quinidine toxicity

8/13/2019 Quinidine Toxicity

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Quinidine is indicated for atrial fibrillation and flutter,and life-threatening ventricular arrhythmia.

Optimalserum concentrationsare in the range of 2.0

to 5.0 mcg/mL, with toxicity apparent at levels > or=6.0 mcg/mL.


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The half life of quinidine is 6 to 8 hours, and the druglacks any significant active metabolites.

Physiologic processes that generally reduce hepatic

metabolism and renal clearance increase serumquinidine levels

while co-medication with cytochrome p450 (CYP)enzyme inducers enhances clearance and results in

lower blood concentrations.


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Treating and preventing certain abnormal heartrhythms.

Quinidine sulfate is an antiarrhythmic.

It works by stabilizing the heart rhythm in conditionsin which the heart is beating too fast or in an irregularrhythm (Antiarrhythmic effect).


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Myasthenia Gravis Complete Heart Block

Partial Heart Block

Prolonged Q-T Interval on EKG

Chronic Heart Failure

Abnormally Low Blood Pressure

Emphysema, Liver Problems

Kidney Disease, Psoriasis Poisoning by the Drug Quinidine

Poisoning by the Heart Medication Digitalis


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Heart Rhythm Problems from Digitalis or Digoxin Condition of Increased Mast Cells

Problems with Food Passing Through the Esophagus

Anemia from Pyruvate Kinase and G6PD Deficiencies

Low Amount of Magnesium in the Blood

Low Amount of Potassium in the Blood

Delay in Activation of the Left Ventricle of the Heart

Defect in Heart's Electrical Intra-ventricularConduction

Decreased Blood Platelets


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QUINIDINE TOXICITYThe toxic reaction of the

body to the substance,possibly via allergic

reaction or overdose.


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ECGchanges

Heartblock

Asystole

Ventriculartachycardia Ventricularfibrillation

Syncope

Seizures

Coma

Death


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Symptoms of toxicity (cinchonism) include :

Tinnitus

light-headedness

prematureventricularcontractionsAtrio-ventricularblock.

Gastrointestinaldistressis a frequent side effect,which becomes more severe and is associated with

nausea and vomiting at higher drug concentrations.


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quinidine toxicity

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