/18
Chen,Irvin LanWang,Ph.D. PekingUnionMedicalCollege 7/1/17topresent
Clarke,Catherine LuciaFernandezdelRio,Ph.D. UniversityofCordoba 10/1/2017to6/30/2018
DeRobertis,Edward
LaurenAlbrecht,Ph.D. NorthwesternUniversity 7/15topresent
GabrieleColozza,Ph.D. UniversityofSiena 6/2012topresent
YiDing,Ph.D. TsinguaUniversity 1/2014topresent
YukiMoriyama,Ph.D. ShizuokaUniversity 6/2013to8/2018
NydiaTejeda,Ph.D. NationalAutonomousUniversityofMexico
9/1/2016topresent
Faull,Kym HaiqiangWu,Ph.D. ShenzhenUniversity 12/17to8/18
Gunsalus,Robert
AnzouMa,Ph.D. ChineseAcademyofSciences 10/1/16to10/17
UsmanAhmad,M.S. GCUniversity(Pakistan) 5/1/17to2/1/18
Houk,Kendall
EricBlock,Ph.D. AlbanyUniversity 1/1/18to6/30/18
Xiao‐SongXue,Ph.D. NankaiUniversity 10/1/17to6/30/18
YileiZhao,Ph.D. ShanghaiJiao‐TongUniversity
7/1/18to6/30/19
Jacobsen,Steven MariaNohales,Ph.D. UniversityofSouthernCalifornia
7/1/17to4/30/18
Johnson,Reid KiyotoKamagata,Ph.D. TohokuUniversity 8/1/17to3/31/18
Johnson,Tracy
ManuelAres,Ph.D. UniversityofCalifornia,SantaCruz
1/2018to3/2018
MaratPavliukov,Ph.D. UniversityofAlabamaatBirmingham
3/2018to5/2018
Kelesidis,Theodoros AnthanasiosKossyvakis,Ph.D. InstitutPasteurInternationalNetwork‐HellenicPasteurInstitute
07/01/17to06/30/18
Lin,Chentao XuWang,Ph.D. FujainAgricultureUniversity 12/1/17to1/31/18
Loo,Joseph XinhuaGuo,Ph.D. JilinUniversity 3/2018topresent
Nakano,Austin AyakoShigenta,MD,Ph.D. ChibaUniversity 1/1/2017to12/31/2017
Pellegrini,Matteo DavideVarnevali,Ph.D. UniversityofParma
Reddy,Srinvasa XinyingYang,Ph.D. ChineseAcademyofSciences 06/2016to09/2017
Reue,Karen YunlanLi,Ph.D. ShanxiMedicalUniversity 9/1/2017to8/31/2018
Rodriguez,Jose GustavoHelguera,Ph.D. CONICET 11/30/2017to02/01/2018
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Yang,X.William ChristianNeri,Ph.D. InstituteofBiologyParis‐Seine
07/2017to08/2017
Yeaman,Michael
LianaChan,Ph.D. UniversityofCalifornia,Berkeley
2014topresent
WpulieNarawatne,M.D. Pediatrics,Harbor‐UCLA 2016topresent
Zhou,Hong KaituoWang,Ph.D. UniversityofCopenhagen 8/1/2016to1/31/2018
XueYang,Ph.D. NankaiUniversity 12/15/2016to12/14/2017
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InstituteforQuantitative&ComputationalBiosciences(QCBio)AlexanderHoffmann,Director
QCBio is housed on the 5th floor of Boyer Hall and encompasses a range of quantitative and computationalbiosciences research, research training and educational program. QCBio Laboratories develop cutting edgequantitativeandcomputationaltools,rangingfromstatisticalanalysisandmodelingapproachestophysics‐basedalgorithms and mechanistic modeling. QCBio functions as the sponsor to the QCBio Collaboratory and theInterdepartmental Graduate Program inBioinformatics to provide research training, and provides coordinationamongotherquantitativeandcomputationalbiosciencesgraduateprograms.QCBioFacultyalsodirectandsupportthe Interdepartmental Undergraduate Programs in Computational & Systems Biology (the CaSB major) and inBioinformatics(aminor),aswellasthefreshmanmathematicsforLifeSciencespre‐majors.QCBioorganizestheBruins‐in‐Genomics(B.I.G.)SummerUndergraduateResearchProgram.QCBiosponsorstheBioinformaticsSeminarseries,aweeklyResearchLunch,ScientificWorkshopsandConferences,SymposiaandanAnnualRetreat.TheseactivitiesaresupportedbyBoyerHallstaff.
MoreinformationontheQCBiocanbefoundat:http://qcb.ucla.edu.
TheQCBioCollaboratory
MatteoPellegrini,CollaboratoryDirector
The mission of the QCBio Collaboratory is to provide computational research support to projects initiated byexperimentalists.Thismissionispursuedatthreelevels:(i)collaborativesupportorconsultingwork;(ii)workshopsto convey commonly used bioinformatics skills for the analysis of Next Gen Sequencing data; (iii) maintainingsoftwareplatforms(e.g.Galaxy)thatenablemultipletypesofanalysesofnextgenerationsequencingdata.TheseactivitiesaresupportedbytheQCBioCollaboratorypostdoctoralfellows,whoareselectedfromabroadapplicantpoolforrenewableannualappointments.QCBCollaboratoryworkshopsalsoformthebasisforgraduatecoursesavailabletoMBI‐IDPandothergraduatestudents.
MoreinformationonTheCollaboratorycanbefoundat:http://qcb.ucla.edu/collaboratory.
