programme i psych annual meeting 1 – 3 j une 2016€¦ · 1-3 june 2016 dear i psych employee or...

FORSLAG 1VINTER / FORÅR

FORSLAG 2FORÅR / SOMMER

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PROGRAMMEi PSYCH ANNUAL MEETING 1 – 3 JUNE 2016




WELCOME TO THE i PSYCH ANNUAL MEETING1-3 JUNE 2016

Dear i PSYCH employee or collaborator,

Welcome to the i PSYCH Annual Meeting 2016.

The aims of this meeting are to continue discussions of the scientific work in i PSYCH, to be inspired by the invited keynote speakers, to meet and to network both within the i PSYCH community and with collaborators in order to strengthen our working relationship across projects and to heighten the quality and outcome of the studies.

We are very pleased that the programme again this year features distin-guished speakers from some of our main collaborators. The programme also includes a poster session, parallel sessions with symposiums, work-shops and business meetings allowing more active and in-depth discus-sions of selected topics.

We are looking forward to seeing you all again.

Best regards,i PSYCH

Merete NordentoftAnders BørglumPreben Bo MortensenThomas WergeOle MorsDavid HougaardMogens Kilian




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PROGRAMMEWEDNESDAY 1 JUNE

11.30 Arrival and lunch (room S4/S5)

13.00 – 13.45 Preben Bo Mortensen: Welcome and opening remarks

13.45 – 14.00 Mogens Kilian: Bibliometric analyses and citations

14.00 – 15.00 George Davey-Smith: Do birth cohorts have a future after the death of the Life and National Children’s Studies?

15.00 – 15.30 Coffee/tea break

15.30 – 16.30 Anne-Marie Nybo Andersen: From birth cohorts to public health

16.45 – 18.00 Parallel Sessions – I

Workshop I: Analysis of exome-sequencing data Chair & moderator: Ditte Demontis

PRESENTATIONS:

a) Exome-sequencing in schizophrenia: snapshot of ongoing analyses on clinical samples – Francesco Lescai b) Exome-sequencing of adult ADHD preliminary results – Ditte Demontis c) Low coverage whole-genome-sequencing and some associated problems in a sample from the isolated population of the Faroe Islands – Thomas Damm Als d) CNVs in iPSYCH exome-sequencing data – preliminary findings – Wiktor Mazin

Business meetings: detailed information on page 20-21

18.30 Dinner

20.00 – 22.00 Poster session Location: room S4

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12.00 – 13.00 Lunch

13.00 – 14.30 Parallel Sessions – III Symposium II: Children at risk Chair & moderator: Anne Thorup

PRESENTATIONS:

a) Placement out of home, living condition during childhood and school marks for children born to parents with mental illness – Anne Ranning b) Childhood mental illness in children born to parents with mental disorders – Anne Thorup c) VIA 7 first results and VIA family – Anne Thorup d) VIA 11, psychopathology and physical health – Merete Nordentoft e) VIA 11, cognition and brain scans – Kerstin Plessen

Workshop II: Genome-wide analyses of prescription data Chair & moderator: Henrik Rasmussen & Thomas Hansen



PROGRAMMETHURSDAY 2 JUNE

PROGRAMMETHURSDAY 2 JUNE (CONTINUED)

07.00 – 09.00 Breakfast

09.00 – 10.00 Akira Sawa: Aberrant maturation of the frontal cortex in adolescence: a triggering mechanism for psychosis


10.30 – 12.00 Parallel Sessions – II Symposium I: Update of newest GWAS results Chair & moderator: Ditte Demontis

PRESENTATIONS:

a) Update on ASD GWAS – Jakob Grove b) Update on ADHD GWAS – Ditte Demontis c) Update on GWAS of alcohol dependence – Mette Nyegaard d) Update on GWAS of bipolar disorder and schizophrenia – Thomas Damm Als e) Update on GWAS of substance use disorder – Ditte Demontis


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PROGRAMMETHURSDAY 2 JUNE (CONTINUED)

