PROSTATE CANCER: ANALYSIS OF 10 – YEAR DATA FROM A CANCER REGISTRY

DR A. T, ATANDA

BAYERO UNIVERSITY/AMINU KANO TEACHING HOSPITAL, KANO

BACKGROUND

Developed countries: progressive decline in the incidence of prostate cancer in the last decade

Developing countries: Paucity of data in this regard from developing countries of West Africa.

This study of 10-year data emanating from a Cancer Registry in Nigeria aims to add to available data.

MATERIALS AND METHODS

Data from Kano Cancer Registry on all biopsy validated prostate cancer cases were retrieved and analyzed for age distribution, age-adjusted incidence rate and tumor grade.

RESULTS2004 – 2013 studied 626 CaP 11.2% of all cancers and 23.9% of all male cancers The ages ranged from 30 to 122 years with mean of 67.2±10.6 years. It ranked 1st among male and 3rd among all cancers.

RESULTS

The Age-standardized rate was 26.4 per 100,000 population and rates increased progressively from the 4th decade to the 7th and over, increase in incidence rate of 37.6% between 2004 -2008 and 2009-2013. crude increase of 221%

RESULTS

Gleason scores 5 – 6, accounted for 37.7%

≥70 years, high grade tumors were more frequent (p = 0.003018).

Age Range 2004 – 2008 2009 – 2013 Total

≤ 40 3 2 5

40 – 49 17 12 29

50 – 59 47 83 130

60 – 69 56 162 218

≥70 52 142 194

Unspec 20 30 50

  195 431 626

 

Ages

No of

prostate

cancers

Total male

cancers

% of total

male

cancers

Person

years

at risk

Standard

world

population

Age SIR

<40 4 765 0.52

4,129.687

68,000 0.07

40 – 49 11 332 3.3

354,573

12,000 0.4

50 – 59 62 431 14.4

211,801

9,000 2.6

60 – 69 196 532 36.8

115,869

7,000 11.8

70+ 308 558 55.2

107,438

4,000 11.5

  581

(626)

2,618 19.8 (22.2) 4,919,368 100,000 26.37

<40 40-49 50-59 60-69 70+0

2

4

6

8

10

12

14

TREND IN AGE STANDARDIZED INCIDENCE RATE FOR KCR PROSTATE Ca

ASIR

INC

IDE

NC

E R

AT

E

Prostate Cancer (C61): 1975-1977 to 2008-2010

European Age-Standardised Incidence Rates per 100,000 Population, by Age, Great Britain

Please include the citation provided in our Frequently Asked Questions when reproducing this chart: http://info.cancerresearchuk.org/cancerstats/faqs/#How Prepared by Cancer Research UK - original data sources are available from http://www.cancerresearchuk.org/cancer-info/cancerstats/

SEERS DATA

Gleason Score Number

of cases

%

2 – 4 158 28.9

5 – 6 206 37.7

7 – 10 183 33.4

  547 100

Age range Gleason

score

2 – 4

Gleason score

5 – 6

Gleason

score

7 – 10

 

≤40 Incomplete incomplete Incomplete  

40 – 49 Incomplete incomplete 2 2

50 – 59 26 19 10 55

60 – 69 44 66 47 157

70+ 71 98 109 278

  141 183 168 492

CONCLUSION In disparity to data from developed

countries there is an increase in incidence rate for prostate cancer among Nigerian men,

higher grade tumors are more frequent among the elderly.

There is need for institution of a national screening program.