UCLA‐DOEInstitute
SabeehaMerchant,Director
The UCLA‐DOE Institute is a team of research laboratories working on fundamental research and technologydevelopmentsinbroadDOEmissionareasrangingfrommicrobes,tobiofuelsandgreenchemistry,tothedesignofnewbiomaterials.BoyerHallhousesfourofthesixUCLA‐DOECoreTechnologyCenters:
•BioinformaticsandComputationalCoreTechnologyCenter‐ToddYeates,Director/DuilioCascio,ManagerProvidescomputerhardwareandsoftwareinstallationandmaintenanceforawiderangeofofficeandscientificapplications;maintainsWWWserviceforsoftwareanddatabasedissemination.•MacromolecularCrystallizationCoreTechnologyCenter‐JamesBowie,Director/MichaelCollazo,ManagerTheMacromolecularCrystallizationCoreprovidesstate‐of‐the‐art,high‐throughput,andcrystallizationservicestoallinstitutions.•ProteinExpressionTechnologyCenter(PETC)‐JamesBowie,Director/MarkArbing,ManagerThePETCprovidessupportinallaspectsofproteinexpressionfromcloningthroughexpressionoptimizationandproteinpurification.•X‐rayCrystallographyCoreTechnologyCenter‐ToddYeates,Director/DuilioCascio,ManagerTheX‐rayCrystallographyCoreprovidesstate‐of‐the‐artresources,enablingthedetailed3‐Danalysisofbiologicalmacromoleculesthatplayessentialrolesinhumanhealth.
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MoreinformationontheDOEanditsCorescanbefoundat:www.doe‐mbi.ucla.edu
FermentationCoreFacilityJamesBowie,Director/MarkArbing,Manager
The Fermentation Core Facility is housed on the 1st floor of Boyer Hall. It consists of three Bio Engineeringfermenterswhichallowthelarge‐scalegrowthofbacteriaoryeastusingcontrolledregulationofcellgrowth,andalsohastheabilitytointroduceadditionalnutrientsand/orsupplementaloxygenthatallowmicrobialgrowthtohighcelldensities.
MoreinformationontheFermentationCorecanbefoundat:www.mbi.ucla.edu/fermentation‐core‐facility
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MOLECULARBIOLOGYINTERDEPARTMENTALPH.DPROGRAM(MBIDP)AshleyTerHorstandStephanieCuellar(SAO)
Sincetheprogram’s initiation in1966‐67,a totalof457individualshaveearnedtheirPh.D.degree inMolecularBiology.Duringthe2017‐18academicyear,therewere130studentsintheMBIDP,including36admissions,and11completingtheirdegreerequirements.The2017‐2018facultymentors intheMolecularBiologyIDPhaveprimaryappointments inthedepartmentsof:Anesthesiology;BiologicalChemistry;Cardiology;Chemical&BiomolecularEngineering;Chemistry&Biochemistry;Dentistry‐Oral Biology; Digestive Diseases; Human Genetics; Microbiology, Immunology & Molecular Genetics;Molecular & Medical Pharmacology; Molecular, Cell & Developmental Biology; Molecular, Cell & IntegrativePhysiology;Neurobiology;Neurology;Pathology&LaboratoryMedicine;PediatricGenetics;Pediatrics;Psychiatry&BehavioralScience;RadiationOncology;SurgeryandUrology.HomeAreaspromotein‐deptheducationalprogramswhilemaintainingflexibilityforstudentstoexplorebeyondasingle home area and faculty to contribute to multiple home areas according to their research interests. TheMolecularBiologyIDPconsistsoffourhomeareas:Cell&DevelopmentalBiology(CDB);Biochemistry,Biophysics,&StructureBiology(BBSB);GeneRegulation,EpigenomicsandTranscriptomics(GREAT);andImmunity,Microbes,&MolecularPathogenesis(IMMP).EachhomeareahasadirectorthatactsastheGraduateAdviserforthatarea’sstudents.
MBIDPSTUDENTS2017‐18
StudentName Mentor 2017‐2018Support
ADELAJA,ADEWUNMI(MSTP) Hoffmann,Alexander VascularBiologyTrainingGrant/GraduateStudentResearcher
AFASIZHEVA,ANNA(MSTP) Plath,Kathrin GraduateStudentResearcherALVAREZ,SANDY Butler,Samantha TeachingAssistantship/CellularandMolecularBiology
(CMB)TrainingGrant/GraduateStudentResearcherARAGON,RAQUEL Iruela‐Arispe,Luisa TeachingAssistantship/HHMIGilliamGraduate
FellowshipAROS,CODY(MSTP) Gomperts,Brigitte UCLAEli&EdytheBroadStemCellResearchCenter
TrainingGrantRecipient/GraduateStudentResearcherBACK,SUNGMIN(PETER) Bradley,Peter TeachingAssistantship/CellularandMolecularBiology
(CMB)TrainingGrant/GraduateStudentResearcherBOWLER,JEANNETTE Eisenberg,David GraduateStudentResearcher
BROWN,TAYLOR Hallem,Elissa CotaRobles/HHMIGilliamGraduateFellowship
CAMPOS,OSCAR KurdistaniSiavash GraduateStudentResearcher
CASTELLON,JOSE Backus,Keriann TeachingAssistantship/NationalScienceFoundationGraduateResearchFellowshipProgram
CHAI,MIN Huang,Jing GraduateStudentResearcher
CHANG,PATRICK Crooks,Gay Whitcome/GraduateStudentResearcher
CHAU,ANTHONY Plath,Kathrin Whitcome/GraduateStudentResearcher
CHEN,YI‐PEI Johnson,Patricia GraduateStudentResearcher
CHENG,QUEN(STAR) Hoffmann,Alexander DeptofMedicine/GraduateStudentResearcher
CHI,FANGTAO Banerjee,Utpal TeachingAssistantship/BroadStemCellResearchCenterTrainingGrant
CHIEN,PEGGIE Pyle,April GPB/TeachingAssistantship/GraduateStudentResearcher
CHITIASHVILI,TSOTNE Plath,Kathrin/Clark,Amander
NRST/BoehringerIngelheimPhDFellowship/GraduateStudentResearcher
CHOI,CHARLESPAUL Bradley,Peter GraduateStudentResearcher
