programmes de recherche européens pour les débutants ... · strategic objectives at eu level 1....
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Institut de recherche expérimentale et clinique (IREC)
NCP Wallonie – 16 février 2017
Pr JL GALA, MD, PhDSrt: 02/764 33 32
Programmes de recherche européens pour les débutants: ”témoignage”
Technological transfer unit - Applied sciences
Spin-off Service to Soc
CTMA / DLD-Bio
R&D Clinical / Ops applicationsTransfert
DNA-based diseases
Bio-markers / -sensors
Dx infectious diseases:
pathogens, virulence &
resistance…
OBJECTIVE
Diagnosis
BE-Defence(DLD)
DLD-Bio
RESOURCES
BioEngineering
Biostatistics
Bioinformatics
BioMed genomics
Multidisciplinary !
Knowledge Engineering
Academic (UCL)
& Clinical pole (CUSL)
Clinical Genetic Testing
Genetic Research
CTMA (Center for Applied Molecular Technologies)
« Academic - Military - Industrial » Interface
EU
Commission
Bio threats
Biomedical
EU Defense
Agency NATO
networks
CTMA DLD-Bio / IREC
EU Space
Agency
Military partners
Community of User for a Safe and Resilent society (EC/ DG HOME)
Academic partners
Inte
rnat
ional
Nat
ional
Industrial
partnership and
valorisation
UCL and CUSL
Academic hospital
Light Fiedable Laboratories (n=3)
Response
time
Selectivity Sensitivity Warning Detection Identifi-
cation
Monito-
ring
Survey /
recce
Molecular
Genetics --- + +++ + +
Immuno - ++ - + -
Optical
detection ? ? +++ ? ? + +
Physical
detection ++ + - ++ +
Hybrid
Technologies
Holy Grail for Diagnostic Innovation: Hybrid identification methods !
Holy Grail
MAIN GOALS : Identification on-site – External support: DRC !Need for robust, reliable, affordable and user-friendly technologies
Bukavu
Investigating the changing endemic Orthopoxvirus (monkeypox)
in Kananga, Occidental Kasaï (DR Congo) 2009. Progressive
developement of the laboratory capacity, deployed in FP7-
PRACTICE (Pionki, PL, 2014) and FP7-EDEN (Bologna, IT, 2016)
Kananga
- Re-equipping and strenghtening local Dx capabilities (infectious
diseases) in South Kivu province (DR Congo) since 2012.
- Surveillance of local pathogen genetics: V.cholerae; ESBL-
producing Enterobacteria
Rapidly deployable laboratory in a major crisis situation like an EBOLA outbreak: the challenge is to use sophisticated technologies in the fiels (DNA-Identification; Point
of care testing; Rapid diagnostic tests !)
Limited space - biosafey measures mandatory - rapid, reliable and safe tests needed !
H2020BioEDEP, JIP-CBRN, CBRN Cat B
COST, PASR, FP7 Horizon 2020
IAP/ARTES20Phase-1Phase-2
CBRN-SIBCRAScience for Peace & Sec (SPS)
EDA
Marshall plan Biowin, Waleo, WBHealthFEDERErasmus Mundi
Regional / FederalR&D
BE-MOD RHID PIC - Internat. CooperationBrain-Belspo
ECESA
NATO
IMG-S (open forum)
MED, LANDDLD, MSP, HFM
BE-Biotech MATRIX (SME’s, Industries)
Multiple Sources of Funding
Service to Society
Strategic Objectives at EU level
1. FP7-SEC-PRACTICE (2011): Preparedness and Resilience against CBRN Terrorism using Integrated Concepts and Equipment
2. FP7- SEC-MIRACLE (2013): MobIle Laboratory for the Rapid Assessment of CBRN Threats Located within and outside the EU (CTMA Coordination)
3. FP7-SEC-EDEN (2013): End-user driven DEmo for CBRNE
4. H2020-DRS-REACHING OUT (2016): DRS-03-2015demonstRation of EU effective lArge sCale tHreat and crIsis maNaGement OUTside the EU.
