quantitative information for juergen reichardt, ph.d. · quantitative information for juergen...

Quantitative Information for Juergen Reichardt, Ph.D.

Universitaet Freiburg B.S 1978 Biology

Universitaet Freiburg B.A. 1979 Philosophy

Universitaet Basel M.S. 1981 Biochemistry

Standford University Ph.D. 1989 Biochemistry

1. List of thesis (PhD and/or MS) supervised

MS Students Trained:

1993-1995: Hsien-Chin Lin (USC)

1993‐1995: Sriveda Koritala (USC) 1994‐1996: Sunita Devgan (USC) 1997‐1999: Jeffrey Jim (USC; graduated from med. school at UCI) 1999‐2000: Lana Ali (USC)

Justin Fuess (USC) Jonathan Koo (USCgraduated med. School Canada) 1999‐2002: Soorena Izadifar (USC)

2000‐2002: Eugene Kim (USC) Patricia Sharpe (USC)

Yahsuan “Nancy” Hsu (USC) Shih‐chi “Nancy” Chen (USC; attended Dental School at Penn)

2001: Duk‐Won “Duck” Kang (USC) 2001‐2003: Prutha Badiani ( USC) 2002: Tom Reese (USC) Althea McCourty (USC) 2002‐2004: Frank Luh (USC) 2003‐2005: Xuemei “Mei” Deng (USC) Albert Kim (USC; graduated med. school in Virginia) Chirag Patel (USC) 2006‐2008: Francine Marques (Brazil) 2009: Adena Spiro (USyd) Nguyen Viet Trung (USyd) 2009‐2010: Dominique Petit (USyd).

PhD Students Trained: 1993‐1995: Nathalie Daude (PhD obtained in Bordeaux, France) 1994‐1997: Nick Makridakis (USC PhD)

1999‐2003: Lucio Ferraz (PhD obtained in Brazil) 2001‐2006: Troy Phipps (USC PhD; DoD Fellowship Recipient) 2002‐2004: Eugene Kim (USC) 2007‐2012: Florence Cheung (USyd).

2. List of publications (at least 100)

Peer‐Reviewed Article

. Reichardt, J.K.V. and Q.H. Gibson (1982) Spectra of Intermediates in Oxidation and Reduction of Cytochrome c Oxidase, J. Biol. Chem. 257, 9268‐ 9270

2. Reichardt, J.K.V. and Q.H. Gibson (1983) Turnover of Cytochrome c Oxidase

from Paracoccus denitrificans, J. Biol. Chem. 258, 1504‐1507

3. Reichardt, J.K.V. and P. Berg (1988) Cloning and Characterization of a cDNA Encoding Human Galactose‐1‐phosphate Uridyl Transferase, Molec. Biol. Med. 5, 107‐122

4. Reichardt, J.K.V. and P. Berg (1988) Conservation of Short Patches of Amino

Acid Sequence Amongst Proteins with a Common Function but Evolutionarily Distinct Origins: Implications for Cloning Genes and for Structure‐Function Analysis, Nucl. Acids Res. 16, 9017‐9026

5. Flach, J.E., J.K.V. Reichardt and L.J. Elsas (1990) Sequence of a cDNA

Encoding Human Galactose‐1‐Phosphate Uridyl Transferase, Mol. Biol. Med. 7, 365‐369

6. Reichardt, J.K.V. and S.L.C. Woo (1991) Molecular Basis of Galactosemia:

Mutations and Polymoprhisms in the Gene Encoding Human Galactose‐1‐ Phosphate Uridylyltransferase, Proc. Natl. Acad. Sci. 88, 2633‐2637

7. Petry, K., H.T. Greinix, E. Nudelman, H. Eisen, S. Hakomori, H.L. Levy and J.K.V.

Reichardt (1991) Characterization of a Novel Biochemical Defect in Galactosemia: Deficiency of Glycolipids Containing Galactose or N‐ Acetylgalactosamine and Accumulation of Precursors, Biochem. Med. Metabol. Biol. 46, 93‐104

8. Reichardt, J.K.V., S. Packman and S.L.C. Woo (1991) Molecular

Characterization of Two Galactosemia Mutations: Correlation of Mutations with Highly Conserved Domains in Galactose‐1‐Phosphate Uridyl Transferase, Am. J. Hum. Genet. 49, 860‐867

9. Reichardt, J.K.V. (1991) Molecular Analysis of 11 Galactosemia Patients,

Nucl. Acids Res. 19, 7049‐7052

10. Reichardt, J.K.V., J.W. Belmont, H.L. Levy and S.L.C. Woo (1992) Characterization of Two Missense Mutations In Human Galactose‐1‐ Phosphate Uridyl Transferase: Different Molecular Mechanisms for Galactosemia, Genomics 12, 596‐600

11. Reichardt, J.K.V., H.L. Levy and S.L.C. Woo (1992) Molecular Characterization

of Two Galactosemia Mutations and One Polymorphism: Implications for

Structure‐Function Analysis of Human Galactose‐1‐phosphate Uridyl Transferase, Biochem. 31, 5430‐5433

12. Reichardt, J.K.V. (1992) Genetic Basis of Galactosemia, Human Mut. 1, 190‐

196

13. Reichardt, J.K.V. (1993) The Molecular Genetic Basis of Galactosemia, Int. Ped. 8, 110‐113

14. Reichardt, J.K.V., G. Novelli and B. Dallapiccola (1993) Molecular

Characterization of the H319Q Galactosemia Mutation, Hum. Molec. Genet. 2, 325‐326

15. Lin, H.‐C., L.T. Kirby, W.G. Ng and J.K.V. Reichardt (1994) On the Molecular

Nature of the Duarte Variant of Galactose‐1‐phosphate Uridyl Transferase (GALT), Hum. Genet. 93, 167‐169

16. Podskarbi, T., J. Reichardt and Y.S. Shin (1994) Studies of DNA in Galactose‐1

phosphate Uridyl Transferase Deficiency and the Duarte Variant in Germany, J. Inher. Metabol. Dis. 17, 149‐150

17. Kaufman, F.R., Reichardt, J.K.V., Ng, W.G., Xu, Y.‐K., Manis, F.R., McBride

Chang, C. and Wolff, J.A. (1994) Correlation of Cognitive, Neurologic and Ovarian Outcome with the Q188R Mutation of the Galactose‐1‐phosphate Uridyltransferase Gene, J. Ped. 125, 225‐227

18. Ng, W.G., Xu, Y.‐K., Kaufman, F.R., Donnell, G.N., Wolff, J., Allen, R.J., Koritala, S.

and Reichardt, J.K.V. (1994) Biochemical and Molecular Studies of 132 Patients with Galactosemia, Hum. Genet. 94, 359‐363

19. Cramer, D.W., Muto, M.G., Reichardt, J.K.V., Xu, H., Welch, W.R., Valles, B. and

Ng, W.G. (1994) Characteristics of Women With a Family History of Ovarian Cancer: I. Galactose Consumption and Metabolism, Cancer: 74, 1309‐1317

20. Cramer, D.W., Barbieri, R.L., Xu, H. and Reichardt, J.K.V. (1994) Determinants

of Basal Follicle Stimulating Hormone Levels in Premenopausal Women, J. Clin. Endo. Metabol. 79, 1105‐1109

21. Lin, H.‐C. and Reichardt, J.K.V. (1995) Linkage Disequilibrium Between a Sac

I Restriction Fragment Length Polymorphism and two Galactosemia Mutations, Hum. Genet. 95, 353‐355

22. Reichardt, JKV (1995) Mutations in Galactosemia, Am. J. Hum. Genet. 57, 978‐

979

23. Ashino, J., Okano, Y., Suyama, I., Yamazaki, T., Yoshino, M., Furuyama, J.‐I., Lin, H.‐C., Reichardt, J.K.V. and Isshiki, G. (1995) Molecular Characterization of Galactosemia Mutations (Type 1) in Japanese, Hum. Mut. 6, 36‐43

24. Ross, R.K., Coetzee, G., Reichardt, J., Skinner, E. and Henderson, B.E. (1995)

Does the Racial‐Ethnic Variation in Prostate Cancer Have a Hormonal Basis?, Cancer 75, 1778‐1782

25. Daude, N., Gallaher, T.K., Zeschnigk, M., Starzinski‐Powitz, A., Petry, K.G.,

Haworth, I.S. and Reichardt, J.K.V. (1995) Molecular Cloning, Characterization and Mapping of A Full‐Length cDNA Encoding Human UDP‐ Galactose 4' Epimerase, Biochem. Molec. Med. 56, 1‐7

26. Reichardt, J.K.V., Makridakis, N., Henderson, B.E., Yu. M.C., Pike, M.C. and

Ross, R.K. (1995) Genetic Variability of the Human SRD5A2 Gene: Implications for Prostate Cancer Risk, Cancer Res. 55, 3973‐3975