CORVALAN,ADRIANA Coller,Hilary GraduateStudentResearcher
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CROWELL,PRESTON Goldstein,Andrew TeachingAssistantship/CellularandMolecularBiology(CMB)TrainingGrant/GraduateStudentResearcher
DALY,ALLISON Smale,Stephen GPB/TeachingAssistantship/GraduateStudentResearcher
DAMODAREN,NIVEDITA Plath,Kathrin/Black,Douglas
NRST/GPB/Teaching Assistantship/GraduateStudentResearcher
DEMARCO,STEPHANIE Hill,Kent DissertationYearFellowship/GraduateStudentResearcher
DENG,WILLIAM(WEIXIAN) Plath,Kathrin/Wohlschlegel,James
NRST/GPB/TeachingAssistantship/GraduateStudentResearcher
DIALAFITZGERALD(MSTP) Johnson,Patricia GraduateStudentResearcher
DIMAPASOC,MELANIE Zack,Jerome TeachingAssistantship/CellularandMolecularBiology(CMB)TrainingGrant/GraduateStudentResearcher
DO,TRAN(MSTP) Modlin,Robert DermatologyScientistTrainingGrant/GraduateStudentResearcher
EDWARDS,SAMANTHA Johnson,Tracy Whitcome/GraduateStudentResearcher
ELAHI,LUBAYNA Kornblum,Harley GPB/TeachingAssistantship/GraduateStudentResearcher
EMAMI,MICHAEL Spencer,Melissa TeachingAssistantship/NationalScienceFoundationGraduateResearchFellowshipProgram/CellularandMolecularBiology(CMB)TrainingGrant
EVANS,DECLAN Houk,Ken TeachingAssistantship/Chemistry‐BiologyInterface(CBI)TrainingGrant/GraduateStudentResearcher
FAN,XIAORUI Wohlschlegel,James Whitcome/GraduateStudentResearcher
FENG,AN‐CHIEH(ANGELA) Smale,Stephen NRST/GPB/TeachingAssistantship/GraduateStudentResearcher
FERRER,DAVID Bradley,Peter CotaRobles/GraduateStudentResearcher
FLORES,AIMEEALYSSA Lowry,William GraduateStudentResearcher
GANG,SPENCER Hallem,Elissa GraduateStudentResearcher
GIBBS,DEVIN Pyle,April/Crosbie‐Watson,Rachelle
GPB/TeachingAssistantship/GraduateStudentResearcher
GLADYS,DEVIN (1styearrotations) NRST/TeachingAssistantship/GatesMillenniumScholar
GOLDEN,LISA Voskuhl,Rhonda Whitcome/GraduateStudentResearcher
GOMEZ,ADAM Jones,Leanne NationalScienceFoundationGraduateResearchFellowshipProgram/GraduateStudentResearcher
GRAY,DAVID Kohn,Donald Whitcome/GraduateStudentResearcher
HANCOCK,GRACE Clark,Amander UCLAEli&EdytheBroadStemCellResearchCenterTrainingGrantRecipient/GraduateStudentResearcher
HERNANDEZ,GLORIA Iruela‐Arispe,Luisa TeachingAssistantship/VascularBiologyTrainingGrant/GraduateStudentResearcher
HILDRETH,ANDREW O’Sullivan,Tim GPB/TeachingAssistantship/GraduateStudentResearcher
HO,CHI‐MIN Egea,Pascal/Zhou,Hong
TeachingAssistantship/MicrobialPathogenesisTrainingGrant/GraduateStudentResearcher
HODGE,RACHEL Jones,Leanne TeachingAssistantship/CellularandMolecularBiology(CMB)TrainingGrant/GraduateStudentResearcher
HSU,EMILY Berk,Arnold VirologyandGeneTherapyTrainingGrant/GraduateStudentResearcher
HU,XUCHEN(MSTP) Young,Stephen VascularBiologyTrainingGrant/GraduateStudentResearcher
ICHINO,LUCIA Jacobsen,Steven NRST/GPB/TeachingAssistantship/GraduateStudentResearcher
JONES,ERIC Kosuri,Sriram GraduateStudentResearcher
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KIM,ELLIOT RobertModlin GraduateStudentResearcher
KO,ARTHUR Pajukanta,Paivi GraduateStudentResearcher
KORSAKOVA,ELENA Lowry,William TeachingAssistantship/BroadStemCellResearchCenterTrainingGrant
KRONENBERG,MICHAEL Carey,Michael TeachingAssistantship/CellularandMolecularBiology(CMB)TrainingGrant/GraduateStudentResearcher
KRYZA,JORDAN Jones,Leanne TeachingAssistantship/CellularandMolecularBiology(CMB)TrainingGrant/GraduateStudentResearcher
LANIADO,JOSHUA Yeates,Todd GraduateStudentResearcher
LEE,DEREK (1styearrotations) GPB/TeachingAssistantship/GraduateStudentResearcher
LEE,HANEUL(SKOTT) Coller,Hilary DissertationYearFellowship/GraduateStudentResearcher
LEE,JOSHZIXI Wang,Yibin GraduateStudentResearcher
LEUNG,CALVIN Johnson,Tracy DissertationYearFellowship/GraduateStudentResearcher
LEWIS,SOPHIA Jones,Leanne GraduateStudentResearcher
LI,YAN Guo,Feng NRST/GPB/TeachingAssistantship/GraduateStudentResearcher
LI,YANRUIDE(CHARLIE) Yang,Lili NRST/GPB/TeachingAssistantship/GraduateStudentResearcher
LIM,HANYOUNG Black,Douglas GraduateStudentResearcher
LIN,TASHA(STAR) Chen,Yvonne STAR,DivisionofHematology‐Oncology,T32HematologyTrainingGrant,T32ImmunologyTrainingGrant
LIN,YING Zipursky,Larry Whitcome/GraduateStudentResearcher
LIU,HUACHUN Lin,Chentao Whitcome/GraduateStudentResearcher
LIU,WANLU Jacobsen,Steve GraduateStudentResearcher
LO,HUNG‐HAO Smale,Stephen GraduateStudentResearcher
LOPEZ,ANDREW Fregoso,Oliver MicrobialPathogenesisTrainingGrant/GraduateStudentResearcher
LOWE,MATTHEW Clark,Amander TeachingAssistantship/CellularandMolecularBiology(CMB)TrainingGrant/GraduateStudentResearcher
MA,FEIYANG Pellegrini,Matteo NRST/GPB/TeachingAssistantship/GraduateStudentResearcher
MASIUK,KATELYN(MSTP) Kohn,Donald GraduateStudentResearcher
MILLER,JARRETT Plath,Kathrin GraduateStudentResearcher
MILLER,JUSTIN Yeates,Todd NIHUCLABiotechnologyTrainingGrant/GraduateStudentResearcher
MILLER,MATTHEW