15.00 – 16.30 Parallel Sessions – IV

Symposium III: i PSYCH CNV analysis Chair & moderator: Thomas Werge & Marcelo Bertalan

PRESENTATIONS:

a) Characterizing CNVs at the population level – Marcelo Bertalan b) Single SNV analysis – Thomas Sparsø c) CNV calling using whole exome data – Wiktor Mazin d) Biological insight from CNV analysis – Marcelo Bertalan

Symposium IV: Patterns in course and outcome Chair & moderator: Christiane Gasse

PRESENTATIONS:

a) Depression and anxiety in the postpartum period and risk of bipolar disorder – Xiaoqin Liu b) Predicting progression from unipolar depression to schizophrenia – Kate Musliner c) Interplay of antipsychotics, diabetes and schizophrenia – Christiane Gasse


19.00 Gala dinner, followed by the live band: Soulmates

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PROGRAMMEFRIDAY 3 JUNE

07.00 – 09.00 Breakfast

09.00 – 10.30 Parallel Sessions – V

Symposium V: Trajectory analyses of health register data Chair & moderator: Thomas Werge & Wesley Thompson

PRESENTATIONS:

a) Trajectories: sequence analysis – Morten Krebs b) Multivariate dynamic survival analyses – Wesley Thompson c) Discovery-based learning algorithm – Anders Jensen


10.30 – 11.00 Coffee/tea Break

11.00 – 12.00 Kasper Lage: Human brain networks perturbed by genetics and targeted by therapeutics in psychiatric diseases

12.00 – 12.15 Closing remarks / Meeting adjourns

12.15 – 13.00 Lunch

13.00 Departure

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KEYNOTE SPEAKERS

ProfessorGeorge Davey Smith

WEDNESDAY 1 JUNE 2016: 14.00 – 15.00DO BIRTH COHORTS HAVE A FUTURE AFTER THE DEATH OF THE LIFE AND NATIONAL CHILDREN’S STUDIES?

Professor George Davey Smith is a clinical epidemiologist and the director of the MRC Integrative Epidemiology Unit (lEU) at the School of Social and Community Medicine, University of Bristol. His research has pio-neered understanding of the causes and alleviation of health inequalities; lifecourse epidemiology; systematic reviewing of

epidemiological evidence; and the study of population health contributions of the new genetics. He is particularly interested in developing and applying Mendelian randomi-zation approaches, interrogating the causal role of behavioral factors (such as alcohol consumption) and intermediate phenotypes on different health outcomes, such as cardiovascular diseases and type 2 diabetes.

He has published over 1100 peer-reviewed journal articles, 15 books/edited collections and numerous editorials, commentaries and reviews. He is a lSI highly cited scholar (h index greater than 150- excluding multi-authorship consortia papers). He is currently Scientific Director of the Avon Longitudinal Study of Parents and Children and co-editor of the International Journal of Epidemiology.

ProfessorAnne-Marie Nybo Andersen

WEDNESDAY 1 JUNE 2016: 15.30 – 16.30FROM BIRTH COHORTS TO PUBLIC HEALTH

Anne-Marie Nybo Andersen received her Medical Degree in 1988. After six years of clinical work, she became a full-time researcher in 1994. She obtained her PhD degree in 2001 with the thesis: Fetal death; Epidemiological studies, a research work carried out at the Danish Epidemiological Science Centre. She has been assistant and associate professor at University of Copen-

hagen (2000-2004), research director for child health at the Danish National Institute for Public Health (2004-2007), Professor of Epidemiology at University of Southern Denmark (2007-2010) and is currently Professor of Social Epidemiology at University of Copenhagen.

Her research group is working with maternal and child health, mainly using epide-miologic approaches but also some health services research. The group finds special interest in the fetal, childhood and long-term health effects of exposures in pregnancy, particularly working conditions, social factors (including maternal and paternal age), infections and health behavior during pregnancy, reproductive immunology, and reproductive conditions among ethnic minorities in Denmark. Furthermore, the group takes an interest in development of epidemiologic methods, register-based research and birth cohort studies. Collaboration between birth cohorts is a key issue and Anne-Marie is founder and web administrator of www.birthcohorts.net.