27. Maceratesi, P., Sangiulo, F., Novelli, G., Ninfali, P., Magnani, M., Reichardt,

J.K.V. and Dallapiccola, B. (1996) Three New Mutations (P183T, V150L, 528insG) and Eleven Sequence Polymorphisms in Italian Patients with Galactose‐1‐phosphate Uridyltransferase (GALT) Deficiency, Hum. Mut. 8, 369‐372

28. Gathof, B.S., Sommer, M., Podskarbi, T., Reichardt, J.K.V., Braun, A., Gresser,

U. and Shin, Y.S. (1995) Characterization of Two Stop Codon Mutations in the Galactose‐1‐phosphate Uridyltransferase Gene of Three Male Galactosemic Patients with Severe Clinical Manifestation, Hum. Genet. 96, 721‐ 725

29. Daude, N., Lestage, J., Reichardt, J.K.V. and Petry, K.G. (1996) Expression of

Galactose‐1‐phosphate Uridyltransferase (GALT) in the Anterior Pituitary of Rat During the Estrous Cycle, Neuroendocrin. 64, 42‐48

30. Cramer, D.W., Goldstein, D.P., Fraer, C. and Reichardt, J.K.V. (1996) Vaginal

Agenesis (Mayer‐Rokitansky‐Kuster‐Hauser Syndrome) Associated with the N314D Mutation of Galactose‐1‐phosphate Uridyl Tranferase (GALT), Molec. Hum. Reprod. 2, 145‐148

31. Daude, N., Ellie, E., Reichardt, J.K.V. and Petry, K.G. (1996) In Vivo and InVitro

Expression of Rat Galactose‐1‐phosphate Uridyltransferase (GALT) in Developing Central and Peripheral Nervous System, Develop. Brain Res. 94, 190‐196

32. Feigelson, H.S., Ross, R.K., Yu, M.C., Coetzee, G.A., Reichardt, J.K.V. and

Henderson, B.E. (1996) Genetic Susceptibility to Cancer from Exogenous and Endogenous Exposures, J. Cell. Biochem. 25, 15‐22

33. Devgan, S.A., Henderson, B.E., Yu, M.C., Shi, C.‐Y., Pike, M.C., Ross, R.K. and Reichardt, J.K.V. (1997) Genetic Variation of 3‐Hydroxysteroid Dehydrogenase Type II in Three Racial/Ethnic Groups: Implications for Prostate Cancer Risk, The Prostate 33, 9‐12

34. Makridakis, N., Ross, R.K., Pike, M.C., Chang, L., Stanczyk, F.Z., Kolonel, L.N.,

Shi, C.‐Y., Yu, M.C., Henderson, B.E. and Reichardt, J.K.V (1997) A Prevalent Missense Substitution that Modulates Activity of Prostatic Steroid 5‐ Reductase, Cancer Res. 57, 1020‐1022

35. Feigelson, H.S., Ross, R.K., Yu, M.C., Coetzee, G.A., Reichardt, J.K.V. and

Henderson, B.E.H. (1998) Sex Steroid Hormones and Genetic Susceptibility to Breast and Prostate Cancer, Drug Metab. Rev. 30, 421‐434

36. Maceratesi, P., Daude, N., Dallapiccola, B., Novelli, G., Allen, R., Okano, Y. and

Reichardt, J. (1998) Human UDP‐Galactose 4’ Epimerase (GALE) Gene and Identification of Five Missense Mutations in Patients with Epimerase Deficiency Galactosemia, Molec. Genet. Metabol. 63, 26‐30

37. Petry, K.G. and Reichardt, J.K.V. (1998) The Fundamental Importance of

Human Galactose Metabolism: Lessons from Genetics and Biochemistry, Trends Genet. 14, 98‐102

38. Ross, R.K., M.C. Pike, G.A. Coetzee, J.K.V. Reichardt, M.C. Yu, H. Feigelson, F.Z.

Stanczyk, L.N. Kolonel and B.E. Henderson (1998) Androgen Metabolism and Prostate Cancer: Establishing a Model of Genetic Susceptibility, Cancer Res. 58, 4497‐4504

39. Akalu , A., Elmajian, D.A., Highshaw, R.A., Nichols, P.W. and Reichardt, J.K.V.

(1999) Somatic Mutations at the SRD5A2 Locus Encoding Prostatic Steroid 5‐Reductase During Prostate Cancer Progression, J. Urol. 161, 1355‐1358

40. Ross RK, Coetzee GA, Pearce CL, Reichardt JK, Bretsky P, Kolonel LN,

Henderson BE, Lander E, Altshuler D, Daley G (1999) Androgen Metabolism and Prostate Cancer: Establishing a Model of Genetic Susceptibility, Eur. Urol. 35, 355‐361

41. Reichardt JK (1999) GEN GEN: the Genomic Genetic Analysis of Androgen

Metabolic Genes and Prostate Cancer as a Paradigm for the Dissection of Complex Phenotypes, Frontiers in Bioscience 4, D596‐600

42. Tyfield, L., Reichardt, J., Fridovich‐Keil, J. et al. (1999) Classical

Galactosaemia and Mutations at the Galactose‐1‐phosphate Uridyl Transferase (GALT) Gene, Hum. Mut. 13, 417‐430

43. Makridakis, N.M, Ross, R.K, Pike, M.C., Crocitto, L.E., Kolonel, L.N., Pearce, C.L., Henderson, B.E. and Reichardt, J.K.V. (1999) A Missense Substitution in the SRD5A2 Gene is Associated with Prostate Cancer in African‐American and Hispanic Men in Los Angeles, The Lancet 354, 975‐978

44. Reichardt, J.K.V. (2000) Prostatic Steroid‐5‐Alpha Reductase, an Androgen

Metabolic Gene, Mayo Clin. Proc. 75, S36‐39

45. Akalu, A. and Reichardt, J.K.V. (1999) A Reliable PCR Amplification Method for Microdissected Tumor Cells Obtained from Paraffin‐Embedded Tissue, Gen. An. 15, 229‐233

46. Makridakis, N.M., di Salle, E. and Reichardt, J.K.V. (2000) Biochemical and Pharmacogenetic Dissection of Human Steroid 5‐Reductase Type II, Pharmacogenet. 10, 407‐413

47. Novelli, G and Reichardt, J.K.V. (2000) Molecular Basis of Disorders of Galactose Metabolism: Past, Present and Future, Molec. Genet. Metabol. 71, 62‐65

48. Margiotti, K, Sangiulo, F, de Luca, A, Froio, F, Pearce, CL, Ricci‐Barbine, V, Micali, F, Bonafe, M, Dallapicccola, B, Novelli, G and Reichardt, JKV (2000) Evidence for an Association between the SRD5A2 (Type II Steroid 5‐ Reductase) Locus and Prostate Cancer in Italian Patients. Dis. Markers 16, 147‐150

49. Novelli, G, Margiotti, K, Sangiulo, F and Reichardt, JKV (2001) Pharmacogenetics of Human Androgens and Prostatic Diseases, Pharamacogenom. 2, 65‐72

50. Okano, Y, Asadal, M, Fujimoto, A, Ohtake, A, Murayama, K, Hsiao, K‐W, Choe, K, Reichardt, JKV, Niihira, S, Imamura, T and Yamano, T (2001) A Genetic Factor for Age‐Related Cataract: Identification and Characterization of a Novel Galactokinase Variant "Osaka" in Asians, Am. J. Hum. Genet. 68, 1036‐ 1042

51. Hsing, AW, Chen, C, Chokkalingam, AP, Gao, Y‐T, Dightman, DA, Nguyen, HT, Deng, J, Cheng, J, Sesterhenn, IA, Mostofi, FK, Stanczyk, FW and Reichardt, JKV (2001) Polymorphic Markers in the SRD5A2 Gene and Prostate Cancer Risk: A Population‐Based Case‐Control Study, Cancer Epi. Biom. Prev. 10, 1077‐1082

52. Ross RK, Reichardt JKV, Ingles SA, Coetzee GA (2001) The Genetic Epidemiology of Prostate Cancer: Closing in on a Complex Disease, in: Prostate Cancer: Biology, Genetics, and the New Therapeutics. (Eds) Chung LWK, Isaacs WB, Simons JW. Humana Press Inc., Totowa, NJ, 111‐121

53. Makridakis, NM and Reichardt, JKV (2001) Molecular Epidemiology of Hormone‐Metabolic Loci in Prostate Cancer, Epidemiol. Rev. 23, 24‐29

54. Hsing, AW, Reichardt, JKV and Stanczyk, FW (2002) Hormones and Prostate Cancer: Current Perspectives and Future Directions, Prostate 52, 213‐235

55. Makridakis, NM and Reichardt, JKV (2001) MAPA: Multiplex Automated Primer Extension Analysis: Simultaneous Genotyping of up to Four Polymorphisms, Biotech. 31, 1374‐1380