Butte,Manish GPB/TeachingAssistantship/GraduateStudentResearcher
MIRANDA,MATILDE
Lowry,William NationalScienceFoundationGraduateResearchFellowshipProgram/GraduateStudentResearcher
MOLGORA,BRENDAMARIA Johnson,Patricia CotaRobles/GraduateStudentResearcherMURRAY,KEVIN(MSTP)
Eisenberg,David Chemistry‐BiologyInterface(CBI)TrainingGrant/GraduateStudentResearcher
NAVARRO,HECTOR
Goldstein,Andrew GPB/TeachingAssistantship/GraduateStudentResearcher
NESTERENKO,PAVLO Witte,Owen GPB/TeachingAssistantship/GraduateStudentResearcher
NEVES,LAURENTAYLOR Johnson,Tracy GraduateStudentResearcher
NITZAHN,MATTHEW Lipshutz,Gerald GraduateStudentResearcher
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OCHOA,JESSICA
Yeates,Todd TeachingAssistantship/HHMIGilliamGraduateFellowship
OKONKWO,SHAWNTEL
Johnson,Tracy NationalScienceFoundationGraduateResearchFellowshipProgram/GraduateStudentResearcher
ONG,JESSICA(MSTP) Reue,Karen GraduateStudentResearcher
PATEL,AANAND(MSTP) Quinlan,Margot GraduateStudentResearcher
PERRONE,IAN Fregoso,Oliver GraduateStudentResearcher
POHL,KATHERINE
Yang,Xianjie GPB/TeachingAssistantship/GraduateStudentResearcher
PRONOVOST,GEOFFREY Hsiao,Elaine MolecularPathogenesisTrainingGrant/GraduateStudentResearcher
QIAN,KEVIN(MSTP)
Tontonoz,Peter GeffenScholarship
READ,GRAHAM (1styearrotations) GPB/TeachingAssistantship/GraduateStudentResearcher
RIGGAN,LUKE
O’Sullivan,Tim GPB/TeachingAssistantship/GraduateStudentResearcher
SAHAKYAN,ANNA Plath,Kathrin GraduateStudentResearcher
SALISBURY,DAVIDALEX
Sallam,Tamer/Tontonoz,Peter
TeachingAssistantship/VascularBiologyTrainingGrant/GraduateStudentResearcher
SANCHEZ,LUIS Quinlan,Margot TeachingAssistant/GraduateStudentResearcher
SANDHU,JASPREETSINGH(MSTP) Tontonoz,Peter GraduateStudentResearcher
SANDOVAL,CARINA
Fregoso,Oliver GPB/TeachingAssistantship/GraduateStudentResearcher
SERCEL,ALEXANDER
Teitell,Michael UCLATumorImmunologyTrainingGrant/GraduateStudentResearcher
SHIA,DAVID(MSTP) Gomperts,Brigitte GraduateStudentResearcher
SHIMADA,ERIKOCHRISTINE Teitell,Michael MichaelTeitellLaboratory
SHU,CYNTHIA
Crosbie‐Watson,Rachelle
MuscleCellBiology,Pathogenesis,andTherapeuticsGrant/EurekaScholarship
SUN,VICTORIA(MSTP) Crooks,Gay GraduateStudentResearcher
TAN,YINGXUANSHAWN Plath,Kathrin GraduateStudentResearcher
TAO,YANG
Martin,Kelsey DissertationYearFellowship/GraduatestudentResearcher
TESSEMA,KALEAB(MSTP) Kornblum,Harley GraduateStudentResearcher
THIND,AMARA
Bradley,Peter GPB/TeachingAssistantship/GraduateStudentResearcher
THURLOW,LAUREN
Johnson,Tracy TeachingAssistantship/NationalScienceFoundationGraduateResearchFellowshipProgram/CellularandMolecularBiology(CMB)TrainingGrant
TISNADO,JERRELLRAY
Gelbart,William NationalScienceFoundationGraduateResearchFellowship/GraduateStudentResearcher
URTECHO,GUILLAUME Kosuri,Sriram CotaRobles/GraduateStudentResearcher
VALLIERE,MEAGHAN Bowie,James TeachingAssistantship/GraduateStudentResearcherVANLOON,AARON Sagasti,Alvaro GraduateStudentResearcherVAN,CHRISTINA Waschek,James GraduateStudentResearcherVAVILINA,ANASTASIA Mikkola,Hanna TeachingAssistantship/VascularBiologyTraining
Grant/GraduateStudentResearcherVUONG,CELINEKIM Black,Douglas DouglasBlackLaboratory
WANG,LULAN Cheng,Genhong GraduateStudentResearcherWATERS,LYNNEARAE Teitell,Michael GraduateStudentResearcherWEISS,DAVID(MSTP) Modlin,Robert GraduateStudentResearcherYANG,EMILY
Li,Melody GPB/TeachingAssistantship/GraduateStudentResearcher
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YOUNG,BRIANDANIEL(MSTP) Wohlschlegel,James JamesWohlschlegelLaboratoryYOUNG,COURTNEY Spencer,Melissa MelissaSpencerLaboratoryYU,JIAJI
Yang,Lili NRST/TeachingAssistantship/BroadStemCellResearchCenterTrainingGrant/GraduateStudentResearcher
ZEMKE,NATHANROBERT Berk,Arnold GraduateStudentResearcherZENG,SAMUEL(MSTP) Yang,Lili GraduateStudentResearcherZHAN,LINGYU Sul,JaeHoon NRST/GPB/TeachingAssistantship/GraduateStudent
ResearcherZHANG,JIAYAN
Zhou,Hong NRST/GPB/TeachingAssistantship/GraduateStudentResearcher
ZHANG,TIANHAO Sun,Ren GraduateStudentResearcherZHANG,YURUN Chute,John GraduateStudentResearcher
STUDENTSWHOADVANCED‐TO‐CANDIDACY2017‐2018
StudentName Mentor
Adelaja,Adewunmi(MSTP) Hoffmann,Alexander
Aros,Cody Gomperts,Brigitte
Brown,Taylor Hallem,Elissa
Chang,Patrick Crooks,Gay
Chau,Anthony Plath,Kathrin
Cheng,Quen Hoffmann,Alexander
Diala,FitzGerald Johnson,Patricia
Fan,Xiaorui Wohlschlegel,James
Hancock,Grace Clark, Amander
Hsu,Emily Berk,Arnold
Hu,Xuchen(MSTP) Young,Stephen
Lim,HanYoung Black,Douglas
Lin,Ying Zipursky,Larry
Lopez,Andrew Fregoso,Oliver
Nitzahn,Matthew Lipshutz,Gerald
Ochoa,Jessica Yeates,Todd
Ong,Jessica Reue,Karen
Patel,Aanand(MSTP) Quinlan,Margot
Sercel,Alexander Teitell,Michael
Weiss,David Modlin,Robert
Zhang,Jiayan Zhou,Hong
Zhang,Tianhao Sun,Ren
STUDENTSAWARDEDPH.Ds2017‐2018
StudentName Mentor DissertationTitle
Aschemeyer,SharrayaLynn Ganz,Tomas Themechanismofactionandregulationofhepcidin.