5. H2020-DRS-PANDEM (2015) PANDemic Risk and Emergency Management
B-LiFE - IAP/ARTES20: Biological Light Fieldable laboratory for Emergencies (CTMA Coordination)- Feasibility (Phase 1): 2012-2013- Demo (Phase 2): 2014-2017
EU SPACE AGENCYEU COMMISSION- FP7/ H2020-SEC
POCT/RDT
1. EBLN-EMS4 - Database of B-agents (Genetic profiling of deadly B-agents)
2. JIP-CBRN call-1 & -2: - BFREE (CBRN mixed samples handling and analysis)
- RACED (monitoring of decontamination
EU DEFENSE AGENCY
RW / BIOWIN
1. WB HEALTH: Biobactil
2. BIOWIN: ALLERT (Handheld Allergens Detector /Détecteur portable d’allergènes alimentaires;
3. WALInnov: TOXINE-ID - 7/6/2016 : Kick Off May 2017
H2020 PROJECTS STARTING IN 2017
1. H2020-SEC-05-DRS (2016): ENCIRCLE (coordination) Chemical, biological, radiological and nuclear (CBRN) cluster
2. H2020-SEC-21–GM (2016): eNOTICE (coordination) EU Network Of CBRN TraIning CEnters
3. H2020-SEC/DRS-EuroBioTox (2016): Validation of biological toxins
measurement after an incident: development of tools and proceduresfor quality control (Au-2016). 57 institutions – 23 countries
FL
NGS
POCT: Point-of-care testingRDT: Rapid Diagnostic Test testing
FL: Rapidly Fieldable LaboratoryNGS: Next Generation Sequencing
ABBREVIATIONS:
Opportunities:
Call SECURITY
CSA:
- Networking et maturation de l’idée - Faciliter l’accès au marché (ENCIRCLE)- Augmenter la visiblité (FP7-MIRACLE)
RIA: développement technologique innovant
Support de la CoU on Safe, Secure and Resilient Society
Contraintes:
Investissement temps: +++
Début: une « bonne » Idée !!!!! - discussion possible avec PO
Préparation du consortium: pas les « amis» mais les « meilleurs »
Bon coordinateur: expérience, trust and knowldege, good network – friendship useful but not compulsory
Contacts répétés : Skype, Telco , preparatory meeetings
Rédaction:
- Sentir le projet – avis PO si besoin
- Bien l’écrire (30 pages ! Dans un anglais de qualité !
- Workpackage - Milestones – Délivrables
- Budget : Partner: Travel, Workshops and Meetings / final conference [ invitation of stakeholders], Equipment, Dissemination, Audit
Third parties
Etre / se mettre en ordre administrativement PIC [Participant ID code] – LEAR (Legal Entity Appointed Representative)
Soumettre avant la deadline : Idéalement commencer un jour avant et updater jusqu’à la dernière minute
Attendre la sélection – NCP informé premierSign
Après sélection:
- Etablir le GA & CA
- Prévoir le KOM (normalement après signature du GA) : Date en concertation avec les partenaires et le PO – preparer Agenda
KOM = Début officiel du projet
Si coordination: beaucoup de travail admin, projet et de suivi de l’état d’avancement (WP, MS, D, Admin, Budget, Reports…..)
Réseau AVANT Publication du Call
FSIGN / LSIGN
LSIGN: Sign grant agreements
FSIGN: Sign financial statements
Aide financière?
- RBx: mécanisme d’aide au montage de projets de RDI :
Mécanisme connect - Innoviris : pas CSA !
- RW: Subvention Horizon Europe – pas pour les call 2016
Actuellement ces mécanismes d’aide à la préparation des projets ne sont plus garantis
Ressources internes
- Experienced staff:
- « Human factors » key of success
- Knowledge of the call and the objectives of the team unit and of the coordinator
- Flexibility, diplomacy, creativity and labour power, espcailly when deadline for submission gets closer and closer!
• Administrative and financial support:• Grant Agremeent / Consortium Agreement• Finances: budget per partner - Person/months - Direct / indirect costs• Time sheets ! (extremely boring … some administration (e.g. Univer.) requests them !)
EBOLA outbreakGuinea 2014-15
H2020 Reaching Out(IA-2015-
DRS-2015: Demonstration activity on large scale disasters and crisis
management and resilience of EU external assets against major
identified threats or causes of crisis
FP7-MIRACLECSA-2012 (coord)
FP7-SEC-2012MobIle Laboratory Capacity for the Rapid Assessment of CBRN Threats Located within and outside the EU
Consortium: Built on successive projects
B-LiFEEuropean Space Agency
IAP /ARTES20 – 2012(Coordination)
Military CBRN
CUSL/UCL :Molecular Genetics
FP7-SEC-2010Preparedness and Resilience
to a CBRN crisisLarge-scale Integrating Project (IP)
FP7-SEC-2012CBRNE Demo Phase IILarge-scale Integrating Project (IP)
Bio3R (PASR-2006)
FP7-CBRN Map(CSA-2009)
FP7-PRACTICE(IP-2010)
FP7-EDEN(IP-2012)
FP7-SEC-2009CBRNE map: road mapping study of CBRNE Demonstrator
H2020- PANDEM (CSA-2014)
H2020-DRS-2014PANDemic risk and Emergency Management
H2020- ENCIRCLECSA-2016 (coord)
H2020 - eNOTICECSA-2016 (coord)
H2020-SEC-21 Pan European Networks of practitioners and other actors in the field of security
H2020-SEC-21-2016Pan European Networks of practitioners and other actors in the field of security
H2020- Euro BioTox-2016 (enduser)
H2020-SEC/DRSValidation of biological toxins measurement after an incident: development of tools and procedures for quality control
Benefits
- Quality of own work
- Sharing with top experts
- Building a EU community of researchers with same or complementary objectives
- Put [Endusers–Customers / Industry-SMEs-Techno. providers / Academic Researchers] together
- Bringing EU policy inside the game: EU common objectives
- Boost adequation between the market and the needs
- Boost innovation and access to the market !
- Boost for new (future) projects !Endusers-guided innovations