56. Pearce, CL, Makridakis, NM, Ross, RK, Pike, MC, Kolonel, LN, Henderson, BE and Reichardt, JKV (2002) SRD5A2 V89L Substitution is Not Associated with Significant Risk of Prostate Cancer in a Multi‐Ethnic Population Study, Cancer Epi., Biom., Prev. 11, 417‐418

57. Cozen W, Peters R, Reichardt JK, Ng W, Felix JC, Wan P, Pike MC (2002) Galactose‐1‐phosphate Uridyl Transferase (GALT) Genotype and Phenotype, Galactose Consumption, and the Risk of Borderline and Invasive Ovarian Cancer (United States), Cancer Causes Control. 13, 113‐120

58. Goodman, MT, Wu, AH, Tung K‐H, McDuffie K, Cramer DW, Wilkens LR, Terda K, Reichardt JKV and WG Ng (2002) Association of the Galactose‐1‐ Phosphate Uridyltransferase (GALT) Activity and N314D Genotype with the Risk of Ovarian Cancer, Am. J. Epidem. 156, 693‐701

59. Margiotti, K, Kim, E, Pearce, CL, Spera, E, Novelli, G and Reichardt, JKV (2002) Association of the G289S Polymorphism in the HSD17B3 Gene with Prostate Cancer in Italian Men, The Prostate 53, 65‐68

60. Allen, NE, Reichardt, JKV, Nguyen, H, and Key, TJ (2003) Association

between Two Polymorphisms in the SRD5A2 Gene and Serum Androgen Concentrations in British Men, Cancer Epidemiol. Biomarkers Prev. 12, 578‐ 581

61. Kobayashi, K, Lu YB, Li MX, Nishi I, Hsiao K‐J, Choeh K, Yang Y, Hwu W‐L,

Reichardt, JKV, Palmieri F, Okano Y and Saheki T (2003) Screening for Nine SLC25A13 Mutations: Their Frequency in Patients with Citrin Deficiency and High Carrier Rates in Asian Populations, Molec. Genet. Metabol. 80, 356‐359

62. Makridakis, NM and Reichardt, JKV (2004) Molecular Epidemiology of Androgen Metabolic Loci in Prostate Cancer and Progression, J. Urol. 171, S25‐S29

63. Foti, D and Reichardt, JKV (2004) YY1 Binding within the Human HSD3B2

Gene Intron 1 is Required for Maximal Basal Promoter Activity: Identification of YY1 as the 31‐A Factor, J. Molec. Endocrin. 33, 99‐119

64. Novelli G, Margiotti K, Chiocca AM, Spera E, Micali F, Reichardt JK (2004)

Pharmacogenetics of Human Androgens and Prostate Cancer--an Update,

Pharmacogenom. 5, 283-294

65. Makridakis, NM, Akalu A, and Reichardt, JKV (2004) Identification and

Characterization of Somatic Steroid 5‐Reductase (SRD5A2) Mutations in Human Prostate Cancer Tissue, Oncogene 23, 7399‐7405

66. Mehrian-Shai, R and Reichardt, JKV (2004) A Renaissance of “Biochemical

Genetics”? SNPs, Haplotypes, Function and Complex Diseases, Molec. Genet. Metabol. 83, 47‐50

67. Salam, MT, Ursin, G, Skinner, EC, Dessissa, T and Reichardt, JKV (2005)

Associations between Polymorphisms in the Steroid 5‐ Reductase Type II (SRD5A2) Gene and Benign Prostatic Hyperplasia and Prostate Cancer, Urol. Oncol., 23, 246‐253

68. Makridakis, N and JKV Reichardt (2005) Pharmacogenetic Analysis of

Human Steroid 5 Reductase Type II: Comparison of Finasteride and Dutasteride, J. Molec. Endocrin. 34, 617‐623

69. Mehrian Shai R, JKV Reichardt, Y-H Hsu, T Kremen, L Liau, T Cloughesy, P

Mischel, SN Nelson (2005) Robustness of Gene Expression Profiling in Glioma

Specimen Samplings and Derived Cell Lines, Molec. Brain Res. 136, 99-103

70. Makridakis, NM, Buchanan, G, Tilley, W and JKV Reichardt (2005) Androgen

Metabolic Genes in Prostate Cancer Predisposition and Progression, Frontiers in

Bioscience 10, 2899-2903

71. Mehrian-Shai, R and Reichardt, JKV (2006) Genomics in Breast and Prostate

Cancer: Assessment of the Current State and Future Perspectives, Fut. Oncol. 2,

357-362

72. Reichardt, JKV (2006) Unexpected Biochemical and Pharmacogenetic

Consequences of SNPs and Haplotypes: A Cautionary Tale for Human Molecular

Genetics and Epidemiology, Genomics 88, 673-674

73. Chokkalingam AP, Stanczyk FZ, Reichardt JKV and Hsing AW (2007)

Molecular Epidemiology of Prostate Cancer: Hormone-Related Genetic Loci,

Frontiers in Bioscience 12, 3436-3460

74. Mehrian Shai R, Chen CD, Shi T, Horvath S, Nelson SF, Reichardt JKV and

Sawyers CL (2007) IGFBP2 is a Biomarker for PTEN Status and PI3K/Akt

Pathway Activation in Glioblastoma and Prostate Cancer, Proc. Natl. Acad. Sci.

104, 5563-5568

75. Reichardt JKV and Tilley WD (2007) The 3rd Pacific Rim Meeting on Breast

and Prostate Cancer: Progress in Hormonal Carcinogenesis and the Enduring Influence of Ron Ross, Cancer Res. 67, 4550‐4552

76. D’Amico F, Biancolella M, Reichardt JKV and Novelli G (2007) Single

Nucleotide Polymorphisms in the Androgen Pathway and Prostate Cancer, Pharmacogenomics 8, 645‐661

77. Reichardt JKV (2007) Quo vadis, genoma? A Call to Pipettes for Biochemists,

Trends Biochem. Sci. 32, 529‐530

78. Reichardt, JKV (2008) Realizing the Potential of the Sequenced Human Genome, Trends Genet. 24, 219‐220

79. Pearce, CL, Van Den Berg, DJ, Makridakis, N, Reichardt, JKV, Ross, RK, Pike,

MC, Kolonel, LN and Henderson, BE (2008) No Association Between the SRD5A2 Gene A49T Missense Variant and Prostate Cancer Risk: Lessons Learned, Hum. Molec. Genet. 17, 2456‐2461

80. Mehrian Shai, R, Reichardt, JKV and Chen, T (2008) Pharmacogenomics of

Brain Cancer and Personalized Medicine in Malignant Gliomas, Fut. Oncol., 4, 525-534

81. Chu, LW, Reichardt, JKV and Hsing, AW (2008) Androgens and the Molecular

Epidemiology of Prostate Cancer, Curr. Opin. Endocrin. Diab. Obes. 15, 261‐ 270

82. Makridakis, NM, Phipps, T and Reichardt, JKV (2009) Genomic Analysis of

Cancer Tissue Reveals that Somatic Mutations Commonly Occur in a Specific Motif, Hum. Mut. 30, 39‐48

83. Flanagan, JM, McMahon, G, Chia, SHB, Fitzpatrick, P, Tighe, O, O’Neill, C,

Briones, P, Gort, L, Kozak, L, Naughten, AME, Radomyska, B, Schwartz, M, Shin, JS, Strobl, W, Tyfield, LA, Waterham, HR, Russell, H, Bertorelle, G, Reichardt, JKV, Mayne, PD, Croke, DT (2010) The Role of Human Demographic History in Determining the Distributionand Frequency of Transferase‐Deficient Galactosaemia Mutations, Heredit. 104, 148‐154

84. Makridakis, NM, Phipps, T, Srivastav, S and Reichardt, JKV (2009) PCR‐Free Method Detects High Frequency of Genomic Instability in Prostate Cancer, Nucl. Acids Res. 37, 7441‐7446

85. Musumeci, L, Arthur, JW, Cheung, FSG, Hoque, A, Lippman, S and Reichardt,

JKV (2010) Single Nucleotide Differences (SNDs) in the dbSNP Database May Lead to Errors in Genotyping and Haplotyping Studies, Hum. Mut. 31, 67‐73 (Commentary by Day, I (2010), Hum. Mut. 31, 2‐4)

86. Das, K Lorena, DN, Ng, LK, Lim, D, Shen, L, Siow, WY, Teh, M, Reichardt, JKV,

Salto‐Tellez, M (2010) Differential Expression of Steroid 5‐Reductase Isozymes and Association With Disease Severity and Angiogenic Genes Predict Their Biological Role in Prostate Cancer, Endocr. Relat. Cancer 17, 757‐770

87. Goodman, P, Tangen, C, Kristal, A, Thompson, I, Lucia, S, Platz, E, Figg, W,

Hoque, A, Hsing, A, Neuhouser, M, Parnes, H, Reichardt, J, Santella, R, Till, C and Lippman, S (2010) Transition of a Clinical Trial into Translational Research: The Prostate Cancer Prevention Trial Experience, Cancer Prev.