Campos,Oscar Kurdistani,Siavash Theeukaryoticnucleosomeregulatescopperhomeostasisviacopperandreduction.
Flores,Aimee Lowry,Bill InvestingtheRoleofMetabolisminTissueHomeostasis andTumorInitiationbyHairFollicleStemCells.
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Li,Yanjing Wu,Lily TargetingCXCR2+Neuroendocrine‐likeCellsfortheTreatmentofCastration‐resistantProstateCancer.
Liu,Wanlu Jacobsen,Steve MechanismsofDNAmethylationcontrolandepigenomeengineering.
Neves,LaurenTaylor Johnson,Tracy HistonevariantH2A.Zcoordinatestheprocessesoftranscriptionandpre‐mRNAsplicing.
Sahakyan,Anna Plath,Kathrin MechanismsofX‐chromosomeRegulationDuringMammalianDevelopment.
Shimada,ErikoChristine Teitell,Michael ManyFacetsofPNPase‐ UncoveringtheRoleofPNPaseintheMitochondria.
Vuong,CelineKim Black,Douglas RegulationofNeuronalExcitabilitybytheRNA‐BindingProteinRbfox1.
Young,Brian Wohlschlegel,James IdentificationofamultisubunitE3ubiquitinligaserequiredforheterotrimericG‐proteinbeta‐subunitubiquitinationandcAMPsignaling.
Young,Courtney Spencer,Melissa DevelopmentofaTherapeuticCRISPR/Cas9PlatformforDuchenneMuscularDystrophy.
EXTRAMURALFELLOWSHIPS&AWARDS
RuthL.KirschsteinNationalResearchServiceAwards
Demarco,Stephanie Emami,Michael Gang,Spencer Molgora,Brenda Loon,AaronVan
NationalScienceFoundationGraduateResearchFellowships
Aragon,Raquel Castellon,Jose Emami,Michael Gomez,Adam Hernandez,Gloria Miranda,Matilde Okonkwo,Shawntel Thurlow,Lauren Tisnado,Jerrell
GRADUATEDIVISIONAWARDSEugeneV.Cota‐RoblesFellowships
Ochoa,Jessica Urtecho,Guillaume
GraduateDivisionDissertationYearFellowshipAwards
Tao,Yang Waters,Lynnea Young,Courtney Demarco,Stephanie
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Lee,HaNeul(Skott) Leung,Calvin
MBIDPGRADUATESTUDENTSEMINARS
ModeledaftertheMBIInterdisciplinaryFacultySeminars, thesetalksarepresentedbyourgraduatestudents intheirthirdandfifthyearwithintheprogram.Facultyarenotpresentforthetalks,whichprovidesourstudentswithanopportunitytopresenttheirresearchinarelaxed,collegialatmosphereoverlunch,andallowsforconstructivediscussionandcritique.Somestudentsusethisforumaspracticefortheiroralqualifyingexamand/ordissertationdefense.Theseminarserieshasproventobeagreatsuccessduetotheformatandtheenthusiasmofourgraduatestudents.Theseminarpresentationsduringthe2017‐2018AcademicYearwere:Date 1stSpeaker 2nd Speaker
Wednesday,October4th
AimeeFlores“InvestigatingtheRoleofMetabolisminTissueHomeostasisandTumorInitiationbyHairFollicleStemCells”
AdewunmiAdelaja“Context‐specificRegulationofNFκBSignalinginPrimaryMacrophages”
Wednesday,October18th
CalvinLeung“AhistonemodificationregulatesRNAsplicingbyunexpectedmechanisms”
DavidWeiss“TheRoleofTh17CellsinHostDefense”
Wednesday,November1st
LulanWang“Studyingtheevolutionofemergingvirusesusinggenomewideanalysis”
AanandPatel“FHODfamilyforminsnucleateactinforcellmotilityandcontractility”
Wednesday,November15th
TaylorBrown"Decipheringtheinteractionsbetweenskin‐penetratingparasiticnematodesandbacteria"
WanluLiu“MechanismsofDNAmethylationcontrolandepigenomeengineering”
Wednesday,November29th
JessicaOng“Diet1andintestinalhomeostasis”
Wednesday,December13th
FitzGeraldDiala“IdentificationandcharacterizationoftheproteintargetsofmetronidazoleinTrichomonasvaginalis”
Tian‐HaoZhang“EffectsofMutationsonReplicativeFitnessandMHC‐IBindingAffinityAreAmongtheDeterminantsUnderlyingCytotoxic‐T‐LymphocyteEscapeofHIV‐1GagEpitopes”
Wednesday,January10th
ChristinaVan“RoleofPACAP/PAC1inprotectingneuronsandmodulatinginflammationinamodelofmultiplesclerosisandopticneuritis”
MattNitzahn“GeneandCellTherapyApproachesfortheUreaCycleDisorderCPS1Deficiency”
Wednesday,January24th
YingLin“Thedevelopmentofsynapticspecificityindrosophilavisualsystem”
Yi‐PeiChen“ATrichomonasvaginaliscadherin‐likeproteinmediatesadherencetoandkillingofhostcells”
Wednesday,February7th
StephanieDeMarco“RegulationofsocialmotilityintheprotozoanparasiteTrypanosomabrucei”
