QuickScout TM

A Comprehensive Tyrosine Kinase Profiling!

Kinase Inhibitor Profiling Service -- Comparative Inhibitory Activity

Our newest profiling services use pre-selected Tyrosine Kinase panels to permit the most rapid and thorough evaluation of potential kinase inhibitor selectivity.

77Tyrosine kinases are available NOW!

Carna Biosciences currently maintains stocks of, and has developed specific assays for 77 of the approximately 90 reported human tyrosine kinases, with more being developed continuously. QuickScout Comprehensive tests your activity modulator against each of these 77 enzymes, and offers the most complete specificity and selectivity assessment on the planet.

--- Also, we are providing custom profiling service such as IC50 determinations. Please contact us for further information! ---

For the customer on a tighter budget, our QuickScout TK Screening Panel provides similar information, but on a smaller 20-enzyme panel of typical tyrosine kinases (contact us for detailed information).

-- Available Kinases for Screening --ABLACKCSKFAK

JAK3SRCSYKTEC

EGFREphA2EphB4FGFR1

FLT3IGF1RKDRMET

PDGFRαTIE2TRKATYRO3

DDR2 TRKADDR1

CCK4

EphB1EphB2

EphB3

EphB4

EphA3EphA5

EphA4

EphA7

EphA6

EphA8

EphA2

EphA1

EphB6

EphA10

ABLARG

LCKHCK

FRK

CTKCSK

TECTXK

ITKBMXBTKALK

LTKROSINSR

IGF1R IRR FERFES

RET

FGFR2FGFR3

FGFR4FGFR1

FLT1KDR FLT4

KITFMS

PDGFRbPDGFRa

FLT3

TIE2TIE1

HER2 EGFR

HER4

HER3MET RYK

AXLTYRO3

ACK TNK1 JAK3JAK1 TYK2

JAK2

SuRTK106

ROR2ROR1

ZAP70SYKFAK

PYK2

BLKFGR

SRC YES

TRKBTRKC

SRMBRK

MER

RON

FYNLYN

MUSK

www.carnabio.com

6

7

8

ABL

ARG

ACK

TNK1 ALK

LTK

AXL

MER

TYRO

3CT

KDD

R2EG

FRHE

R2HE

R4Ep

hA1

EphA

2Ep

hA3

EphA

4Ep

hA5

EphA

6Ep

hA7

EphA

8Ep

hB1

EphB

2Ep

hB3

EphB

4FG

FR1

FGFR

2FG

FR3

FGFR

4FA

KPY

K2 FER

FES

IGF1

RIN

SR IRR

JAK1

JAK2

JAK3

TYK2 ME

TRO

NFL

T3 FMS KIT

PDGF

RαPD

GFRβ RE

TRO

SBL

KBR

KFG

RFR

KFY

NHC

KLC

KLY

NSR

CSR

MYE

SSY

KZA

P70

BMX

BTK

TEC

TXK

TIE2

TRKA

TRKB

TRKC

FLT1

FLT4 CSK

MUSK ITK KD

R

6

7

8

ABL

ARG

ACK

TNK1 ALK

LTK

AXL

MER

TYRO

3CT

KDD

R2EG

FRHE

R2HE

R4Ep

hA1

EphA

2Ep

hA3

EphA

4Ep

hA5

EphA

6Ep

hA7

6

7

8

ABL

ARG

ACK

TNK1 ALK

LTK

AXL

MER

TYRO

3CT

KDD

R2EG

FRHE

R2HE

R4Ep

hA1

EphA

2Ep

hA3

EphA

4Ep

hA5

EphA

6Ep

hA7

EphA

8Ep

hB1

EphB

2Ep

hB3

EphB

4FG

FR1

FGFR

2FG

FR3

FGFR

4FA

KPY

K2 FER

FES

IGF1

RIN

SR IRR

JAK1

JAK2

JAK3

TYK2 ME