Research 3, 1523‐1533

88. Hulin‐Curtis, SL, Petit, D, Figg, WD, Hsing, AW and Reichardt, JKV (2010) Finasteride Metabolism and Pharmacogenetics: New Approaches to Personalised Prevention of Prostate Cancer, Fut. Oncol. 6, 1897‐1913

89. Price, DK, Chau, CH, Till, C, Goodman, PJ, Baum, CE, Ockers, SB, English, BC,

Minasian, L, Parnes, HL, Hsing, AW, Reichardt, JKV, Hoque, A, Tangen, CM, Kristal, AR, Thompson, IM, Figg, WD (2010) Androgen Receptor CAG Repeat Length and Association with Prostate Cancer Risk: Results from the Prostate Cancer Prevention Trial, J. Urol. 184, 2297‐2302

90. Arthur, JW and Reichardt, JKV (2010) Modelling Single Nucleotide

Polymorphisms in The Human AKR1C1 And AKR1C2 Genes: Implications for Functional and Genotyping Analyses, PLoS ONE 5, 1‐9

91. Tang, L, Song, Y, Till, C, Goodman, P, Tangen, C, Yu, W, Kristal, A, Platz, E,

Neuhouser, M, Stanczyk, F, Reichardt, J, Santella, R, Hsing, A, Hoque, A, Lippman, S, Thompson, I, Ambrosone, C (2011) Repeat Polymorphisms in Estrogen Metabolism Genes and Prostate Cancer Risk: Results From the Prostate Cancer Prevention Trial, Carcinogen. 32, 1500‐1506

92. Yao, S, Till, C, Kristal, AR, Goodman, PJ, Hsing, AW, Tangen, CM, Platz, EA,

Stanczyk, FZ, Reichardt, JKV, Tang, L, Neuhouser, ML, Santella, RM, Figg, WD, Price, DK, Parnes, HL, Lippman, SM, Thompson, IM, Ambrosone, CB and Hoque, A (2011) Serum Estrogen Levels and Prostate Cancer Risk in the

Prostate Cancer Prevention Trial: a Nested Case‐Control Study, Cancer Causes Control 22, 1121‐1131

93. Cheung, FSG, Lovicu, FJ and Reichardt, JKV (2012) Current Progress In Using

Vitamin D And Its Analogs For Cancer Prevention And Treatment, Expert Rev. Anticancer Ther., 12, 811‐837

94. AR Kristal, C Till, CM Tangen, PJ Goodman, ML Neuhouser, FZ Stanczyk , LW Chu, SK Patel, I Thompson, JK Reichardt, A Hoque, EA Platz, WD Figg, A Van Bokhoven, SM Lippman, AW Hsing (2012) Associations of serum sex steroid hormones and 5α‐androstane‐3α,17β‐diol glucuronide concentrations with prostate cancer risk among men treated with finasteride, Cancer Epi. Biomark. Prev. 21, 1823‐1832

95. Makridakis, NM and Reichardt, JKV (2012) Translesion DNA Polymerase and

Cancer, Front. Pharmacogen. 3, article 174

96. Ho, G, Reichardt, J and Christodoulou, J (2013) In Vitro Read‐through Of Phenylalanine Hydroxylase (PAH) Nonsense Mutations Using Aminoglycosides: A Potential Therapy For Phenylketonuria, J. Inh. Metabol. Dis. 36, 955‐959

97. WD Figg, CH Chau, DK Price, C Till, PJ Goodman, Y Cho, M Varella‐Garcia, JKV

Reichardt, CM Tangen, RJ Leach, A van Bokhoven, IM Thompson, MS Lucia (2014) Androgen Receptor CAG Repeat Length and TMPRSS2:ETS Prostate Cancer Risk: Results From the Prostate Cancer Prevention Trial, Urology, 84, 127‐131

98. Toren A, Reichardt JK, Andalibi A, Hsu NY, Doherty J, Slattery W, Mehrian‐

Shai R (2014) Novel Age‐Dependent Targets in Vestibular Schwannomas, Hum Genom. 8, doi: 10.1186/1479‐7364‐8‐10

99. Yao, S, Till, CA, Kristal, AR, Goodman, PJ, Hsing, AW, Tangen, CM, Platz, EA,

Stanczyk, FZ, Reichardt, J, van Bokhoven, A, Neuhouser, ML, Santella, RM, Figg, WD, Price, DK, Parnes, HL, Lippman, SL, Ambrosone, CB and Thompson, IM (2015) Effect of Finasteride on Serum Androstenedione and Risk of Prostate Cancer within the Prostate Cancer Prevention Trial: Differential Effect on High and Low Grade Disease, Urology, in press

100.Arthur, JW, Cheung, FSG and Reichardt, JKV (2015) Single Nucleotide

Differences (SNDs) Continue to Contaminate the dbSNP Database With Consequences For Human Genomics and Health Hum. Mut. in press.

Book Chapters

101. Reichardt, J and B Ludwig (1981) Cytochrome c Interacts with Subunit II of the Cytochrome c Oxidase Isolated from Paraccccus denitrificans, in Vectorial Reactions in Electron Transport in Mitochondria and Bacteria (Palmieri, F. et al., eds.), 3‐10 102. Greenwood, C, AJ Thomson, CP Barrett, Peterson, GN George, JA Fee

and J Reichardt (1988) Some Spectroscopic Views of the CuA Site in Cytochrome c Oxidase Preparations, Ann. NY Acad. Sci. 550, 47‐52

103. Reichardt, JKV (1993) Galactosemia is Caused by Missense Mutations: Molecular Studies and Implications for Therapy, in Galactosemia: New Frontiers for Research (Donnell, G.N., ed.), 199‐213 104. Reichardt, JKV (1993) Molecular Analysis of Galactosemia, in Current

Progress in Perinatal Medicine (Cosmi, E.V. and G.C. Di Renzo, eds.), Parthenon, 225‐229

105. Daude, N and JKV Reichardt (1996) Molecular Genetic Basis of Epimerase-Deficiency Galactosemia, in Diagnosis and Treatment of Inborn Errors of Metabolism (Demirkol, M. and Y.S. Shin, eds.), Turkish Society for PKU, 49‐55

106. Reichardt, JKV (1996) Molecular Genetic Basis of Galactosemia, in Diagnosis and Treatment of Inborn Errors of Metabolism” (Demirkol, M. and Y.S. Shin, eds.), Turkish Society for PKU, 39‐48

107. Petry, KG, N Daude, LLC Prestoz, E Ellie and JKV Reichardt (1996) Implication of Galactose‐1‐phosphate Uridyl Transferase (GALT) in the Process of Myelination and in the Ovarian Cycle, in Diagnosis and Treatment of Inborn Errors of Metabolism (Demirkol, M. and Y.S. Shin, eds.), Turkish Society for PKU, 153‐164

108. Akalu, A and Reichardt, JKV (2002) Increasing PCR Sensitivity for Amplification from Paraffin‐Embedded Tissues, in PCR Cloning Protocols, 2nd Edition (Chen, B.‐Y. and H.W. James, eds.), Methods Molec. Biol. 192, 67‐74 109. Ross RK, Makridakis NM, Reichardt JKV (2003) Prostate Cancer: Epidemiology and Molecular Endocrinology, in: Hormones, Genes, and Cancer, (Henderson BE, Ponder B, Ross RK, eds.), Oxford University Press, Inc., New York, NY, 273‐287

110. Makridakis, NM, Ross RK and Reichardt, JKV (2004) Human Genetic Variation at Hormone‐Metabolic Loci and Prostate Cancer Risk, in Disorders of the Prostate (Habib, F, ed.) 63‐69

111. Novelli, G, Margiotti, K, Spera, E, Micali, F and Reichardt, JKV (2005)

Pharmacogenetics of Androgen‐Metabolic Genes and Prostate Cancer, in Horizons in Cancer Research vol. 1 “Prostate Cancer” (Lucas, JN ed.), 81‐101

112. Reichardt, JKV and Hsing, AW (2009) Androgen Metabolic Genes in

Prostate Cancer Predisposition and Progression, in Androgen Action in Prostate (Tindal, DJ and Mohler, JL, eds.), 141‐154

113. Mehrian‐Shai, R, and Reichardt, JKV (2009) The Future of Human

Genomics Research: Three Unanswered Questions, in Human Genome: Features, Variations and Genetic Disorders (Columbus, F., ed.), in press

114. Cheung, FSG and Reichardt, JKV (2010) Molecular Biology of Vitamin

D Metabolism and Skin Cancer, in Vitamin D and Cancer (Johnson, C and Trump, D, eds.) Springer, 191‐219

115. Marques, FZC and Reichardt, JKV (2010) Pharmacogenetics of the

Androgen Metabolic Pathway, in Drug Management of Prostate Cancer

(Figg, WD et al., eds.), Springer, 109-121. Webpublications

116. Reichardt, JKV (2008) The Future of Human Genomics, The Science Advisory Board: http://www.scienceboard.net/community/perspectives.205.html

117. Reichardt, JKV and Mehrian‐Shai, R (2008) Can Human Genomics Research Fulfill Its Promise? Science (E‐Letter online), 3 july 2008 http://www.sciencemag.org/cgi/eletters/319/5871/1733#10837 118. Reichardt, JKV and Mehrian‐Shai, R (2009) The Future of the Human SNP Identification: Which Individuals to Sequence? (Letter (Online Only)) Proc. Natl.