CharlesChoi“AphotocrosslinkableunnaturalaminoacidsystemtostudytheToxoplasmagondiiinnermembranecomplex”
Wednesday,February21st
CourtneyYoung“DevelopmentofaCRISPR/Cas9geneeditingplatformforDuchennemusculardystrophy”
PatrickChang“Engineeringstemcell‐derivedTcellsforimmunotherapy”
Wednesday,March7th
JessicaOchoa“ExploitingMicrocompartmentShellProteinstoExploreMechanismsofSubcellularOrganizationandtoCreateNovelMaterials”
EmilyHsu“TranscriptionalactivationofearlyviralgenesbyadenoviruslargeE1Aviainteractionswithp300”
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Wednesday,March21st
HanYoungLim“ChromatinRetentionofPre‐mRNAasaMechanismformRNAQualityControl”
XiaoruiFan“Molecularmechanismofiron‐sulfurproteinmaturationmediatedbycytosolicFe/Sclusterassemblypathway”
Wednesday,April4th
EricJones“AScalable,MultiplexedAssayforDecodingReceptor‐LigandInteractions”
YangTao“Howdoesagingalterhippocampalchromatinaccessibilityandgeneexpressionpattern”
Wednesday,April18th
SkottLee“DefiningthemechanisticbasisfortheeffectofRECKalternativepolyadenylationoncellmigrationandinvasion”
CodyAros“Wnt/Beta‐cateninsignalingregulatesairwaybasalstemcellhomeostasis”
Wednesday,May2nd
AndrewLopez“HowdoesHIVactivatetheDNAdamageresponse?”
QuenCheng“ConditioningwithTypeIorIIinterferonaltershumanmacrophageresponsesinagene‐andstimulus‐specificmanner”
Wednesday,May16th
AdrianaCorvalan“UnderstandingtheroleofH4K20me3andSuv4‐20h2incellularquiescence”
AnthonyChau“InvestigatingtheRoleoftheCRepeatinXistFunction”
Wednesday,May30th
AlexSercel“Usingmitochondrialtransferandtissueengineeringtomodelandengineertherapiesformitochondrialdisordersofthecentralnervoussystem”
GraceHancock“Transcriptionfactorsfornaïvepluripotencyinprimordialgermcelldevelopment”
CONFERENCEPARTICIPATION
Adelaja,Adewunmi
MD‐PhDNationalStudentConference;Keystone,CO.July2017. SouthernCaliforniaBiomedicalSciencesGraduateSymposium;LosAngeles,CA.October2017. APSAWestRegionalMeeting;Irvine,CA.December2017. AAP/ASCI/APSAJointConference;Chicago,IL.April2018. SystemsBiologyofHumanDisease;LosAngeles,CA.June2018. ImmunologyLA;LosAngeles,CA.June2018.
Aros,Cody
GordonResearchConferenceonWntSignaling;Stowe,VT.August6‐11,2017. UCLAEli&EdytheBroadStemCellResearchSymposium;UCLA.February2,2018.
Bowler,Jeannette
FASEBScienceResearchConference;SteamboatSprings,CO.June11‐16,2017.Brown,Taylor
WWAMImeeting,Caltech.Chai,Min
KeystoneSymposiaMitochondrialBiology&SelectiveAutophagy;Kyoto,Japan.April22‐26,2018.Chang,Patrick
LaJollaImmunology;SanDiego,CA.October17‐19,2017. BroadStemCellCenterSymposium;UCLA.February5,2018. DavidBaltimoreSymposium;Caltech,Pasadena,CA.March23,2018. EngineeringImmunity;LakeArrowhead,CA.May7‐8,2018. I3TRetreat;UCLA,LosAngeles,CA.June12,2018. UCLABiomedical/LifeScienceInnovationDay;UCLA,LosAngeles,CA.June13,2018.
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Chen,Yi‐Pei
MolecularParasitologyMeeting;WoodsHole,MA.September2017. AmericanSocietyforTropicalMedicineHygiene;Baltimore,MD.November2017. SouthernCaliforniaEukaryoticPathogenSymposium;Riverside,CA.December2017. MicrobialPathogenesisTrainingGrantTraineeSeminars;LosAngeles,CA.May2018.
Cheng,Quen
KeystoneConferenceonMyeloidCells;Breckenridge,CO.April2018.Chi,Fangtao
ColdSpringsHarborAsia‐Cancer&Metabolism;Suzhou,China.March2018.Crowell,Preston
KeystoneTumorMetabolismConference;SnowbirdSkiResort,UT.January21‐25,2018.Demarco,Stephanie
SouthernCaliforniaEukaryoticPathogensSymposium;UCRiverside,CA.December6,2017.Deng,William(Weixian)
AmericanSocietyofMassSpectrometryAnnualConference;SanDiego,CA;June2‐5,2018.Diala,FitzGerald(MSTP)
AmericanPhysicianScientistsAssociationWestRegionalConference;Irvine,CA.December2,2017. 2018StudentNationalMedicalAssociation(SNMA)AnnualMedicalEducationConference(AMEC);San
Francisco,CA.March29‐April1,2018. 2018AmericanSocietyforMicrobiology(ASM)MicrobeConference;Atlanta,GA.June7‐10,2018.