TRO

NFL

T3 FMS KIT

PDGF

RαPD

GFRβ RE

TRO

SBL

KBR

KFG

RFR

KFY

NHC

KLC

KLY

NSR

CSR

MYE

SSY

KZA

P70

BMX

BTK

TEC

TXK

TIE2

TRKA

TRKB

TRKC

FLT1

FLT4 CSK

MUSK ITK KD

R

Staurosporine

6

7

8

ABL

ARG

ACK

TNK1 ALK

LTK

AXL

MER

TYRO

3CT

KDD

R2EG

FRHE

R2HE

R4Ep

hA1

EphA

2Ep

hA3

EphA

4Ep

hA5

EphA

6Ep

hA7

EphA

8Ep

hB1

EphB

2Ep

hB3

EphB

4FG

FR1

FGFR

2FG

FR3

FGFR

4FA

KPY

K2 FER

FES

IGF1

RIN

SR IRR

JAK1

JAK2

JAK3

TYK2 ME

TRO

NFL

T3 FMS KIT

PDGF

RαPD

GFRβ RE

TRO

SBL

KBR

KFG

RFR

KFY

NHC

KLC

KLY

NSR

CSR

MYE

SSY

KZA

P70

BMX

BTK

TEC

TXK

TIE2

TRKA

TRKB

TRKC

FLT1

FLT4 CSK

MUSK ITK KD

R

6

7

8

ABL

ARG

ACK

TNK1 ALK

LTK

AXL

MER

TYRO

3CT

KDD

R2EG

FRHE

R2HE

R4Ep

hA1

EphA

2Ep

hA3

EphA

4Ep

hA5

EphA

6Ep

hA7

6

7

8

ABL

ARG

ACK

TNK1 ALK

LTK

AXL

MER

TYRO

3CT

KDD

R2EG

FRHE

R2HE

R4Ep

hA1

EphA

2Ep

hA3

EphA

4Ep

hA5

EphA

6Ep

hA7

EphA

8Ep

hB1

EphB

2Ep

hB3

EphB

4FG

FR1

FGFR

2FG

FR3

FGFR

4FA

KPY

K2 FER

FES

IGF1

RIN

SR IRR

JAK1

JAK2

JAK3

TYK2 ME

TRO

NFL

T3 FMS KIT

PDGF

RαPD

GFRβ RE

TRO

SBL

KBR

KFG

RFR

KFY

NHC

KLC

KLY

NSR

CSR

MYE

SSY

KZA

P70

BMX

BTK

TEC

TXK

TIE2

TRKA

TRKB

TRKC

FLT1

FLT4 CSK

MUSK ITK KD

R

Gleevec

6

7

8

ABL

ARG

ACK

TNK1 ALK

LTK

AXL

MER

TYRO

3CT

KDD

R2EG

FRHE

R2HE

R4Ep

hA1

EphA

2Ep

hA3

EphA

4Ep

hA5

EphA

6Ep

hA7

EphA

8Ep

hB1

EphB

2Ep

hB3

EphB

4FG

FR1

FGFR

2FG

FR3

FGFR

4FA

KPY

K2 FER

FES

IGF1

RIN

SR IRR

JAK1

JAK2

JAK3

TYK2 ME

TRO

NFL

T3 FMS KIT

PDGF

RαPD

GFRβ RE

TRO

SBL

KBR

KFG

RFR

KFY

NHC

KLC

KLY

NSR

CSR

MYE

SSY

KZA

P70

BMX

BTK

TEC

TXK

TIE2

TRKA

TRKB

TRKC

FLT1

FLT4 CSK

MUSK ITK KD

R

6

7

8

ABL

ARG

ACK

TNK1 ALK

LTK

AXL

MER

TYRO

3CT

KDD

R2EG

FRHE

R2HE

R4Ep

hA1

EphA

2Ep

hA3

EphA

4Ep

hA5

EphA

6Ep

hA7

6

7

8

ABL

ARG

ACK

TNK1 ALK

LTK

AXL

MER

TYRO

3CT

KDD

R2EG

FRHE

R2HE

R4Ep

hA1

EphA

2Ep

hA3

EphA

4Ep

hA5

EphA

6Ep

hA7

EphA

8Ep

hB1

EphB

2Ep

hB3

EphB

4FG

FR1

FGFR

2FG

FR3

FGFR

4FA

KPY

K2 FER

FES

IGF1

RIN

SR IRR

JAK1

JAK2

JAK3

TYK2 ME

TRO

NFL

T3 FMS KIT

PDGF

RαPD

GFRβ RE

TRO

SBL

KBR

KFG

RFR

KFY

NHC

KLC

KLY

NSR

CSR

MYE

SSY

KZA

P70

BMX

BTK

TEC

TXK

TIE2

TRKA

TRKB

TRKC

FLT1

FLT4 CSK

MUSK ITK KD

R

Iressa

pIC5

0pI

C50

pIC5

0

TM

Comprehensive TK Panel ver 1.0QuickScout

TMQuickScoutTK Screen Panel ver 1.0