Acad. Sci., 12 may 2009 http://www.pnas.org/content/106/19/E50.full?sid=b14eab01‐bd71‐4045‐88f3‐

3add6a556879

http://www.scienceboard.net/community/perspectives.205.html

http://www.sciencemag.org/cgi/eletters/319/5871/1733#10837

http://www.pnas.org/content/106/19/E50.full

3. List of high‐impact publications (at least 30)

1. Reichardt, J.K.V. and Q.H. Gibson (1982) Spectra of Intermediates in Oxidation and Reduction of Cytochrome c Oxidase, J. Biol. Chem. 257, 9268‐ 9270

2. Reichardt, J.K.V. and Q.H. Gibson (1983) Turnover of Cytochrome c Oxidase

from Paracoccus denitrificans, J. Biol. Chem. 258, 1504‐1507

3. Reichardt, J.K.V. and P. Berg (1988) Conservation of Short Patches of Amino Acid Sequence Amongst Proteins with a Common Function but Evolutionarily Distinct Origins: Implications for Cloning Genes and for Structure‐Function Analysis, Nucl. Acids Res. 16, 9017‐9026

4. Reichardt, J.K.V. and S.L.C. Woo (1991) Molecular Basis of Galactosemia:

Mutations and Polymoprhisms in the Gene Encoding Human Galactose‐1‐ Phosphate Uridylyltransferase, Proc. Natl. Acad. Sci. 88, 2633‐2637

5. Reichardt, J.K.V., S. Packman and S.L.C. Woo (1991) Molecular

Characterization of Two Galactosemia Mutations: Correlation of Mutations with Highly Conserved Domains in Galactose‐1‐Phosphate Uridyl Transferase, Am. J. Hum. Genet. 49, 860‐867

6. Reichardt, J.K.V. (1991) Molecular Analysis of 11 Galactosemia Patients,

Nucl. Acids Res. 19, 7049‐7052

7. Reichardt, J.K.V., J.W. Belmont, H.L. Levy and S.L.C. Woo (1992) Characterization of Two Missense Mutations In Human Galactose‐1‐ Phosphate Uridyl Transferase: Different Molecular Mechanisms for Galactosemia, Genomics 12, 596‐600

8. Podskarbi, T., J. Reichardt and Y.S. Shin (1994) Studies of DNA in Galactose‐1

phosphate Uridyl Transferase Deficiency and the Duarte Variant in Germany, J. Inher. Metabol. Dis. 17, 149‐150

9. Cramer, D.W., Barbieri, R.L., Xu, H. and Reichardt, J.K.V. (1994) Determinants

of Basal Follicle Stimulating Hormone Levels in Premenopausal Women, J. Clin. Endo. Metabol. 79, 1105‐1109

10. Reichardt, JKV (1995) Mutations in Galactosemia, Am. J. Hum. Genet. 57, 978‐

979

11. Daude, N., Gallaher, T.K., Zeschnigk, M., Starzinski‐Powitz, A., Petry, K.G., Haworth, I.S. and Reichardt, J.K.V. (1995) Molecular Cloning, Characterization and Mapping of A Full‐Length cDNA Encoding Human UDP‐ Galactose 4' Epimerase, Biochem. Molec. Med. 56, 1‐7

12. Reichardt, J.K.V., Makridakis, N., Henderson, B.E., Yu. M.C., Pike, M.C. and

Ross, R.K. (1995) Genetic Variability of the Human SRD5A2 Gene: Implications for Prostate Cancer Risk, Cancer Res. 55, 3973‐3975

13. Devgan, S.A., Henderson, B.E., Yu, M.C., Shi, C.‐Y., Pike, M.C., Ross, R.K. and

Reichardt, J.K.V. (1997) Genetic Variation of 3‐Hydroxysteroid Dehydrogenase Type II in Three Racial/Ethnic Groups: Implications for Prostate Cancer Risk, The Prostate 33, 9‐12

14. Makridakis, N., Ross, R.K., Pike, M.C., Chang, L., Stanczyk, F.Z., Kolonel, L.N.,

Shi, C.‐Y., Yu, M.C., Henderson, B.E. and Reichardt, J.K.V (1997) A Prevalent Missense Substitution that Modulates Activity of Prostatic Steroid 5‐ Reductase, Cancer Res. 57, 1020‐1022

15. Ross, R.K., M.C. Pike, G.A. Coetzee, J.K.V. Reichardt, M.C. Yu, H. Feigelson, F.Z.

Stanczyk, L.N. Kolonel and B.E. Henderson (1998) Androgen Metabolism and Prostate Cancer: Establishing a Model of Genetic Susceptibility, Cancer Res. 58, 4497‐4504

16. Akalu , A., Elmajian, D.A., Highshaw, R.A., Nichols, P.W. and Reichardt, J.K.V.

(1999) Somatic Mutations at the SRD5A2 Locus Encoding Prostatic Steroid 5‐Reductase During Prostate Cancer Progression, J. Urol. 161, 1355‐1358

17. Makridakis, N.M, Ross, R.K, Pike, M.C., Crocitto, L.E., Kolonel, L.N., Pearce, C.L.,

Henderson, B.E. and Reichardt, J.K.V. (1999) A Missense Substitution in the SRD5A2 Gene is Associated with Prostate Cancer in African‐American and Hispanic Men in Los Angeles, The Lancet 354, 975‐978

18. Akalu, A. and Reichardt, J.K.V. (1999) A Reliable PCR Amplification Method

for Microdissected Tumor Cells Obtained from Paraffin‐Embedded Tissue, Gen. An. 15, 229‐233

19. Makridakis, N.M., di Salle, E. and Reichardt, J.K.V. (2000) Biochemical and

Pharmacogenetic Dissection of Human Steroid 5‐Reductase Type II, Pharmacogenet. 10, 407‐413

20. Okano, Y, Asadal, M, Fujimoto, A, Ohtake, A, Murayama, K, Hsiao, K‐W, Choe,

K, Reichardt, JKV, Niihira, S, Imamura, T and Yamano, T (2001) A Genetic Factor for Age‐Related Cataract: Identification and Characterization of a Novel Galactokinase Variant "Osaka" in Asians, Am. J. Hum. Genet. 68, 1036‐ 1042

21. Hsing, AW, Chen, C, Chokkalingam, AP, Gao, Y‐T, Dightman, DA, Nguyen, HT, Deng, J, Cheng, J, Sesterhenn, IA, Mostofi, FK, Stanczyk, FW and Reichardt, JKV (2001) Polymorphic Markers in the SRD5A2 Gene and Prostate Cancer Risk: A Population‐Based Case‐Control Study, Cancer Epi. Biom. Prev. 10, 1077‐1082

22. Makridakis, NM and Reichardt, JKV (2001) MAPA: Multiplex Automated

Primer Extension Analysis: Simultaneous Genotyping of up to Four Polymorphisms, Biotech. 31, 1374‐1380

23. Pearce, CL, Makridakis, NM, Ross, RK, Pike, MC, Kolonel, LN, Henderson, BE

and Reichardt, JKV (2002) SRD5A2 V89L Substitution is Not Associated with Significant Risk of Prostate Cancer in a Multi‐Ethnic Population Study, Cancer Epi., Biom., Prev. 11, 417‐418

24. Goodman, MT, Wu, AH, Tung K‐H, McDuffie K, Cramer DW, Wilkens LR, Terda

K, Reichardt JKV and WG Ng (2002) Association of the Galactose‐1‐ Phosphate Uridyltransferase (GALT) Activity and N314D Genotype with the Risk of Ovarian Cancer, Am. J. Epidem. 156, 693‐701

25. Margiotti, K, Kim, E, Pearce, CL, Spera, E, Novelli, G and Reichardt, JKV

(2002) Association of the G289S Polymorphism in the HSD17B3 Gene with Prostate Cancer in Italian Men, The Prostate 53, 65‐68

26. Allen, NE, Reichardt, JKV, Nguyen, H, and Key, TJ (2003) Association

between Two Polymorphisms in the SRD5A2 Gene and Serum Androgen Concentrations in British Men, Cancer Epidemiol. Biomarkers Prev. 12, 578‐ 581

27. Foti, D and Reichardt, JKV (2004) YY1 Binding within the Human HSD3B2

Gene Intron 1 is Required for Maximal Basal Promoter Activity: Identification of YY1 as the 31‐A Factor, J. Molec. Endocrin. 33, 99‐119

28. Makridakis, NM, Akalu A, and Reichardt, JKV (2004) Identification and

Characterization of Somatic Steroid 5‐Reductase (SRD5A2) Mutations in Human Prostate Cancer Tissue, Oncogene 23, 7399‐7405

29. Makridakis, N and JKV Reichardt (2005) Pharmacogenetic Analysis of

Human Steroid 5 Reductase Type II: Comparison of Finasteride and Dutasteride, J. Molec. Endocrin. 34, 617‐623

30. Reichardt, JKV (2006) Unexpected Biochemical and Pharmacogenetic

Consequences of SNPs and Haplotypes: A Cautionary Tale for Human Molecular

Genetics and Epidemiology, Genomics 88, 673-674

31. Mehrian Shai R, Chen CD, Shi T, Horvath S, Nelson SF, Reichardt JKV and

Sawyers CL (2007) IGFBP2 is a Biomarker for PTEN Status and PI3K/Akt

Pathway Activation in Glioblastoma and Prostate Cancer, Proc. Natl. Acad. Sci.