Do,Tran(MSTP)
AmericanAcademyofDermatologistAnnualMeeting;SanDiego,CA.February16‐20,2018. InternationalInvestigativeDermatologyConference;Orlando,FL.May16‐19,2018.
Edwards,Samantha
RNASocietyMeeting;Berkeley,CA.May29‐June3,2018.Emami,Michael
AnnualBiomedicalConferenceforMinorityStudents(ABRMCS);Phoenix,AZ.November1‐4,2017. AmericanSocietyofGeneandCellTherapy;May16‐19,2018. NewDirectionsofBiologyandDiseaseinSkeletalMuscleConference;NewOrleans,LA.June25,2018.
Fan,Xiaorui
AmericanSocietyforMassSpectrometryAnnualConference;SanDiego,CA.Feng,An‐Chieh(Angela)
AAIImmunologyAdvancedTrainingCourse2018;Boston,MA.July22‐27,2018.Gang,Spencer
FASEBMolecularPathogenesis:MechanismsofInfectiousDisease;Snowmass,CO.July9‐14,2017.Golden,Lisa
ACTRIMS;SanDiego,CA.February1‐3,2018.
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Gray,David AnnualMeetingoftheAmericanSocietyforGeneandCellTherapy;Chicago,IL. GenomeEngineering:TheCRISPR‐CasRevolution;ColdSpringsHarborLaboratory,LongIsland,NY.
Hancock,Grace
FromStemCellstoHumanDevelopment;Surrey,UK.September23‐26,2018.Ho,Chi‐Min
ThreeDimensionalElectronMicroscopyGRC;LesDiablerets,Switzerland;June11‐16,2017. 28thAnnualMolecularParasitologyMeeting;WoodsHole,Massachusett.September10‐14,2017.Biology
ofHost‐ParasiteInteractionsGRC;Newport,RI.June10‐15,2018.Hsu,Emily
DNATumorVirusMeeting;Birmingham,UK.July17‐22,2017.Hu,Xuchen(MSTP)
DeuelConferenceonLipids;March2018.Jones,Eric
GPCRWorkshop;Kona,HI.December5‐9,2017. ProteinSocietyAnnualMeeting;Boston,MA.July9‐12,2018
Kronenberg,Michael
MechanismsofEukaryoticTranscription2017;ColdSpring,NY.August29‐September2,2017.Lee,HaNeul(Skott)
MBIDPRetreat;Ventura,CA.April2018. ASCBConference;Philadelphia,PA.December2017.
Lee,JoshZixi
ColdSpringHarborAsia:StemCellCrossroads;Suzhou,China.May7‐10.Leung,Calvin
2018RNAMeeting;Berkeley,CA.2017. ASBMBAnnualMeeting;Chicago.
Liu,Wanlu
HHMISciencemeeting;ChevyChase,Maryland.March2018.Lo,Hung‐Hao
I3TRetreat;LosAngeles,CA.June12,2018.Lopez,Andrew
AmericanSocietyforVirology(ASV);CollegePark,Maryland.July14‐18,2018.Lowe,Matthew
StemCellSymposium;UCLA.February2,2018. MWRI;Pittsburgh,PA.April3‐4,2018.
Masiuk,Katelyn(MSTP)
AmericanSocietyofHematology;SanDiego,CA.December2017 EmergingCellularTherapies:TCellsandBeyond;Keystone,CO.February2018.
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AmericanSocietyofGeneandCellTherapy;WashingtonDC.May2018.Molgora,Brenda
SouthernCaliforniaEukaryoticPathogenSymposium;Riverside,CA.December6,2017 AmericanSocietyforMicrobiology(ASM)MicrobeConference;Atlanta,GA.June7‐11,2018.
Murray,Kevin(MSTP)
RosettaCon;Seattle,WA.July2017.Nitzahn,Matthew
AmericanSocietyofGeneandCellTherapy21stAnnualConference;May15‐19,2018.Patel,Aanand(MSTP)
GordonResearchSeminar&ConferenceonMotile&ContractileSystems;NewLondon,NH.July29‐August4,2017.
BiophysicalSocietyAnnualMeeting;SanFrancisco,CA.February17‐21,2018. AmericanSocietyforCellBiologyAnnualMeeting;Philadelphia,PA.December2‐6,2017.
Salisbury,David(Alex)
KeystoneSymposiaonNoncodingRNAs:Form,Function,Physiology;Keystone,CO.February25‐March1,2018.
Sercel,Alexander
CellSymposiaMultifacetedMitochondria;ParadisePoint,SanDiego,CA.June4‐6,2018.Shu,Cynthia
NewDirectionsinBiologyandDiseaseofSkeletalMuscleConference;NewOrleans,LA.June25‐28,2018.Tan,YinXuan(Shawn)
14thAnnualStemCellConference(UCLA)Thurlow,Lauren
2017SACNASNationalConference;SaltLakeCity,UT.October18‐21,2017. UCLAMolecular,CellandDevelopmentalBiologyResearchConference;LakeArrowhead,CA.December1‐
3,2017. 23rdAnnualMeetingoftheRNASociety;Berkeley,CA.May29‐June3,2018.
Urtecho,Guillaume
MarineBiologicalLaboratoryAdvancedResearchCourse‐MicrobialDiversity;WoodsHole,MA.July7‐August23.
Valliere,Meaghan
BASFResearchForumattheendofAugustVanLoon,Aaron
GRC:MotileandContractileSystems;Colby‐SawyerCollege,NewLondon,NH.July30‐August4,2017. InternationalZebrafishConference;UniversityofWisconsin,Madison,WI.June20‐24,2018.
Van,Christina
MovingTargetsSymposium;USC,LosAngeles,CA.August17,2017. 13thInternationalSymposiumonPACAP,VIP,andRelatedPeptides;HongKong,China.December5,2017. CURE:DigestiveDiseasesResearchCenterAnnualMeeting;UCLA,LosAngeles,CA.March23,2018.