Anne-Marie has been a board member of Danish Epidemiology Society and European Councillor for International Epidemiological Association. Among other tasks, she is currently in the Danish National Birth Cohort’s Board of Directors and member of the Scientific Advisory Committee for several European birth cohorts.

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KEYNOTE SPEAKERS (CONTINUED)

PhDKasper Lage

FRIDAY 3 JUNE 2016: 11.00 – 12.00 HUMAN BRAIN NETWORKS PERTURBED BY GENETICS AND TARGETED BY THERAPEUTICS IN PSYCHIATRIC DISEASES

Kasper is a Research Leader at the Institute of Biological Psychiatry, Mental Health Centre Sct. Hans and University of Copenhagen. He also serves as Director of Bioinformatics of the Department of Surgery of Massachusetts General Hospital and is an Assistant Professor at Harvard Medical School.

His work revolves around the interpretation of large genomic datasets to identify pathways and networks incriminated in complex diseases. These efforts have led to the identification of specific genes and networks involved in metabolic, reproductive and cardiovascular disorders and he has recently begun applying his analytical frameworks to genetic data from psychiatric diseases. His group has contributed to several technolo-gies, algorithms, and web platforms that are widely used in the genetics communities to interpret genomic data. Examples include the human protein-protein interaction network InWeb, the algorithm DAPPLE, and the Broad Institute Web Platform for Genome Net-works (GeNets). Major pharmaceutical companies such as Merck (US), Pfizer and Biogen have used or licensed the technologies Kasper’s lab has developed for target discovery and validation and he has consulted for or collaborated with several of these companies. In addition, he is currently part of the Leadership Group of the Stanley Center for Psychi-atric Research at the Broad Institute. He has been involved in several biotech startups in bioinformatics and translational genetics that together have raised >24MUSD in funding.

Kasper received his MSc from the University of Copenhagen and his PhD from the Technical University of Denmark. He completed his postdoctoral fellowship at Mas-sachusetts General Hospital, Harvard Medical School and the Broad Institute where he joined the faculty in 2012 and became an Assistant Professor and Director of Bioinfor-matics in 2014. He joined the Institute of Biological Psychiatry Mental Health Centre Sct. Hans and the Leadership Group of the Stanley Center for Psychiatric Research in 2015.

ProfessorAkira Sawa

THURSDAY 2 JUNE 2016: 09.00 – 10.00ABERRANT MATURATION OF THE FRONTAL CORTEX IN ADOLESCENCE: A TRIGGERING MECHANISM FOR PSYCHOSIS

Akira Sawa, MD, PhD is the Director of the Johns Hopkins Schizophrenia Center, Sachiko Kuno and Ryuji Ueno Innovation Chair in Psychiatry, and Professor of Psychiatry, Mental Health, Neuroscience, and Genetic Medicine at the Johns Hopkins University School of Medicine and Bloomberg School of Public Health. Johns Hopkins Schizophrenia

Center aims towards well-balanced academic activities that encompass patient care, research, professional education, and public outreach for better care and cures for major mental conditions, such as psychotic disorders.

Based on Dr. Sawa’s training in both clinical psychiatry and basic molecular neuroscience, his own research programme aims towards translational studies for major mental illnesses, such as schizophrenia and mood disorders, with a particular em-phasis on early detection and early intervention of the pathological conditions. The programme includes comprehensive, multifaceted clinical/translational research on first episode psychosis. This study is designed in a longitudinal manner and combines clinical and neuropsychological characterizations, multiple facets of brain imaging (structural, functional, and molecular imaging), stem cell biology using patient samples, as well as comprehensive molecular and genetic profiling. Furthermore, based on the support of a P50 Silvo O. Conte center grant from National Institute of Mental Heath (NIMH) and related grants, Dr. Sawa runs a collaborative preclinical/translational study on aberrant cortical maturation in adolescence and psychotic disorders. In this project, his team utilizes multiple animal and human cell models and dissects the pathological mechanisms at the molecular level.