104, 5563-5568

32. Reichardt JKV (2007) Quo vadis, genoma? A Call to Pipettes for Biochemists,

Trends Biochem. Sci. 32, 529‐530

33. Reichardt, JKV (2008) Realizing the Potential of the Sequenced Human Genome, Trends Genet. 24, 219‐220

34. Reichardt, JKV and Mehrian‐Shai, R (2008) Can Human Genomics Research

Fulfill Its Promise? Science (E‐Letter online), 3 july 2008 http://www.sciencemag.org/cgi/eletters/319/5871/1733#10837

35. Makridakis, NM, Phipps, T and Reichardt, JKV (2009) Genomic Analysis of

Cancer Tissue Reveals that Somatic Mutations Commonly Occur in a Specific Motif, Hum. Mut. 30, 39‐48

36. Makridakis, NM, Phipps, T, Srivastav, S and Reichardt, JKV (2009) PCR‐Free

Method Detects High Frequency of Genomic Instability in Prostate Cancer, Nucl. Acids Res. 37, 7441‐7446

37. Goodman, P, Tangen, C, Kristal, A, Thompson, I, Lucia, S, Platz, E, Figg, W,

Hoque, A, Hsing, A, Neuhouser, M, Parnes, H, Reichardt, J, Santella, R, Till, C and Lippman, S (2010) Transition of a Clinical Trial into Translational Research: The Prostate Cancer Prevention Trial Experience, Cancer Prev.

Research 3, 1523‐1533

38. Price, DK, Chau, CH, Till, C, Goodman, PJ, Baum, CE, Ockers, SB, English, BC, Minasian, L, Parnes, HL, Hsing, AW, Reichardt, JKV, Hoque, A, Tangen, CM, Kristal, AR, Thompson, IM, Figg, WD (2010) Androgen Receptor CAG Repeat Length and Association with Prostate Cancer Risk: Results from the Prostate Cancer Prevention Trial, J. Urol. 184, 2297‐2302

39. AR Kristal, C Till, CM Tangen, PJ Goodman, ML Neuhouser, FZ Stanczyk , LW

Chu, SK Patel, I Thompson, JK Reichardt, A Hoque, EA Platz, WD Figg, A Van Bokhoven, SM Lippman, AW Hsing (2012) Associations of serum sex steroid hormones and 5α‐androstane‐3α,17β‐diol glucuronide concentrations with prostate cancer risk among men treated with finasteride, Cancer Epi. Biomark. Prev. 21, 1823‐1832

40. Ho, G, Reichardt, J and Christodoulou, J (2013) In Vitro Read‐through Of

Phenylalanine Hydroxylase (PAH) Nonsense Mutations Using

http://www.sciencemag.org/cgi/eletters/319/5871/1733#10837

Genetic and Biochemical Basis of Galactosemia J. Reichardt, PI 1992‐1995

Zumberge Faculty Research and Innovation Fund Award A Combined Biochemical and Genetic Analysis of Human Galactose‐1‐phosphate Uridyl Transferase J. Reichardt, PI 1993‐1995

ACS‐IRG (American Cancer Society) Ovarian Cancer and the Human Galactose‐1‐phosphate Uridyl Transferase (GALT) Gene J. Reichardt, PI 1994‐1995

Wright Foundation Ovarian Cancer and the Human Galactose‐1‐phosphate Uridyl Transferase (GALT) Gene J. Reichardt, PI 1994‐1996

NIDDK P30 DK48522 New Investigator Award J. Reichradt, PI 1995‐1996

NIDDK P30 DK48522

Aminoglycosides: A Potential Therapy For Phenylketonuria, J. Inh. Metabol. Dis. 36, 955‐959

41. WD Figg, CH Chau, DK Price, C Till, PJ Goodman, Y Cho, M Varella‐Garcia, JKV

Reichardt, CM Tangen, RJ Leach, A van Bokhoven, IM Thompson, MS Lucia (2014) Androgen Receptor CAG Repeat Length and TMPRSS2:ETS Prostate Cancer Risk: Results From the Prostate Cancer Prevention Trial, Urology, 84, 127‐131

42. Arthur, JW, Cheung, FSG and Reichardt, JKV (2015) Single Nucleotide

Differences (SNDs) Continue to Contaminate the dbSNP Database With Consequences For Human Genomics and Health Hum. Mut. in press

4. List of research projects Funded: March of Dimes Basil O’ Connor (Young Investigator) Award

Molecular Basis of Epimerase Deficiency Galactosemia (P/F Project)

N. Kaplowitz, PI,; J. Reichardt, PI of P/F project 1995‐1997 NCI P30 CA14089‐22 Translational Research Project Benign Prostatic Hyperplasia and the Human SRD5A2 Gene P. Jones, PI; J. Reichardt, PI of project 1997‐1998

NCI R01 CA61132 Case/Control Study of Ovarian Cancer in Los Angeles M. Pike, PI; J. Reichardt, Co‐PI 1994‐1998 NCI R01 CA68581 5‐Alpha Reductase Genotype, Race and Prostate Cancer Risk J. Reichardt, PI 1995‐2004 NIDDK P30 DK48522 USC Liver Disease Research Center N. Kaplowitz, PI; J. Reichardt, Associate Director, Molecular Biology Core 1995‐2000 ACS 4‐21‐98 (American Cancer Society) Molecular Epidemiology of Prostate Cancer and Hyperplasia

J. Reichardt, PI (for Nick Makridakis, PhD; postdoctoral fellow)

1998‐2000

NCI U01 CA63464 Genetic Susceptibility to Cancer in Multiethnic Cohorts B. Henderson, PI; J. Reichardt, Co‐PI 1996‐2006 NCI R03 CA83112

Variation of the HSD17B3 Gene and Prostate Cancer

J. Reichardt, PI 1999‐2001 Martell Foundation

Androgen‐Metabolic Genes and Prostate Cancer Risk: A Molecular Epidemiologic Investigation of the HSD3B2 Gene

J. Reichardt, PI 2001‐2004


CRP 864A‐8704‐S3516 Mutations, Oral Contraceptives and Ovarian Cancer W. Cozen, PI; J. Reichardt, Co‐PI 1999‐2001

CRP 99‐0053V‐10150 Benign Prostatic Hypertrophy (BPH) and the SRD5A2 Gene


SWOG COOP‐02014 Androgen and 5‐Alpha Reductase Pilot for the PCPT J. Reichardt, PI 2002‐2003

NCI R01 CA84979 Risk Factors for Advanced Prostate Cancer S. Ingles, PI; J. Reichardt, Co‐PI 1999‐2004 DoD Prostate Cancer Center PC992018

Molecular Determinants of Prostate Cancer Risk and Progression Across Racial‐Ethnic Groups

R. Ross, PI; J. Reichardt, Co‐PI; PI (JR) of Project 1 2000-2003

Wright Foundation Molecular Epidemiology of the Human 3‐Hydroxy 3‐

methylglutaryl Coenzyme A Reductase (HMGCR) Gene and Atherosclerosis


Fondazione Berti per l’ Arte e la Scienza Supplementation for Dr. Clemente Capasso J. Reichardt, PI 2004‐2005

DoD PC 001280 Genetic Variation of the HSD3B2 Gene and Prostate Cancer

GSK

Steroid 5 Alpha Reductase Inhibitors: Biochemical, Genetic and Molecular Investigations J. Reichardt, PI 2003‐2004

DoD PC020368 SRD5A1 Genetic Variation and Prostate Cancer Epidemiology Predoctoral Fellowship for Troy Phipps J. Reichardt, nominal PI 2003‐2006