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InauguralI3TScientificRetreat;UCLA,LosAngeles,CA.June12,2018.Wang,Lulan
ImmunologyLA;SkirballCenter.June15,2018.Waters,Lynnea
LaJollaImmunologyConference;LaJolla,CA.October2017.Young,Courtney
AmericanSocietyforGeneandCellTherapy(ASGCT)AnnualMeeting;Chicago,IL.May16‐19,2018. WorldMuscleSociety;St.Malo,France.Oct3‐7,2017. PPMDConnectConference;Chicago,IL.June29‐July1,2017.
Yu,Jiaji
ImmunologyLA;LosAngeles,CA. 14thAnnualStemCellSymposium;UCLA.
Zemke,Nathan
DNATumorVirusMeeting;UniversityofBirmingham,UK.July17‐22,2017.Zhan,Lingyu
SymposiumofFrontiersandCareersincryoEM;CNSI,UCLA.April27‐28,2018. SouthernCaliforniaSocietyforMicroscopyandMicroanalysis(SCSMMspringmeeting);MichelsonCenter
forConvergentBioscienceatUSC.April13,2018.Zhang,Tianhao
PalmSpringHIV/AIDSannualsymposium;PalmSprings,CA.March2018.
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Mack,J.J.,Mosqueiro,T.S.,Archer,B.J.,Jones,W.M.,Sunshine,H.,Faas,G.C.,Briot,A.,Aragon,R.,Su,Y.T.,Romay,M.C.,McDonald,A.I.,Kuo,C.,Lizama,C.O.,Lane,T.F.,Zovein,A.C.,Fang,Y.,Tarling,E.J.,deAguiarVallim,T.Q.,Navab,M.,Fogelman,A.M.,Bouchard,L.S.,Iruela‐Arispe,M.L.2017.NOTCH1isamechanosensorinadultarteries.NatureCommunications.8(1),1620.
Brown,Taylor
Mercer,Frances,Ng,ShekHang,Brown,TaylorM.,Boatman,Grace,Johnson,PJ.NeutrophilsKilltheParasiteTrichomonasvaginalisusingTrogocytosis.PLoSBiol.(2017);16(2):e2003885.
Chen,Yi‐Pei
Janssen,BD,Chen,YP,Molgora,B,Wang,SE,Simoes‐Barbosa,A,andJohnson,PJ(2018)CRISPR/Cas9‐mediatedgenemodificationandgeneknockoutinthehuman‐infectiveparasiteTrichomonasvaginalis.Sci.Rep.8(1):270.
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RajbhandariP,ThomasBJ,FengAC,HongC,WangJ,VergnesL,SallamT,WangB,SandhuJ,SeldinMM,LusisAJ,FongLG,KatzM,LeeR,YoungSG,ReueK,SmaleST,TontonozP.IL‐10SignalingRemodelsAdiposeChromatinArchitecturetoLimitThermogenesisandEnergyExpenditure.Cell.2018;172(1‐2):218‐233.e17.
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Korsakova,Elena
OhashiM.,Korsakova,E.,LeeP.,AllenD.,FuK.,VargasB.,CinkornpuminJ.,SalasC.,ParkJ.,GermanguzI.,ChronisK.,KuoyE.,TranS.,XiaoG.,PellegriniM.,PlathK.,LowryW.(2018).LossofMECP2leadstoactivationofp53andneuronalsenescence.StemCellReports,10,1453‐1463.
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WHITCOMEPRE‐DOCTORALTRAININGPROGRAM
TheWhitcomePre‐doctoralTrainingProgramsupportsstudentswithaMB‐IDPmentorintheir3rd,4thor5thyearofgraduateschool.Traineesareeligibleforoneyearofsupportwithpossibilityforcompetitiverenewal.Therearenocitizenshiprestrictionsforthisprogram;internationalstudentsarewelcometoapply.Theprogramiscompetitiveandmeritbased.Congratulationstothefollowinggraduatestudents,whowereselectedfortheWhitcomeTrainingProgramthisyear:Name GraduateProgram MentorNatalieChen Molecular,Cellular&IntegrativePhysiology StephenYoungCharlesChoi MBIDP(Immunity,MicrobesandMolecularPathogenesis) PeterBradleyHaNeulLee MBIDP(CellandDevelopmentalBiology) HilaryCollerHanYoungLim MBIDP(Biochemistry,Biophysics,andStructuralBiology) DouglasBlackCalvinLeung MBIDP(Biochemistry,Biophysics,andStructuralBiology) TracyJohnsonWanluLiu MBIDP(CellandDevelopmentalBiology) SteveJacobsenJerryLo MBIDP(Immunity,MicrobesandMolecularPathogenesis) StephenSmale
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LizhenFang,TylerG.Saint‐Denis,BuckL.H.Taylor,SethAhlquist,KaiHong,SaiSaiLiu,LiLiHan,K.N.Houk,
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BrianJ.Levandowski,TrevorA.Hamlin,F.MatthiasBickelhaupt,andK.N.Houk:"RoleofOrbital
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CyndiQixinHe,AdamSimon,Yu‐hongLam,AndrewP.J.Brunskill,NobuyoshiYasuda,JiajingTan,AlanM.
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Chen‐ChenZhou,M.FrederickHawthorne,K.N.Houk,andGonzaloJimenez‐Oses:"MultipleMechanisms
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YaoLi,Guo‐HuiYang,CyndiQixinHe,XinLi,K.N.Houk,andJin‐PeiCheng:"ChiralitySensingofa‐
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AmyE.Fraley,MarcGarcia‐Borras,AshootoshTripathi,DheerajKhare,EduardoV.Mercado‐Marin,HongTran,QingyunDan,GabrielleP.Webb,KatherineR.Watts,PhillipCrews,RichmondSarpong,RobertM.Williams,JanetL.Smith,K.N.Houk,andDavidH.Sherman:"FunctionandStructureofMalA/MalA’,IterativeHalogenasesforLate‐StageC‐HFunctionalizationofIndoleAlkaloids,"J.Am.Chem.Soc.,139,12060‐12068.2017.
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MasaoOhashi,FangLiu,YangHai,MengbinChen,Man‐chengTang,ZhongyueYang,MichioSato,Kenji
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