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The Old Little Belt Bridge

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Symposium IV: Patterns in course and outcomeThursday 2 June: 15.00 – 16.30

In this symposium, we will focus on illness patterns and outcome. We will present different iPSYCH studies exploring illness course in patients with schizophrenia, depression and bipolar disorder. The first study examined use of antidepressants in the early postpartum period as a potential marker of underlying bipolar disorder. The second study explored, whether depres-sion can configure a prodromal manifestation of psychosis. The third pres-entation targets the comorbidity of diabetes with schizophrenia including medication effects.

Symposium V: Trajectory analyses of health register dataFriday 3 June: 09.00 – 10.30

This symposium will address the topic of how top model multivariate longitudinal diagnoses are obtained from the national health register data. A key advantage of these data is the ability to determine the temporal sequence of diagnoses across multiple diagnostic categories, with respect to both psychiatric outcomes and somatic comorbidities. Moreover, lev-eraging the iPSYCH study design it is possible to make inferences about outcome trajectories that are valid for the entire population of Denmark, i.e., not subject to selection biases. The presenters will discuss three differ-ent methods of constructing such trajectories: sequence analysis, multivariate dynamic survival analyses and discovery-based learning algorithm.

Symposium I: Update of newest GWAS resultsThursday 2 June: 10.30 – 12.00

The latest results from GWAS of ASD, ADHD and cross disorder analysis of ADHD+ASD will be presented as well as the latest results from GWAS of depression, alcohol dependence and bipolar disorder.

GWAS results based on iPSYCH data alone and meta-analyses with PGC data will be shown. SNP heritability estimates, genetic correlations and ad-ditional results from secondary analyses will be presented.

Symposium II: Children at riskThursday 2 June: 13.00 – 14.30

In this symposium we will present the results of different iPSYCH studies of children at risk. We present register-based studies of children born to par-ents with schizophrenia, bipolar disorder and unipolar depression. We will present how often they are placed out of home, with whom they grow up, and which proportion of these children are diagnosed with childhood men-tal disorder and to which degree these children have motor dysfunction.

Symposium III: iPSYCH CNV analysisThursday 2 June: 15.00 – 16.30

This symposium will address the challenges to assessing structural vari-ants in the Danish iPSYCH sample, the proper epidemiological analysis of genetic data leveraging on the population sampling, as well as the insight into risk variants and corresponding biologies linked to predisposition to mental disorders.

ABSTRACTS FOR SYMPOSIUMSAND WORKSHOPS




ABSTRACTS FOR SYMPOSIUMSAND WORKSHOPS (CONTINUED)

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Workshop I: Analysis of exome-sequencing dataWednesday 1 June: 16.45 – 18.00

Preliminary results from analyses of exome-sequencing data will be pre-sented. This will include results from initial analyses of the clinical exome-sequencing of adult ADHD and schizophrenia (single marker, gene-based and CNV analysis). Additionally, preliminary results and challenges with low-coverage whole-genome sequencing will be presented. This workshop will give people working with sequencing data the op-portunity to update each other with the newest results, future plans and discuss common interests. Additionally different analytical approaches and methods as well as potential problems/challenges will be addressed.

Workshop II: Genome-wide analyses on prescription dataThursday 2 June: 13.00 – 14.30

The aims of this workshop are to (1) Discuss methods and procedures nec-essary (e.g., using polygenic risk scores) to make genome-wide analyses possible at Statistics Denmark. (2) Discuss how to construct disease-relevant prescription outcomes using the prescription registry data at Statistics Den-mark (e.g., treatment for infection, side effects treatment). (3) How to com-bine phenotypes from prescription and health register data, e.g. depression as a combination of admission and prescription to anti-depression. We will also discuss strategies for boosting phenotype numbers, and working with complex phenotypes.