CRP 3GS0106 SRD5A1 Genetic Variation and Prostate Cancer Epidemiology Predoctoral Fellowship for Troy Phipps J. Reichardt, nominal PI

2003‐2006 (declined due to overlap with the DoD fellowship above)

NCI R01 CA96830 Molecular Epidemiology of Colorectal Adenomas R. Haile, PI; J. Reichardt, Co‐PI 2003‐2006

NHLBI R01 HL079353 Role of the 5‐Lipoxygenase Pathway in Atherosclerosis H. Allayee, PI; J. Reichardt, Co‐PI (Co‐PI declined because of move to Australia) 2005‐2009

ARC LE0775587

Correlating Genomics and Proteomics for Systems Biology: integrating the '‐omics'

Bergquist, Baker, Ferrari, Dawes, Graham, Stock, Trent, Hunt, Reichardt, Scott

2007

Cancer Institute NSW 07/RIG/01‐36

PHERAstar and POLARstar Optima Multi‐functional Plate Readers with Robotic High Throughput Screening System for Multi‐Disciplinary Cancer Research Richardson (CI1), Reichardt (CI5) et al. 2007

ARC DP0771015 Discovering Genes for Complex Traits Involving Gene‐Environment Interactions

Yu, Trent, Pamphlett, Reichardt 2007

ARC LE0882512 Advanced High Throughput Functional Genomics and Gene Mapping

Dawes, Bergquist, Trent, Scott, Hogg, Wilkins, Reichardt, Hunt, Baker, Dunkley 2008 NHMRC equipment grant

A Large‐Scale Recombinant Protein Production System for the New Multi‐User PC2 Molecular Biology Facility in the Blackburn‐Bosch Precinct DR Richardson, Stocker R. Halliday, G.M., Hunt N.H., Vandenberg R, Twigg S, Black J.L., Bishop G.A., King, N.J.C., Allen D.G., Mason R.S., Sharland, A.F., Lee C.S., Grau G. E., Chan‐Ling T, Ju Y.K., Lovicu F. J., Joshua D.E., McLennan S.V., Dampney R.A.L, Bao S., Zreiqat H., Chadban S.J., Ho P.J., Burgess J.K., Wu H., Ryan R.M., Lovejoy D.B., Hambly B.D., Codd R., Reichardt JK. 2008

Medical Foundation; University of Sydney J. Reichardt, CI 2005‐2009 NHMRC 402516

Pharmacogenetics of Androgen Action: Activating Metabolism and Tissue Sensitivity

D. Handelsman (CI A); J. Reichardt (CI B)

2006‐2009 NCI P01 CA108964

Biology of the Prostate Cancer Prevention Trial (PCPT) S. Lippman, PI (up to 2009; then I. Thompson); J. Reichardt PI of project 1

2005‐2010 (no cost extension to 2014) ARC LE100100130

Next Generation Sequencing


2010

Cancer Institute NSW 07/RIG/01‐36 PHERAstar and POLARstar Optima multi‐functional plate readers with robotic high throughput screening system for multi‐ disciplinary cancer research DR Richardson, Halliday GM, Lee CS, Joshua D, Reichardt J, Ho PJ, Dong Q, Iland HJ, Mason R, Grau GE, Assinder S, King NJC, Hunt N, Lovejoy D, Murphy C, Bishop GA, Sharland AF, Conigrave A, Cook D. 2007‐2011

Cancer Institute NSW 09/REG/1‐07 PALM Microbeam Laser Microdissection (LM) Microscope for the Multi‐User Sydney Cancer Gene Expression Facility Prof. Des Richardson, Prof. Gary Halliday, Prof. Rebecca Mason, Prof. Chris Murphy, A/Prof. Naresh Kumar, Dr Lisa Horvath, Prof. Wolfgang Weninger, Prof Cheok Soon Lee, Dr Guy Lyons, Prof. Peter Lay, Dr Michael Boyer, Dr Scott Byrne, Dr Stephen Assinder, Dr Yohan Rahmanto, A/Prof Harry Iland, A/Prof Joanne Jamie, A/Prof Subramanyan Vemulpad, Prof. Mathew Vadas, Dr Jenny Gamble, A/Prof Shisan Bao, Prof. Trevor Hambley, Dr Nikolas Haass, Prof. Mathew Vadas, Dr Phillipa O'Brien, Prof. James Kench, A/Prof. Qihan Dong, Dr Danuta Kalinowski, Prof. Jeurgen Reichardt, Prof. John Rasko, Dr David Lovejoy, Prof Nick King 2009‐2014

PCFA 2009 Luminex 200 Analysis System for the Bosch Prostate Cancer Research Focus Group in the Multi‐User Bosch Institute Molecular Biology Facility Richardson DR, Reichardt JKV, Dong Q, Lee CS, Assinder SJ, Kalinowski D, Lovejoy D, Mangs H, Dixon K, Murphy CR 2009‐2012

Cancer Institute of NSW Research Equipment Grant 10/REG/1‐16

GenomeLab GeXP Genetic Analysis System for the Multi‐ Disciplinary Sydney Cancer Gene Expression Facility Richardson DR, Halliday GM, Scolyer R, Clarke S, Lee CS, Reichardt JK, Murray M, Clarke C, Boyer M, Kefford R, Mason

RS, Murphy CR, McLachlan, Gamble JR, Lay P, Dong Q, Kumar N, Lyons G, Byrne G, Gurney HP, Davies M, Assinder SJ, Rahmanto Y, Jamie J, Vemulpad S, Bao S, Haass NK, Kench , JG, Kalinowski DS, Lovejoy DB, Groundwater P, Hawkins C, De Souza P, Lane D, Zhang D, Moscato P, Lai D 2010‐2011

PCFA 2011 xCELLigence Real Time Cell Analysis System

Richardson D, Reichardt J, Dong Q, Lee C, Assinder S, Kalinowski D, Lovejoy D, Dixon, K, Mangs H, Murphy C 2011‐2014

Heart Foundation (Australia) G 10S 5276 Molecular Characterization of Genetic Variants in HMG CoA Reductase (HMGCR) and Their Association with Response to Statins Reichardt, J (PI), Keech, A, Tonkin, A, Yu, B 2011‐2013 (declined due to heavy administrative load)

5. List of patents filed List all patents filed Patent Awarded: “Androgen‐Metabolic Gene Mutations and Prostate Cancer Risk”;

US Patent 09/235,538; 2/2002. 6. Track record of positions held List all academic or relevant professional positions held

1982 Visiting Scientist: Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY; mentor: Dr. Quentin H. Gibson

1982‐1989 Graduate Education (PhD): Department of Biochemistry,

Stanford University School of Medicine, Stanford, CA; advisor: Dr. Paul Berg

1989‐1991 Postdoctoral Training: Baylor College of Medicine/Howard

Hughes Medical Institute, Houston, TX; mentor: Dr. Savio L. C. Woo.

1991‐1992 Research Instructor: Department of Cell Biology, Baylor

College of Medicine, Houston, TX, USA

1992‐2000 Assistant Professor: Institute for Genetic Medicine and Department of Biochemistry and Molecular Biology, University of Southern California School of Medicine, Los Angeles, CA, USA

2000‐2005 Associate Professor with tenure: Institute for Genetic Medicine

and Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA

2000‐2005 Associate Professor (dual appointment): Department of

Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA

2005‐2011 Plunkett Chair and Professor of Molecular Biology (Medicine), University of Sydney, Camperdown NSW, Australia

2011‐present Professor and Head, School of Pharmacy and Molecular

Sciences, James Cook University, Townsville QLD, Australia 2012‐present Associate Dean Research, Faculty Medicine, Health and

Molecular Sciences, James Cook University, Townsville QLD, Australia

7. Fund raising capacity List all funded research projects or any other funds raised

March of Dimes Basil O’ Connor (Young Investigator) Award Genetic and Biochemical Basis of Galactosemia J. Reichardt, PI 1992‐1995

Zumberge Faculty Research and Innovation Fund Award A Combined

Biochemical and Genetic Analysis of Human Galactose‐1‐phosphate Uridyl Transferase J. Reichardt, PI 1993‐1995

ACS‐IRG (American Cancer Society) Ovarian Cancer and the Human Galactose‐1‐phosphate Uridyl Transferase (GALT) Gene J. Reichardt, PI 1994‐1995

Wright Foundation Ovarian Cancer and the Human Galactose‐1‐phosphate

Uridyl Transferase (GALT) Gene J. Reichardt, PI 1994‐1996

NIDDK P30 DK48522 New Investigator award J. Reichradt, PI 1995‐1996

NIDDK P30 DK48522 Molecular Basis of Epimerase Deficiency Galactosemia Project)

N. Kaplowitz, PI,; J. Reichardt, PI of P/F project 1995‐1997

NCI P30 CA14089‐22, Translational Research Project, Benign Prostatic

Hyperplasia and the Human SRD5A2 Gene P. Jones, PI; J. Reichardt, PI of project 1997‐1998


