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Gly

cosy

latio

n

Made By:Asmaa Alkhawaga

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Gly

cosy

latio

n

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Gly

cosy

latio

n

Introduction

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Gly

cosy

latio

n

Introduction

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Gly

cosy

latio

n

Post-translational modification

PTM is the chemical modification of a protein after its translation.

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Gly

cosy

latio

n

Post-translational modification AcetylationADP-ribosylationCarboxylationGlycosylationFatty AcylationHydroxylationMethylationPhosphorylationPrenylation

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Gly

cosy

latio

n

Definition

enzymes Glycosylation

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Gly

cosy

latio

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Definition

enzymes

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Gly

cosy

latio

n

Definition

Glycan and polysaccharide are

compounds consisting of a large number of monosaccharaides

linked glycosidically.

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Gly

cosy

latio

n

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Gly

cosy

latio

n

Definition

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Gly

cosy

latio

n

Definition

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Gly

cosy

latio

n

Definition

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Gly

cosy

latio

n

Definition

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Gly

cosy

latio

n

Definition

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Gly

cosy

latio

n

Definition

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Gly

cosy

latio

n

Definition

Aglycosylation, is a feature of engineered antibodies to bypass glycosylation.

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Gly

cosy

latio

n

Purpose

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Gly

cosy

latio

n

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Gly

cosy

latio

n

Glycoprotein Diversity

• It is the set of expressed proteins in a given type of cell or organism, at a given time, under defined conditions.

Glycosylation increases diversity in the Proteome.

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Gly

cosy

latio

n

Glycoprotein Diversity

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Gly

cosy

latio

n

Mechanism

The most complex post-translational modification.

The donor molecule is often an activated nucleotide sugar.

It is a site-specific modification.

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Gly

cosy

latio

n

Clinical

Over 40 disorders of glycosylation have been reported in humans.

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Gly

cosy

latio

n

Clinical

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Gly

cosy

latio

n

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Gly

cosy

latio

n