ABSTRACTS FOR SYMPOSIUMSAND WORKSHOPS




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THURSDAY 2 JUNE:

10.30 – 12.00 Somatic comorbidity Participants: Christiane Gasse, Ole Köhler, Merete Nordentoft, Michael Benros, Wesley Thompson and Anita Tønder Nielsen

13.00 – 14.30 Inflammation and mental illness Participants: Michael Benros, Preben B Mortensen, Philip Nielsen, Kristin Skogstrand and Wesley Thompson

Population genetics and genealogy studies Participants: Wesley Thompson, Alfonso Buil, Anders Rosengren, Thomas D Als, Jakob Grove and Marcelo Bertalan

15.00 – 16.30 Substance abuse Participants: Merete Nordentoft, Carsten Hjorthøj, Mette Nyegaard and Søren Dalsgaard

Epigentics: Methylome analysis Participants: Shantel Weinsheimer, Anna Starnawska, Nicklas Staunstrup, Christine Søholm-Hansen, Alfonso Buil, Mette Nyegaard and Anders Lade Nielsen

FRIDAY 3 JUNE:

09.00 – 10.30 Cognition, intelligence and school performance Participants: Liselotte Petersen, Esben Agerbo, Gry Poulsen, Alfonso Buil and Merete Nordentoft

WEDNESDAY 1 JUNE:

16.45 – 18.00 Good/bad outcome and treatment non-response Participants: Christiane Gasse, Merete Nordentoft, Wesley Thompson and Carsten Hjorthøj 19.00 – 20.00 Genetic predictors of suicidal behaviour: a GWAS study Participants: Annette Erlangsen, Esben Agerbo, Wesley Thompson and Merete Nordentoft

BUSINESSMEETINGS




BUSINESSMEETINGS

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A Drosophila functional characterization of CNV genes that confer risk of schizophreniaKim Rewitz & Stanislav Nagy

Association between Schizophrenia and Dementia: Does Schizophrenia in Offspring Increase the Risk of Developing Dementia?Christoffer Rohde

Behavioural and transcriptomic changes in the 15q13 homozygous knockout miceAnnika Forsingdal

Cancer Incidence and Mortality after Cancer Diagnosis among Persons with Severe Mental IllnessAnita Tønder-Nielsen

Creating a Brd1 overexpression knock-in mouse for assessing the implication of Brd1 in brain development, cognition and stress resilienceSanne Hage Larsen

Covariance Association Test (CVAT) Identify Genetic Markers Associated with Schizo-phrenia in Functionally Associated Biological ProcessesPalle Duun Rohde

Gene-environmental interactions between genetic variants in antiviral response genes and prenatal maternal infections in schizophreniaVeera Manikandan Rajagopal

Electrophysiological characterisation of 22q11.2 deletion carriers - A translational inves-tigation in humans and miceMichelle Birknow

Molecular Interactions of ZEB1 schizophrenia related geneDesiree Leduc

Neuroproteomic changes in mice with decreased expression of the schizophrenia and bipolar disorder associated Brd1 geneVeerle Paternoster

Risk of epilepsy and autism in full- and half-siblings – a population-based cohort studyJakob Christensen

The Brd1+/- mouse under scrutiny: Understanding the neuro-biological, -chemical and -molecular effect of Brd1 deficiencyPer Qvist

POSTER SESSIONTUESDAY 2 JUNE, 19.30 – 22.00




WHERETrinity Hotel & Konference CenterGl. Færgevej 30DK-7000 FredericiaLocation for the meeting: “the auditorium”

TRANSPORTATION (look for the bus with an i PSYCH logo)Wednesday 1 June

FROM VALBYDeparture from Valby St., Lyshøjgaardsvej, 2500 Valby at 09.00

FROM AARHUSDeparture from Aarhus University, Fuglesangs Allé 4, 8210 Aarhus V. at 10.15

Friday 3 JuneDeparture to Valby and Aarhus at 13.00Expected arrival at Valby St. at 15.30, and Aarhus University at 14.15

CONTACTIf you have any questions please contact project coordinator Annette Bang Rasmussen at:

Mail: [email protected]: +45 2326 6332

PRACTICALINFORMATION

programme i psych annual meeting 1 – 3 j une 2016€¦ · 1-3 june 2016 dear i psych employee or...

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