NCI R03 CA83112 Variation of the HSD17B3 Gene and Prostate Cancer

J. Reichardt, PI 1999‐2001 Martell Foundation

Androgen‐Metabolic Genes and Prostate Cancer Risk: A Molecular Epidemiologic Investigation of the HSD3B2 Gene


CRP 864A‐8704‐S3516 Mutations, Oral Contraceptives and Ovarian Cancer W. Cozen, PI; J. Reichardt, Co‐PI 1999‐2001 CRP 99‐0053V‐10150

Benign Prostatic Hypertrophy (BPH) and the SRD5A2 Gene

NCI R01 CA68581 5‐Alpha Reductase Genotype, Race and Prostate Cancer Risk J. Reichardt, PI 1995‐2004

NIDDK P30 DK48522 USC Liver Disease Research Center N. Kaplowitz, PI; J. Reichardt, Associate Director, Molecular Biology Core 1995‐2000

ACS 4‐21‐98 (American Cancer Society) Molecular Epidemiology of Prostate Cancer and Hyperplasia J. Reichardt, PI (for Nick Makridakis, PhD; postdoctoral fellow) 1998‐2000

NCI U01 CA63464 Genetic Susceptibility to Cancer in Multiethnic Cohorts B. Henderson, PI; J. Reichardt, Co‐PI 1996‐2006

SRD5A1 Genetic Variation and Prostate Cancer Epidemiology Predoctoral Fellowship for Troy Phipps J. Reichardt, nominal PI 2003‐2006

SWOG COOP‐02014

Androgen and 5‐Alpha Reductase Pilot for the PCPT J. Reichardt, PI 2002‐2003

NCI R01 CA84979 Risk Factors for Advanced Prostate Cancer S. Ingles, PI; J. Reichardt, Co‐PI 1999‐2004 DoD Prostate Cancer Center PC992018

Molecular Determinants of Prostate Cancer Risk and Progression Across Racial‐Ethnic Groups

R. Ross, PI; J. Reichardt, Co‐PI; PI (JR) of Project 1 2000-2003

Wright Foundation Molecular Epidemiology of the Human 3‐Hydroxy 3‐

methylglutaryl Coenzyme A Reductase (HMGCR) Gene and Atherosclerosis


Fondazione Berti per l’ Arte e la Scienza Supplementation for Dr. Clemente Capasso J. Reichardt, PI 2004‐2005

DoD PC 001280 Genetic Variation of the HSD3B2 Gene and Prostate Cancer


GSK Steroid 5 Alpha Reductase Inhibitors: Biochemical, Genetic and Molecular Investigations J. Reichardt, PI 2003‐2004

DoD PC020368

CRP 3GS0106 SRD5A1 Genetic Variation and Prostate Cancer Epidemiology Predoctoral Fellowship for Troy Phipps J. Reichardt, nominal PI

2003‐2006 (declined due to overlap with the DoD fellowship above)

NCI R01 CA96830 Molecular Epidemiology of Colorectal Adenomas R. Haile, PI; J. Reichardt, Co‐PI 2003‐2006

NHLBI R01 HL079353 Role of the 5‐Lipoxygenase Pathway in Atherosclerosis H. Allayee, PI; J. Reichardt, Co‐PI (Co‐PI declined because of move to Australia) 2005‐2009

ARC LE0775587

Correlating Genomics and Proteomics for Systems Biology: integrating the '‐omics'


2007

Cancer Institute NSW 07/RIG/01‐36

PHERAstar and POLARstar Optima Multi‐functional Plate Readers with Robotic High Throughput Screening System for Multi‐Disciplinary Cancer Research Richardson (CI1), Reichardt (CI5) et al.

2007

ARC DP0771015 Discovering Genes for Complex Traits Involving Gene‐Environment Interactions

Yu, Trent, Pamphlett, Reichardt 2007

ARC LE0882512 Advanced High Throughput Functional Genomics and Gene Mapping

Dawes, Bergquist, Trent, Scott, Hogg, Wilkins, Reichardt, Hunt, Baker, Dunkley

2008 NHMRC equipment grant

A Large‐Scale Recombinant Protein Production System for the New Multi‐User PC2 Molecular Biology Facility in the Blackburn‐Bosch Precinct DR Richardson, Stocker R. Halliday, G.M., Hunt N.H., Vandenberg R, Twigg S, Black J.L., Bishop G.A., King, N.J.C., Allen D.G., Mason R.S., Sharland, A.F., Lee C.S., Grau G. E., Chan‐Ling T, Ju Y.K., Lovicu F. J., Joshua D.E., McLennan S.V., Dampney R.A.L, Bao S., Zreiqat H., Chadban S.J., Ho P.J., Burgess J.K., Wu H., Ryan R.M., Lovejoy D.B., Hambly B.D., Codd R., Reichardt JK. 2008

Medical Foundation; University of Sydney J. Reichardt, CI 2005‐2009 NHMRC 402516

Pharmacogenetics of Androgen Action: Activating Metabolism and Tissue Sensitivity

D. Handelsman (CI A); J. Reichardt (CI B)

2006‐2009 NCI P01 CA108964

Biology of the Prostate Cancer Prevention Trial (PCPT) S. Lippman, PI (up to 2009; then I. Thompson); J. Reichardt PI of project 1

2005‐2010 (no cost extension to 2014) ARC LE100100130

Next Generation Sequencing


2010

Cancer Institute NSW 07/RIG/01‐36 PHERAstar and POLARstar Optima multi‐functional plate readers with robotic high throughput screening system for multi‐ disciplinary cancer research DR Richardson, Halliday GM, Lee CS, Joshua D, Reichardt J, Ho PJ, Dong Q, Iland HJ, Mason R, Grau GE, Assinder S, King NJC,

Hunt N, Lovejoy D, Murphy C, Bishop GA, Sharland AF, Conigrave A, Cook D. 2007‐2011

Cancer Institute NSW 09/REG/1‐07 PALM Microbeam Laser Microdissection (LM) Microscope for the Multi‐User Sydney Cancer Gene Expression Facility Prof. Des Richardson, Prof. Gary Halliday, Prof. Rebecca Mason, Prof. Chris Murphy, A/Prof. Naresh Kumar, Dr Lisa Horvath, Prof. Wolfgang Weninger, Prof Cheok Soon Lee, Dr Guy Lyons, Prof. Peter Lay, Dr Michael Boyer, Dr Scott Byrne, Dr Stephen Assinder, Dr Yohan Rahmanto, A/Prof Harry Iland, A/Prof Joanne Jamie, A/Prof Subramanyan Vemulpad, Prof. Mathew Vadas, Dr Jenny Gamble, A/Prof Shisan Bao, Prof. Trevor Hambley, Dr Nikolas Haass, Prof. Mathew Vadas, Dr Phillipa O'Brien, Prof. James Kench, A/Prof. Qihan Dong, Dr Danuta Kalinowski, Prof. Jeurgen Reichardt, Prof. John Rasko, Dr David Lovejoy, Prof Nick King 2009‐2014

PCFA 2009 Luminex 200 Analysis System for the Bosch Prostate Cancer Research Focus Group in the Multi‐User Bosch Institute Molecular Biology Facility Richardson DR, Reichardt JKV, Dong Q, Lee CS, Assinder SJ, Kalinowski D, Lovejoy D, Mangs H, Dixon K, Murphy CR 2009‐2012

Cancer Institute of NSW Research Equipment Grant 10/REG/1‐16

GenomeLab GeXP Genetic Analysis System for the Multi‐ Disciplinary Sydney Cancer Gene Expression Facility Richardson DR, Halliday GM, Scolyer R, Clarke S, Lee CS, Reichardt JK, Murray M, Clarke C, Boyer M, Kefford R, Mason RS, Murphy CR, McLachlan, Gamble JR, Lay P, Dong Q, Kumar N, Lyons G, Byrne G, Gurney HP, Davies M, Assinder SJ, Rahmanto Y, Jamie J, Vemulpad S, Bao S, Haass NK, Kench , JG, Kalinowski DS, Lovejoy DB, Groundwater P, Hawkins C, De Souza P, Lane D, Zhang D, Moscato P, Lai D 2010‐2011

PCFA 2011 xCELLigence Real Time Cell Analysis System

Richardson D, Reichardt J, Dong Q, Lee C, Assinder S, Kalinowski D, Lovejoy D, Dixon, K, Mangs H, Murphy C

2011‐2014

Heart Foundation (Australia) G 10S 5276 Molecular Characterization of Genetic Variants in HMG CoA Reductase (HMGCR) and Their Association with Response to Statins Reichardt, J (PI), Keech, A, Tonkin, A, Yu, B 2011‐2013 (declined due to heavy administrative load)

EIF (Education Investment Fund; Department of Industry, Innovation, Climate Change, Science, Research and Tertiary Education; Australia)

The Science Place (TSP); JC 2013‐2016.

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